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Fri Jun 3 10:17:24 2005

Reconstitution of gamma-secretase activity
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
NATURE CELL BIOLOGY 5 (5): 486-488 MAY 2003

Nodes: 141, Authors: 523, Journals: 55, Outer References: 4251, Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by first author.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
101110492 2004 NATURE CELL BIOLOGY 6 (11): 1054-1061
Selkoe DJ
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
00
102628139 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724
Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi
22
10312664 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43046-43051
Shen JS; Prywes R
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
00
104106282 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al.
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
00
105105663 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
78
10664279 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
88
107558100 2004 NEUROSCIENCE 129 (3): 615-628
Siman R; Salidas S
Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
00
10813647 2004 HUMAN MOLECULAR GENETICS 13: R123-R126
Singleton A; Myers A; Hardy J
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases
012
10915776 2004 JOURNAL OF NEUROCHEMISTRY 88 (4): 869-877
Smith IF; Boyle JP; Green KN; Pearson HA; Peers C
Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing
03
110220422 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341
Stein TD; Johnson JA
Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity
04
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1112104115 2005 CELL 120 (4): 545-555
Tanzi RE; Bertram L
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
00
112658108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 (1): 1-5
Teng FYH; Tang BL
Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
00
1131105103 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418
Thinakaran G; Parent AT
Identification of the role of presenilins beyond Alzheimer's disease
14
11413341 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
11515948 2004 HUMAN MOLECULAR GENETICS 13 (13): 1321-1331
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; et al.
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice
13
116650129 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
117334140 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888
Urban S; Wolfe MS
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity
01
11815480 2004 JOURNAL OF NEUROCHEMISTRY 90 (3): 712-723
van Dijk R; Fischer DF; Sluijs JA; Sonnemans MAF; Hobo B; et al.
Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta 40
00
11914689 2004 MOLECULAR PSYCHIATRY 9 (6): 594-602
Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; et al.
Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells
00
1201127102 2004 PHARMACOLOGICAL RESEARCH 50 (4): 397-409
Verdile G; Fuller S; Atwood CS; Laws SM; Gandy SE; et al.
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
12116475 2004 JOURNAL OF CELL SCIENCE 117 (19): 4435-4448
von Rotz RC; Kohli BM; Bosset J; Meier M; Suzuki T; et al.
The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
14
1221602 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
28
123138131 2005 JOURNAL OF NEUROCHEMISTRY 92 (2): 294-301
Walker ES; Martinez M; Brunkan AL; Goate A
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in A beta 42/40 ratios
11
12487562 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
13
1251598 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
210
126126035 2004 CLINICAL GENETICS 66 (1): 1-16
Wellington CL
Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism
00
127410336 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
00
12846773 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (51): 53205-53212
Westmeyer GG; Willem M; Lichtenthaler SF; Lurman G; Multhaup G; et al.
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
11
129150107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20
Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
00
13017786 2004 MOLECULAR AND CELLULAR BIOLOGY 24 (1): 454-464
Wilhelmsen K; van der Geer P
Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events
15
#LCRNCRNode / Date / Journal / AuthorLCSGCS
13135839 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
132111218 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 361-369
Wilson CA; Doms RW; Lee VMY
Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular A beta production
35
133973105 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
411
13423781 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
1351377123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
13616915 2003 JOURNAL OF CELL SCIENCE 116 (14): 2839-2844
Xia WM; Wolfe MS
Intramembrane proteolysis by presenilin and presenilin-like proteases
511
137631130 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
13827249 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36 (12): 2531-2540
Yu WH; Kumar A; Peterhoff C; Kulnane LS; Uchiyama Y; et al.
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
13
139168116 2005 FEBS JOURNAL 272 (6): 1386-1400
Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al.
Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast
00
140236112 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1411044125 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
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