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Wed Jun 1 16:44:12 2005

The role of presenilin cofactors in the gamma-secretase complex
TAKASUGI N, TOMITA T, HAYASHI I, et al.
NATURE 422: 438-441 2003
and the citing papers

Nodes: 130, Authors: 480, Journals: 60, Outer References: 3273, Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by LCR.
Page 1 of 2: [  1  2 ]

#LCRNCRNode / Date / Journal / AuthorLCSGCS
12168118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
220282125 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792
Brunkan AL; Goate AM
Presenilin function and gamma-secretase activity
00
31511386 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322
Periz G; Fortini ME
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
46
41553116 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478
Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
00
51577117 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
6145671 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
88
7146395 2004 NEUROBIOLOGY OF DISEASE 17 (2): 260-272
Hebert SS; Serneels L; Dejaegere T; Horre K; Dabrowski M; et al.
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity
33
81436126 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198
Ma GJ; Li T; Price DL; Wong PC
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
11
91344120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
101173104 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
311
#LCRNCRNode / Date / Journal / AuthorLCSGCS
111125109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072
Saito S; Takahashi-Sasaki N; Araki W
Identification and characterization of a novel human APH-1b splice variant lacking exon 4
00
121125114 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001
Kim SH; Sisodia SS
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
00
13104281 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
78
14106284 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al.
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
00
1593768 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315
Edbauer D; Kaether C; Steiner H; Haass C
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
11
1697570 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
23
1797674 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954
Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al.
Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes
410
189178113 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146
Marambaud P; Robakis NK
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation
00
19952121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
00
2085838 2004 BIOCHEMISTRY 43 (12): 3555-3563
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
56
#LCRNCRNode / Date / Journal / AuthorLCSGCS
21811744 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719
Harrison T; Churcher I; Beher D
gamma-Secretase as a target for drug intervention in Alzheimer's disease
03
22831123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
2374837 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
2474864 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
1010
25722108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 (1): 18-22
Salto S; Araki W
Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes
00
26753110 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
27750122 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
28735124 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020
Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al.
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch
00
29768127 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73
Brunkan AL; Martinez M; Walker ES; Goate AM
Presenilin endoproteolysis is an intrarnolecular cleavage
00
3066939 2004 BIOCHEMISTRY 43 (30): 9774-9789
Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al.
Purification and characterization of the human gamma-secretase complex
46
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3165551 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385
Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al.
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
57
3263861 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152
Lee SF; Shah S; Yu C; Wigley WC; Li H; et al.
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
912
3364069 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046
Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al.
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
23
3464873 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426
Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al.
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism
13
3562676 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619
Kim SH; Yin YI; Li YM; Sisodia SS
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
34
3665185 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237
Ilaya NT; Evin G; Masters CL; Culvenor JG
Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
00
37654115 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
38628128 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724
Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi
22
3953422 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523
Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al.
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
68
4052846 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383
Iwatsubo T
The gamma-secretase complex: machinery for intramembrane proteolysis
25
#LCRNCRNode / Date / Journal / AuthorLCSGCS
4155847 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
4254849 2004 EMBO JOURNAL 23 (3): 483-488
Haass C
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
1130
4354360 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1111
4453672 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156
Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
01
45511193 2004 NATURE REVIEWS NEUROSCIENCE : S26-S33
Koo EH; Kopan R
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
00
4655898 2004 NEUROSCIENCE 129 (3): 615-628
Siman R; Salidas S
Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
00
47548102 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (49): 17050-17055
Tarassishin L; Yin YI; Bassit L; Li YM
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
01
4846730 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 (22): 13075-13080
Schroeter EH; Ilagan MXG; Brunkan AL; Hecimovic S; Li YM; et al.
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
2334
49410432 2003 SCIENCE 302 (5646): 814-818
Aguzzi A; Haass C
Games played by rogue proteins in prion disorders and Alzheimer's disease
223
50410343 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
5142350 2004 EMBO REPORTS 5 (4): 405-411
Loewer A; Soba P; Beyreuther K; Paro R; Merdes G
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development
22
5243666 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338
Pitsi D; Octave JN
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
01
5344678 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798
Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al.
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
11
5446279 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111
Gowrishankar K; Zeidler MG; Vincenz C
Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD
01
554108119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832
Xie J; Guo Q
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
00
5636210 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678
Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA
A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
34
5734618 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
1923
58320431 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341
Stein TD; Johnson JA
Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity
04
5939136 2004 BIOCHEMICAL JOURNAL 381: 619-628
Suga K; Tomiyama T; Mori H; Akagawa K
Syntaxin 5 interacts with presenilin holoproteins, but not with their N-or C-terminal fragments, and affects beta-amyloid peptide production
00
6033348 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
#LCRNCRNode / Date / Journal / AuthorLCSGCS
61312253 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13 (4): 303-314
Bullock R
Future directions in the treatment of Alzheimer's disease
01
6234365 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (23): 24343-24354
Araki Y; Miyagi N; Kato N; Yoshida T; Wada S; et al.
Coordinated metabolism of alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation
11
6334767 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34130-34137
Xie ZC; Romano DM; Kovacs DM; Tanzi RE
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation
11
6432975 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463
Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
33
6535377 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
00
6633783 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
6735188 2004 MOLECULAR MEMBRANE BIOLOGY 21 (6): 373-383
Harnasch M; Grau S; Behrends C; Dove SL; Hochschild A; et al.
Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins
01
6831389 2004 MOLECULAR PSYCHIATRY 9 (1): 8-10
Iwatsubo T
Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors
12
69314105 2004 SEIKAGAKU 76 (7): 666-670
Tomita T; Iwatsubo T
Recent advances in Alzheimer's disease-related gamma-secretase complex
00
70336111 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
71334129 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888
Urban S; Wolfe MS
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity
01
72331130 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235
Kornilova AY; Bihel F; Das C; Wolfe MS
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
00
732449 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
Martoglio B; Golde TE
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs
010
7425913 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
210
7523316 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al.
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
4249
7627319 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43430-43436
Nyabi O; Bentahir M; Horre K; Herreman A; Gottardi-Littell N; et al.
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin
1825
7728435 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
12
7823841 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938
Esler WP; Das C; Wolfe MS
Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties
01
79229542 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178
Makarova A; Williams SE; Strickland DK
Proteases and lipoprotein receptors in Alzheimer's disease
00
8027745 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14 (5): 506-512
Kadesch T
Notch signaling: the demise of elegant simplicity
01
#LCRNCRNode / Date / Journal / AuthorLCSGCS
81230554 2004 HUMAN GENETICS 114 (5): 413-438
Bertoli-Avella AM; Oostra BA; Heutink P
Chasing genes in Alzheimer's and Parkinson's disease
02
8223357 2004 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13 (1): 121-125
Kume H; Maruyama K; Kametani F
Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage
01
8323663 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160
Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
69
8425980 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
47
8523692 2004 NATURE MEDICINE 10 (9): 959-965
He WX; Lu YF; Qahwash I; Hu XY; Chang AS; et al.
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation
02
86227106 2004 TETRAHEDRON LETTERS 45 (11): 2323-2326
Fuwa H; Okamura Y; Morohashi Y; Tomita T; Iwatsubo T; et al.
Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of omega-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues
03
871231 2003 ANNALS OF NEUROLOGY 54 (2): 143-144
Hardy J
Alzheimer's disease: Genetic evidence points to a single pathogenesis
14
881742 2003 ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 38 38: 41-50
Kornilova AY; Wolfe MS
Secretase inhibitors for Alzheimer's disease
01
891453 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 502-509
Marlow L; Canet RM; Haugabook SJ; Hardy JA; Lahiri DK; et al.
APH1, PEN2, and Nicastrin increase A beta levels and gamma-secretase activity
49
901484 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 529-533
Piper SC; Amtul Z; Galinanes-Garcia L; Howard VG; Ziani-Cherif C; et al.
Peptide-based, irreversible inhibitors of gamma-secretase activity
00
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911605 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
38
921436 2003 CURRENT BIOLOGY 13 (15): 1348-1354
Costa RM; Honjo T; Silva AJ
Learning and memory deficits in Notch mutant mice
110
931377 2003 EXPERIMENTAL NEUROLOGY 183 (2): 673-681
Huang XG; Yee BK; Nag S; Chan STH; Tang F
Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235
03
941298 2003 FEBS LETTERS 553 (1-2): 151-156
Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al.
The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation
01
9514611 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (20): 18664-18670
Takahashi Y; Hayashi I; Tominari Y; Rikimaru K; Morohashi Y; et al.
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces A beta 42 generation
1128
9615712 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284
Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al.
Partial purification and characterization of gamma-secretase from post-mortem human brain
1320
9713814 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (35): 33445-33449
Li JH; Fici GJ; Mao CA; Myers RL; Shuang R; et al.
Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model
34
9816315 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002
Kim SH; Ikeuchi T; Yu CJ; Sisodia SS
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
2325
9914417 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
524
10013320 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (48): 47370-47375
Lleo A; Berezovska O; Ramdya P; Fukumoto H; Raju S; et al.
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression
37

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