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Nodes: 141,
Authors: 523,
Journals: 55,
Outer References: 4251,
Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by journal name.
Page 1 of 2: [ 1 2 ]
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 1 | 50 | 107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20 Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation | 0 | 0 |
| 2 | 1 | 23 | 1 2003 ANNALS OF NEUROLOGY 54 (2): 143-144 Hardy J Alzheimer's disease: Genetic evidence points to a single pathogenesis | 0 | 4 |
| 3 | 2 | 84 | 24 2004 ANNUAL REVIEW OF GENETICS 38: 709-724 Ehrmann M; Clausen T Proteolysis as aregulatory mechanism | 1 | 2 |
| 4 | 6 | 58 | 108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 (1): 1-5 Teng FYH; Tang BL Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria? | 0 | 0 |
| 5 | 11 | 25 | 109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| 6 | 2 | 39 | 110 2005 BIOCHEMICAL JOURNAL 385: 545-550 Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; et al. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site | 0 | 0 |
| 7 | 1 | 60 | 2 2003 BIOCHEMISTRY 42 (47): 13977-13986 Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al. gamma-secretase activity is present in rafts but is not cholesterol-dependent | 2 | 8 |
| 8 | 6 | 48 | 25 2004 BIOCHEMISTRY 43 (2): 323-333 Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | 17 | 20 |
| 9 | 7 | 58 | 26 2004 BIOCHEMISTRY 43 (12): 3555-3563 Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation | 5 | 6 |
| 10 | 1 | 45 | 27 2004 BIOCHEMISTRY 43 (20): 6208-6218 Knappenberger KS; Tian GC; Ye XM; Sobotka-Briner C; Ghanekar SV; et al. Mechanism of gamma-secretase cleavage activation: Is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop? | 1 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 11 | 4 | 69 | 28 2004 BIOCHEMISTRY 43 (30): 9774-9789 Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al. Purification and characterization of the human gamma-secretase complex | 4 | 6 |
| 12 | 1 | 29 | 29 2004 BIOCHEMISTRY 43 (42): 13532-13540 Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42 | 0 | 1 |
| 13 | 5 | 53 | 111 2005 BIOCHEMISTRY 44 (11): 4332-4341 Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex | 0 | 0 |
| 14 | 2 | 36 | 112 2005 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 15 | 1 | 42 | 30 2004 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1674 (1): 29-39 Middendorp O; Ortler C; Neumann U; Paganetti P; Luthi U; et al. Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase | 0 | 0 |
| 16 | 1 | 70 | 113 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267 King ME Can tau filaments be both physiologically beneficial and toxic? | 0 | 0 |
| 17 | 1 | 31 | 31 2004 BIOLOGICAL CHEMISTRY 385 (6): 481-485 Middendorp O; Luthi U; Hausch F; Barberis A Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase | 0 | 1 |
| 18 | 1 | 38 | 32 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938 Esler WP; Das C; Wolfe MS Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties | 0 | 1 |
| 19 | 1 | 22 | 114 2005 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (7): 1891-1894 Gundersen E; Fan K; Haas K; Huryn D; Jacobsen JS; et al. Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors | 0 | 0 |
| 20 | 2 | 104 | 115 2005 CELL 120 (4): 545-555 Tanzi RE; Bertram L Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 21 | 1 | 295 | 33 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178 Makarova A; Williams SE; Strickland DK Proteases and lipoprotein receptors in Alzheimer's disease | 0 | 0 |
| 22 | 1 | 103 | 34 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (3): 326-335 Johansson J; Weaver TE; Tjernberg LO Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide | 0 | 3 |
| 23 | 1 | 260 | 35 2004 CLINICAL GENETICS 66 (1): 1-16 Wellington CL Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism | 0 | 0 |
| 24 | 4 | 103 | 36 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178 Westlund B; Stilwell G; Sluder A Invertebrate disease models in neurotherapeutic discovery | 0 | 0 |
| 25 | 7 | 117 | 37 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719 Harrison T; Churcher I; Beher D gamma-Secretase as a target for drug intervention in Alzheimer's disease | 1 | 3 |
| 26 | 5 | 28 | 38 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383 Iwatsubo T The gamma-secretase complex: machinery for intramembrane proteolysis | 1 | 5 |
| 27 | 3 | 58 | 39 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588 Wilquet V; De Strooper B Amyloid-beta precursor protein processing in neurodegeneration | 0 | 1 |
| 28 | 1 | 71 | 3 2003 CURRENT OPINION IN RHEUMATOLOGY 15 (6): 737-744 Askanas V; Engel WK Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging | 0 | 8 |
| 29 | 5 | 222 | 40 2004 CYTOKINE & GROWTH FACTOR REVIEWS 15 (5): 337-351 Landman N; Kim TW Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling | 0 | 1 |
| 30 | 1 | 33 | 41 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325 Tomita T; Iwatsubo T The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease | 1 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 31 | 4 | 48 | 42 2004 EMBO JOURNAL 23 (3): 483-488 Haass C Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation | 15 | 30 |
| 32 | 2 | 64 | 43 2004 EMBO JOURNAL 23 (15): 3041-3050 Haffner C; Frauli M; Topp S; Irmler M; Hofmann K; et al. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists | 0 | 0 |
| 33 | 6 | 35 | 44 2004 EMBO JOURNAL 23 (24): 4738-4748 Kaether C; Capell A; Edbauer D; Winkler E; Novak B; et al. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity | 2 | 3 |
| 34 | 5 | 55 | 45 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385 Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al. Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations | 5 | 7 |
| 35 | 1 | 34 | 46 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (22): 4485-4494 Pastorcic M; Das HK Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells - The role of Ets factors in the regulation of presenilin 1 | 0 | 0 |
| 36 | 1 | 68 | 116 2005 FEBS JOURNAL 272 (6): 1386-1400 Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al. Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast | 0 | 0 |
| 37 | 1 | 25 | 4 2003 FEBS LETTERS 550 (1-3): 30-34 Hebert SS; Godin C; Levesque G Oligomerization of human presenilin-1 fragments | 2 | 3 |
| 38 | 9 | 178 | 117 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146 Marambaud P; Robakis NK Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation | 0 | 0 |
| 39 | 1 | 44 | 5 2003 HUMAN MOLECULAR GENETICS 12: R201-R206 Martoglio B; Golde TE Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs | 0 | 10 |
| 40 | 2 | 62 | 6 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678 Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA A reporter for amyloid precursor protein gamma-secretase activity in Drosophila | 2 | 4 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 41 | 1 | 36 | 47 2004 HUMAN MOLECULAR GENETICS 13: R123-R126 Singleton A; Myers A; Hardy J The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases | 0 | 12 |
| 42 | 1 | 59 | 48 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331 Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice | 1 | 3 |
| 43 | 2 | 72 | 49 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36 (12): 2531-2540 Yu WH; Kumar A; Peterhoff C; Kulnane LS; Uchiyama Y; et al. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease | 1 | 3 |
| 44 | 2 | 125 | 50 2004 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 22 (7): 453-465 Gotz J; Schild A; Hoerndli F; Pennanen L Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models | 0 | 2 |
| 45 | 1 | 144 | 51 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65 Pasternak SH; Callahan JW; Mahuran DJ The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective | 1 | 3 |
| 46 | 1 | 57 | 7 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284 Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al. Partial purification and characterization of gamma-secretase from post-mortem human brain | 15 | 20 |
| 47 | 1 | 59 | 8 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754 Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al. A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain | 2 | 10 |
| 48 | 1 | 63 | 9 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002 Kim SH; Ikeuchi T; Yu CJ; Sisodia SS Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates | 21 | 25 |
| 49 | 2 | 33 | 10 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222 LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | 38 | 49 |
| 50 | 1 | 44 | 11 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169 Jung KM; Tan S; Landman N; Petrova K; Murray S; et al. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor | 6 | 24 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 51 | 2 | 46 | 12 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291 Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex | 20 | 23 |
| 52 | 4 | 34 | 13 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523 Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain | 6 | 8 |
| 53 | 4 | 43 | 52 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693 Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex | 10 | 11 |
| 54 | 5 | 38 | 53 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152 Lee SF; Shah S; Yu C; Wigley WC; Li H; et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex | 9 | 12 |
| 55 | 2 | 36 | 54 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160 Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor | 6 | 9 |
| 56 | 1 | 32 | 55 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (16): 16744-16753 Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; et al. Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin | 10 | 13 |
| 57 | 6 | 48 | 56 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261 Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex | 10 | 10 |
| 58 | 3 | 36 | 57 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338 Pitsi D; Octave JN Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity | 0 | 1 |
| 59 | 1 | 75 | 58 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (28): 29469-29477 Li AM; Dong JX; Harris DA Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes | 0 | 1 |
| 60 | 9 | 37 | 59 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315 Edbauer D; Kaether C; Steiner H; Haass C Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1 | 1 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 61 | 4 | 40 | 60 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046 Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles | 2 | 3 |
| 62 | 2 | 55 | 61 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (38): 39710-39717 Schmechel A; Strauss M; Schlicksupp A; Pipkorn R; Haass C; et al. Human BACE forms dimers and colocalizes with APP | 2 | 2 |
| 63 | 8 | 75 | 62 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566 Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components | 1 | 3 |
| 64 | 10 | 56 | 63 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345 Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H Identification of distinct gamma-secretase complexes with different APH-1 variants | 7 | 8 |
| 65 | 1 | 26 | 64 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43046-43051 Shen JS; Prywes R Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6 | 0 | 0 |
| 66 | 4 | 36 | 65 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156 Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin | 0 | 1 |
| 67 | 4 | 48 | 66 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426 Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al. Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism | 1 | 3 |
| 68 | 3 | 29 | 67 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463 Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes | 3 | 3 |
| 69 | 5 | 26 | 68 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619 Kim SH; Yin YI; Li YM; Sisodia SS Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway | 3 | 4 |
| 70 | 1 | 55 | 69 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49105-49112 Ghersi E; Noviello C; D'Adamio L Amyloid-beta protein precursor (A beta PP) intracellular domain-associated protein-1 proteins bind to A beta PP and modulate its processing in an isoform-specific manner | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 71 | 3 | 53 | 70 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532 Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway | 0 | 0 |
| 72 | 3 | 46 | 71 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798 Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins | 1 | 1 |
| 73 | 3 | 41 | 72 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 51654-51660 Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; et al. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria | 1 | 2 |
| 74 | 4 | 67 | 73 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (51): 53205-53212 Westmeyer GG; Willem M; Lichtenthaler SF; Lurman G; Multhaup G; et al. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme | 1 | 1 |
| 75 | 11 | 25 | 118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| 76 | 4 | 54 | 119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392 Chyung JH; Raper DM; Selkoe DJ gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage | 0 | 1 |
| 77 | 16 | 53 | 120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478 Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al. gamma-secretase complex assembly within the early secretory pathway | 0 | 0 |
| 78 | 1 | 54 | 121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 7758-7768 Kim J; Hamamoto S; Ravazzola M; Orci L; Schekman R Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles | 0 | 0 |
| 79 | 1 | 40 | 122 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (10): 9313-9319 Haas IG; Frank M; Veron N; Kemler R Presenilin-dependent processing and nuclear function of gamma-protocadherins | 0 | 0 |
| 80 | 13 | 77 | 123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 81 | 18 | 68 | 124 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975 Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions | 0 | 0 |
| 82 | 10 | 44 | 125 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 83 | 3 | 60 | 126 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (18): 17930-17937 Angeletti B; Waldron KJ; Freeman KB; Bawagan H; Hussain I; et al. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper | 0 | 0 |
| 84 | 4 | 52 | 127 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077 Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides | 0 | 0 |
| 85 | 4 | 91 | 128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19331-19342 Cowan JW; Wang XD; Guan R; He K; Jiang J; et al. Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage | 0 | 0 |
| 86 | 1 | 24 | 14 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690 Hu Y; Fortini ME Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | 37 | 44 |
| 87 | 1 | 69 | 15 2003 JOURNAL OF CELL SCIENCE 116 (14): 2839-2844 Xia WM; Wolfe MS Intramembrane proteolysis by presenilin and presenilin-like proteases | 5 | 11 |
| 88 | 2 | 62 | 74 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111 Gowrishankar K; Zeidler MG; Vincenz C Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD | 1 | 1 |
| 89 | 1 | 64 | 75 2004 JOURNAL OF CELL SCIENCE 117 (19): 4435-4448 von Rotz RC; Kohli BM; Bosset J; Meier M; Suzuki T; et al. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor | 1 | 4 |
| 90 | 6 | 50 | 129 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 91 | 6 | 31 | 130 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| 92 | 1 | 57 | 76 2004 JOURNAL OF NEUROCHEMISTRY 88 (4): 869-877 Smith IF; Boyle JP; Green KN; Pearson HA; Peers C Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing | 0 | 3 |
| 93 | 1 | 79 | 77 2004 JOURNAL OF NEUROCHEMISTRY 88 (5): 1140-1150 Pierrot N; Ghisdal P; Caumont AS; Octave JN Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death | 0 | 2 |
| 94 | 1 | 59 | 78 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53 Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein | 4 | 7 |
| 95 | 6 | 42 | 79 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527 Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 | 8 | 8 |
| 96 | 1 | 54 | 80 2004 JOURNAL OF NEUROCHEMISTRY 90 (3): 712-723 van Dijk R; Fischer DF; Sluijs JA; Sonnemans MAF; Hobo B; et al. Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta 40 | 0 | 0 |
| 97 | 2 | 37 | 81 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320 Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding | 5 | 5 |
| 98 | 10 | 62 | 82 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413 Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation | 0 | 0 |
| 99 | 6 | 51 | 83 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237 Ilaya NT; Evin G; Masters CL; Culvenor JG Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle | 0 | 0 |
| 100 | 1 | 38 | 131 2005 JOURNAL OF NEUROCHEMISTRY 92 (2): 294-301 Walker ES; Martinez M; Brunkan AL; Goate A Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in A beta 42/40 ratios | 1 | 1 |
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