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ASPARAGINE HYDROXYLATION OF THE HIF TRANSACTIVATION DOMAIN: A HYPOXIC SWITCH
LANDO D; PEET DJ; WHELAN DA; GORMAN JJ; WHITELAW ML SCIENCE 295:(5556)858-861 FEB 1 2002 and the citing papers |
Nodes: 199
Authors: 610,
Journals: 112,
Outer References: 6717
Collection span: 2002 - 2004
View: Overview. Sorted by first author.
Page 1: 1 (Abraham RT) 2 (Lewis MD)
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
---|---|---|---|---|---|
1 | 2 | 72 | 141 2003 TOR-TARGET OF RAPAMYCIN 279:299-319 Abraham RT MTOR as a positive regulator of tumor cell responses to hypoxia | 0 | 0 |
2 | 1 | 183 | 25 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(9):562-575 Acker T; Plate KH A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology | 2 | 9 |
3 | 5 | 135 | 65 2003 CELL AND TISSUE RESEARCH 314(1):145-155 Acker T; Plate KH Role of hypoxia in tumor angiogenesis - molecular and cellular angiogenic crosstalk | 0 | 0 |
4 | 10 | 42 | 182 2004 JOURNAL OF CELLULAR BIOCHEMISTRY 92(3):491-501 Aprelikova O; Chandramouli GVR; Wood M; Vasselli JR; Riss J; Maranchie JK; Linehan WM; Barrett JC Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors | 0 | 0 |
5 | 4 | 131 | 150 2004 ANTIOXIDANTS & REDOX SIGNALING 6(1):155-167 Asikainen TM; White CW Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: Implications for antioxidant therapy | 0 | 1 |
6 | 1 | 39 | 92 2003 HISTOCHEMISTRY AND CELL BIOLOGY 120(5):343-352 Baby SM; Roy A; Mokashi AM; Lahiri S Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1 alpha and -1 beta in the rat carotid body and glomus cells | 1 | 3 |
7 | 9 | 84 | 155 2004 BIOESSAYS 26(3):262-269 Bardos JI; Athcroft M Hypoxia-inducible factor-1 and oncogenic signalling | 0 | 0 |
8 | 2 | 55 | 142 2003 TRENDS IN ENDOCRINOLOGY AND METABOLISM 14(10):453-459 Baysal BE On the association of succinate dehydrogenase mutations with hereditary paraganglioma | 0 | 1 |
9 | 2 | 5 | 94 2003 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 56(4):917-919 Begg AC Is HIF-1 alpha a good marker for tumor hypoxia? | 0 | 1 |
10 | 2 | 37 | 157 2004 BIOLOGICAL CHEMISTRY 385(3-4):231-237 Berchner-Pfannschmidt U; Wotzlaw C; Merten E; Acker H; Fandrey J Visualization of the three-dimensional organization of hypoxia-inducible factor-1 alpha and interacting cofactors in subnuclear structures | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
11 | 7 | 49 | 80 2003 EMBO JOURNAL 22(16):4082-4090 Berra E; Benizri E; Ginouves A; Volmat V; Roux D; Pouyssegur J HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 alpha in normoxia | 10 | 25 |
12 | 1 | 59 | 23 2002 JOURNAL OF EXPERIMENTAL BIOLOGY 205(23):3579-3586 Bickler PE; Donohoe PH Adaptive responses of vertebrate neurons to hypoxia | 0 | 7 |
13 | 1 | 78 | 47 2002 TRENDS IN PHARMACOLOGICAL SCIENCES 23(12):576-582 Bikfalvi A; Bicknell R Recent advances in angiogenesis, anti-angiogenesis and vascular targeting | 0 | 19 |
14 | 4 | 69 | 82 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):791-798 Bilton RL; Booker GW The subtle side to hypoxia inducible factor (HIF alpha) regulation | 5 | 11 |
15 | 10 | 62 | 77 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(6):650-656 Binley K; Kan O; White J; Naylor S Exploiting the hypoxia response | 0 | 1 |
16 | 11 | 260 | 67 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(7):1376-1393 Bracken CP; Whitelaw ML; Peet DJ The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses | 2 | 4 |
17 | 2 | 128 | 89 2003 FRONTIERS IN BIOSCIENCE 8:D100-D116 Brat DJ; Kaur B; Van Meir EG Genetic modulation of hypoxia induced gene expression and angiogenesis: Relevance to brain tumors | 0 | 5 |
18 | 2 | 58 | 49 2003 ANNALS OF INTERNAL MEDICINE 138(8):659-668 Brat DJ; Mapstone TB Malignant glioma physiology: Cellular response to hypoxia and its role in tumor progression | 0 | 3 |
19 | 1 | 4 | 14 2002 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 54(5):1299-1301 Brown JM; Le QT Tumor hypoxia is important in radiotherapy, but how should we measure it? | 0 | 2 |
20 | 19 | 89 | 91 2003 GENES & DEVELOPMENT 17(21):2614-2623 Bruick RK Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor | 3 | 12 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
21 | 1 | 16 | 42 2002 SCIENCE 295(5556):807-808 Bruick RK; McKnight SL Transcription - Oxygen sensing gets a second wind | 14 | 28 |
22 | 3 | 81 | 73 2003 CURRENT MEDICINAL CHEMISTRY 10(10):845-855 Brune B; Zhou J The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1 alpha (HIF-1 alpha) | 1 | 4 |
23 | 2 | 24 | 21 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(42):40112-40117 Chan DA; Sutphin PD; Denko NC; Giaccia AJ Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1 alpha | 17 | 31 |
24 | 2 | 202 | 88 2003 FREE RADICAL BIOLOGY AND MEDICINE 35(2):117-132 Chen K; Thomas SR; Keaney JF Beyond LDL oxidation: ROS in vascular signal transduction | 0 | 9 |
25 | 4 | 99 | 95 2003 JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 36(1):120-127 Choi KS; Bae MK; Jeong JW; Moon HE; Kim KW Hypoxia-induced angiogenesis during carcinogenesis | 0 | 6 |
26 | 1 | 40 | 131 2003 NEOPLASMA 50(1):13-21 Chrastina A; Pastorekova S; Pastorek J Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by I-125-labeled M75 monoclonal antibody | 0 | 2 |
27 | 4 | 23 | 54 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303(3):947-953 Cioffi CL; Liu XQ; Kosinski PA; Garay M; Bowen BR Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells | 8 | 16 |
28 | 4 | 513 | 162 2004 CHEMICAL REVIEWS 104(2):939-986 Costas M; Mehn MP; Jensen MP; Que L Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates | 0 | 5 |
29 | 1 | 21 | 154 2004 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1691(1):17-22 Daly EB; Wind T; Jiang XM; Sun L; Hogg PJ Secretion of phosphoglycerate kinase from tumour cells is controlled by oxygen-sensing hydroxylases | 0 | 0 |
30 | 1 | 45 | 34 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5271-5276 Dames SA; Martinez-Yamout M; De Guzman RN; Dyson HJ; Wright PE Structural basis for Hif-1 alpha/CBP recognition in the cellular hypoxic response | 31 | 45 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
31 | 2 | 42 | 40 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24):15351-15356 Dann CE; Bruick RK; Deisenhofer J Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | 20 | 27 |
32 | 1 | 34 | 158 2004 CANCER RESEARCH 64(2):456-462 Datta K; Li JP; Bhattacharya R; Gasparian L; Wang EF; Mukhopadhyay D Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer | 1 | 2 |
33 | 2 | 34 | 125 2003 MOLECULAR PHARMACOLOGY 64(6):1485-1493 Davidson T; Salnikow K; Costa M Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel | 0 | 0 |
34 | 5 | 32 | 178 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(4):3042-3049 De Guzman RN; Martinez-Yamout MA; Dyson HJ; Wright PE Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2 - Regulation by competition between intrinsically unstructured ligands for non-identical binding sites | 0 | 0 |
35 | 1 | 59 | 102 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(25):22316-22324 Del Toro R; Levitsky KL; Lopez-Barneo J; Chiara MD Induction of T-type calcium channel gene expression by chronic hypoxia | 0 | 5 |
36 | 5 | 44 | 57 2003 BIOCHEMISTRY 42(33):9937-9945 Dial R; Sun ZYJ; Freedman SJ Three conformational states of the p300 CH1 domain define its functional properties | 0 | 1 |
37 | 6 | 135 | 151 2004 ARTHRITIS AND RHEUMATISM 50(1):10-23 Distler JHW; Wenger RH; Gassmann M; Kurowska M; Hirth A; Gay S; Distler O Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis | 0 | 1 |
38 | 1 | 90 | 52 2003 ANTIOXIDANTS & REDOX SIGNALING 5(1):123-132 Dulak J; Jozkowicz A Regulation of vascular endothelial growth factor synthesis by nitric oxide: Facts and controversies | 0 | 7 |
39 | 8 | 165 | 146 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(6):R977-R988 Fandrey J Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression | 0 | 0 |
40 | 8 | 48 | 130 2003 NATURE STRUCTURAL BIOLOGY 10(7):504-512 Freedman SJ; Sun ZYJ; Kung AL; France DS; Wagner G; Eck MJ Structural basis for negative regulation of hypoxia-inducible factor-1 alpha by CITED2 | 2 | 6 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
41 | 1 | 42 | 35 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(8):5367-5372 Freedman SJ; Sun ZYJ; Poy F; Kung AL; Livingston DM; Wagner G; Eck MJ Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha | 35 | 58 |
42 | 8 | 56 | 126 2003 MOLECULES AND CELLS 16(1):1-12 Freeman RS; Hasbani DM; Lipscomb EA; Straub JA; Xie L SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases | 0 | 1 |
43 | 11 | 116 | 129 2003 NATURE REVIEWS DRUG DISCOVERY 2(10):803-811 Giaccia A; Siim BG; Johnson RS HIF-1 as a target for drug development | 2 | 15 |
44 | 6 | 59 | 53 2003 ANTIOXIDANTS & REDOX SIGNALING 5(4):467-473 Goda N; Dozier SJ; Johnson RS HIF-1 in cell cycle regulation, apoptosis, and tumor progression | 0 | 2 |
45 | 1 | 42 | 118 2003 MOLECULAR AND CELLULAR BIOLOGY 23(1):359-369 Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia | 6 | 24 |
46 | 1 | 111 | 27 2002 MASS SPECTROMETRY REVIEWS 21(3):183-216 Gorman JJ; Wallis TP; Pitt JJ Protein disulfide bond determination by mass spectrometry | 0 | 8 |
47 | 1 | 52 | 175 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(10):1279-1288 Goyal P; Weissmann N; Grimminger F; Hegel C; Bader L; Rose F; Fink L; Ghofrani HA; Schermuly RT; Schmidt HHHW; Seeger W; Hanze J Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species | 0 | 0 |
48 | 1 | 26 | 16 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(26):23508-23514 Gradin K; Takasaki C; Fujii-Kuriyama Y; Sogawa K The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine | 10 | 13 |
49 | 1 | 45 | 58 2003 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1626(1-3):10-18 Graven KK; Bellur D; Klahn BD; Lowrey SL; Amberger E HIF-2 alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells | 1 | 4 |
50 | 2 | 191 | 41 2002 RESPIRATORY RESEARCH 3(1) Haddad JJ Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology | 0 | 6 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
51 | 2 | 71 | 152 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 316(4):969-977 Haddad JJ Oxygen sensing and oxidant/redox-related pathways | 0 | 0 |
52 | 7 | 146 | 74 2003 CURRENT MEDICINAL CHEMISTRY 10(12):1005-1019 Hanauske-Abel HM; Popowicz AM The HAG mechanism: A molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases | 0 | 0 |
53 | 3 | 33 | 55 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 312(3):571-577 Hanze J; Eul BG; Savai R; Krick S; Goyal P; Grimminger F; Seeger W; Rose F RNA interference for HIF-1 alpha inhibits its downstream signalling and affects cellular proliferation | 2 | 3 |
54 | 8 | 340 | 163 2004 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 39(1):21-68 Hausinger RP Fe(II)/alpha-ketoglutarate-dependent hydroxylases and related enzymes | 0 | 0 |
55 | 8 | 71 | 56 2003 BIOCHEMICAL SOCIETY TRANSACTIONS 31:510-515 Hewitson KS; McNeill LA; Elkins JM; Schofield CJ The role of iron and 2-oxoglutarate oxygenases in signalling | 2 | 4 |
56 | 3 | 32 | 17 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26351-26355 Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | 61 | 81 |
57 | 21 | 144 | 165 2004 CURRENT PHARMACEUTICAL DESIGN 10(8):821-833 Hewitson KS; McNeill LA; Schofield CJ Modulating the hypoxia-inducible factor signaling pathway: Applications from cardiovascular disease to cancer | 0 | 1 |
58 | 1 | 21 | 134 2003 RAPID COMMUNICATIONS IN MASS SPECTROMETRY 17(5):371-376 Hirota J; Satomi Y; Yoshikawa K; Takao T epsilon-N,N,N-Trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry | 0 | 2 |
59 | 4 | 30 | 103 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30772-30780 Hirsila M; Koivunen P; Gunzler V; Kivirikko KI; Myllyharju J Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor | 8 | 20 |
60 | 3 | 31 | 60 2003 BIOESSAYS 25(5):515-519 Hochachka PW; Rupert JL Fine tuning the HIF-1 'global' O-2 sensor for hypobaric hypoxia in Andean high-altitude natives | 0 | 1 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
61 | 5 | 167 | 93 2003 HYPOXIA: THROUGH THE LIFECYCLE 543:89-115 Hopfl G; Ogunshola O; Gassmann M Hypoxia and high altitude - The molecular response | 0 | 1 |
62 | 18 | 268 | 145 2004 AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 286(4):R608-R623 Hopfl G; Ogunshola O; Gassmann M HIFs and tumors - causes and consequences | 0 | 4 |
63 | 5 | 111 | 121 2003 MOLECULAR AND CELLULAR BIOLOGY 23(24):9361-9374 Hu CJ; Wang LY; Chodosh LA; Keith B; Simon MC Differential roles of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in hypoxic gene regulation | 1 | 6 |
64 | 9 | 79 | 100 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):19575-19578 Huang LE; Bunn HF Hypoxia-inducible factor and its biomedical relevance | 9 | 21 |
65 | 5 | 53 | 22 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):41750-41755 Huang LE; Pete EA; Schau M; Milligan J; Gu J Leu-574 of HIF-1 alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway | 4 | 7 |
66 | 2 | 52 | 31 2002 MOLECULAR AND CELLULAR BIOLOGY 22(20):7004-7014 Hudson CC; Liu M; Chiang GG; Otterness DM; Loomis DC; Kaper F; Giaccia AJ; Abraham RT Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin | 6 | 41 |
67 | 1 | 80 | 18 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(33):29936-29944 Isaacs JS; Jung YJ; Mimnaugh EG; Martinez A; Cuttitta F; Neckers LM Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway | 19 | 53 |
68 | 2 | 39 | 39 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(21):13459-13464 Ivan M; Haberberger T; Gervasi DC; Michelson KS; Gunzler V; Kondo K; Yang HF; Sorokina I; Conaway RC; Conaway JW; Kaelin WG Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor | 25 | 48 |
69 | 2 | 54 | 15 2002 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 54(5):1537-1549 Janssen HLK; Haustermans KMG; Sprong D; Blommestijn G; Hofland I; Hoebers FJ; Blijweert E; Raleigh JA; Semenza GL; Varia MA; Balm AJ; van Velthuysen MLF; Delaere P; Sciot R; Begg AC HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors | 3 | 8 |
70 | 1 | 70 | 113 2003 JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 26(9):832-837 Jelkmann W Erythropoietin | 0 | 0 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
71 | 3 | 88 | 183 2004 JOURNAL OF NEUROSURGERY 100(3):488-497 Jensen RL; Gillespie D; House P; Layfield L; Shelton C Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1 alpha expression | 0 | 0 |
72 | 2 | 49 | 6 2002 CELL 111(5):709-720 Jeong JW; Bae MK; Ahn MY; Kim SH; Sohn TK; Bae MH; Yoo MA; Song EJ; Lee KJ; Kim KW Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation | 23 | 43 |
73 | 2 | 48 | 172 2004 FASEB JOURNAL 18(10) Jurgensen JS; Rosenberger C; Wiesener MS; Warnecke C; Horstrup JH; Grafe M; Philipp S; Griethe W; Maxwell PH; Frei U; Bachmann S; Willenbrock R; Eckardt KU Persistent induction of HIF-1 alpha and -2 alpha in cardiomyocytes and stromal cells of ischemic myocardium | 0 | 0 |
74 | 3 | 41 | 13 2002 GENES & DEVELOPMENT 16(12):1441-1445 Kaelin WG How oxygen makes its presence felt | 8 | 31 |
75 | 5 | 144 | 33 2002 NATURE REVIEWS CANCER 2(9):673-682 Kaelin WG Molecular basis of the VHL hereditary cancer syndrome | 11 | 59 |
76 | 11 | 43 | 170 2004 FASEB JOURNAL 18(6) Kageyama Y; Koshiji M; To KKW; Tian YM; Ratcliffe PJ; Huang LE Leu-574 of human HIF-1a is a molecular determinant of prolyl hydroxylation | 0 | 0 |
77 | 3 | 118 | 66 2003 CELLULAR AND MOLECULAR BIOLOGY 49(1):77-87 Karhausen J; Ibla JC; Colgan SP Implications of hypoxia on mucosal barrier function | 1 | 1 |
78 | 2 | 40 | 69 2003 CIRCULATION RESEARCH 93(11):1074-1081 Kelly BD; Hackett SF; Hirota K; Oshima Y; Cai ZQ; Berg-Dixon S; Rowan A; Yan ZJ; Campochiaro PA; Semenza GL Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1 | 1 | 3 |
79 | 1 | 53 | 140 2003 THROMBOSIS AND HAEMOSTASIS 89(4):666-673 Kietzmann T; Jungermann K; Gorlach A Regulation of the hypoxia-dependent plasminogen activator inhibitor I expression by MAP kinases | 0 | 4 |
80 | 2 | 83 | 62 2003 BLOOD 101(3):907-914 Kietzmann T; Samoylenko A; Roth U; Jungermann K Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes | 1 | 7 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
81 | 1 | 120 | 26 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80(11):703-714 Kim KR; Moon HE; Kim KW Hypoxia-induced angiogenesis in human hepatocellular carcinoma | 0 | 1 |
82 | 8 | 60 | 76 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(1):55-60 Kim W; Kaelin WG The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer | 2 | 11 |
83 | 1 | 278 | 174 2004 FREE RADICAL BIOLOGY AND MEDICINE 36(6):718-744 Kinnula VL; Crapo JD Superoxide dismutases in malignant cells and human tumors | 1 | 3 |
84 | 3 | 91 | 173 2004 FEBS LETTERS 569(1-3):1-6 Kinnula VL; Paakko P; Soini Y Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung | 0 | 0 |
85 | 1 | 18 | 115 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(16):4710-4711 Kinzie SD; Thevis M; Ngo K; Whitelegge J; Loo JA; Abu-Omar MM Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron | 0 | 2 |
86 | 2 | 50 | 64 2003 CANCER SCIENCE 94(12):1021-1028 Kizaka-Kondoh S; Inoue M; Harada H; Hiraoka M Tumor hypoxia: A target for selective cancer therapy | 0 | 2 |
87 | 1 | 58 | 105 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33384-33391 Kodama T; Shimizu N; Yoshikawa N; Makino Y; Ouchida R; Okamoto K; Hisada T; Nakamura H; Morimoto C; Tanaka H Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression | 0 | 0 |
88 | 9 | 31 | 179 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(11):9899-9904 Koivunen P; Hirsila M; Gunzler V; Kivirikko KI; Myllyharju J Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | 1 | 1 |
89 | 2 | 58 | 195 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(28):10440-10445 Kong TQ; Eltzschig HK; Karhausen J; Colgan SP; Shelley CS Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of beta 2 integrin gene expression | 0 | 0 |
90 | 1 | 26 | 4 2002 BULLETIN DU CANCER 89(3):257-260 L'Allemain G The hypoxia-inducible factor HIF as a new target in cancer research | 0 | 2 |
# | LCR | NCR | Nodes / Date / Journal / Authors | LCS | GCS |
91 | 2 | 33 | 10 2002 FASEB JOURNAL 16(13) La Ferla K; Reimann C; Jelkmann W; Hellwig-Burgel T Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappa B | 0 | 0 |
92 | 2 | 97 | 135 2003 REDOX REPORT 8(6):325-340 Land SC Oxygen-sensing pathways and the development of mammalian gas exchange | 0 | 0 |
93 | 7 | 121 | 81 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270(5):781-790 Lando D; Gorman JJ; Whitelaw ML; Peet DJ Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation | 9 | 16 |
94 | 0 | 28 | 43 2002 SCIENCE 295(5556):858-861 Lando D; Peet DJ; Whelan DA; Gorman JJ; Whitelaw ML Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch | 198 | 198 |
95 | 1 | 57 | 30 2002 MOLECULAR AND CELLULAR BIOLOGY 22(19):6842-6853 Lavista-Llanos S; Centanin L; Irisarri M; Russo DM; Gleadle JM; Bocca SN; Muzzopappa M; Ratcliffe PJ; Wappner P Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar | 11 | 23 |
96 | 4 | 39 | 97 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(9):7558-7563 Lee C; Kim SJ; Jeong DG; Lee SM; Ryu SE Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau | 10 | 14 |
97 | 1 | 39 | 32 2002 MOLECULES AND CELLS 14(1):9-15 Lee E; Yim S; Lee SK; Park H Two transactivation domains of hypoxia-inducible factor-1 alpha regulated by the MEK-1/p42/p44 MAPK pathway | 0 | 3 |
98 | 10 | 123 | 167 2004 EXPERIMENTAL AND MOLECULAR MEDICINE 36(1):1-12 Lee JW; Bae SH; Jeong JW; Kim SH; Kim KW Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions | 0 | 0 |
99 | 1 | 63 | 106 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(38):35878-35888 Lees MJ; Peet DJ; Whitelaw ML Defining the role for XAP2 in stabilization of the dioxin receptor | 0 | 2 |
100 | 3 | 51 | 107 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(41):40296-40304 Leonard MO; Cottell DC; Godson C; Brady HR; Taylor CT The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia | 0 | 3 |
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