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Wed Jun 1 16:44:10 2005

The role of presenilin cofactors in the gamma-secretase complex
TAKASUGI N, TOMITA T, HAYASHI I, et al.
NATURE 422: 438-441 2003
and the citing papers

Nodes: 130, Authors: 480, Journals: 60, Outer References: 3273, Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by journal name.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
111433 2004 ACTA PHARMACOLOGICA SINICA 25 (12): 1613-1618
Lu HM; Deng H; Xiao F; Gao Q; Weng W; et al.
Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA
00
2150107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20
Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
00
316734 2004 AMERICAN JOURNAL OF PATHOLOGY 165 (5): 1465-1477
Langui D; Girardot N; El Hachimi KH; Allinquant B; Blanchard V; et al.
Subcellular topography of neuronal A beta peptide in APPxPS1 transgenic mice
00
41231 2003 ANNALS OF NEUROLOGY 54 (2): 143-144
Hardy J
Alzheimer's disease: Genetic evidence points to a single pathogenesis
14
51742 2003 ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 38 38: 41-50
Kornilova AY; Wolfe MS
Secretase inhibitors for Alzheimer's disease
01
628435 2004 ANNUAL REVIEW OF GENETICS 38: 709-724
Ehrmann M; Clausen T
Proteolysis as aregulatory mechanism
12
71453 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 502-509
Marlow L; Canet RM; Haugabook SJ; Hardy JA; Lahiri DK; et al.
APH1, PEN2, and Nicastrin increase A beta levels and gamma-secretase activity
49
81484 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305 (3): 529-533
Piper SC; Amtul Z; Galinanes-Garcia L; Howard VG; Ziani-Cherif C; et al.
Peptide-based, irreversible inhibitors of gamma-secretase activity
00
9722108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 (1): 18-22
Salto S; Araki W
Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes
00
101125109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072
Saito S; Takahashi-Sasaki N; Araki W
Identification and characterization of a novel human APH-1b splice variant lacking exon 4
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1139136 2004 BIOCHEMICAL JOURNAL 381: 619-628
Suga K; Tomiyama T; Mori H; Akagawa K
Syntaxin 5 interacts with presenilin holoproteins, but not with their N-or C-terminal fragments, and affects beta-amyloid peptide production
00
121605 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
38
1374837 2004 BIOCHEMISTRY 43 (2): 323-333
Fraering PC; LaVoie MJ; Ye WJ; Ostaszewski BL; Kimberly WT; et al.
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
1720
1485838 2004 BIOCHEMISTRY 43 (12): 3555-3563
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; et al.
Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation
56
1566939 2004 BIOCHEMISTRY 43 (30): 9774-9789
Fraering PC; Ye WJ; Strub JM; Dolios G; LaVoie MJ; et al.
Purification and characterization of the human gamma-secretase complex
46
1612940 2004 BIOCHEMISTRY 43 (42): 13532-13540
Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al.
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42
01
17753110 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
18336111 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
19170112 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267
King ME
Can tau filaments be both physiologically beneficial and toxic?
00
2023841 2004 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14 (8): 1935-1938
Esler WP; Das C; Wolfe MS
Probing pockets S2-S4 ' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimeties
01
#LCRNCRNode / Date / Journal / AuthorLCSGCS
21229542 2004 CELL BIOCHEMISTRY AND BIOPHYSICS 41 (1): 139-178
Makarova A; Williams SE; Strickland DK
Proteases and lipoprotein receptors in Alzheimer's disease
00
221436 2003 CURRENT BIOLOGY 13 (15): 1348-1354
Costa RM; Honjo T; Silva AJ
Learning and memory deficits in Notch mutant mice
110
23410343 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
00
24811744 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (5): 709-719
Harrison T; Churcher I; Beher D
gamma-Secretase as a target for drug intervention in Alzheimer's disease
03
2527745 2004 CURRENT OPINION IN GENETICS & DEVELOPMENT 14 (5): 506-512
Kadesch T
Notch signaling: the demise of elegant simplicity
01
2652846 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383
Iwatsubo T
The gamma-secretase complex: machinery for intramembrane proteolysis
25
2755847 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
2833348 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
2954849 2004 EMBO JOURNAL 23 (3): 483-488
Haass C
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
1130
3042350 2004 EMBO REPORTS 5 (4): 405-411
Loewer A; Soba P; Beyreuther K; Paro R; Merdes G
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development
22
#LCRNCRNode / Date / Journal / AuthorLCSGCS
3165551 2004 EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (2): 375-385
Culvenor JG; Ilaya NT; Ryan MT; Canterford L; Hoke DE; et al.
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
57
3214152 2004 EUROPEAN JOURNAL OF IMMUNOLOGY 34 (4): 1217-1227
Mayne M; Moffatt T; Kong H; McLaren PJ; Fowke KR; et al.
CYFIP2 is highly abundant in CD4(+) cells from multiple sclerosis patients and is involved in T cell adhesion
00
331377 2003 EXPERIMENTAL NEUROLOGY 183 (2): 673-681
Huang XG; Yee BK; Nag S; Chan STH; Tang F
Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235
03
34312253 2004 EXPERT OPINION ON INVESTIGATIONAL DRUGS 13 (4): 303-314
Bullock R
Future directions in the treatment of Alzheimer's disease
01
351298 2003 FEBS LETTERS 553 (1-2): 151-156
Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al.
The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation
01
369178113 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146
Marambaud P; Robakis NK
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation
00
37230554 2004 HUMAN GENETICS 114 (5): 413-438
Bertoli-Avella AM; Oostra BA; Heutink P
Chasing genes in Alzheimer's and Parkinson's disease
02
382449 2003 HUMAN MOLECULAR GENETICS 12: R201-R206
Martoglio B; Golde TE
Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs
010
3936210 2003 HUMAN MOLECULAR GENETICS 12 (20): 2669-2678
Guo M; Hong EJ; Fernandes J; Zipursky SL; Hay BA
A reporter for amyloid precursor protein gamma-secretase activity in Drosophila
34
4013655 2004 HUMAN MOLECULAR GENETICS 13: R123-R126
Singleton A; Myers A; Hardy J
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases
012
#LCRNCRNode / Date / Journal / AuthorLCSGCS
4118056 2004 HUMAN MOLECULAR GENETICS 13 (2): 159-170
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; et al.
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
010
4223357 2004 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13 (1): 121-125
Kume H; Maruyama K; Kametani F
Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage
01
4312458 2004 INTERNATIONAL JOURNAL OF NEUROSCIENCE 114 (10): 1277-+
Hwang DY; Kim YK; Lim CJ; Cho JS
Mutant nicastrin protein can induce the cytochrome c release and the Bax expression
00
44114459 2004 JOURNAL OF ALZHEIMERS DISEASE 6 (1): 53-65
Pasternak SH; Callahan JW; Mahuran DJ
The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective
03
4514611 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (20): 18664-18670
Takahashi Y; Hayashi I; Tominari Y; Rikimaru K; Morohashi Y; et al.
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces A beta 42 generation
1128
4615712 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (27): 24277-24284
Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; et al.
Partial purification and characterization of gamma-secretase from post-mortem human brain
1320
4725913 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
210
4813814 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (35): 33445-33449
Li JH; Fici GJ; Mao CA; Myers RL; Shuang R; et al.
Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model
34
4916315 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (36): 33992-34002
Kim SH; Ikeuchi T; Yu CJ; Sisodia SS
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex - Evidence for differential intramembranous processing of transmembrane substrates
2325
5023316 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222
LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al.
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
4249
#LCRNCRNode / Date / Journal / AuthorLCSGCS
5114417 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (43): 42161-42169
Jung KM; Tan S; Landman N; Petrova K; Murray S; et al.
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
524
5234618 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43284-43291
Morais VA; Crystal AS; Pijak DS; Carlin D; Costa J; et al.
The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex
1923
5327319 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (44): 43430-43436
Nyabi O; Bentahir M; Horre K; Herreman A; Gottardi-Littell N; et al.
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type presenilin
1825
5413320 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (48): 47370-47375
Lleo A; Berezovska O; Ramdya P; Fukumoto H; Raju S; et al.
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression
37
5515421 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (49): 49448-49458
Araki Y; Tomita S; Yamaguchi H; Miyagi N; Sumioka A; et al.
Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism
14
5653422 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523
Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al.
Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
68
5754360 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (5): 3685-3693
Fortna RR; Crystal AS; Morais VA; Pijak DS; Lee VMY; et al.
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
1111
5863861 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4144-4152
Lee SF; Shah S; Yu C; Wigley WC; Li H; et al.
A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex
912
5916162 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (6): 4596-4603
Guo Q; Xie J
AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with par-4
14
6023663 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (15): 15153-15160
Nyborg AC; Kornilova AY; Jansen K; Ladd TB; Wolfe MS; et al.
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
69
#LCRNCRNode / Date / Journal / AuthorLCSGCS
6174864 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (22): 23255-23261
Prokop S; Shirotani K; Edbauer D; Haass C; Steiner H
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
1010
6234365 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (23): 24343-24354
Araki Y; Miyagi N; Kato N; Yoshida T; Wada S; et al.
Coordinated metabolism of alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation
11
6343666 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (24): 25333-25338
Pitsi D; Octave JN
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity
01
6434767 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34130-34137
Xie ZC; Romano DM; Kovacs DM; Tanzi RE
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation
11
6593768 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 37311-37315
Edbauer D; Kaether C; Steiner H; Haass C
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
11
6664069 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (36): 38040-38046
Hayashi I; Urano Y; Fukuda R; Isoo N; Kodama T; et al.
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
23
6797570 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
23
68145671 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (40): 41340-41345
Shirotani K; Edbauer D; Prokop S; Haass C; Steiner H
Identification of distinct gamma-secretase complexes with different APH-1 variants
88
6953672 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (41): 43148-43156
Nyborg AC; Jansen K; Ladd TB; Fauq A; Golde TE
A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin
01
7064873 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (42): 43419-43426
Beher D; Clarke EE; Wrigley JDJ; Martin ACL; Nadin A; et al.
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site - Evidence for an allosteric mechanism
13
#LCRNCRNode / Date / Journal / AuthorLCSGCS
7197674 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954
Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al.
Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes
410
7232975 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463
Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
33
7362676 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619
Kim SH; Yin YI; Li YM; Sisodia SS
Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway
34
7435377 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532
Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS
Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
00
7544678 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798
Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al.
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins
11
761125114 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001
Kim SH; Sisodia SS
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
00
77654115 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
781553116 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478
Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
00
791577117 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
802168118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
814108119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832
Xie J; Guo Q
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
00
821344120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
83952121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
00
8412423 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690
Hu Y; Fortini ME
Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
4044
8546279 2004 JOURNAL OF CELL SCIENCE 117 (18): 4099-4111
Gowrishankar K; Zeidler MG; Vincenz C
Release of a membrane-bound death domain by gamma-secretase processing of the p75(NTR) homolog NRADD
01
8614624 2003 JOURNAL OF CLINICAL INVESTIGATION 112 (3): 440-449
Eriksen JL; Sagi SA; Smith TE; Weggen S; Das P; et al.
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower A beta 42 in vivo
434
87750122 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
88831123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
8925980 2004 JOURNAL OF NEUROCHEMISTRY 89 (1): 44-53
Laudon H; Mathews PM; Karlstrom H; Bergman A; Farmery MR; et al.
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein
47
90104281 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
78
#LCRNCRNode / Date / Journal / AuthorLCSGCS
9115782 2004 JOURNAL OF NEUROCHEMISTRY 90 (4): 800-806
da Costa CA; Ayral E; Hernandez JF; St George-Hyslop P; Checler F
Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells
00
9233783 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
93106284 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1402-1413
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; et al.
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation
00
9465185 2004 JOURNAL OF NEUROCHEMISTRY 91 (1): 230-237
Ilaya NT; Evin G; Masters CL; Culvenor JG
Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
00
95735124 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020
Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al.
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch
00
9620282125 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792
Brunkan AL; Goate AM
Presenilin function and gamma-secretase activity
00
971436126 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198
Ma GJ; Li T; Price DL; Wong PC
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
11
9817425 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74 (3): 353-360
Kimberly WT; Wolfe MS
Identity and function of gamma-secretase
415
991511386 2004 JOURNAL OF NEUROSCIENCE RESEARCH 77 (3): 309-322
Periz G; Fortini ME
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
46
100768127 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73
Brunkan AL; Martinez M; Walker ES; Goate AM
Presenilin endoproteolysis is an intrarnolecular cleavage
00

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