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Nodes: 141,
Authors: 523,
Journals: 55,
Outer References: 4251,
Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by NCR.
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| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 101 | 4 | 40 | 60 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046 Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles | 2 | 3 |
| 102 | 1 | 40 | 122 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (10): 9313-9319 Haas IG; Frank M; Veron N; Kemler R Presenilin-dependent processing and nuclear function of gamma-protocadherins | 0 | 0 |
| 103 | 2 | 39 | 110 2005 BIOCHEMICAL JOURNAL 385: 545-550 Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; et al. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site | 0 | 0 |
| 104 | 1 | 38 | 32 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938 Esler WP; Das C; Wolfe MS Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties | 0 | 1 |
| 105 | 5 | 38 | 53 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152 Lee SF; Shah S; Yu C; Wigley WC; Li H; et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex | 9 | 12 |
| 106 | 1 | 38 | 131 2005 JOURNAL OF NEUROCHEMISTRY 92 (2): 294-301 Walker ES; Martinez M; Brunkan AL; Goate A Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in A beta 42/40 ratios | 1 | 1 |
| 107 | 9 | 37 | 59 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315 Edbauer D; Kaether C; Steiner H; Haass C Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1 | 1 | 1 |
| 108 | 2 | 37 | 81 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320 Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding | 5 | 5 |
| 109 | 1 | 36 | 47 2004 HUMAN MOLECULAR GENETICS 13: R123-R126 Singleton A; Myers A; Hardy J The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases | 0 | 12 |
| 110 | 2 | 36 | 54 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160 Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor | 6 | 9 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 111 | 3 | 36 | 57 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338 Pitsi D; Octave JN Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity | 0 | 1 |
| 112 | 4 | 36 | 65 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156 Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin | 0 | 1 |
| 113 | 2 | 36 | 93 2004 NATURE MEDICINE 10 (9): 959-965 He WX; Lu YF; Qahwash I; Hu XY; Chang AS; et al. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation | 0 | 2 |
| 114 | 2 | 36 | 112 2005 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 115 | 12 | 36 | 135 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198 Ma GJ; Li T; Price DL; Wong PC APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | 1 | 1 |
| 116 | 6 | 35 | 44 2004 EMBO JOURNAL 23 (24): 4738-4748 Kaether C; Capell A; Edbauer D; Winkler E; Novak B; et al. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity | 2 | 3 |
| 117 | 9 | 35 | 132 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020 Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch | 0 | 0 |
| 118 | 4 | 34 | 13 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523 Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain | 6 | 8 |
| 119 | 1 | 34 | 46 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (22): 4485-4494 Pastorcic M; Das HK Alternative initiation of transcription of the human presenilin 1 gene in SH-SY5Y and SK-N-SH cells - The role of Ets factors in the regulation of presenilin 1 | 0 | 0 |
| 120 | 3 | 34 | 140 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888 Urban S; Wolfe MS Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | 0 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 121 | 2 | 33 | 10 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222 LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | 38 | 49 |
| 122 | 1 | 33 | 41 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325 Tomita T; Iwatsubo T The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease | 1 | 2 |
| 123 | 1 | 32 | 55 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (16): 16744-16753 Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; et al. Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin | 10 | 13 |
| 124 | 1 | 31 | 31 2004 BIOLOGICAL CHEMISTRY 385 (6): 481-485 Middendorp O; Luthi U; Hausch F; Barberis A Searching for the most effective screening system to identify cell-active inhibitors of beta-secretase | 0 | 1 |
| 125 | 6 | 31 | 130 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| 126 | 2 | 31 | 141 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235 Kornilova AY; Bihel F; Das C; Wolfe MS The initial substrate-binding site of gamma-secretase is located on presenilin near the active site | 0 | 0 |
| 127 | 1 | 29 | 29 2004 BIOCHEMISTRY 43 (42): 13532-13540 Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42 | 0 | 1 |
| 128 | 3 | 29 | 67 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463 Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes | 3 | 3 |
| 129 | 5 | 28 | 38 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383 Iwatsubo T The gamma-secretase complex: machinery for intramembrane proteolysis | 1 | 5 |
| 130 | 6 | 28 | 139 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724 Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi | 2 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 131 | 1 | 26 | 64 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43046-43051 Shen JS; Prywes R Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6 | 0 | 0 |
| 132 | 5 | 26 | 68 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619 Kim SH; Yin YI; Li YM; Sisodia SS Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway | 3 | 4 |
| 133 | 1 | 25 | 4 2003 FEBS LETTERS 550 (1-3): 30-34 Hebert SS; Godin C; Levesque G Oligomerization of human presenilin-1 fragments | 2 | 3 |
| 134 | 11 | 25 | 109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| 135 | 11 | 25 | 118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| 136 | 1 | 24 | 14 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690 Hu Y; Fortini ME Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | 37 | 44 |
| 137 | 1 | 23 | 1 2003 ANNALS OF NEUROLOGY 54 (2): 143-144 Hardy J Alzheimer's disease: Genetic evidence points to a single pathogenesis | 0 | 4 |
| 138 | 1 | 22 | 104 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (4): 905-906 Kim J; Schekman R The ins and outs of presenilin 1 membrane topology | 2 | 3 |
| 139 | 1 | 22 | 114 2005 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (7): 1891-1894 Gundersen E; Fan K; Haas K; Huryn D; Jacobsen JS; et al. Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors | 0 | 0 |
| 140 | 0 | 15 | 20 2003 NATURE CELL BIOLOGY 5 (5): 486-488 Edbauer D; Winkler E; Regula JT; Pesold B; Steiner H; et al. Reconstitution of gamma-secretase activity | 140 | 140 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 141 | 3 | 13 | 88 2004 MOLECULAR PSYCHIATRY 9 (1): 8-10 Iwatsubo T Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors | 2 | 2 |
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