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Nodes: 130,
Authors: 480,
Journals: 60,
Outer References: 3273,
Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by journal name.
Page 1 of 2: [ 1 2 ]
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 1 | 1 | 14 | 33 2004 ACTA PHARMACOLOGICA SINICA 25 (12): 1613-1618 Lu HM; Deng H; Xiao F; Gao Q; Weng W; et al. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA | 0 | 0 |
| 2 | 1 | 50 | 107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20 Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation | 0 | 0 |
| 3 | 1 | 67 | 34 2004 AMERICAN JOURNAL OF PATHOLOGY 165 (5): 1465-1477 Langui D; Girardot N; El Hachimi KH; Allinquant B; Blanchard V; et al. Subcellular topography of neuronal A beta peptide in APPxPS1 transgenic mice | 0 | 0 |
| 4 | 1 | 23 | 1 2003 ANNALS OF NEUROLOGY 54 (2): 143-144 Hardy J Alzheimer's disease: Genetic evidence points to a single pathogenesis | 1 | 4 |
| 5 | 1 | 74 | 2 2003 ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 38 38: 41-50 Kornilova AY; Wolfe MS Secretase inhibitors for Alzheimer's disease | 0 | 1 |
| 6 | 2 | 84 | 35 2004 ANNUAL REVIEW OF GENETICS 38: 709-724 Ehrmann M; Clausen T Proteolysis as aregulatory mechanism | 1 | 2 |
| 7 | 1 | 45 | 3 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 502-509 Marlow L; Canet RM; Haugabook SJ; Hardy JA; Lahiri DK; et al. APH1, PEN2, and Nicastrin increase A beta levels and gamma-secretase activity | 4 | 9 |
| 8 | 1 | 48 | 4 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 529-533 Piper SC; Amtul Z; Galinanes-Garcia L; Howard VG; Ziani-Cherif C; et al. Peptide-based, irreversible inhibitors of gamma-secretase activity | 0 | 0 |
| 9 | 7 | 22 | 108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 (1): 18-22 Salto S; Araki W Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes | 0 | 0 |
| 10 | 11 | 25 | 109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 11 | 3 | 91 | 36 2004 BIOCHEMICAL JOURNAL 381: 619-628 Suga K; Tomiyama T; Mori H; Akagawa K Syntaxin 5 interacts with presenilin holoproteins, but not with their N-or C-terminal fragments, and affects beta-amyloid peptide production | 0 | 0 |
| 12 | 1 | 60 | 5 2003 BIOCHEMISTRY 42 (47): 13977-13986 Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al. gamma-secretase activity is present in rafts but is not cholesterol-dependent | 3 | 8 |
| 13 | 7 | 48 | 37 2004 BIOCHEMISTRY 43 (2): 323-333 Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | 17 | 20 |
| 14 | 8 | 58 | 38 2004 BIOCHEMISTRY 43 (12): 3555-3563 Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation | 5 | 6 |
| 15 | 6 | 69 | 39 2004 BIOCHEMISTRY 43 (30): 9774-9789 Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al. Purification and characterization of the human gamma-secretase complex | 4 | 6 |
| 16 | 1 | 29 | 40 2004 BIOCHEMISTRY 43 (42): 13532-13540 Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42 | 0 | 1 |
| 17 | 7 | 53 | 110 2005 BIOCHEMISTRY 44 (11): 4332-4341 Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex | 0 | 0 |
| 18 | 3 | 36 | 111 2005 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 19 | 1 | 70 | 112 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267 King ME Can tau filaments be both physiologically beneficial and toxic? | 0 | 0 |
| 20 | 2 | 38 | 41 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938 Esler WP; Das C; Wolfe MS Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties | 0 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 21 | 2 | 295 | 42 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178 Makarova A; Williams SE; Strickland DK Proteases and lipoprotein receptors in Alzheimer's disease | 0 | 0 |
| 22 | 1 | 43 | 6 2003 CURRENT BIOLOGY 13 (15): 1348-1354 Costa RM; Honjo T; Silva AJ Learning and memory deficits in Notch mutant mice | 1 | 10 |
| 23 | 4 | 103 | 43 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178 Westlund B; Stilwell G; Sluder A Invertebrate disease models in neurotherapeutic discovery | 0 | 0 |
| 24 | 8 | 117 | 44 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719 Harrison T; Churcher I; Beher D gamma-Secretase as a target for drug intervention in Alzheimer's disease | 0 | 3 |
| 25 | 2 | 77 | 45 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14 (5): 506-512 Kadesch T Notch signaling: the demise of elegant simplicity | 0 | 1 |
| 26 | 5 | 28 | 46 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383 Iwatsubo T The gamma-secretase complex: machinery for intramembrane proteolysis | 2 | 5 |
| 27 | 5 | 58 | 47 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588 Wilquet V; De Strooper B Amyloid-beta precursor protein processing in neurodegeneration | 0 | 1 |
| 28 | 3 | 33 | 48 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325 Tomita T; Iwatsubo T The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease | 1 | 2 |
| 29 | 5 | 48 | 49 2004 EMBO JOURNAL 23 (3): 483-488 Haass C Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation | 11 | 30 |
| 30 | 4 | 23 | 50 2004 EMBO REPORTS 5 (4): 405-411 Loewer A; Soba P; Beyreuther K; Paro R; Merdes G Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development | 2 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 31 | 6 | 55 | 51 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385 Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al. Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations | 5 | 7 |
| 32 | 1 | 41 | 52 2004 EUROPEAN JOURNAL OF IMMUNOLOGY 34 (4): 1217-1227 Mayne M; Moffatt T; Kong H; McLaren PJ; Fowke KR; et al. CYFIP2 is highly abundant in CD4(+) cells from multiple sclerosis patients and is involved in T cell adhesion | 0 | 0 |
| 33 | 1 | 37 | 7 2003 EXPERIMENTAL NEUROLOGY 183 (2): 673-681 Huang XG; Yee BK; Nag S; Chan STH; Tang F Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235 | 0 | 3 |
| 34 | 3 | 122 | 53 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13 (4): 303-314 Bullock R Future directions in the treatment of Alzheimer's disease | 0 | 1 |
| 35 | 1 | 29 | 8 2003 FEBS LETTERS 553 (1-2): 151-156 Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al. The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation | 0 | 1 |
| 36 | 9 | 178 | 113 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146 Marambaud P; Robakis NK Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation | 0 | 0 |
| 37 | 2 | 305 | 54 2004 HUMAN GENETICS 114 (5): 413-438 Bertoli-Avella AM; Oostra BA; Heutink P Chasing genes in Alzheimer's and Parkinson's disease | 0 | 2 |
| 38 | 2 | 44 | 9 2003 HUMAN MOLECULAR GENETICS 12: R201-R206 Martoglio B; Golde TE Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs | 0 | 10 |
| 39 | 3 | 62 | 10 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678 Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA A reporter for amyloid precursor protein gamma-secretase activity in Drosophila | 3 | 4 |
| 40 | 1 | 36 | 55 2004 HUMAN MOLECULAR GENETICS 13: R123-R126 Singleton A; Myers A; Hardy J The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases | 0 | 12 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 41 | 1 | 80 | 56 2004 HUMAN MOLECULAR GENETICS 13 (2): 159-170 Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase | 0 | 10 |
| 42 | 2 | 33 | 57 2004 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13 (1): 121-125 Kume H; Maruyama K; Kametani F Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage | 0 | 1 |
| 43 | 1 | 24 | 58 2004 INTERNATIONAL JOURNAL OF NEUROSCIENCE 114 (10): 1277-+ Hwang DY; Kim YK; Lim CJ; Cho JS Mutant nicastrin protein can induce the cytochrome c release and the Bax expression | 0 | 0 |
| 44 | 1 | 144 | 59 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65 Pasternak SH; Callahan JW; Mahuran DJ The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective | 0 | 3 |
| 45 | 1 | 46 | 11 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (20): 18664-18670 Takahashi Y; Hayashi I; Tominari Y; Rikimaru K; Morohashi Y; et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces A beta 42 generation | 11 | 28 |
| 46 | 1 | 57 | 12 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284 Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al. Partial purification and characterization of gamma-secretase from post-mortem human brain | 13 | 20 |
| 47 | 2 | 59 | 13 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754 Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al. A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain | 2 | 10 |
| 48 | 1 | 38 | 14 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (35): 33445-33449 Li JH; Fici GJ; Mao CA; Myers RL; Shuang R; et al. Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model | 3 | 4 |
| 49 | 1 | 63 | 15 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002 Kim SH; Ikeuchi T; Yu CJ; Sisodia SS Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates | 23 | 25 |
| 50 | 2 | 33 | 16 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222 LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | 42 | 49 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 51 | 1 | 44 | 17 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169 Jung KM; Tan S; Landman N; Petrova K; Murray S; et al. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor | 5 | 24 |
| 52 | 3 | 46 | 18 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291 Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex | 19 | 23 |
| 53 | 2 | 73 | 19 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43430-43436 Nyabi O; Bentahir M; Horre K; Herreman A; Gottardi-Littell N; et al. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin | 18 | 25 |
| 54 | 1 | 33 | 20 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (48): 47370-47375 Lleo A; Berezovska O; Ramdya P; Fukumoto H; Raju S; et al. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression | 3 | 7 |
| 55 | 1 | 54 | 21 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (49): 49448-49458 Araki Y; Tomita S; Yamaguchi H; Miyagi N; Sumioka A; et al. Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism | 1 | 4 |
| 56 | 5 | 34 | 22 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523 Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain | 6 | 8 |
| 57 | 5 | 43 | 60 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693 Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex | 11 | 11 |
| 58 | 6 | 38 | 61 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152 Lee SF; Shah S; Yu C; Wigley WC; Li H; et al. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex | 9 | 12 |
| 59 | 1 | 61 | 62 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4596-4603 Guo Q; Xie J AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with par-4 | 1 | 4 |
| 60 | 2 | 36 | 63 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160 Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor | 6 | 9 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 61 | 7 | 48 | 64 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261 Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex | 10 | 10 |
| 62 | 3 | 43 | 65 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (23): 24343-24354 Araki Y; Miyagi N; Kato N; Yoshida T; Wada S; et al. Coordinated metabolism of alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation | 1 | 1 |
| 63 | 4 | 36 | 66 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338 Pitsi D; Octave JN Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity | 0 | 1 |
| 64 | 3 | 47 | 67 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34130-34137 Xie ZC; Romano DM; Kovacs DM; Tanzi RE Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation | 1 | 1 |
| 65 | 9 | 37 | 68 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315 Edbauer D; Kaether C; Steiner H; Haass C Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1 | 1 | 1 |
| 66 | 6 | 40 | 69 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046 Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al. Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles | 2 | 3 |
| 67 | 9 | 75 | 70 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566 Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components | 2 | 3 |
| 68 | 14 | 56 | 71 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345 Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H Identification of distinct gamma-secretase complexes with different APH-1 variants | 8 | 8 |
| 69 | 5 | 36 | 72 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156 Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin | 0 | 1 |
| 70 | 6 | 48 | 73 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426 Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al. Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism | 1 | 3 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 71 | 9 | 76 | 74 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954 Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al. Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes | 4 | 10 |
| 72 | 3 | 29 | 75 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463 Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes | 3 | 3 |
| 73 | 6 | 26 | 76 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619 Kim SH; Yin YI; Li YM; Sisodia SS Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway | 3 | 4 |
| 74 | 3 | 53 | 77 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532 Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway | 0 | 0 |
| 75 | 4 | 46 | 78 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798 Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins | 1 | 1 |
| 76 | 11 | 25 | 114 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| 77 | 6 | 54 | 115 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392 Chyung JH; Raper DM; Selkoe DJ gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage | 0 | 1 |
| 78 | 15 | 53 | 116 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478 Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al. gamma-secretase complex assembly within the early secretory pathway | 0 | 0 |
| 79 | 15 | 77 | 117 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| 80 | 21 | 68 | 118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975 Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 81 | 4 | 108 | 119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832 Xie J; Guo Q PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein | 0 | 0 |
| 82 | 13 | 44 | 120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 83 | 9 | 52 | 121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077 Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides | 0 | 0 |
| 84 | 1 | 24 | 23 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690 Hu Y; Fortini ME Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | 40 | 44 |
| 85 | 4 | 62 | 79 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111 Gowrishankar K; Zeidler MG; Vincenz C Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD | 0 | 1 |
| 86 | 1 | 46 | 24 2003 JOURNAL OF CLINICAL INVESTIGATION 112 (3): 440-449 Eriksen JL; Sagi SA; Smith TE; Weggen S; Das P; et al. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower A beta 42 in vivo | 4 | 34 |
| 87 | 7 | 50 | 122 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| 88 | 8 | 31 | 123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| 89 | 2 | 59 | 80 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53 Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein | 4 | 7 |
| 90 | 10 | 42 | 81 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527 Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 | 7 | 8 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 91 | 1 | 57 | 82 2004 JOURNAL OF NEUROCHEMISTRY 90 (4): 800-806 da Costa CA; Ayral E; Hernandez JF; St George-Hyslop P; Checler F Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells | 0 | 0 |
| 92 | 3 | 37 | 83 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320 Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding | 5 | 5 |
| 93 | 10 | 62 | 84 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413 Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation | 0 | 0 |
| 94 | 6 | 51 | 85 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237 Ilaya NT; Evin G; Masters CL; Culvenor JG Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle | 0 | 0 |
| 95 | 7 | 35 | 124 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020 Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch | 0 | 0 |
| 96 | 20 | 282 | 125 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792 Brunkan AL; Goate AM Presenilin function and gamma-secretase activity | 0 | 0 |
| 97 | 14 | 36 | 126 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198 Ma GJ; Li T; Price DL; Wong PC APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | 1 | 1 |
| 98 | 1 | 74 | 25 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 353-360 Kimberly WT; Wolfe MS Identity and function of gamma-secretase | 4 | 15 |
| 99 | 15 | 113 | 86 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322 Periz G; Fortini ME Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2 | 4 | 6 |
| 100 | 7 | 68 | 127 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73 Brunkan AL; Martinez M; Walker ES; Goate AM Presenilin endoproteolysis is an intrarnolecular cleavage | 0 | 0 |
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