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Wed Jun 1 16:44:12 2005

The role of presenilin cofactors in the gamma-secretase complex
TAKASUGI N, TOMITA T, HAYASHI I, et al.
NATURE 422: 438-441 2003
and the citing papers

Nodes: 130, Authors: 480, Journals: 60, Outer References: 3273, Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by GCS.
Page 1 of 2: [  1  2 ]

#LCRNCRNode / Date / Journal / AuthorLCSGCS
102827 2003 NATURE 422 (6930): 438-441
Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; et al.
The role of presenilin cofactors in the gamma-secretase complex
129130
212229 2003 NEURON 38 (1): 9-12
De Strooper B
Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex
48118
323316 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al.
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
4249
412423 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690
Hu Y; Fortini ME
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
4044
514624 2003 JOURNAL OF CLINICAL INVESTIGATION 112 (3): 440-449
Eriksen JL; Sagi SA; Smith TE; Weggen S; Das P; et al.
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower A beta 42 in vivo
434
646730 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080
Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al.
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
2334
719990 2004 NATURE 430 (7000): 631-639
Mattson MP
Pathways towards and away from Alzheimer's disease
033
854849 2004 EMBO JOURNAL 23 (3): 483-488
Haass C
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
1130
914611 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (20): 18664-18670
Takahashi Y; Hayashi I; Tominari Y; Rikimaru K; Morohashi Y; et al.
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces A beta 42 generation
1128
1016315 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002
Kim SH; Ikeuchi T; Yu CJ; Sisodia SS
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
2325
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1127319 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43430-43436
Nyabi O; Bentahir M; Horre K; Herreman A; Gottardi-Littell N; et al.
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin
1825
1214417 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
524
1334618 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
1923
14410432 2003 SCIENCE 302 (5646): 814-818
Aguzzi A; Haass C
Games played by rogue proteins in prion disorders and Alzheimer's disease
223
1515712 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284
Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al.
Partial purification and characterization of gamma-secretase from post-mortem human brain
1320
1674837 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
1717425 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 353-360
Kimberly WT; Wolfe MS
Identity and function of gamma-secretase
415
1813655 2004 HUMAN MOLECULAR GENETICS 13: R123-R126
Singleton A; Myers A; Hardy J
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases
012
1963861 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152
Lee SF; Shah S; Yu C; Wigley WC; Li H; et al.
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
912
2054360 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1111
#LCRNCRNode / Date / Journal / AuthorLCSGCS
211173104 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
311
221436 2003 CURRENT BIOLOGY 13 (15): 1348-1354
Costa RM; Honjo T; Silva AJ
Learning and memory deficits in Notch mutant mice
110
232449 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
Martoglio B; Golde TE
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs
010
2425913 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
210
2515228 2003 NEUROBIOLOGY OF DISEASE 14 (2): 194-204
Baulac S; LaVoie MJ; Kimberly WT; Strahle J; Wolfe MS; et al.
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates
910
2618056 2004 HUMAN MOLECULAR GENETICS 13 (2): 159-170
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; et al.
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
010
2774864 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
1010
2897674 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954
Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al.
Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes
410
29153101 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (17): 6623-6628
Iijima K; Liu HP; Chiang AS; Hearn SA; Konsolaki M; et al.
Dissecting the pathological effects of human A beta 40 and A beta 42 in Drosophila: A potential model for Alzheimer's disease
010
301453 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 502-509
Marlow L; Canet RM; Haugabook SJ; Hardy JA; Lahiri DK; et al.
APH1, PEN2, and Nicastrin increase A beta levels and gamma-secretase activity
49
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3123663 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160
Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
69
321605 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
38
3353422 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523
Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al.
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
68
34145671 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
88
35104281 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
78
3613320 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (48): 47370-47375
Lleo A; Berezovska O; Ramdya P; Fukumoto H; Raju S; et al.
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression
37
3765551 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385
Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al.
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
57
3825980 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
47
3914194 2004 NEUROBIOLOGY OF DISEASE 15 (3): 654-666
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes
37
4085838 2004 BIOCHEMISTRY 43 (12): 3555-3563
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
56
#LCRNCRNode / Date / Journal / AuthorLCSGCS
4166939 2004 BIOCHEMISTRY 43 (30): 9774-9789
Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al.
Purification and characterization of the human gamma-secretase complex
46
421511386 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322
Periz G; Fortini ME
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
46
4352846 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383
Iwatsubo T
The gamma-secretase complex: machinery for intramembrane proteolysis
25
4433783 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
451231 2003 ANNALS OF NEUROLOGY 54 (2): 143-144
Hardy J
Alzheimer's disease: Genetic evidence points to a single pathogenesis
14
4636210 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678
Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA
A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
34
4713814 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (35): 33445-33449
Li JH; Fici GJ; Mao CA; Myers RL; Shuang R; et al.
Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model
34
4815421 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (49): 49448-49458
Araki Y; Tomita S; Yamaguchi H; Miyagi N; Sumioka A; et al.
Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism
14
49320431 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341
Stein TD; Johnson JA
Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity
04
5016162 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4596-4603
Guo Q; Xie J
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with par-4
14
#LCRNCRNode / Date / Journal / AuthorLCSGCS
5162676 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619
Kim SH; Yin YI; Li YM; Sisodia SS
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
34
521105100 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418
Thinakaran G; Parent AT
Identification of the role of presenilins beyond Alzheimer's disease
24
531377 2003 EXPERIMENTAL NEUROLOGY 183 (2): 673-681
Huang XG; Yee BK; Nag S; Chan STH; Tang F
Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235
03
5411126 2003 NATURE 422 (6930): 385-387
Mattson MP
Neurobiology - Ballads of a protein quartet
03
55811744 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719
Harrison T; Churcher I; Beher D
gamma-Secretase as a target for drug intervention in Alzheimer's disease
03
56114459 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65
Pasternak SH; Callahan JW; Mahuran DJ
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
03
5764069 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046
Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al.
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
23
5897570 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
23
5964873 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426
Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al.
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism
13
6032975 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463
Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
33
#LCRNCRNode / Date / Journal / AuthorLCSGCS
61146395 2004 NEUROBIOLOGY OF DISEASE 17 (2): 260-272
Hebert SS; Serneels L; Dejaegere T; Horre K; Dabrowski M; et al.
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
33
62227106 2004 TETRAHEDRON LETTERS 45 (11): 2323-2326
Fuwa H; Okamura Y; Morohashi Y; Tomita T; Iwatsubo T; et al.
Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of omega-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues
03
6328435 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
12
6433348 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
6542350 2004 EMBO REPORTS 5 (4): 405-411
Loewer A; Soba P; Beyreuther K; Paro R; Merdes G
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development
22
66230554 2004 HUMAN GENETICS 114 (5): 413-438
Bertoli-Avella AM; Oostra BA; Heutink P
Chasing genes in Alzheimer's and Parkinson's disease
02
6731389 2004 MOLECULAR PSYCHIATRY 9 (1): 8-10
Iwatsubo T
Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors
12
6823692 2004 NATURE MEDICINE 10 (9): 959-965
He WX; Lu YF; Qahwash I; Hu XY; Chang AS; et al.
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation
02
69628128 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724
Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi
22
701742 2003 ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 38 38: 41-50
Kornilova AY; Wolfe MS
Secretase inhibitors for Alzheimer's disease
01
#LCRNCRNode / Date / Journal / AuthorLCSGCS
711298 2003 FEBS LETTERS 553 (1-2): 151-156
Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al.
The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation
01
7212940 2004 BIOCHEMISTRY 43 (42): 13532-13540
Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al.
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42
01
7323841 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938
Esler WP; Das C; Wolfe MS
Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties
01
7427745 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14 (5): 506-512
Kadesch T
Notch signaling: the demise of elegant simplicity
01
7555847 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
76312253 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13 (4): 303-314
Bullock R
Future directions in the treatment of Alzheimer's disease
01
7723357 2004 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13 (1): 121-125
Kume H; Maruyama K; Kametani F
Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage
01
7834365 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (23): 24343-24354
Araki Y; Miyagi N; Kato N; Yoshida T; Wada S; et al.
Coordinated metabolism of alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation
11
7943666 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338
Pitsi D; Octave JN
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
01
8034767 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34130-34137
Xie ZC; Romano DM; Kovacs DM; Tanzi RE
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation
11
#LCRNCRNode / Date / Journal / AuthorLCSGCS
8193768 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315
Edbauer D; Kaether C; Steiner H; Haass C
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
11
8253672 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156
Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
01
8344678 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798
Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al.
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
11
8446279 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111
Gowrishankar K; Zeidler MG; Vincenz C
Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD
01
8535188 2004 MOLECULAR MEMBRANE BIOLOGY 21 (6): 373-383
Harnasch M; Grau S; Behrends C; Dove SL; Hochschild A; et al.
Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins
01
8611097 2004 NEUROLOGY 63 (9): 1702-1704
Godbolt AK; Beck JA; Collinge J; Garrard P; Warren JD; et al.
A presenilin 1 R278I mutation presenting with language impairment
11
8715499 2004 ONCOGENE 23 (42): 7076-7086
Saleh AZM; Fang AT; Arch AE; Neupane D; El Fiky A; et al.
Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor
01
88548102 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (49): 17050-17055
Tarassishin L; Yin YI; Bassit L; Li YM
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
01
89654115 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
901436126 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198
Ma GJ; Li T; Price DL; Wong PC
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
11
#LCRNCRNode / Date / Journal / AuthorLCSGCS
91334129 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888
Urban S; Wolfe MS
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity
01
921484 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 529-533
Piper SC; Amtul Z; Galinanes-Garcia L; Howard VG; Ziani-Cherif C; et al.
Peptide-based, irreversible inhibitors of gamma-secretase activity
00
9311433 2004 ACTA PHARMACOLOGICA SINICA 25 (12): 1613-1618
Lu HM; Deng H; Xiao F; Gao Q; Weng W; et al.
Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA
00
9416734 2004 AMERICAN JOURNAL OF PATHOLOGY 165 (5): 1465-1477
Langui D; Girardot N; El Hachimi KH; Allinquant B; Blanchard V; et al.
Subcellular topography of neuronal A beta peptide in APPxPS1 transgenic mice
00
9539136 2004 BIOCHEMICAL JOURNAL 381: 619-628
Suga K; Tomiyama T; Mori H; Akagawa K
Syntaxin 5 interacts with presenilin holoproteins, but not with their N-or C-terminal fragments, and affects beta-amyloid peptide production
00
96229542 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178
Makarova A; Williams SE; Strickland DK
Proteases and lipoprotein receptors in Alzheimer's disease
00
97410343 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
00
9814152 2004 EUROPEAN JOURNAL OF IMMUNOLOGY 34 (4): 1217-1227
Mayne M; Moffatt T; Kong H; McLaren PJ; Fowke KR; et al.
CYFIP2 is highly abundant in CD4(+) cells from multiple sclerosis patients and is involved in T cell adhesion
00
9912458 2004 INTERNATIONAL JOURNAL OF NEUROSCIENCE 114 (10): 1277-+
Hwang DY; Kim YK; Lim CJ; Cho JS
Mutant nicastrin protein can induce the cytochrome c release and the Bax expression
00
10035377 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
00

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