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Nodes: 141,
Authors: 523,
Journals: 55,
Outer References: 4251,
Words: 603
Collection span: 2003 - 2005
View: Overview. Sorted by year, source, volume, issue, page.
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| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 101 | 3 | 54 | 101 2004 ONCOGENE 23 (42): 7076-7086 Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al. Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor | 0 | 1 |
| 102 | 1 | 127 | 102 2004 PHARMACOLOGICAL RESEARCH 50 (4): 397-409 Verdile G; Fuller S; Atwood CS; Laws SM; Gandy SE; et al. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? | 0 | 0 |
| 103 | 1 | 105 | 103 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418 Thinakaran G; Parent AT Identification of the role of presenilins beyond Alzheimer's disease | 1 | 4 |
| 104 | 1 | 22 | 104 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (4): 905-906 Kim J; Schekman R The ins and outs of presenilin 1 membrane topology | 2 | 3 |
| 105 | 9 | 73 | 105 2004 SCIENCE 305 (5687): 1119-1123 Wolfe MS; Kopan R Intramembrane proteotysis: Theme and variations | 4 | 11 |
| 106 | 1 | 110 | 106 2004 SEMINARS IN CANCER BIOLOGY 14 (5): 320-328 Hansson EM; Lendahl U; Chapman G Notch signaling in development and disease | 1 | 5 |
| 107 | 1 | 50 | 107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20 Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation | 0 | 0 |
| 108 | 6 | 58 | 108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 (1): 1-5 Teng FYH; Tang BL Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria? | 0 | 0 |
| 109 | 11 | 25 | 109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| 110 | 2 | 39 | 110 2005 BIOCHEMICAL JOURNAL 385: 545-550 Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; et al. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 111 | 5 | 53 | 111 2005 BIOCHEMISTRY 44 (11): 4332-4341 Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex | 0 | 0 |
| 112 | 2 | 36 | 112 2005 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 113 | 1 | 70 | 113 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267 King ME Can tau filaments be both physiologically beneficial and toxic? | 0 | 0 |
| 114 | 1 | 22 | 114 2005 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (7): 1891-1894 Gundersen E; Fan K; Haas K; Huryn D; Jacobsen JS; et al. Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors | 0 | 0 |
| 115 | 2 | 104 | 115 2005 CELL 120 (4): 545-555 Tanzi RE; Bertram L Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective | 0 | 0 |
| 116 | 1 | 68 | 116 2005 FEBS JOURNAL 272 (6): 1386-1400 Zabrocki P; Pellens K; Vanhelmont T; Vandebroek T; Griffioen G; et al. Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast | 0 | 0 |
| 117 | 9 | 178 | 117 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146 Marambaud P; Robakis NK Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation | 0 | 0 |
| 118 | 11 | 25 | 118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| 119 | 4 | 54 | 119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392 Chyung JH; Raper DM; Selkoe DJ gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage | 0 | 1 |
| 120 | 16 | 53 | 120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478 Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al. gamma-secretase complex assembly within the early secretory pathway | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 121 | 1 | 54 | 121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (9): 7758-7768 Kim J; Hamamoto S; Ravazzola M; Orci L; Schekman R Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles | 0 | 0 |
| 122 | 1 | 40 | 122 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (10): 9313-9319 Haas IG; Frank M; Veron N; Kemler R Presenilin-dependent processing and nuclear function of gamma-protocadherins | 0 | 0 |
| 123 | 13 | 77 | 123 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| 124 | 18 | 68 | 124 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975 Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions | 0 | 0 |
| 125 | 10 | 44 | 125 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 126 | 3 | 60 | 126 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (18): 17930-17937 Angeletti B; Waldron KJ; Freeman KB; Bawagan H; Hussain I; et al. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper | 0 | 0 |
| 127 | 4 | 52 | 127 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077 Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides | 0 | 0 |
| 128 | 4 | 91 | 128 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19331-19342 Cowan JW; Wang XD; Guan R; He K; Jiang J; et al. Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage | 0 | 0 |
| 129 | 6 | 50 | 129 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| 130 | 6 | 31 | 130 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 131 | 1 | 38 | 131 2005 JOURNAL OF NEUROCHEMISTRY 92 (2): 294-301 Walker ES; Martinez M; Brunkan AL; Goate A Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in A beta 42/40 ratios | 1 | 1 |
| 132 | 9 | 35 | 132 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020 Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch | 0 | 0 |
| 133 | 2 | 43 | 133 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1158-1169 Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities | 1 | 1 |
| 134 | 21 | 282 | 134 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792 Brunkan AL; Goate AM Presenilin function and gamma-secretase activity | 0 | 0 |
| 135 | 12 | 36 | 135 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198 Ma GJ; Li T; Price DL; Wong PC APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | 1 | 1 |
| 136 | 2 | 113 | 136 2005 JOURNAL OF NEUROSCIENCE RESEARCH 80 (2): 151-159 Kerr ML; Small DH Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development | 0 | 0 |
| 137 | 8 | 68 | 137 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73 Brunkan AL; Martinez M; Walker ES; Goate AM Presenilin endoproteolysis is an intrarnolecular cleavage | 0 | 0 |
| 138 | 2 | 137 | 138 2005 NEUROBIOLOGY OF AGING 26 (3): 373-382 Nixon RA Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases | 0 | 0 |
| 139 | 6 | 28 | 139 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724 Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi | 2 | 2 |
| 140 | 3 | 34 | 140 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888 Urban S; Wolfe MS Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | 0 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 141 | 2 | 31 | 141 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235 Kornilova AY; Bihel F; Das C; Wolfe MS The initial substrate-binding site of gamma-secretase is located on presenilin near the active site | 0 | 0 |
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