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Fri Jun 3 10:17:24 2005

Reconstitution of gamma-secretase activity
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
NATURE CELL BIOLOGY 5 (5): 486-488 MAY 2003

Nodes: 141, Authors: 523, Journals: 55, Outer References: 4251, Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by NCR.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
1129533 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178
Makarova A; Williams SE; Strickland DK
Proteases and lipoprotein receptors in Alzheimer's disease
00
221282134 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792
Brunkan AL; Goate AM
Presenilin function and gamma-secretase activity
00
3126035 2004 CLINICAL GENETICS 66 (1): 1-16
Wellington CL
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
00
4522240 2004 CYTOKINE & GROWTH FACTOR REVIEWS 15 (5): 337-351
Landman N; Kim TW
Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling
01
5120690 2004 MOLECULAR PSYCHIATRY 9 (7): 664-683
Gotz J; Streffer JR; David D; Schild A; Hoerndli F; et al.
Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy
17
6220422 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341
Stein TD; Johnson JA
Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity
04
79178117 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146
Marambaud P; Robakis NK
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation
00
8114451 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65
Pasternak SH; Callahan JW; Mahuran DJ
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
13
92137138 2005 NEUROBIOLOGY OF AGING 26 (3): 373-382
Nixon RA
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
00
101127102 2004 PHARMACOLOGICAL RESEARCH 50 (4): 397-409
Verdile G; Fuller S; Atwood CS; Laws SM; Gandy SE; et al.
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
11212550 2004 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 22 (7): 453-465
Gotz J; Schild A; Hoerndli F; Pennanen L
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models
02
12711737 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719
Harrison T; Churcher I; Beher D
gamma-Secretase as a target for drug intervention in Alzheimer's disease
13
131311384 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322
Periz G; Fortini ME
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
56
142113136 2005 JOURNAL OF NEUROSCIENCE RESEARCH 80 (2): 151-159
Kerr ML; Small DH
Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development
00
15111218 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 361-369
Wilson CA; Doms RW; Lee VMY
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular A beta production
35
16411196 2004 NATURE REVIEWS NEUROSCIENCE : S26-S33
Koo EH; Kopan R
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
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171110106 2004 SEMINARS IN CANCER BIOLOGY 14 (5): 320-328
Hansson EM; Lendahl U; Chapman G
Notch signaling in development and disease
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18110794 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5 (3): 188-197
Freeman M
Proteolysis within the membrane: Rhomboids revealed
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19210695 2004 NATURE REVIEWS NEUROSCIENCE : S2-S9
Bossy-Wetzel E; Schwarzenbacher R; Lipton SA
Molecular pathways to neurodegeneration
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201105103 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418
Thinakaran G; Parent AT
Identification of the role of presenilins beyond Alzheimer's disease
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
21310423 2003 SCIENCE 302 (5646): 814-818
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Games played by rogue proteins in prion disorders and Alzheimer's disease
223
22110492 2004 NATURE CELL BIOLOGY 6 (11): 1054-1061
Selkoe DJ
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
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232104115 2005 CELL 120 (4): 545-555
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Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
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24110334 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (3): 326-335
Johansson J; Weaver TE; Tjernberg LO
Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide
03
25410336 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
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2629597 2004 NATURE REVIEWS NEUROSCIENCE 5 (9): 677-685
Citron M
Strategies for disease modification in Alzheimer's disease
110
27491128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19331-19342
Cowan JW; Wang XD; Guan R; He K; Jiang J; et al.
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage
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2828424 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
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2917977 2004 JOURNAL OF NEUROCHEMISTRY 88 (5): 1140-1150
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Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death
02
3017786 2004 MOLECULAR AND CELLULAR BIOLOGY 24 (1): 454-464
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Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events
15
#LCRNCRNode / Date / Journal / AuthorLCSGCS
311377123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
3217558 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (28): 29469-29477
Li AM; Dong JX; Harris DA
Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes
01
3387562 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
13
3417417 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 353-360
Kimberly WT; Wolfe MS
Identity and function of gamma-secretase
415
35973105 2004 SCIENCE 305 (5687): 1119-1123
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411
3627249 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36 (12): 2531-2540
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Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
13
371713 2003 CURRENT OPINION IN RHEUMATOLOGY 15 (6): 737-744
Askanas V; Engel WK
Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging
08
38170113 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267
King ME
Can tau filaments be both physiologically beneficial and toxic?
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3916915 2003 JOURNAL OF CELL SCIENCE 116 (14): 2839-2844
Xia WM; Wolfe MS
Intramembrane proteolysis by presenilin and presenilin-like proteases
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Purification and characterization of the human gamma-secretase complex
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41168116 2005 FEBS JOURNAL 272 (6): 1386-1400
Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al.
Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast
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421868124 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
43868137 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73
Brunkan AL; Martinez M; Walker ES; Goate AM
Presenilin endoproteolysis is an intrarnolecular cleavage
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4436721 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080
Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al.
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
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Westmeyer GG; Willem M; Lichtenthaler SF; Lurman G; Multhaup G; et al.
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
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4626443 2004 EMBO JOURNAL 23 (15): 3041-3050
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Nicalin and its binding partner Nomo are novel Nodal signaling antagonists
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4716475 2004 JOURNAL OF CELL SCIENCE 117 (19): 4435-4448
von Rotz RC; Kohli BM; Bosset J; Meier M; Suzuki T; et al.
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
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A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
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5126274 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111
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Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD
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Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al.
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
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gamma-secretase activity is present in rafts but is not cholesterol-dependent
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Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
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5615948 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al.
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
13
5715978 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
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Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
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60558100 2004 NEUROSCIENCE 129 (3): 615-628
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Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
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Partial purification and characterization of gamma-secretase from post-mortem human brain
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Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing
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Mutations in APP have independent effects on A beta and CTF gamma generation
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Identification of distinct gamma-secretase complexes with different APH-1 variants
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Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
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Schmechel A; Strauss M; Schlicksupp A; Pipkorn R; Haass C; et al.
Human BACE forms dimers and colocalizes with APP
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Ghersi E; Noviello C; D'Adamio L
Amyloid-beta protein precursor (A beta PP) intracellular domain-associated protein-1 proteins bind to A beta PP and modulate its processing in an isoform-specific manner
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Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta 40
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Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al.
Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor
01
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71454119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
72154121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 7758-7768
Kim J; Hamamoto S; Ravazzola M; Orci L; Schekman R
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles
00
7335370 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
00
74553111 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
751653120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478
Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
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Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
00
7715119 2003 MOLECULAR AND CELLULAR NEUROSCIENCE 24 (3): 646-655
Harrison SM; Harper AJ; Hawkins J; Duddy G; Grau E; et al.
BACE1 (beta-secretase) transgenic neurochernical deficits ind knockout mice: identification of and behavioral changes
27
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Ilaya NT; Evin G; Masters CL; Culvenor JG
Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
00
7935187 2004 MOLECULAR MEMBRANE BIOLOGY 21 (6): 373-383
Harnasch M; Grau S; Behrends C; Dove SL; Hochschild A; et al.
Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins
01
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Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
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Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
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8264825 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
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Haass C
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
1530
8464856 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
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8544866 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426
Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al.
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism
13
8614891 2004 NATURE BIOTECHNOLOGY 22 (6): 724-731
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Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
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Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al.
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
11
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Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; et al.
Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells
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9014527 2004 BIOCHEMISTRY 43 (20): 6208-6218
Knappenberger KS; Tian GC; Ye XM; Sobotka-Briner C; Ghanekar SV; et al.
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12
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911445 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
Martoglio B; Golde TE
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs
010
9214411 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
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9314485 2004 JOURNAL OF VIROLOGY 78 (21): 11766-11777
Ogino T; Fukuda H; Imajoh-Ohmi S; Kohara M; Nomoto A
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Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
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9544352 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1011
96243133 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1158-1169
Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM
A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities
11
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Middendorp O; Ortler C; Neumann U; Paganetti P; Luthi U; et al.
Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase
00
9864279 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
88
9914116 2003 JOURNAL OF NEUROSCIENCE 23 (27): 9097-9106
Lilliehook C; Bozdagi O; Yao J; Gomez-Ramirez M; Zaidi NF; et al.
Altered A beta formation and long-term potentiation in a calsenilin knock-out
09
10034172 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 51654-51660
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; et al.
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria
12

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