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| ASPARAGINE HYDROXYLATION OF THE HIF TRANSACTIVATION DOMAIN: A HYPOXIC SWITCH
LANDO D; PEET DJ; WHELAN DA; GORMAN JJ; WHITELAW ML SCIENCE 295:(5556)858-861 FEB 1 2002 and the citing papers |
Nodes: 199
Authors: 610,
Journals: 112,
Outer References: 6717
Collection span: 2002 - 2004
View: Overview. Sorted by LCR.
Page 1: 1 (24) 2 (2)
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 24 | 185 | 169 2004 EXPERT OPINION ON THERAPEUTIC PATENTS 14(7):951-966 Zhong H Targeting hypoxia-inducible factor-1 for therapy and prevention | 0 | 0 |
| 2 | 22 | 108 | 187 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5(5):343-354 Schofield CJ; Ratcliffe PJ Oxygen sensing by HIF hydroxylases | 0 | 0 |
| 3 | 21 | 90 | 156 2004 BIOLOGICAL CHEMISTRY 385(3-4):223-230 Metzen E; Ratcliffe PJ HIF hydroxylation and cellular oxygen sensing | 0 | 0 |
| 4 | 21 | 144 | 165 2004 CURRENT PHARMACEUTICAL DESIGN 10(8):821-833 Hewitson KS; McNeill LA; Schofield CJ Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer | 0 | 1 |
| 5 | 19 | 89 | 91 2003 GENES & DEVELOPMENT 17(21):2614-2623 Bruick RK Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor | 3 | 12 |
| 6 | 18 | 268 | 145 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(4):R608-R623 Hopfl G; Ogunshola O; Gassmann M HIFs and tumors - causes and consequences | 0 | 4 |
| 7 | 17 | 97 | 110 2003 JOURNAL OF CELL SCIENCE 116(15):3041-3049 Masson N; Ratcliffe PJ HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O-2 levels | 2 | 8 |
| 8 | 14 | 190 | 188 2004 NATURE REVIEWS NEUROSCIENCE 5(6):437-448 Sharp FR; Bernaudin M HIf1 and oxygen sensing in the brain | 0 | 0 |
| 9 | 11 | 260 | 67 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(7):1376-1393 Bracken CP; Whitelaw ML; Peet DJ The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses | 2 | 4 |
| 10 | 11 | 104 | 117 2003 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14(11):2712-2722 Maxwell P HIF-1: An oxygen response system with special relevance to the kidney | 2 | 2 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 11 | 11 | 107 | 128 2003 NATURE REVIEWS CANCER 3(10):721-732 Semenza GL Targeting HIF-1 for cancer therapy | 6 | 47 |
| 12 | 11 | 116 | 129 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811 Giaccia A; Siim BG; Johnson RS HIF-1 as a target for drug development | 2 | 15 |
| 13 | 11 | 43 | 170 2004 FASEB JOURNAL 18(6) Kageyama Y; Koshiji M; To KKW; Tian YM; Ratcliffe PJ; Huang LE Leu-574 of human HIF-1a is a molecular determinant of prolyl hydroxylation | 0 | 0 |
| 14 | 10 | 62 | 77 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(6):650-656 Binley K; Kan O; White J; Naylor S Exploiting the hypoxia response | 0 | 1 |
| 15 | 10 | 123 | 167 2004 EXPERIMENTAL AND MOLECULAR MEDICINE 36(1):1-12 Lee JW; Bae SH; Jeong JW; Kim SH; Kim KW Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions | 0 | 0 |
| 16 | 10 | 35 | 181 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):14391-14397 Linke S; Stojkoski C; Kewley RJ; Booker GW; Whitelaw ML; Peet DJ Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor | 2 | 2 |
| 17 | 10 | 42 | 182 2004 JOURNAL OF CELLULAR BIOCHEMISTRY 92(3):491-501 Aprelikova O; Chandramouli GVR; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors | 0 | 0 |
| 18 | 9 | 79 | 100 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19575-19578 Huang LE; Bunn HF Hypoxia-inducible factor and its biomedical relevance | 9 | 21 |
| 19 | 9 | 84 | 155 2004 BIOESSAYS 26(3):262-269 Bardos JI; Athcroft M Hypoxia-inducible factor-1 and oncogenic signalling | 0 | 0 |
| 20 | 9 | 31 | 179 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(11):9899-9904 Koivunen P; Hirsila M; Gunzler V; Kivirikko KI; Myllyharju J Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | 1 | 1 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 21 | 8 | 71 | 56 2003 BIOCHEMICAL SOCIETY TRANSACTIONS 31:510-515 Hewitson KS; McNeill LA; Elkins JM; Schofield CJ The role of iron and 2-oxoglutarate oxygenases in signalling | 2 | 4 |
| 22 | 8 | 60 | 76 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(1):55-60 Kim W; Kaelin WG The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer | 2 | 11 |
| 23 | 8 | 56 | 126 2003 MOLECULES AND CELLS 16(1):1-12 Freeman RS; Hasbani DM; Lipscomb EA; Straub JA; Xie L SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases | 0 | 1 |
| 24 | 8 | 115 | 127 2003 NATURE MEDICINE 9(6):677-684 Pugh CW; Ratcliffe PJ Regulation of angiogenesis by hypoxia: role of the HIF system | 10 | 66 |
| 25 | 8 | 48 | 130 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512 Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2 | 2 | 6 |
| 26 | 8 | 165 | 146 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(6):R977-R988 Fandrey J Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression | 0 | 0 |
| 27 | 8 | 40 | 161 2004 CELL CYCLE 3(2):156-159 Maxwell PH HIF-1's relationship to oxygen - Simple yet sophisticated | 0 | 1 |
| 28 | 8 | 340 | 163 2004 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 39(1):21-68 Hausinger RP Fe(II)/alpha-ketoglutarate-dependent hydroxylases and related enzymes | 0 | 0 |
| 29 | 8 | 45 | 164 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14(1):81-85 Poellinger L; Johnson RS HIF-1 and hypoxic response: the plot thickens | 0 | 0 |
| 30 | 7 | 146 | 74 2003 CURRENT MEDICINAL CHEMISTRY 10(12):1005-1019 Hanauske-Abel HM; Popowicz AM The HAG mechanism: A molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 31 | 7 | 49 | 80 2003 EMBO JOURNAL 22(16):4082-4090 Berra E; Benizri E; Ginouves A; Volmat V; Roux D; Pouyssegur J HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 alpha in normoxia | 10 | 25 |
| 32 | 7 | 121 | 81 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):781-790 Lando D; Gorman JJ; Whitelaw ML; Peet DJ Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation | 9 | 16 |
| 33 | 7 | 174 | 166 2004 DRUG RESISTANCE UPDATES 7(1):25-40 Wouters BG; van den Beucken T; Magagnin MG; Lambin P; Koumenis C Targeting hypoxia tolerance in cancer | 0 | 0 |
| 34 | 7 | 74 | 184 2004 JOURNAL OF PHARMACOLOGICAL SCIENCES 94(3):221-232 Park JW; Chun YS; Kim NS Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools | 0 | 0 |
| 35 | 6 | 71 | 50 2003 ANNALS OF MEDICINE 35(3):183-190 Wiesener MS; Maxwell PH HIF and oxygen sensing; as important to life as the air we breathe? | 1 | 6 |
| 36 | 6 | 59 | 53 2003 ANTIOXIDANTS & REDOX SIGNALING 5(4):467-473 Goda N; Dozier SJ; Johnson RS HIF-1 in cell cycle regulation, apoptosis, and tumor progression | 0 | 2 |
| 37 | 6 | 75 | 112 2003 JOURNAL OF CLINICAL INVESTIGATION 111(6):779-783 Safran M; Kaelin WG HIF hydroxylation and the mammalian oxygen-sensing pathway | 1 | 23 |
| 38 | 6 | 59 | 123 2003 MOLECULAR BIOLOGY OF THE CELL 14(8):3470-3481 Metzen E; Zhou J; Jelkmann W; Fandrey J; Brune B Nitric oxide impairs normoxic degradation of HIF-1 alpha by inhibition of prolyl hydroxylases | 6 | 13 |
| 39 | 6 | 135 | 151 2004 ARTHRITIS AND RHEUMATISM 50(1):10-23 Distler JHW; Wenger RH; Gassmann M; Kurowska M; Hirth A; Gay S; Distler O Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis | 0 | 1 |
| 40 | 5 | 53 | 22 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755 Huang LE; Pete EA; Schau M; Milligan J; Gu J Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 4 | 7 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 41 | 5 | 144 | 33 2002 NATURE REVIEWS CANCER 2(9):673-682 Kaelin WG Molecular basis of the VHL hereditary cancer syndrome | 11 | 59 |
| 42 | 5 | 109 | 51 2003 ANNALS OF MEDICINE 35(6):380-390 Pugh CW Oxygen sensing in cancer | 0 | 0 |
| 43 | 5 | 44 | 57 2003 BIOCHEMISTRY 42(33):9937-9945 Dial R; Sun ZYJ; Freedman SJ Three conformational states of the p300 CH1 domain define its functional properties | 0 | 1 |
| 44 | 5 | 135 | 65 2003 CELL AND TISSUE RESEARCH 314(1):145-155 Acker T; Plate KH Role of hypoxia in tumor angiogenesis - molecular and cellular angiogenic crosstalk | 0 | 0 |
| 45 | 5 | 167 | 93 2003 HYPOXIA: THROUGH THE LIFECYCLE 543:89-115 Hopfl G; Ogunshola O; Gassmann M Hypoxia and high altitude - The molecular response | 0 | 1 |
| 46 | 5 | 55 | 98 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(16):14013-14019 Sang NL; Stiehl DP; Bohensky J; Leshchinsky I; Srinivas V; Caro J MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300 | 6 | 20 |
| 47 | 5 | 111 | 121 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374 Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation | 1 | 6 |
| 48 | 5 | 44 | 171 2004 FASEB JOURNAL 18(10) Warnecke C; Zaborowska Z; Kurreck J; Erdmann VA; Frei U; Wiesener M; Eckardt KU Differentiating the functional role of hypoxia-inducible factor (HIF)-1 alpha and HIF-2 alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2 alpha target gene in Hep3B and Kelly cells | 0 | 0 |
| 49 | 5 | 32 | 178 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(4):3042-3049 De Guzman RN; Martinez-Yamout MA; Dyson HJ; Wright PE Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2 - Regulation by competition between intrinsically unstructured ligands for non-identical binding sites | 0 | 0 |
| 50 | 5 | 41 | 180 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(14):13506-13513 Zhou J; Schmid T; Frank R; Brune B PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1 alpha from pVHL-independent degradation | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 51 | 5 | 168 | 186 2004 NATURE REVIEWS CANCER 4(5):381-393 Pavlovich CP; Schmidt LS Searching for the hereditary causes of renal-cell carcinoma | 0 | 0 |
| 52 | 4 | 31 | 2 2002 BIOCHEMICAL JOURNAL 367:571-575 McNeill LA; Hewitson KS; Claridge TD; Seibel JF; Horsfall LE; Schofield CJ Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 | 17 | 22 |
| 53 | 4 | 47 | 20 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38723-38730 Ruas JL; Poellinger L; Pereira T Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation - identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein | 9 | 10 |
| 54 | 4 | 23 | 54 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303(3):947-953 Cioffi CL; Liu XQ; Kosinski PA; Garay M; Bowen BR Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells | 8 | 16 |
| 55 | 4 | 29 | 61 2003 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13(16):2677-2680 Mole DR; Schlemminger I; McNeill LA; Hewitson KS; Pugh CW; Ratcliffe PJ; Schofield CJ 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase | 3 | 3 |
| 56 | 4 | 181 | 75 2003 CURRENT MEDICINAL CHEMISTRY 10(22):2461-2470 Shiao YH The von Hippel-Lindau gene and protein in tumorigenesis and angiogenesis: A potential target for therapeutic designs | 0 | 1 |
| 57 | 4 | 69 | 82 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):791-798 Bilton RL; Booker GW The subtle side to hypoxia inducible factor (HIF alpha) regulation | 5 | 11 |
| 58 | 4 | 99 | 95 2003 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 36(1):120-127 Choi KS; Bae MK; Jeong JW; Moon HE; Kim KW Hypoxia-induced angiogenesis during carcinogenesis | 0 | 6 |
| 59 | 4 | 39 | 97 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):7558-7563 Lee C; Kim SJ; Jeong DG; Lee SM; Ryu SE Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau | 10 | 14 |
| 60 | 4 | 30 | 103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30772-30780 Hirsila M; Koivunen P; Gunzler V; Kivirikko KI; Myllyharju J Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor | 8 | 20 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 61 | 4 | 36 | 104 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(34):31895-31901 Naranjo-Suarez S; Castellanos MC; Alvarez-Tejado M; Vara A; Landazuri MO; del Peso L Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation | 0 | 2 |
| 62 | 4 | 42 | 108 2003 JOURNAL OF CELL SCIENCE 116(7):1319-1326 Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Burgel T; Jelkmann W; Acker H; Fandrey J Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing | 9 | 22 |
| 63 | 4 | 49 | 119 2003 MOLECULAR AND CELLULAR BIOLOGY 23(14):4959-4971 Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha | 5 | 14 |
| 64 | 4 | 57 | 133 2003 PLACENTA 24(10):941-950 Schaffer L; Scheid A; Spielmann P; Breymann C; Zimmermann R; Meuli M; Gassmann M; Marti HH; Wenger RH Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation | 1 | 2 |
| 65 | 4 | 56 | 137 2003 SEIKAGAKU 75(7):577-587 Tomita T; Saito MI Recent progress in biochemical studies of hemoprotein | 0 | 0 |
| 66 | 4 | 152 | 143 2004 AMERICAN JOURNAL OF NEPHROLOGY 24(1):1-13 Maynard MA; Ohh M von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer | 0 | 0 |
| 67 | 4 | 62 | 144 2004 AMERICAN JOURNAL OF PATHOLOGY 164(6):1875-1882 Michiels C Physiological and pathological responses to hypoxia | 0 | 0 |
| 68 | 4 | 89 | 149 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 287(1):F1-F6 Sufan RI; Jewett MAS; Ohh M The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma | 0 | 0 |
| 69 | 4 | 131 | 150 2004 ANTIOXIDANTS & REDOX SIGNALING 6(1):155-167 Asikainen TM; White CW Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: Implications for antioxidant therapy | 0 | 1 |
| 70 | 4 | 114 | 160 2004 CARDIOVASCULAR RESEARCH 62(1):43-52 Martinez-Ruiz A; Lamas S S-nitrosylation: a potential new paradigm in signal transduction | 0 | 1 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 71 | 4 | 513 | 162 2004 CHEMICAL REVIEWS 104(2):939-986 Costas M; Mehn MP; Jensen MP; Que L Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates | 0 | 5 |
| 72 | 4 | 27 | 191 2004 OXYGEN SENSING 381:305-320 Masson N; Ratcliffe PJ Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing | 0 | 0 |
| 73 | 3 | 41 | 13 2002 GENES & DEVELOPMENT 16(12):1441-1445 Kaelin WG How oxygen makes its presence felt | 8 | 31 |
| 74 | 3 | 32 | 17 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26351-26355 Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | 61 | 81 |
| 75 | 3 | 38 | 38 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11570-11572 Semenza GL Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP | 3 | 5 |
| 76 | 3 | 5 | 44 2002 SCIENTIST 16(14):40-40 Maher BA Faculty of 1000 - Hypoxic response takes shape | 1 | 1 |
| 77 | 3 | 33 | 55 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 312(3):571-577 Hanze J; Eul BG; Savai R; Krick S; Goyal P; Grimminger F; Seeger W; Rose F RNA interference for HIF-1 alpha inhibits its downstream signalling and affects cellular proliferation | 2 | 3 |
| 78 | 3 | 31 | 60 2003 BIOESSAYS 25(5):515-519 Hochachka PW; Rupert JL Fine tuning the HIF-1 'global' O-2 sensor for hypobaric hypoxia in Andean high-altitude natives | 0 | 1 |
| 79 | 3 | 118 | 66 2003 CELLULAR AND MOLECULAR BIOLOGY 49(1):77-87 Karhausen J; Ibla JC; Colgan SP Implications of hypoxia on mucosal barrier function | 1 | 1 |
| 80 | 3 | 81 | 73 2003 CURRENT MEDICINAL CHEMISTRY 10(10):845-855 Brune B; Zhou J The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1 alpha (HIF-1 alpha) | 1 | 4 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 81 | 3 | 45 | 84 2003 FASEB JOURNAL 17(6) Warnecke C; Griethe W; Weidemann A; Jurgensen JS; Willam C; Bachmann S; Ivashchenko Y; Wagner I; Frei U; Wiesener M; Eckardt KU Activation of the hypoxia-inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors | 0 | 0 |
| 82 | 3 | 43 | 90 2003 GENE THERAPY 10(25):2081-2089 Sun X; Kanwar JR; Leung E; Vale M; Krissansen GW Regression of solid tumors by engineered overexpression of von Hippel-Lindau tumor suppressor protein and antisense hypoxia-inducible factor-1 alpha | 1 | 2 |
| 83 | 3 | 37 | 96 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):6816-6823 Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor gene product | 3 | 8 |
| 84 | 3 | 51 | 107 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40296-40304 Leonard MO; Cottell DC; Godson C; Brady HR; Taylor CT The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia | 0 | 3 |
| 85 | 3 | 74 | 124 2003 MOLECULAR CANCER THERAPEUTICS 2(3):235-243 Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation | 4 | 12 |
| 86 | 3 | 54 | 148 2004 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 286(2):F338-F348 Turcotte S; Desrosiers RR; Beliveau R Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma | 0 | 0 |
| 87 | 3 | 38 | 153 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317(1):84-91 Takahashi R; Kobayashi C; Kondo Y; Nakatani Y; Kudo I; Kunimoto M; Imura N; Hara S Subcellular localization and regulation of hypoxia-inducible factor-2 alpha in vascular endothelial cells | 0 | 0 |
| 88 | 3 | 91 | 173 2004 FEBS LETTERS 569(1-3):1-6 Kinnula VL; Paakko P; Soini Y Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung | 0 | 0 |
| 89 | 3 | 88 | 183 2004 JOURNAL OF NEUROSURGERY 100(3):488-497 Jensen RL; Gillespie D; House P; Layfield L; Shelton C Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1 alpha expression | 0 | 0 |
| 90 | 3 | 40 | 185 2004 MOLECULAR CANCER RESEARCH 2(1):43-52 Qi H; Gervais ML; Li W; DeCaprio JA; Challis JRG; Ohh M Molecular cloning and characterization of the von Hippel-Lindau-like protein | 0 | 0 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 91 | 3 | 34 | 192 2004 OXYGEN SENSING 381:467-487 Peet DJ; Lando D; Whelan DA; Whitelaw ML; Gorman JJ Oxygen-dependent asparagine hydroxylation | 0 | 0 |
| 92 | 3 | 27 | 196 2004 RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 141(2):115-123 Roy A; Li JQ; Baby SM; Mokashi A; Buerk DG; Lahiri S Effects of iron-chelators on ion-channels and HIF-1 alpha in the carotid body | 0 | 0 |
| 93 | 2 | 49 | 6 2002 CELL 111(5):709-720 Jeong JW; Bae MK; Ahn MY; Kim SH; Sohn TK; Bae MH; Yoo MA; Song EJ; Lee KJ; Kim KW Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation | 23 | 43 |
| 94 | 2 | 33 | 10 2002 FASEB JOURNAL 16(13) La Ferla K; Reimann C; Jelkmann W; Hellwig-Burgel T Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappa B | 0 | 0 |
| 95 | 2 | 54 | 15 2002 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 54(5):1537-1549 Janssen HLK; Haustermans KMG; Sprong D; Blommestijn G; Hofland I; Hoebers FJ; Blijweert E; Raleigh JA; Semenza GL; Varia MA; Balm AJ; van Velthuysen MLF; Delaere P; Sciot R; Begg AC HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors | 3 | 8 |
| 96 | 2 | 24 | 21 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):40112-40117 Chan DA; Sutphin PD; Denko NC; Giaccia AJ Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha | 17 | 31 |
| 97 | 2 | 188 | 28 2002 MASS SPECTROMETRY REVIEWS 21(5):305-348 Rusconi F; Guillonneau F; Praseuth D Contributions of mass spectrometry in the study of nucleic acid-binding proteins and of nucleic acid-protein interactions | 0 | 3 |
| 98 | 2 | 52 | 31 2002 MOLECULAR AND CELLULAR BIOLOGY 22(20):7004-7014 Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin | 6 | 41 |
| 99 | 2 | 39 | 39 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(21):13459-13464 Ivan M; Haberberger T; Gervasi DC; Michelson KS; Gunzler V; Kondo K; Yang HF; Sorokina I; Conaway RC; Conaway JW; Kaelin WG Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor | 25 | 48 |
| 100 | 2 | 42 | 40 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15351-15356 Dann CE; Bruick RK; Deisenhofer J Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | 20 | 27 |
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