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Fri Jun 3 10:17:23 2005

Reconstitution of gamma-secretase activity
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
NATURE CELL BIOLOGY 5 (5): 486-488 MAY 2003

Nodes: 141, Authors: 523, Journals: 55, Outer References: 4251, Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by year, source, volume, issue, page.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
101354101 2004 ONCOGENE 23 (42): 7076-7086
Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al.
Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor
01
1021127102 2004 PHARMACOLOGICAL RESEARCH 50 (4): 397-409
Verdile G; Fuller S; Atwood CS; Laws SM; Gandy SE; et al.
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
00
1031105103 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418
Thinakaran G; Parent AT
Identification of the role of presenilins beyond Alzheimer's disease
14
104122104 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (4): 905-906
Kim J; Schekman R
The ins and outs of presenilin 1 membrane topology
23
105973105 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
411
1061110106 2004 SEMINARS IN CANCER BIOLOGY 14 (5): 320-328
Hansson EM; Lendahl U; Chapman G
Notch signaling in development and disease
15
107150107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20
Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
00
108658108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 (1): 1-5
Teng FYH; Tang BL
Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria?
00
1091125109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072
Saito S; Takahashi-Sasaki N; Araki W
Identification and characterization of a novel human APH-1b splice variant lacking exon 4
00
110239110 2005 BIOCHEMICAL JOURNAL 385: 545-550
Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; et al.
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
111553111 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
112236112 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
113170113 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267
King ME
Can tau filaments be both physiologically beneficial and toxic?
00
114122114 2005 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (7): 1891-1894
Gundersen E; Fan K; Haas K; Huryn D; Jacobsen JS; et al.
Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors
00
1152104115 2005 CELL 120 (4): 545-555
Tanzi RE; Bertram L
Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
00
116168116 2005 FEBS JOURNAL 272 (6): 1386-1400
Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al.
Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast
00
1179178117 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146
Marambaud P; Robakis NK
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation
00
1181125118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001
Kim SH; Sisodia SS
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
00
119454119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
1201653120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478
Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
121154121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 7758-7768
Kim J; Hamamoto S; Ravazzola M; Orci L; Schekman R
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles
00
122140122 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (10): 9313-9319
Haas IG; Frank M; Veron N; Kemler R
Presenilin-dependent processing and nuclear function of gamma-protocadherins
00
1231377123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
1241868124 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
1251044125 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
126360126 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (18): 17930-17937
Angeletti B; Waldron KJ; Freeman KB; Bawagan H; Hussain I; et al.
BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
00
127452127 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
00
128491128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19331-19342
Cowan JW; Wang XD; Guan R; He K; Jiang J; et al.
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage
00
129650129 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
130631130 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
131138131 2005 JOURNAL OF NEUROCHEMISTRY 92 (2): 294-301
Walker ES; Martinez M; Brunkan AL; Goate A
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in A beta 42/40 ratios
11
132935132 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020
Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al.
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch
00
133243133 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1158-1169
Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM
A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities
11
13421282134 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792
Brunkan AL; Goate AM
Presenilin function and gamma-secretase activity
00
1351236135 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198
Ma GJ; Li T; Price DL; Wong PC
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
11
1362113136 2005 JOURNAL OF NEUROSCIENCE RESEARCH 80 (2): 151-159
Kerr ML; Small DH
Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development
00
137868137 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73
Brunkan AL; Martinez M; Walker ES; Goate AM
Presenilin endoproteolysis is an intrarnolecular cleavage
00
1382137138 2005 NEUROBIOLOGY OF AGING 26 (3): 373-382
Nixon RA
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases
00
139628139 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724
Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi
22
140334140 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888
Urban S; Wolfe MS
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity
01
#LCRNCRNode / Date / Journal / AuthorLCSGCS
141231141 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235
Kornilova AY; Bihel F; Das C; Wolfe MS
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
00

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