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| ASPARAGINE HYDROXYLATION OF THE HIF TRANSACTIVATION DOMAIN: A HYPOXIC SWITCH
LANDO D; PEET DJ; WHELAN DA; GORMAN JJ; WHITELAW ML SCIENCE 295:(5556)858-861 FEB 1 2002 and the citing papers |
Nodes: 199
Authors: 610,
Journals: 112,
Outer References: 6717
Collection span: 2002 - 2004
View: Overview. Sorted by GCS.
Page 1: 1 (198) 2 (2)
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 0 | 28 | 43 2002 SCIENCE 295(5556):858-861 Lando D; Peet DJ; Whelan DA; Gorman JJ; Whitelaw ML Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch | 198 | 198 |
| 2 | 1 | 178 | 9 2002 FASEB JOURNAL 16(10) Wenger RH Cellular adaptation to hypoxia: O-2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O-2-regulated gene expression | 0 | 117 |
| 3 | 3 | 32 | 17 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26351-26355 Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | 61 | 81 |
| 4 | 1 | 37 | 46 2002 TRENDS IN MOLECULAR MEDICINE 8(4):S62-S67 Semenza GL HIF-1 and tumor progression: pathophysiology and therapeutics | 0 | 79 |
| 5 | 8 | 115 | 127 2003 NATURE MEDICINE 9(6):677-684 Pugh CW; Ratcliffe PJ Regulation of angiogenesis by hypoxia: role of the HIF system | 10 | 66 |
| 6 | 5 | 144 | 33 2002 NATURE REVIEWS CANCER 2(9):673-682 Kaelin WG Molecular basis of the VHL hereditary cancer syndrome | 11 | 59 |
| 7 | 1 | 42 | 35 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5367-5372 Freedman SJ; Sun ZYJ; Poy F; Kung AL; Livingston DM; Wagner G; Eck MJ Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha | 35 | 58 |
| 8 | 1 | 80 | 18 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(33):29936-29944 Isaacs JS; Jung YJ; Mimnaugh EG; Martinez A; Cuttitta F; Neckers LM Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway | 19 | 53 |
| 9 | 2 | 39 | 39 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(21):13459-13464 Ivan M; Haberberger T; Gervasi DC; Michelson KS; Gunzler V; Kondo K; Yang HF; Sorokina I; Conaway RC; Conaway JW; Kaelin WG Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor | 25 | 48 |
| 10 | 11 | 107 | 128 2003 NATURE REVIEWS CANCER 3(10):721-732 Semenza GL Targeting HIF-1 for cancer therapy | 6 | 47 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 11 | 1 | 45 | 34 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5271-5276 Dames SA; Martinez-Yamout M; De Guzman RN; Dyson HJ; Wright PE Structural basis for Hif-1 alpha/CBP recognition in the cellular hypoxic response | 31 | 45 |
| 12 | 2 | 49 | 6 2002 CELL 111(5):709-720 Jeong JW; Bae MK; Ahn MY; Kim SH; Sohn TK; Bae MH; Yoo MA; Song EJ; Lee KJ; Kim KW Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation | 23 | 43 |
| 13 | 2 | 52 | 31 2002 MOLECULAR AND CELLULAR BIOLOGY 22(20):7004-7014 Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin | 6 | 41 |
| 14 | 1 | 19 | 19 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(36):32405-32408 Makino Y; Kanopka A; Wilson WJ; Tanaka H; Poellinger L Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3 alpha locus | 19 | 33 |
| 15 | 3 | 41 | 13 2002 GENES & DEVELOPMENT 16(12):1441-1445 Kaelin WG How oxygen makes its presence felt | 8 | 31 |
| 16 | 2 | 24 | 21 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):40112-40117 Chan DA; Sutphin PD; Denko NC; Giaccia AJ Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha | 17 | 31 |
| 17 | 1 | 16 | 42 2002 SCIENCE 295(5556):807-808 Bruick RK; McKnight SL Transcription - Oxygen sensing gets a second wind | 14 | 28 |
| 18 | 2 | 42 | 40 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15351-15356 Dann CE; Bruick RK; Deisenhofer J Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | 20 | 27 |
| 19 | 1 | 29 | 37 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(16):10423-10428 Willam C; Masson N; Tian YM; Mahmood SA; Wilson MI; Bicknell R; Eckardt KU; Maxwell PH; Ratcliffe PJ; Pugh CW Peptide blockade of HIF alpha degradation modulates cellular metabolism and angiogenesis | 16 | 25 |
| 20 | 7 | 49 | 80 2003 EMBO JOURNAL 22(16):4082-4090 Berra E; Benizri E; Ginouves A; Volmat V; Roux D; Pouyssegur J HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 alpha in normoxia | 10 | 25 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 21 | 1 | 42 | 118 2003 MOLECULAR AND CELLULAR BIOLOGY 23(1):359-369 Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia | 6 | 24 |
| 22 | 1 | 57 | 30 2002 MOLECULAR AND CELLULAR BIOLOGY 22(19):6842-6853 Lavista-Llanos S; Centanin L; Irisarri M; Russo DM; Gleadle JM; Bocca SN; Muzzopappa M; Ratcliffe PJ; Wappner P Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar | 11 | 23 |
| 23 | 6 | 75 | 112 2003 JOURNAL OF CLINICAL INVESTIGATION 111(6):779-783 Safran M; Kaelin WG HIF hydroxylation and the mammalian oxygen-sensing pathway | 1 | 23 |
| 24 | 4 | 31 | 2 2002 BIOCHEMICAL JOURNAL 367:571-575 McNeill LA; Hewitson KS; Claridge TD; Seibel JF; Horsfall LE; Schofield CJ Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 | 17 | 22 |
| 25 | 4 | 42 | 108 2003 JOURNAL OF CELL SCIENCE 116(7):1319-1326 Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Burgel T; Jelkmann W; Acker H; Fandrey J Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing | 9 | 22 |
| 26 | 9 | 79 | 100 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19575-19578 Huang LE; Bunn HF Hypoxia-inducible factor and its biomedical relevance | 9 | 21 |
| 27 | 2 | 78 | 138 2003 SEMINARS IN CANCER BIOLOGY 13(1):83-89 Pugh CW; Ratcliffe PJ The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis | 3 | 21 |
| 28 | 5 | 55 | 98 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(16):14013-14019 Sang NL; Stiehl DP; Bohensky J; Leshchinsky I; Srinivas V; Caro J MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300 | 6 | 20 |
| 29 | 4 | 30 | 103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30772-30780 Hirsila M; Koivunen P; Gunzler V; Kivirikko KI; Myllyharju J Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor | 8 | 20 |
| 30 | 1 | 78 | 47 2002 TRENDS IN PHARMACOLOGICAL SCIENCES 23(12):576-582 Bikfalvi A; Bicknell R Recent advances in angiogenesis, anti-angiogenesis and vascular targeting | 0 | 19 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 31 | 1 | 23 | 99 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(18):15911-15916 Yuan Y; Hilliard G; Ferguson T; Millhorn DE Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha | 3 | 19 |
| 32 | 4 | 23 | 54 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303(3):947-953 Cioffi CL; Liu XQ; Kosinski PA; Garay M; Bowen BR Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells | 8 | 16 |
| 33 | 1 | 61 | 63 2003 CANCER CELL 3(1):75-88 Mack FA; Rathmell WK; Arsham AM; Gnarra J; Keith B; Simon MC Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth | 6 | 16 |
| 34 | 7 | 121 | 81 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):781-790 Lando D; Gorman JJ; Whitelaw ML; Peet DJ Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation | 9 | 16 |
| 35 | 1 | 64 | 5 2002 CANCER RESEARCH 62(17):5089-5095 Welsh SJ; Bellamy WT; Briehl MA; Powis G The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1 alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis | 4 | 15 |
| 36 | 11 | 116 | 129 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811 Giaccia A; Siim BG; Johnson RS HIF-1 as a target for drug development | 2 | 15 |
| 37 | 4 | 39 | 97 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):7558-7563 Lee C; Kim SJ; Jeong DG; Lee SM; Ryu SE Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau | 10 | 14 |
| 38 | 4 | 49 | 119 2003 MOLECULAR AND CELLULAR BIOLOGY 23(14):4959-4971 Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha | 5 | 14 |
| 39 | 1 | 26 | 16 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23508-23514 Gradin K; Takasaki C; Fujii-Kuriyama Y; Sogawa K The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine | 10 | 13 |
| 40 | 1 | 70 | 36 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(14):9480-9485 Su H; Arakawa-Hoyt J; Kan YW Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model | 1 | 13 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 41 | 6 | 59 | 123 2003 MOLECULAR BIOLOGY OF THE CELL 14(8):3470-3481 Metzen E; Zhou J; Jelkmann W; Fandrey J; Brune B Nitric oxide impairs normoxic degradation of HIF-1 alpha by inhibition of prolyl hydroxylases | 6 | 13 |
| 42 | 1 | 134 | 70 2003 CLINICAL & EXPERIMENTAL METASTASIS 20(3):237-250 Subarsky P; Hill RP The hypoxic tumour microenvironment and metastatic progression | 0 | 12 |
| 43 | 19 | 89 | 91 2003 GENES & DEVELOPMENT 17(21):2614-2623 Bruick RK Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor | 3 | 12 |
| 44 | 3 | 74 | 124 2003 MOLECULAR CANCER THERAPEUTICS 2(3):235-243 Welsh SJ; Williams RR; Birmingham A; Newman DJ; Kirkpatrick DL; Powis G The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1 alpha and vascular endothelial growth factor formation | 4 | 12 |
| 45 | 1 | 125 | 12 2002 FREE RADICAL BIOLOGY AND MEDICINE 33(9):1231-1242 Michiels C; Minet E; Mottet D; Raes M Regulation of gene expression by oxygen: NF-kappa B and HIF-1, two extremes | 0 | 11 |
| 46 | 8 | 60 | 76 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(1):55-60 Kim W; Kaelin WG The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer | 2 | 11 |
| 47 | 4 | 69 | 82 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):791-798 Bilton RL; Booker GW The subtle side to hypoxia inducible factor (HIF alpha) regulation | 5 | 11 |
| 48 | 4 | 47 | 20 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(41):38723-38730 Ruas JL; Poellinger L; Pereira T Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation - identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein | 9 | 10 |
| 49 | 2 | 107 | 116 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(26):7828-7842 Mehn MP; Fujisawa K; Hegg EL; Que L Oxygen activation by nonheme iron(II) complexes: alpha-keto carboxylate versus carboxylate | 1 | 10 |
| 50 | 1 | 183 | 25 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(9):562-575 Acker T; Plate KH A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology | 2 | 9 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 51 | 2 | 202 | 88 2003 FREE RADICAL BIOLOGY AND MEDICINE 35(2):117-132 Chen K; Thomas SR; Keaney JF Beyond LDL oxidation: ROS in vascular signal transduction | 0 | 9 |
| 52 | 2 | 54 | 15 2002 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 54(5):1537-1549 Janssen HLK; Haustermans KMG; Sprong D; Blommestijn G; Hofland I; Hoebers FJ; Blijweert E; Raleigh JA; Semenza GL; Varia MA; Balm AJ; van Velthuysen MLF; Delaere P; Sciot R; Begg AC HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors | 3 | 8 |
| 53 | 1 | 111 | 27 2002 MASS SPECTROMETRY REVIEWS 21(3):183-216 Gorman JJ; Wallis TP; Pitt JJ Protein disulfide bond determination by mass spectrometry | 0 | 8 |
| 54 | 3 | 37 | 96 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):6816-6823 Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor gene product | 3 | 8 |
| 55 | 17 | 97 | 110 2003 JOURNAL OF CELL SCIENCE 116(15):3041-3049 Masson N; Ratcliffe PJ HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O-2 levels | 2 | 8 |
| 56 | 1 | 50 | 111 2003 JOURNAL OF CLINICAL INVESTIGATION 111(5):571-574 Soberman RJ The expanding network of redox signaling: new observations, complexities, and perspectives | 0 | 8 |
| 57 | 5 | 53 | 22 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755 Huang LE; Pete EA; Schau M; Milligan J; Gu J Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 4 | 7 |
| 58 | 1 | 59 | 23 2002 JOURNAL OF EXPERIMENTAL BIOLOGY 205(23):3579-3586 Bickler PE; Donohoe PH Adaptive responses of vertebrate neurons to hypoxia | 0 | 7 |
| 59 | 1 | 44 | 48 2003 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 284(2):C439-C446 Zhou J; Fandrey J; Schumann J; Tiegs G; Brune B NO and TNF-alpha released from activated macrophages stabilize HIF-1 alpha in resting tubular LLC-PK1 cells | 0 | 7 |
| 60 | 1 | 90 | 52 2003 ANTIOXIDANTS & REDOX SIGNALING 5(1):123-132 Dulak J; Jozkowicz A Regulation of vascular endothelial growth factor synthesis by nitric oxide: Facts and controversies | 0 | 7 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 61 | 2 | 83 | 62 2003 BLOOD 101(3):907-914 Kietzmann T; Samoylenko A; Roth U; Jungermann K Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes | 1 | 7 |
| 62 | 1 | 55 | 132 2003 PLACENTA 24(2-3):199-208 Rajakumar A; Doty K; Daftary A; Harger G; Conrad KP Impaired oxygen-dependent reduction of HIF-1 alpha and -2 alpha proteins in pre-eclamptic placentae | 4 | 7 |
| 63 | 1 | 49 | 3 2002 BLOOD PURIFICATION 20(5):445-450 Ratcliffe PJ From erythropoietin to oxygen: Hypoxia-inducible factor hydroxylases and the hypoxia signal pathway | 3 | 6 |
| 64 | 2 | 191 | 41 2002 RESPIRATORY RESEARCH 3(1) Haddad JJ Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology | 0 | 6 |
| 65 | 6 | 71 | 50 2003 ANNALS OF MEDICINE 35(3):183-190 Wiesener MS; Maxwell PH HIF and oxygen sensing; as important to life as the air we breathe? | 1 | 6 |
| 66 | 1 | 130 | 59 2003 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1619(2):113-124 Templeton DM; Liu Y Genetic regulation of cell function in response to iron overload or chelation | 0 | 6 |
| 67 | 4 | 99 | 95 2003 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 36(1):120-127 Choi KS; Bae MK; Jeong JW; Moon HE; Kim KW Hypoxia-induced angiogenesis during carcinogenesis | 0 | 6 |
| 68 | 5 | 111 | 121 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374 Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation | 1 | 6 |
| 69 | 8 | 48 | 130 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512 Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2 | 2 | 6 |
| 70 | 1 | 26 | 1 2002 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 283(5):L918-L921 Schumacker PT Hypoxia, anoxia, and O-2 sensing: the search continues | 0 | 5 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 71 | 3 | 38 | 38 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11570-11572 Semenza GL Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1 alpha with p300 and CBP | 3 | 5 |
| 72 | 1 | 52 | 79 2003 EMBO JOURNAL 22(8):1857-1867 Li ZB; Wang DK; Na X; Schoen SR; Messing EM; Wu G The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1 alpha transcriptional activity | 3 | 5 |
| 73 | 2 | 128 | 89 2003 FRONTIERS IN BIOSCIENCE 8:D100-D116 Brat DJ; Kaur B; Van Meir EG Genetic modulation of hypoxia induced gene expression and angiogenesis: Relevance to brain tumors | 0 | 5 |
| 74 | 1 | 59 | 102 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(25):22316-22324 Del Toro R; Levitsky KL; Lopez-Barneo J; Chiara MD Induction of T-type calcium channel gene expression by chronic hypoxia | 0 | 5 |
| 75 | 1 | 49 | 109 2003 JOURNAL OF CELL SCIENCE 116(11):2247-2260 Turcotte S; Desrosiers RR; Beliveau R HIF-1 alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma | 2 | 5 |
| 76 | 4 | 513 | 162 2004 CHEMICAL REVIEWS 104(2):939-986 Costas M; Mehn MP; Jensen MP; Que L Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates | 0 | 5 |
| 77 | 1 | 22 | 11 2002 FEBS LETTERS 530(1-3):186-190 Saarikoski ST; Rivera SP; Hankinson O Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia | 1 | 4 |
| 78 | 8 | 71 | 56 2003 BIOCHEMICAL SOCIETY TRANSACTIONS 31:510-515 Hewitson KS; McNeill LA; Elkins JM; Schofield CJ The role of iron and 2-oxoglutarate oxygenases in signalling | 2 | 4 |
| 79 | 1 | 45 | 58 2003 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1626(1-3):10-18 Graven KK; Bellur D; Klahn BD; Lowrey SL; Amberger E HIF-2 alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells | 1 | 4 |
| 80 | 11 | 260 | 67 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(7):1376-1393 Bracken CP; Whitelaw ML; Peet DJ The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses | 2 | 4 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 81 | 3 | 81 | 73 2003 CURRENT MEDICINAL CHEMISTRY 10(10):845-855 Brune B; Zhou J The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1 alpha (HIF-1 alpha) | 1 | 4 |
| 82 | 1 | 50 | 78 2003 CURRENT OPINION IN NEUROBIOLOGY 13(4):493-499 Lopez-Barneo J Oxygen and glucose sensing by carotid body glomus cells | 0 | 4 |
| 83 | 2 | 41 | 120 2003 MOLECULAR AND CELLULAR BIOLOGY 23(19):6739-6749 Tomita S; Ueno M; Sakamoto M; Kitahama Y; Ueki M; Maekawa N; Sakamoto H; Gassmann M; Kageyama R; Ueda N; Gonzalez FJ; Takahama Y Defective brain development in mice lacking the Hif-1 alpha gene in neural cells | 3 | 4 |
| 84 | 2 | 35 | 122 2003 MOLECULAR BIOLOGY OF THE CELL 14(6):2216-2225 Zhou J; Schmid T; Brune B Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1 alpha through a nuclear factor-kappa B-dependent pathway | 3 | 4 |
| 85 | 1 | 53 | 140 2003 THROMBOSIS AND HAEMOSTASIS 89(4):666-673 Kietzmann T; Jungermann K; Gorlach A Regulation of the hypoxia-dependent plasminogen activator inhibitor I expression by MAP kinases | 0 | 4 |
| 86 | 18 | 268 | 145 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(4):R608-R623 Hopfl G; Ogunshola O; Gassmann M HIFs and tumors - causes and consequences | 0 | 4 |
| 87 | 2 | 188 | 28 2002 MASS SPECTROMETRY REVIEWS 21(5):305-348 Rusconi F; Guillonneau F; Praseuth D Contributions of mass spectrometry in the study of nucleic acid-binding proteins and of nucleic acid-protein interactions | 0 | 3 |
| 88 | 1 | 57 | 29 2002 METHODS 28(2):259-266 Tang Y; Schmitt-Ott K; Qian KP; Kagiyama S; Phillips MI Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases | 1 | 3 |
| 89 | 1 | 39 | 32 2002 MOLECULES AND CELLS 14(1):9-15 Lee E; Yim S; Lee SK; Park H Two transactivation domains of hypoxia-inducible factor-1 alpha regulated by the MEK-1/p42/p44 MAPK pathway | 0 | 3 |
| 90 | 2 | 59 | 45 2002 TRENDS IN CARDIOVASCULAR MEDICINE 12(8):362-367 Vincent KA; Feron O; Kelly RA Harnessing the response to tissue hypoxia - HIF-1 alpha and therapeutic angiogenesis | 1 | 3 |
| # | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
| 91 | 2 | 58 | 49 2003 ANNALS OF INTERNAL MEDICINE 138(8):659-668 Brat DJ; Mapstone TB Malignant glioma physiology: Cellular response to hypoxia and its role in tumor progression | 0 | 3 |
| 92 | 3 | 33 | 55 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 312(3):571-577 Hanze J; Eul BG; Savai R; Krick S; Goyal P; Grimminger F; Seeger W; Rose F RNA interference for HIF-1 alpha inhibits its downstream signalling and affects cellular proliferation | 2 | 3 |
| 93 | 4 | 29 | 61 2003 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13(16):2677-2680 Mole DR; Schlemminger I; McNeill LA; Hewitson KS; Pugh CW; Ratcliffe PJ; Schofield CJ 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase | 3 | 3 |
| 94 | 2 | 40 | 69 2003 CIRCULATION RESEARCH 93(11):1074-1081 Kelly BD; Hackett SF; Hirota K; Oshima Y; Cai ZQ; Berg-Dixon S; Rowan A; Yan ZJ; Campochiaro PA; Semenza GL Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1 | 1 | 3 |
| 95 | 1 | 39 | 92 2003 HISTOCHEMISTRY AND CELL BIOLOGY 120(5):343-352 Baby SM; Roy A; Mokashi AM; Lahiri S Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1 alpha and -1 beta in the rat carotid body and glomus cells | 1 | 3 |
| 96 | 1 | 34 | 101 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20235-20239 Wright G; Higgin JJ; Raines RT; Steenbergen C; Murphy E Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes | 2 | 3 |
| 97 | 3 | 51 | 107 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40296-40304 Leonard MO; Cottell DC; Godson C; Brady HR; Taylor CT The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia | 0 | 3 |
| 98 | 1 | 278 | 174 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(6):718-744 Kinnula VL; Crapo JD Superoxide dismutases in malignant cells and human tumors | 1 | 3 |
| 99 | 1 | 26 | 4 2002 BULLETIN DU CANCER 89(3):257-260 L'Allemain G The hypoxia-inducible factor HIF as a new target in cancer research | 0 | 2 |
| 100 | 1 | 32 | 7 2002 EXPERIMENTAL GERONTOLOGY 37(8-9):1077-1088 Trubiani O; Di Giulio C; Tripodi D; Bianchi G; Paganelli R; Di Primio R Thymic sensitivity to hypoxic condition in young and old rats. Age-dependent expression of NF-kappa B | 0 | 2 |
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