| Missing Links? Citation Matrix | Graphs | Glossary HistCite Guide About |
Nodes: 141,
Authors: 523,
Journals: 55,
Outer References: 4251,
Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by NCR.
Page 1 of 2: [ 1 2 ]
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 1 | 295 | 33 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178 Makarova A; Williams SE; Strickland DK Proteases and lipoprotein receptors in Alzheimer's disease | 0 | 0 |
| 2 | 21 | 282 | 134 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792 Brunkan AL; Goate AM Presenilin function and gamma-secretase activity | 0 | 0 |
| 3 | 1 | 260 | 35 2004 CLINICAL GENETICS 66 (1): 1-16 Wellington CL Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism | 0 | 0 |
| 4 | 5 | 222 | 40 2004 CYTOKINE & GROWTH FACTOR REVIEWS 15 (5): 337-351 Landman N; Kim TW Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling | 0 | 1 |
| 5 | 1 | 206 | 90 2004 MOLECULAR PSYCHIATRY 9 (7): 664-683 Gotz J; Streffer JR; David D; Schild A; Hoerndli F; et al. Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy | 1 | 7 |
| 6 | 2 | 204 | 22 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341 Stein TD; Johnson JA Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity | 0 | 4 |
| 7 | 9 | 178 | 117 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146 Marambaud P; Robakis NK Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation | 0 | 0 |
| 8 | 1 | 144 | 51 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65 Pasternak SH; Callahan JW; Mahuran DJ The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective | 1 | 3 |
| 9 | 2 | 137 | 138 2005 NEUROBIOLOGY OF AGING 26 (3): 373-382 Nixon RA Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases | 0 | 0 |
| 10 | 1 | 127 | 102 2004 PHARMACOLOGICAL RESEARCH 50 (4): 397-409 Verdile G; Fuller S; Atwood CS; Laws SM; Gandy SE; et al. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 11 | 2 | 125 | 50 2004 INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 22 (7): 453-465 Gotz J; Schild A; Hoerndli F; Pennanen L Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models | 0 | 2 |
| 12 | 7 | 117 | 37 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719 Harrison T; Churcher I; Beher D gamma-Secretase as a target for drug intervention in Alzheimer's disease | 1 | 3 |
| 13 | 13 | 113 | 84 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322 Periz G; Fortini ME Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2 | 5 | 6 |
| 14 | 2 | 113 | 136 2005 JOURNAL OF NEUROSCIENCE RESEARCH 80 (2): 151-159 Kerr ML; Small DH Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development | 0 | 0 |
| 15 | 1 | 112 | 18 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 361-369 Wilson CA; Doms RW; Lee VMY Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular A beta production | 3 | 5 |
| 16 | 4 | 111 | 96 2004 NATURE REVIEWS NEUROSCIENCE : S26-S33 Koo EH; Kopan R Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration | 0 | 0 |
| 17 | 1 | 110 | 106 2004 SEMINARS IN CANCER BIOLOGY 14 (5): 320-328 Hansson EM; Lendahl U; Chapman G Notch signaling in development and disease | 1 | 5 |
| 18 | 1 | 107 | 94 2004 NATURE REVIEWS MOLECULAR CELL BIOLOGY 5 (3): 188-197 Freeman M Proteolysis within the membrane: Rhomboids revealed | 1 | 7 |
| 19 | 2 | 106 | 95 2004 NATURE REVIEWS NEUROSCIENCE : S2-S9 Bossy-Wetzel E; Schwarzenbacher R; Lipton SA Molecular pathways to neurodegeneration | 0 | 0 |
| 20 | 1 | 105 | 103 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418 Thinakaran G; Parent AT Identification of the role of presenilins beyond Alzheimer's disease | 1 | 4 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 21 | 3 | 104 | 23 2003 SCIENCE 302 (5646): 814-818 Aguzzi A; Haass C Games played by rogue proteins in prion disorders and Alzheimer's disease | 2 | 23 |
| 22 | 1 | 104 | 92 2004 NATURE CELL BIOLOGY 6 (11): 1054-1061 Selkoe DJ Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases | 0 | 0 |
| 23 | 2 | 104 | 115 2005 CELL 120 (4): 545-555 Tanzi RE; Bertram L Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective | 0 | 0 |
| 24 | 1 | 103 | 34 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (3): 326-335 Johansson J; Weaver TE; Tjernberg LO Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide | 0 | 3 |
| 25 | 4 | 103 | 36 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178 Westlund B; Stilwell G; Sluder A Invertebrate disease models in neurotherapeutic discovery | 0 | 0 |
| 26 | 2 | 95 | 97 2004 NATURE REVIEWS NEUROSCIENCE 5 (9): 677-685 Citron M Strategies for disease modification in Alzheimer's disease | 1 | 10 |
| 27 | 4 | 91 | 128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19331-19342 Cowan JW; Wang XD; Guan R; He K; Jiang J; et al. Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage | 0 | 0 |
| 28 | 2 | 84 | 24 2004 ANNUAL REVIEW OF GENETICS 38: 709-724 Ehrmann M; Clausen T Proteolysis as aregulatory mechanism | 1 | 2 |
| 29 | 1 | 79 | 77 2004 JOURNAL OF NEUROCHEMISTRY 88 (5): 1140-1150 Pierrot N; Ghisdal P; Caumont AS; Octave JN Intraneuronal amyloid-beta 1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death | 0 | 2 |
| 30 | 1 | 77 | 86 2004 MOLECULAR AND CELLULAR BIOLOGY 24 (1): 454-464 Wilhelmsen K; van der Geer P Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events | 1 | 5 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 31 | 13 | 77 | 123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| 32 | 1 | 75 | 58 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (28): 29469-29477 Li AM; Dong JX; Harris DA Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes | 0 | 1 |
| 33 | 8 | 75 | 62 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566 Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components | 1 | 3 |
| 34 | 1 | 74 | 17 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 353-360 Kimberly WT; Wolfe MS Identity and function of gamma-secretase | 4 | 15 |
| 35 | 9 | 73 | 105 2004 SCIENCE 305 (5687): 1119-1123 Wolfe MS; Kopan R Intramembrane proteotysis: Theme and variations | 4 | 11 |
| 36 | 2 | 72 | 49 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36 (12): 2531-2540 Yu WH; Kumar A; Peterhoff C; Kulnane LS; Uchiyama Y; et al. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease | 1 | 3 |
| 37 | 1 | 71 | 3 2003 CURRENT OPINION IN RHEUMATOLOGY 15 (6): 737-744 Askanas V; Engel WK Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging | 0 | 8 |
| 38 | 1 | 70 | 113 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267 King ME Can tau filaments be both physiologically beneficial and toxic? | 0 | 0 |
| 39 | 1 | 69 | 15 2003 JOURNAL OF CELL SCIENCE 116 (14): 2839-2844 Xia WM; Wolfe MS Intramembrane proteolysis by presenilin and presenilin-like proteases | 5 | 11 |
| 40 | 4 | 69 | 28 2004 BIOCHEMISTRY 43 (30): 9774-9789 Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al. Purification and characterization of the human gamma-secretase complex | 4 | 6 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 41 | 1 | 68 | 116 2005 FEBS JOURNAL 272 (6): 1386-1400 Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al. Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast | 0 | 0 |
| 42 | 18 | 68 | 124 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975 Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions | 0 | 0 |
| 43 | 8 | 68 | 137 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73 Brunkan AL; Martinez M; Walker ES; Goate AM Presenilin endoproteolysis is an intrarnolecular cleavage | 0 | 0 |
| 44 | 3 | 67 | 21 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080 Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al. A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis | 23 | 34 |
| 45 | 4 | 67 | 73 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (51): 53205-53212 Westmeyer GG; Willem M; Lichtenthaler SF; Lurman G; Multhaup G; et al. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme | 1 | 1 |
| 46 | 2 | 64 | 43 2004 EMBO JOURNAL 23 (15): 3041-3050 Haffner C; Frauli M; Topp S; Irmler M; Hofmann K; et al. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists | 0 | 0 |
| 47 | 1 | 64 | 75 2004 JOURNAL OF CELL SCIENCE 117 (19): 4435-4448 von Rotz RC; Kohli BM; Bosset J; Meier M; Suzuki T; et al. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor | 1 | 4 |
| 48 | 1 | 63 | 9 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002 Kim SH; Ikeuchi T; Yu CJ; Sisodia SS Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates | 21 | 25 |
| 49 | 12 | 63 | 99 2004 NEUROBIOLOGY OF DISEASE 17 (2): 260-272 Hebert SS; Serneels L; Dejaegere T; Horre K; Dabrowski M; et al. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity | 3 | 3 |
| 50 | 2 | 62 | 6 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678 Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA A reporter for amyloid precursor protein gamma-secretase activity in Drosophila | 2 | 4 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 51 | 2 | 62 | 74 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111 Gowrishankar K; Zeidler MG; Vincenz C Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD | 1 | 1 |
| 52 | 10 | 62 | 82 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413 Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation | 0 | 0 |
| 53 | 1 | 60 | 2 2003 BIOCHEMISTRY 42 (47): 13977-13986 Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al. gamma-secretase activity is present in rafts but is not cholesterol-dependent | 2 | 8 |
| 54 | 3 | 60 | 126 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (18): 17930-17937 Angeletti B; Waldron KJ; Freeman KB; Bawagan H; Hussain I; et al. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper | 0 | 0 |
| 55 | 1 | 59 | 8 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754 Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al. A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain | 2 | 10 |
| 56 | 1 | 59 | 48 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331 Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice | 1 | 3 |
| 57 | 1 | 59 | 78 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53 Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein | 4 | 7 |
| 58 | 7 | 58 | 26 2004 BIOCHEMISTRY 43 (12): 3555-3563 Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation | 5 | 6 |
| 59 | 3 | 58 | 39 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588 Wilquet V; De Strooper B Amyloid-beta precursor protein processing in neurodegeneration | 0 | 1 |
| 60 | 5 | 58 | 100 2004 NEUROSCIENCE 129 (3): 615-628 Siman R; Salidas S Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 61 | 6 | 58 | 108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 (1): 1-5 Teng FYH; Tang BL Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria? | 0 | 0 |
| 62 | 1 | 57 | 7 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284 Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al. Partial purification and characterization of gamma-secretase from post-mortem human brain | 15 | 20 |
| 63 | 1 | 57 | 76 2004 JOURNAL OF NEUROCHEMISTRY 88 (4): 869-877 Smith IF; Boyle JP; Green KN; Pearson HA; Peers C Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing | 0 | 3 |
| 64 | 1 | 57 | 98 2004 NEUROBIOLOGY OF DISEASE 17 (2): 205-218 Hecimovic S; Wang J; Dolios G; Martinez M; Wang R; et al. Mutations in APP have independent effects on A beta and CTF gamma generation | 3 | 3 |
| 65 | 10 | 56 | 63 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345 Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H Identification of distinct gamma-secretase complexes with different APH-1 variants | 7 | 8 |
| 66 | 5 | 55 | 45 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385 Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al. Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations | 5 | 7 |
| 67 | 2 | 55 | 61 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (38): 39710-39717 Schmechel A; Strauss M; Schlicksupp A; Pipkorn R; Haass C; et al. Human BACE forms dimers and colocalizes with APP | 2 | 2 |
| 68 | 1 | 55 | 69 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49105-49112 Ghersi E; Noviello C; D'Adamio L Amyloid-beta protein precursor (A beta PP) intracellular domain-associated protein-1 proteins bind to A beta PP and modulate its processing in an isoform-specific manner | 0 | 0 |
| 69 | 1 | 54 | 80 2004 JOURNAL OF NEUROCHEMISTRY 90 (3): 712-723 van Dijk R; Fischer DF; Sluijs JA; Sonnemans MAF; Hobo B; et al. Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta 40 | 0 | 0 |
| 70 | 3 | 54 | 101 2004 ONCOGENE 23 (42): 7076-7086 Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al. Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor | 0 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 71 | 4 | 54 | 119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392 Chyung JH; Raper DM; Selkoe DJ gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage | 0 | 1 |
| 72 | 1 | 54 | 121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 7758-7768 Kim J; Hamamoto S; Ravazzola M; Orci L; Schekman R Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles | 0 | 0 |
| 73 | 3 | 53 | 70 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532 Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway | 0 | 0 |
| 74 | 5 | 53 | 111 2005 BIOCHEMISTRY 44 (11): 4332-4341 Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex | 0 | 0 |
| 75 | 16 | 53 | 120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478 Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al. gamma-secretase complex assembly within the early secretory pathway | 0 | 0 |
| 76 | 4 | 52 | 127 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077 Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides | 0 | 0 |
| 77 | 1 | 51 | 19 2003 MOLECULAR AND CELLULAR NEUROSCIENCE 24 (3): 646-655 Harrison SM; Harper AJ; Hawkins J; Duddy G; Grau E; et al. BACE1 (beta-secretase) transgenic neurochernical deficits ind knockout mice: identification of and behavioral changes | 2 | 7 |
| 78 | 6 | 51 | 83 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237 Ilaya NT; Evin G; Masters CL; Culvenor JG Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle | 0 | 0 |
| 79 | 3 | 51 | 87 2004 MOLECULAR MEMBRANE BIOLOGY 21 (6): 373-383 Harnasch M; Grau S; Behrends C; Dove SL; Hochschild A; et al. Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins | 0 | 1 |
| 80 | 1 | 50 | 107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20 Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 81 | 6 | 50 | 129 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| 82 | 6 | 48 | 25 2004 BIOCHEMISTRY 43 (2): 323-333 Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | 17 | 20 |
| 83 | 4 | 48 | 42 2004 EMBO JOURNAL 23 (3): 483-488 Haass C Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation | 15 | 30 |
| 84 | 6 | 48 | 56 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261 Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex | 10 | 10 |
| 85 | 4 | 48 | 66 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426 Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al. Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism | 1 | 3 |
| 86 | 1 | 48 | 91 2004 NATURE BIOTECHNOLOGY 22 (6): 724-731 Schmitt-Ulms G; Hansen K; Liu JL; Cowdrey C; Yang J; et al. Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues | 0 | 2 |
| 87 | 2 | 46 | 12 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291 Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex | 20 | 23 |
| 88 | 3 | 46 | 71 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798 Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins | 1 | 1 |
| 89 | 1 | 46 | 89 2004 MOLECULAR PSYCHIATRY 9 (6): 594-602 Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; et al. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells | 0 | 0 |
| 90 | 1 | 45 | 27 2004 BIOCHEMISTRY 43 (20): 6208-6218 Knappenberger KS; Tian GC; Ye XM; Sobotka-Briner C; Ghanekar SV; et al. Mechanism of gamma-secretase cleavage activation: Is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop? | 1 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 91 | 1 | 44 | 5 2003 HUMAN MOLECULAR GENETICS 12: R201-R206 Martoglio B; Golde TE Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs | 0 | 10 |
| 92 | 1 | 44 | 11 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169 Jung KM; Tan S; Landman N; Petrova K; Murray S; et al. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor | 6 | 24 |
| 93 | 1 | 44 | 85 2004 JOURNAL OF VIROLOGY 78 (21): 11766-11777 Ogino T; Fukuda H; Imajoh-Ohmi S; Kohara M; Nomoto A Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells | 0 | 0 |
| 94 | 10 | 44 | 125 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 95 | 4 | 43 | 52 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693 Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex | 10 | 11 |
| 96 | 2 | 43 | 133 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1158-1169 Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities | 1 | 1 |
| 97 | 1 | 42 | 30 2004 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1674 (1): 29-39 Middendorp O; Ortler C; Neumann U; Paganetti P; Luthi U; et al. Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase | 0 | 0 |
| 98 | 6 | 42 | 79 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527 Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 | 8 | 8 |
| 99 | 1 | 41 | 16 2003 JOURNAL OF NEUROSCIENCE 23 (27): 9097-9106 Lilliehook C; Bozdagi O; Yao J; Gomez-Ramirez M; Zaidi NF; et al. Altered A beta formation and long-term potentiation in a calsenilin knock-out | 0 | 9 |
| 100 | 3 | 41 | 72 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 51654-51660 Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; et al. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria | 1 | 2 |
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