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| ASPARAGINE HYDROXYLATION OF THE HIF TRANSACTIVATION DOMAIN: A HYPOXIC SWITCH
LANDO D; PEET DJ; WHELAN DA; GORMAN JJ; WHITELAW ML SCIENCE 295:(5556)858-861 FEB 1 2002 and the citing papers |
Nodes: 199
Authors: 610,
Journals: 112,
Outer References: 6717
Collection span: 2002 - 2004
View: Overview. Sorted by journal name.
Page 2: 1 (AMERICAN JOURNAL OF NEPHROLOGY) 2 (JOURNAL OF BIOLOGICAL CHEMISTRY)
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
|---|---|---|---|---|---|
| 101 | 1 | 80 | 18 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(33):29936-29944 Isaacs JS; Jung YJ; Mimnaugh EG; Martinez A; Cuttitta F; Neckers LM Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway | 19 | 53 |
| 102 | 1 | 19 | 19 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(36):32405-32408 Makino Y; Kanopka A; Wilson WJ; Tanaka H; Poellinger L Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus | 19 | 33 |
| 103 | 4 | 47 | 20 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38723-38730 Ruas JL; Poellinger L; Pereira T Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation - identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein | 9 | 10 |
| 104 | 2 | 24 | 21 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):40112-40117 Chan DA; Sutphin PD; Denko NC; Giaccia AJ Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha | 17 | 31 |
| 105 | 5 | 53 | 22 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755 Huang LE; Pete EA; Schau M; Milligan J; Gu J Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 4 | 7 |
| 106 | 3 | 37 | 96 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):6816-6823 Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor gene product | 3 | 8 |
| 107 | 4 | 39 | 97 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):7558-7563 Lee C; Kim SJ; Jeong DG; Lee SM; Ryu SE Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau | 10 | 14 |
| 108 | 5 | 55 | 98 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(16):14013-14019 Sang NL; Stiehl DP; Bohensky J; Leshchinsky I; Srinivas V; Caro J MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300 | 6 | 20 |
| 109 | 1 | 23 | 99 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(18):15911-15916 Yuan Y; Hilliard G; Ferguson T; Millhorn DE Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha | 3 | 19 |
| 110 | 9 | 79 | 100 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19575-19578 Huang LE; Bunn HF Hypoxia-inducible factor and its biomedical relevance | 9 | 21 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 111 | 1 | 34 | 101 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20235-20239 Wright G; Higgin JJ; Raines RT; Steenbergen C; Murphy E Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes | 2 | 3 |
| 112 | 1 | 59 | 102 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(25):22316-22324 Del Toro R; Levitsky KL; Lopez-Barneo J; Chiara MD Induction of T-type calcium channel gene expression by chronic hypoxia | 0 | 5 |
| 113 | 4 | 30 | 103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30772-30780 Hirsila M; Koivunen P; Gunzler V; Kivirikko KI; Myllyharju J Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor | 8 | 20 |
| 114 | 4 | 36 | 104 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(34):31895-31901 Naranjo-Suarez S; Castellanos MC; Alvarez-Tejado M; Vara A; Landazuri MO; del Peso L Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation | 0 | 2 |
| 115 | 1 | 58 | 105 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33384-33391 Kodama T; Shimizu N; Yoshikawa N; Makino Y; Ouchida R; Okamoto K; Hisada T; Nakamura H; Morimoto C; Tanaka H Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression | 0 | 0 |
| 116 | 1 | 63 | 106 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(38):35878-35888 Lees MJ; Peet DJ; Whitelaw ML Defining the role for XAP2 in stabilization of the dioxin receptor | 0 | 2 |
| 117 | 3 | 51 | 107 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40296-40304 Leonard MO; Cottell DC; Godson C; Brady HR; Taylor CT The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia | 0 | 3 |
| 118 | 5 | 32 | 178 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(4):3042-3049 De Guzman RN; Martinez-Yamout MA; Dyson HJ; Wright PE Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2 - Regulation by competition between intrinsically unstructured ligands for non-identical binding sites | 0 | 0 |
| 119 | 9 | 31 | 179 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(11):9899-9904 Koivunen P; Hirsila M; Gunzler V; Kivirikko KI; Myllyharju J Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | 1 | 1 |
| 120 | 5 | 41 | 180 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):13506-13513 Zhou J; Schmid T; Frank R; Brune B PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1 alpha from pVHL-independent degradation | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 121 | 10 | 35 | 181 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):14391-14397 Linke S; Stojkoski C; Kewley RJ; Booker GW; Whitelaw ML; Peet DJ Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor | 2 | 2 |
| 122 | 4 | 42 | 108 2003 JOURNAL OF CELL SCIENCE 116(7):1319-1326 Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Burgel T; Jelkmann W; Acker H; Fandrey J Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing | 9 | 22 |
| 123 | 1 | 49 | 109 2003 JOURNAL OF CELL SCIENCE 116(11):2247-2260 Turcotte S; Desrosiers RR; Beliveau R HIF-1 alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma | 2 | 5 |
| 124 | 17 | 97 | 110 2003 JOURNAL OF CELL SCIENCE 116(15):3041-3049 Masson N; Ratcliffe PJ HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O-2 levels | 2 | 8 |
| 125 | 10 | 42 | 182 2004 JOURNAL OF CELLULAR BIOCHEMISTRY 92(3):491-501 Aprelikova O; Chandramouli GVR; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors | 0 | 0 |
| 126 | 1 | 50 | 111 2003 JOURNAL OF CLINICAL INVESTIGATION 111(5):571-574 Soberman RJ The expanding network of redox signaling: new observations, complexities, and perspectives | 0 | 8 |
| 127 | 6 | 75 | 112 2003 JOURNAL OF CLINICAL INVESTIGATION 111(6):779-783 Safran M; Kaelin WG HIF hydroxylation and the mammalian oxygen-sensing pathway | 1 | 23 |
| 128 | 1 | 70 | 113 2003 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 26(9):832-837 Jelkmann W Erythropoietin | 0 | 0 |
| 129 | 1 | 59 | 23 2002 JOURNAL OF EXPERIMENTAL BIOLOGY 205(23):3579-3586 Bickler PE; Donohoe PH Adaptive responses of vertebrate neurons to hypoxia | 0 | 7 |
| 130 | 1 | 50 | 24 2002 JOURNAL OF EXPERIMENTAL ZOOLOGY 294(1):17-29 Powell WH; Hahn ME Identification and functional characterization of hypoxia-inducible factor 2 alpha from the estuarine teleost, Fundulus heteroclitus: Interaction of HIF-2 alpha with two ARNT2 splice variants | 0 | 2 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 131 | 1 | 46 | 114 2003 JOURNAL OF IMMUNOLOGY 171(12):6534-6540 Makino Y; Nakamura H; Ikeda E; Ohnuma K; Yamauchi K; Yabe Y; Poellinger L; Okada Y; Morimoto C; Tanaka H Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells | 0 | 0 |
| 132 | 1 | 183 | 25 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(9):562-575 Acker T; Plate KH A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology | 2 | 9 |
| 133 | 1 | 120 | 26 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(11):703-714 Kim KR; Moon HE; Kim KW Hypoxia-induced angiogenesis in human hepatocellular carcinoma | 0 | 1 |
| 134 | 3 | 88 | 183 2004 JOURNAL OF NEUROSURGERY 100(3):488-497 Jensen RL; Gillespie D; House P; Layfield L; Shelton C Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1 alpha expression | 0 | 0 |
| 135 | 7 | 74 | 184 2004 JOURNAL OF PHARMACOLOGICAL SCIENCES 94(3):221-232 Park JW; Chun YS; Kim NS Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools | 0 | 0 |
| 136 | 1 | 18 | 115 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(16):4710-4711 Kinzie SD; Thevis M; Ngo K; Whitelegge J; Loo JA; Abu-Omar MM Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron | 0 | 2 |
| 137 | 2 | 107 | 116 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(26):7828-7842 Mehn MP; Fujisawa K; Hegg EL; Que L Oxygen activation by nonheme iron(II) complexes: alpha-keto carboxylate versus carboxylate | 1 | 10 |
| 138 | 11 | 104 | 117 2003 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14(11):2712-2722 Maxwell P HIF-1: An oxygen response system with special relevance to the kidney | 2 | 2 |
| 139 | 1 | 111 | 27 2002 MASS SPECTROMETRY REVIEWS 21(3):183-216 Gorman JJ; Wallis TP; Pitt JJ Protein disulfide bond determination by mass spectrometry | 0 | 8 |
| 140 | 2 | 188 | 28 2002 MASS SPECTROMETRY REVIEWS 21(5):305-348 Rusconi F; Guillonneau F; Praseuth D Contributions of mass spectrometry in the study of nucleic acid-binding proteins and of nucleic acid-protein interactions | 0 | 3 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 141 | 1 | 57 | 29 2002 METHODS 28(2):259-266 Tang Y; Schmitt-Ott K; Qian KP; Kagiyama S; Phillips MI Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases | 1 | 3 |
| 142 | 1 | 57 | 30 2002 MOLECULAR AND CELLULAR BIOLOGY 22(19):6842-6853 Lavista-Llanos S; Centanin L; Irisarri M; Russo DM; Gleadle JM; Bocca SN; Muzzopappa M; Ratcliffe PJ; Wappner P Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar | 11 | 23 |
| 143 | 2 | 52 | 31 2002 MOLECULAR AND CELLULAR BIOLOGY 22(20):7004-7014 Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin | 6 | 41 |
| 144 | 1 | 42 | 118 2003 MOLECULAR AND CELLULAR BIOLOGY 23(1):359-369 Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia | 6 | 24 |
| 145 | 4 | 49 | 119 2003 MOLECULAR AND CELLULAR BIOLOGY 23(14):4959-4971 Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha | 5 | 14 |
| 146 | 2 | 41 | 120 2003 MOLECULAR AND CELLULAR BIOLOGY 23(19):6739-6749 Tomita S; Ueno M; Sakamoto M; Kitahama Y; Ueki M; Maekawa N; Sakamoto H; Gassmann M; Kageyama R; Ueda N; Gonzalez FJ; Takahama Y Defective brain development in mice lacking the Hif-1 alpha gene in neural cells | 3 | 4 |
| 147 | 5 | 111 | 121 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374 Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation | 1 | 6 |
| 148 | 2 | 35 | 122 2003 MOLECULAR BIOLOGY OF THE CELL 14(6):2216-2225 Zhou J; Schmid T; Brune B Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1 alpha through a nuclear factor-kappa B-dependent pathway | 3 | 4 |
| 149 | 6 | 59 | 123 2003 MOLECULAR BIOLOGY OF THE CELL 14(8):3470-3481 Metzen E; Zhou J; Jelkmann W; Fandrey J; Brune B Nitric oxide impairs normoxic degradation of HIF-1 alpha by inhibition of prolyl hydroxylases | 6 | 13 |
| 150 | 3 | 40 | 185 2004 MOLECULAR CANCER RESEARCH 2(1):43-52 Qi H; Gervais ML; Li W; DeCaprio JA; Challis JRG; Ohh M Molecular cloning and characterization of the von Hippel-Lindau-like protein | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 151 | 3 | 74 | 124 2003 MOLECULAR CANCER THERAPEUTICS 2(3):235-243 Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation | 4 | 12 |
| 152 | 2 | 34 | 125 2003 MOLECULAR PHARMACOLOGY 64(6):1485-1493 Davidson T; Salnikow K; Costa M Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel | 0 | 0 |
| 153 | 1 | 39 | 32 2002 MOLECULES AND CELLS 14(1):9-15 Lee E; Yim S; Lee SK; Park H Two transactivation domains of hypoxia-inducible factor-1 alpha regulated by the MEK-1/p42/p44 MAPK pathway | 0 | 3 |
| 154 | 8 | 56 | 126 2003 MOLECULES AND CELLS 16(1):1-12 Freeman RS; Hasbani DM; Lipscomb EA; Straub JA; Xie L SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases | 0 | 1 |
| 155 | 8 | 115 | 127 2003 NATURE MEDICINE 9(6):677-684 Pugh CW; Ratcliffe PJ Regulation of angiogenesis by hypoxia: role of the HIF system | 10 | 66 |
| 156 | 5 | 144 | 33 2002 NATURE REVIEWS CANCER 2(9):673-682 Kaelin WG Molecular basis of the VHL hereditary cancer syndrome | 11 | 59 |
| 157 | 11 | 107 | 128 2003 NATURE REVIEWS CANCER 3(10):721-732 Semenza GL Targeting HIF-1 for cancer therapy | 6 | 47 |
| 158 | 5 | 168 | 186 2004 NATURE REVIEWS CANCER 4(5):381-393 Pavlovich CP; Schmidt LS Searching for the hereditary causes of renal-cell carcinoma | 0 | 0 |
| 159 | 11 | 116 | 129 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811 Giaccia A; Siim BG; Johnson RS HIF-1 as a target for drug development | 2 | 15 |
| 160 | 22 | 108 | 187 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5(5):343-354 Schofield CJ; Ratcliffe PJ Oxygen sensing by HIF hydroxylases | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 161 | 14 | 190 | 188 2004 NATURE REVIEWS NEUROSCIENCE 5(6):437-448 Sharp FR; Bernaudin M HIf1 and oxygen sensing in the brain | 0 | 0 |
| 162 | 8 | 48 | 130 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512 Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2 | 2 | 6 |
| 163 | 1 | 40 | 131 2003 NEOPLASMA 50(1):13-21 Chrastina A; Pastorekova S; Pastorek J Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by I-125-labeled M75 monoclonal antibody | 0 | 2 |
| 164 | 2 | 23 | 189 2004 ONCOGENE 23(13):2315-2323 Lewis MD; Roberts BJ Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity | 0 | 0 |
| 165 | 1 | 27 | 190 2004 OXYGEN SENSING 381:133-+ Roy S; Khanna S; Sen CK Perceived hyperoxia: Oxygen-regulated signal transduction pathways in the heart | 0 | 0 |
| 166 | 4 | 27 | 191 2004 OXYGEN SENSING 381:305-320 Masson N; Ratcliffe PJ Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing | 0 | 0 |
| 167 | 3 | 34 | 192 2004 OXYGEN SENSING 381:467-487 Peet DJ; Lando D; Whelan DA; Whitelaw ML; Gorman JJ Oxygen-dependent asparagine hydroxylation | 0 | 0 |
| 168 | 1 | 45 | 193 2004 PEDIATRIC RESEARCH 55(3):385-394 Wang XH; Deng JX; Boyle DW; Zhong J; Lee WH Potential role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: Activation of hypoxia-inducible factor 1 alpha | 0 | 0 |
| 169 | 1 | 55 | 132 2003 PLACENTA 24(2-3):199-208 Rajakumar A; Doty K; Daftary A; Harger G; Conrad KP Impaired oxygen-dependent reduction of HIF-1 alpha and -2 alpha proteins in pre-eclamptic placentae | 4 | 7 |
| 170 | 4 | 57 | 133 2003 PLACENTA 24(10):941-950 Schaffer L; Scheid A; Spielmann P; Breymann C; Zimmermann R; Meuli M; Gassmann M; Marti HH; Wenger RH Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation | 1 | 2 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 171 | 1 | 45 | 34 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5271-5276 Dames SA; Martinez-Yamout M; De Guzman RN; Dyson HJ; Wright PE Structural basis for Hif-1 alpha/CBP recognition in the cellular hypoxic response | 31 | 45 |
| 172 | 1 | 42 | 35 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5367-5372 Freedman SJ; Sun ZYJ; Poy F; Kung AL; Livingston DM; Wagner G; Eck MJ Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha | 35 | 58 |
| 173 | 1 | 70 | 36 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(14):9480-9485 Su H; Arakawa-Hoyt J; Kan YW Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model | 1 | 13 |
| 174 | 1 | 29 | 37 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(16):10423-10428 Willam C; Masson N; Tian YM; Mahmood SA; Wilson MI; Bicknell R; Eckardt KU; Maxwell PH; Ratcliffe PJ; Pugh CW Peptide blockade of HIF alpha degradation modulates cellular metabolism and angiogenesis | 16 | 25 |
| 175 | 3 | 38 | 38 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11570-11572 Semenza GL Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP | 3 | 5 |
| 176 | 2 | 39 | 39 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(21):13459-13464 Ivan M; Haberberger T; Gervasi DC; Michelson KS; Gunzler V; Kondo K; Yang HF; Sorokina I; Conaway RC; Conaway JW; Kaelin WG Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor | 25 | 48 |
| 177 | 2 | 42 | 40 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15351-15356 Dann CE; Bruick RK; Deisenhofer J Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | 20 | 27 |
| 178 | 1 | 40 | 194 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(12):4302-4307 Liu Q; Berchner-Pfannschmidt U; Moller U; Brecht M; Wotzlaw C; Acker H; Jungermann K; Kietzmann T A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression | 2 | 2 |
| 179 | 2 | 58 | 195 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(28):10440-10445 Kong TQ; Eltzschig HK; Karhausen J; Colgan SP; Shelley CS Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of beta 2 integrin gene expression | 0 | 0 |
| 180 | 1 | 21 | 134 2003 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 17(5):371-376 Hirota J; Satomi Y; Yoshikawa K; Takao T epsilon-N,N,N-Trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry | 0 | 2 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 181 | 2 | 97 | 135 2003 REDOX REPORT 8(6):325-340 Land SC Oxygen-sensing pathways and the development of mammalian gas exchange | 0 | 0 |
| 182 | 3 | 27 | 196 2004 RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 141(2):115-123 Roy A; Li JQ; Baby SM; Mokashi A; Buerk DG; Lahiri S Effects of iron-chelators on ion-channels and HIF-1 alpha in the carotid body | 0 | 0 |
| 183 | 2 | 191 | 41 2002 RESPIRATORY RESEARCH 3(1) Haddad JJ Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology | 0 | 6 |
| 184 | 1 | 16 | 42 2002 SCIENCE 295(5556):807-808 Bruick RK; McKnight SL Transcription - Oxygen sensing gets a second wind | 14 | 28 |
| 185 | 0 | 28 | 43 2002 SCIENCE 295(5556):858-861 Lando D; Peet DJ; Whelan DA; Gorman JJ; Whitelaw ML Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch | 198 | 198 |
| 186 | 3 | 5 | 44 2002 SCIENTIST 16(14):40-40 Maher BA Faculty of 1000 - Hypoxic response takes shape | 1 | 1 |
| 187 | 2 | 14 | 136 2003 SCIENTIST 17(8):34-35 Russo E Discovering HIF regulation | 0 | 0 |
| 188 | 4 | 56 | 137 2003 SEIKAGAKU 75(7):577-587 Tomita T; Saito MI Recent progress in biochemical studies of hemoprotein | 0 | 0 |
| 189 | 2 | 78 | 138 2003 SEMINARS IN CANCER BIOLOGY 13(1):83-89 Pugh CW; Ratcliffe PJ The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis | 3 | 21 |
| 190 | 2 | 107 | 197 2004 SEMINARS IN CANCER BIOLOGY 14(2):123-130 Mukhopadhyay D; Datta K Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 191 | 2 | 82 | 139 2003 STRAHLENTHERAPIE UND ONKOLOGIE 179(12):801-811 Vordermark D; Brown JM Endogenous markers of tumor hypoxia - Predictors of clinical radiation resistance? | 0 | 2 |
| 192 | 1 | 22 | 198 2004 THORAX 59(2):90-92 Walmsley SR; Sheares KKK; Sobolewski A; Morrell NW; Chilvers ER New insights into oxygen sensing at a cellular level | 0 | 0 |
| 193 | 1 | 53 | 140 2003 THROMBOSIS AND HAEMOSTASIS 89(4):666-673 Kietzmann T; Jungermann K; Gorlach A Regulation of the hypoxia-dependent plasminogen activator inhibitor I expression by MAP kinases | 0 | 4 |
| 194 | 2 | 72 | 141 2003 TOR-TARGET OF RAPAMYCIN 279:299-319 Abraham RT MTOR as a positive regulator of tumor cell responses to hypoxia | 0 | 0 |
| 195 | 1 | 16 | 199 2004 TOXICOLOGY AND APPLIED PHARMACOLOGY 196(3):404-409 Zhao JH; Chen HB; Davidson T; Kluz T; Zhang QW; Costa M Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway | 0 | 0 |
| 196 | 2 | 59 | 45 2002 TRENDS IN CARDIOVASCULAR MEDICINE 12(8):362-367 Vincent KA; Feron O; Kelly RA Harnessing the response to tissue hypoxia - HIF-1 alpha and therapeutic angiogenesis | 1 | 3 |
| 197 | 2 | 55 | 142 2003 TRENDS IN ENDOCRINOLOGY AND METABOLISM 14(10):453-459 Baysal BE On the association of succinate dehydrogenase mutations with hereditary paraganglioma | 0 | 1 |
| 198 | 1 | 37 | 46 2002 TRENDS IN MOLECULAR MEDICINE 8(4):S62-S67 Semenza GL HIF-1 and tumor progression: pathophysiology and therapeutics | 0 | 79 |
| 199 | 1 | 78 | 47 2002 TRENDS IN PHARMACOLOGICAL SCIENCES 23(12):576-582 Bikfalvi A; Bicknell R Recent advances in angiogenesis, anti-angiogenesis and vascular targeting | 0 | 19 |
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