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Reconstitution of gamma-secretase activity
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
NATURE CELL BIOLOGY 5 (5): 486-488 MAY 2003

Nodes: 141, Authors: 523, Journals: 55, Outer References: 4251, Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by LCS.
Page 1 of 2: [  1  2 ]

#LCRNCRNode / Date / Journal / AuthorLCSGCS
101520 2003 NATURE CELL BIOLOGY 5 (5): 486-488
Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; et al.
Reconstitution of gamma-secretase activity
140140
223310 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al.
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
3849
312414 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690
Hu Y; Fortini ME
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
3744
436721 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080
Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al.
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
2334
51639 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002
Kim SH; Ikeuchi T; Yu CJ; Sisodia SS
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
2125
624612 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
2023
764825 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
81577 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284
Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al.
Partial purification and characterization of gamma-secretase from post-mortem human brain
1520
944842 2004 EMBO JOURNAL 23 (3): 483-488
Haass C
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
1530
1044352 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1011
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1113255 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (16): 16744-16753
Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; et al.
Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin
1013
1264856 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
1010
1353853 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152
Lee SF; Shah S; Yu C; Wigley WC; Li H; et al.
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
912
1464279 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
88
15105663 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
78
1614411 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
624
1743413 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523
Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al.
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
68
1823654 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160
Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
69
1916915 2003 JOURNAL OF CELL SCIENCE 116 (14): 2839-2844
Xia WM; Wolfe MS
Intramembrane proteolysis by presenilin and presenilin-like proteases
511
2075826 2004 BIOCHEMISTRY 43 (12): 3555-3563
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
56
#LCRNCRNode / Date / Journal / AuthorLCSGCS
2155545 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385
Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al.
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
57
2223781 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
231311384 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322
Periz G; Fortini ME
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
56
2417417 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 353-360
Kimberly WT; Wolfe MS
Identity and function of gamma-secretase
415
2546928 2004 BIOCHEMISTRY 43 (30): 9774-9789
Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al.
Purification and characterization of the human gamma-secretase complex
46
2615978 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
47
27973105 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
411
28111218 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 361-369
Wilson CA; Doms RW; Lee VMY
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular A beta production
35
2932967 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463
Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
33
3052668 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619
Kim SH; Yin YI; Li YM; Sisodia SS
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
34
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3115798 2004 NEUROBIOLOGY OF DISEASE 17 (2): 205-218
Hecimovic S; Wang J; Dolios G; Martinez M; Wang R; et al.
Mutations in APP have independent effects on A beta and CTF gamma generation
33
32126399 2004 NEUROBIOLOGY OF DISEASE 17 (2): 260-272
Hebert SS; Serneels L; Dejaegere T; Horre K; Dabrowski M; et al.
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
33
331602 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
28
341254 2003 FEBS LETTERS 550 (1-3): 30-34
Hebert SS; Godin C; Levesque G
Oligomerization of human presenilin-1 fragments
23
352626 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678
Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA
A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
24
361598 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
210
3715119 2003 MOLECULAR AND CELLULAR NEUROSCIENCE 24 (3): 646-655
Harrison SM; Harper AJ; Hawkins J; Duddy G; Grau E; et al.
BACE1 (beta-secretase) transgenic neurochernical deficits ind knockout mice: identification of and behavioral changes
27
38310423 2003 SCIENCE 302 (5646): 814-818
Aguzzi A; Haass C
Games played by rogue proteins in prion disorders and Alzheimer's disease
223
3963544 2004 EMBO JOURNAL 23 (24): 4738-4748
Kaether C; Capell A; Edbauer D; Winkler E; Novak B; et al.
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity
23
4044060 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046
Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al.
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
23
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4125561 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (38): 39710-39717
Schmechel A; Strauss M; Schlicksupp A; Pipkorn R; Haass C; et al.
Human BACE forms dimers and colocalizes with APP
22
4231388 2004 MOLECULAR PSYCHIATRY 9 (1): 8-10
Iwatsubo T
Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors
22
43122104 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (4): 905-906
Kim J; Schekman R
The ins and outs of presenilin 1 membrane topology
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44628139 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724
Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi
22
4528424 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
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4614527 2004 BIOCHEMISTRY 43 (20): 6208-6218
Knappenberger KS; Tian GC; Ye XM; Sobotka-Briner C; Ghanekar SV; et al.
Mechanism of gamma-secretase cleavage activation: Is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
12
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gamma-Secretase as a target for drug intervention in Alzheimer's disease
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Iwatsubo T
The gamma-secretase complex: machinery for intramembrane proteolysis
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The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
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Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
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Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
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5487562 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
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Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
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A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities
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APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
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721445 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
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Amyloid-beta precursor protein processing in neurodegeneration
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PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
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Ilaya NT; Evin G; Masters CL; Culvenor JG
Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
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10014485 2004 JOURNAL OF VIROLOGY 78 (21): 11766-11777
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Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells
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