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Nodes: 130,
Authors: 480,
Journals: 60,
Outer References: 3273,
Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by date.
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| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 101 | 6 | 26 | 76 2004 NOV 19 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619 Kim SH; Yin YI; Li YM; Sisodia SS Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway | 3 | 4 |
| 102 | 3 | 53 | 77 2004 NOV 19 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 49523-49532 Liao YF; Wang BJ; Cheng HT; Kuo LH; Wolfe MS Tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway | 0 | 0 |
| 103 | 4 | 46 | 78 2004 DEC 3 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (49): 50790-50798 Friedmann E; Lemberg MK; Weihofen A; Dev KK; Dengler U; et al. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins | 1 | 1 |
| 104 | 5 | 48 | 102 2004 DEC 7 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (49): 17050-17055 Tarassishin L; Yin YI; Bassit L; Li YM Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct | 0 | 1 |
| 105 | 1 | 14 | 33 2004 DEC [15] ACTA PHARMACOLOGICA SINICA 25 (12): 1613-1618 Lu HM; Deng H; Xiao F; Gao Q; Weng W; et al. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA | 0 | 0 |
| 106 | 1 | 113 | 87 2004 DEC 20 MOLECULAR BRAIN RESEARCH 132 (2): 260-270 Genc S; Koroglu TF; Genc K RNA interference in neuroscience | 0 | 0 |
| 107 | 1 | 70 | 112 2005 JAN 3 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267 King ME Can tau filaments be both physiologically beneficial and toxic? | 0 | 0 |
| 108 | 1 | 50 | 107 2005 JAN 5 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20 Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation | 0 | 0 |
| 109 | 14 | 36 | 126 2005 JAN 5 JOURNAL OF NEUROSCIENCE 25 (1): 192-198 Ma GJ; Li T; Price DL; Wong PC APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | 1 | 1 |
| 110 | 11 | 25 | 114 2005 JAN 21 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 111 | 6 | 28 | 128 2005 FEB 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724 Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi | 2 | 2 |
| 112 | 7 | 22 | 108 2005 FEB 4 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 (1): 18-22 Salto S; Araki W Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes | 0 | 0 |
| 113 | 3 | 34 | 129 2005 FEB 8 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888 Urban S; Wolfe MS Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | 0 | 1 |
| 114 | 6 | 54 | 115 2005 FEB 11 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392 Chyung JH; Raper DM; Selkoe DJ gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage | 0 | 1 |
| 115 | 15 | 53 | 116 2005 FEB 25 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478 Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al. gamma-secretase complex assembly within the early secretory pathway | 0 | 0 |
| 116 | 3 | 31 | 130 2005 MAR 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235 Kornilova AY; Bihel F; Das C; Wolfe MS The initial substrate-binding site of gamma-secretase is located on presenilin near the active site | 0 | 0 |
| 117 | 7 | 35 | 124 2005 MAR [15] JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020 Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch | 0 | 0 |
| 118 | 7 | 53 | 110 2005 MAR 22 BIOCHEMISTRY 44 (11): 4332-4341 Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex | 0 | 0 |
| 119 | 3 | 36 | 111 2005 MAR 22 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 120 | 15 | 77 | 117 2005 APR 1 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 121 | 21 | 68 | 118 2005 APR 1 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975 Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al. Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions | 0 | 0 |
| 122 | 4 | 108 | 119 2005 APR 8 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832 Xie J; Guo Q PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein | 0 | 0 |
| 123 | 9 | 178 | 113 2005 APR [15] GENES BRAIN AND BEHAVIOR 4 (3): 134-146 Marambaud P; Robakis NK Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation | 0 | 0 |
| 124 | 13 | 44 | 120 2005 APR 29 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 125 | 9 | 52 | 121 2005 MAY 13 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077 Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides | 0 | 0 |
| 126 | 7 | 50 | 122 2005 MAY [15] JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| 127 | 20 | 282 | 125 2005 MAY [15] JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792 Brunkan AL; Goate AM Presenilin function and gamma-secretase activity | 0 | 0 |
| 128 | 7 | 68 | 127 2005 MAY [15] MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73 Brunkan AL; Martinez M; Walker ES; Goate AM Presenilin endoproteolysis is an intrarnolecular cleavage | 0 | 0 |
| 129 | 11 | 25 | 109 2005 MAY 20 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| 130 | 8 | 31 | 123 2005 [JUN 30] JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
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