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Fri Jun 3 10:17:21 2005

Reconstitution of gamma-secretase activity
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
NATURE CELL BIOLOGY 5 (5): 486-488 MAY 2003

Nodes: 141, Authors: 523, Journals: 55, Outer References: 4251, Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by journal name.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
1150107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20
Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
00
21231 2003 ANNALS OF NEUROLOGY 54 (2): 143-144
Hardy J
Alzheimer's disease: Genetic evidence points to a single pathogenesis
04
328424 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
12
4658108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 (1): 1-5
Teng FYH; Tang BL
Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
00
51125109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072
Saito S; Takahashi-Sasaki N; Araki W
Identification and characterization of a novel human APH-1b splice variant lacking exon 4
00
6239110 2005 BIOCHEMICAL JOURNAL 385: 545-550
Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; et al.
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site
00
71602 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
28
864825 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
975826 2004 BIOCHEMISTRY 43 (12): 3555-3563
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
56
1014527 2004 BIOCHEMISTRY 43 (20): 6208-6218
Knappenberger KS; Tian GC; Ye XM; Sobotka-Briner C; Ghanekar SV; et al.
Mechanism of gamma-secretase cleavage activation: Is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
12
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1146928 2004 BIOCHEMISTRY 43 (30): 9774-9789
Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al.
Purification and characterization of the human gamma-secretase complex
46
1212929 2004 BIOCHEMISTRY 43 (42): 13532-13540
Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al.
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42
01
13553111 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
14236112 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
1514230 2004 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1674 (1): 29-39
Middendorp O; Ortler C; Neumann U; Paganetti P; Luthi U; et al.
Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase
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16170113 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267
King ME
Can tau filaments be both physiologically beneficial and toxic?
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1713131 2004 BIOLOGICAL CHEMISTRY 385 (6): 481-485
Middendorp O; Luthi U; Hausch F; Barberis A
Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase
01
1813832 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938
Esler WP; Das C; Wolfe MS
Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties
01
19122114 2005 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (7): 1891-1894
Gundersen E; Fan K; Haas K; Huryn D; Jacobsen JS; et al.
Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors
00
202104115 2005 CELL 120 (4): 545-555
Tanzi RE; Bertram L
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
21129533 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178
Makarova A; Williams SE; Strickland DK
Proteases and lipoprotein receptors in Alzheimer's disease
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22110334 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (3): 326-335
Johansson J; Weaver TE; Tjernberg LO
Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide
03
23126035 2004 CLINICAL GENETICS 66 (1): 1-16
Wellington CL
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
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24410336 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
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25711737 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719
Harrison T; Churcher I; Beher D
gamma-Secretase as a target for drug intervention in Alzheimer's disease
13
2652838 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383
Iwatsubo T
The gamma-secretase complex: machinery for intramembrane proteolysis
15
2735839 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
281713 2003 CURRENT OPINION IN RHEUMATOLOGY 15 (6): 737-744
Askanas V; Engel WK
Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging
08
29522240 2004 CYTOKINE & GROWTH FACTOR REVIEWS 15 (5): 337-351
Landman N; Kim TW
Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling
01
3013341 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3144842 2004 EMBO JOURNAL 23 (3): 483-488
Haass C
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
1530
3226443 2004 EMBO JOURNAL 23 (15): 3041-3050
Haffner C; Frauli M; Topp S; Irmler M; Hofmann K; et al.
Nicalin and its binding partner Nomo are novel Nodal signaling antagonists
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3363544 2004 EMBO JOURNAL 23 (24): 4738-4748
Kaether C; Capell A; Edbauer D; Winkler E; Novak B; et al.
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
23
3455545 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385
Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al.
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
57
3513446 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (22): 4485-4494
Pastorcic M; Das HK
Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells - The role of Ets factors in the regulation of presenilin 1
00
36168116 2005 FEBS JOURNAL 272 (6): 1386-1400
Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al.
Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast
00
371254 2003 FEBS LETTERS 550 (1-3): 30-34
Hebert SS; Godin C; Levesque G
Oligomerization of human presenilin-1 fragments
23
389178117 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146
Marambaud P; Robakis NK
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation
00
391445 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
Martoglio B; Golde TE
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs
010
402626 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678
Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA
A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
24
#LCRNCRNode / Date / Journal / AuthorLCSGCS
4113647 2004 HUMAN MOLECULAR GENETICS 13: R123-R126
Singleton A; Myers A; Hardy J
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases
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4215948 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al.
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
13
4327249 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36 (12): 2531-2540
Yu WH; Kumar A; Peterhoff C; Kulnane LS; Uchiyama Y; et al.
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
13
44212550 2004 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 22 (7): 453-465
Gotz J; Schild A; Hoerndli F; Pennanen L
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models
02
45114451 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65
Pasternak SH; Callahan JW; Mahuran DJ
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
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461577 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284
Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al.
Partial purification and characterization of gamma-secretase from post-mortem human brain
1520
471598 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
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481639 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002
Kim SH; Ikeuchi T; Yu CJ; Sisodia SS
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
2125
4923310 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al.
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
3849
5014411 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
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5124612 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
2023
5243413 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523
Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al.
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
68
5344352 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1011
5453853 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152
Lee SF; Shah S; Yu C; Wigley WC; Li H; et al.
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
912
5523654 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160
Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
69
5613255 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (16): 16744-16753
Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; et al.
Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin
1013
5764856 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
1010
5833657 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338
Pitsi D; Octave JN
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
01
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Li AM; Dong JX; Harris DA
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Edbauer D; Kaether C; Steiner H; Haass C
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
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6144060 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046
Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al.
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
23
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Schmechel A; Strauss M; Schlicksupp A; Pipkorn R; Haass C; et al.
Human BACE forms dimers and colocalizes with APP
22
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Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
13
64105663 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
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6512664 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43046-43051
Shen JS; Prywes R
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
00
6643665 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156
Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
01
6744866 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426
Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al.
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism
13
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Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
33
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Kim SH; Yin YI; Li YM; Sisodia SS
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
34
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Ghersi E; Noviello C; D'Adamio L
Amyloid-beta protein precursor (A beta PP) intracellular domain-associated protein-1 proteins bind to A beta PP and modulate its processing in an isoform-specific manner
00
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7135370 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
00
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Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al.
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
11
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Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; et al.
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
12
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Westmeyer GG; Willem M; Lichtenthaler SF; Lurman G; Multhaup G; et al.
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
11
751125118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001
Kim SH; Sisodia SS
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
00
76454119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
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Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
00
78154121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 7758-7768
Kim J; Hamamoto S; Ravazzola M; Orci L; Schekman R
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles
00
79140122 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (10): 9313-9319
Haas IG; Frank M; Veron N; Kemler R
Presenilin-dependent processing and nuclear function of gamma-protocadherins
00
801377123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
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811868124 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
821044125 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
83360126 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (18): 17930-17937
Angeletti B; Waldron KJ; Freeman KB; Bawagan H; Hussain I; et al.
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
00
84452127 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
00
85491128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19331-19342
Cowan JW; Wang XD; Guan R; He K; Jiang J; et al.
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage
00
8612414 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690
Hu Y; Fortini ME
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
3744
8716915 2003 JOURNAL OF CELL SCIENCE 116 (14): 2839-2844
Xia WM; Wolfe MS
Intramembrane proteolysis by presenilin and presenilin-like proteases
511
8826274 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111
Gowrishankar K; Zeidler MG; Vincenz C
Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD
11
8916475 2004 JOURNAL OF CELL SCIENCE 117 (19): 4435-4448
von Rotz RC; Kohli BM; Bosset J; Meier M; Suzuki T; et al.
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
14
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Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
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91631130 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
9215776 2004 JOURNAL OF NEUROCHEMISTRY 88 (4): 869-877
Smith IF; Boyle JP; Green KN; Pearson HA; Peers C
Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing
03
9317977 2004 JOURNAL OF NEUROCHEMISTRY 88 (5): 1140-1150
Pierrot N; Ghisdal P; Caumont AS; Octave JN
Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death
02
9415978 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
47
9564279 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
88
9615480 2004 JOURNAL OF NEUROCHEMISTRY 90 (3): 712-723
van Dijk R; Fischer DF; Sluijs JA; Sonnemans MAF; Hobo B; et al.
Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta 40
00
9723781 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
98106282 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al.
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
00
9965183 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237
Ilaya NT; Evin G; Masters CL; Culvenor JG
Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
00
100138131 2005 JOURNAL OF NEUROCHEMISTRY 92 (2): 294-301
Walker ES; Martinez M; Brunkan AL; Goate A
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in A beta 42/40 ratios
11

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