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Nodes: 130,
Authors: 480,
Journals: 60,
Outer References: 3273,
Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by NCR.
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| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 101 | 5 | 34 | 22 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (52): 52519-52523 Capell A; Kaether C; Edbauer D; Shirotani K; Merkl S; et al. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain | 6 | 8 |
| 102 | 3 | 34 | 129 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888 Urban S; Wolfe MS Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | 0 | 1 |
| 103 | 2 | 33 | 16 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (39): 37213-37222 LaVoie MJ; Fraering PC; Ostaszewski BL; Ye WJ; Kimberly WT; et al. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | 42 | 49 |
| 104 | 1 | 33 | 20 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (48): 47370-47375 Lleo A; Berezovska O; Ramdya P; Fukumoto H; Raju S; et al. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression | 3 | 7 |
| 105 | 3 | 33 | 48 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325 Tomita T; Iwatsubo T The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease | 1 | 2 |
| 106 | 2 | 33 | 57 2004 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 13 (1): 121-125 Kume H; Maruyama K; Kametani F Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage | 0 | 1 |
| 107 | 8 | 31 | 123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| 108 | 3 | 31 | 130 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235 Kornilova AY; Bihel F; Das C; Wolfe MS The initial substrate-binding site of gamma-secretase is located on presenilin near the active site | 0 | 0 |
| 109 | 1 | 29 | 8 2003 FEBS LETTERS 553 (1-2): 151-156 Sai XR; Kokame K; Shiraishi H; Kawamura Y; Miyata T; et al. The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amylold beta-protein generation | 0 | 1 |
| 110 | 1 | 29 | 40 2004 BIOCHEMISTRY 43 (42): 13532-13540 Funamoto S; Morshima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; et al. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42 | 0 | 1 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 111 | 3 | 29 | 75 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45): 46455-46463 Hasegawa H; Sanjo N; Chen FS; Gu YJ; Shier C; et al. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes | 3 | 3 |
| 112 | 0 | 28 | 27 2003 NATURE 422 (6930): 438-441 Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; et al. The role of presenilin cofactors in the gamma-secretase complex | 129 | 130 |
| 113 | 5 | 28 | 46 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (3): 379-383 Iwatsubo T The gamma-secretase complex: machinery for intramembrane proteolysis | 2 | 5 |
| 114 | 6 | 28 | 128 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724 Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi | 2 | 2 |
| 115 | 2 | 27 | 106 2004 TETRAHEDRON LETTERS 45 (11): 2323-2326 Fuwa H; Okamura Y; Morohashi Y; Tomita T; Iwatsubo T; et al. Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of omega-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues | 0 | 3 |
| 116 | 6 | 26 | 76 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (47): 48615-48619 Kim SH; Yin YI; Li YM; Sisodia SS Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway | 3 | 4 |
| 117 | 1 | 25 | 103 2004 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31 (3): 198-203 Zhou QJ; Hu RZ; Shao JZ; Xiang LX Notch signal transduction and regulation | 0 | 0 |
| 118 | 11 | 25 | 109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072 Saito S; Takahashi-Sasaki N; Araki W Identification and characterization of a novel human APH-1b splice variant lacking exon 4 | 0 | 0 |
| 119 | 11 | 25 | 114 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001 Kim SH; Sisodia SS A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1 | 0 | 0 |
| 120 | 1 | 24 | 23 2003 JOURNAL OF CELL BIOLOGY 161 (4): 685-690 Hu Y; Fortini ME Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | 40 | 44 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 121 | 1 | 24 | 58 2004 INTERNATIONAL JOURNAL OF NEUROSCIENCE 114 (10): 1277-+ Hwang DY; Kim YK; Lim CJ; Cho JS Mutant nicastrin protein can induce the cytochrome c release and the Bax expression | 0 | 0 |
| 122 | 1 | 23 | 1 2003 ANNALS OF NEUROLOGY 54 (2): 143-144 Hardy J Alzheimer's disease: Genetic evidence points to a single pathogenesis | 1 | 4 |
| 123 | 4 | 23 | 50 2004 EMBO REPORTS 5 (4): 405-411 Loewer A; Soba P; Beyreuther K; Paro R; Merdes G Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development | 2 | 2 |
| 124 | 1 | 22 | 29 2003 NEURON 38 (1): 9-12 De Strooper B Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex | 48 | 118 |
| 125 | 7 | 22 | 108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 (1): 18-22 Salto S; Araki W Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes | 0 | 0 |
| 126 | 1 | 14 | 33 2004 ACTA PHARMACOLOGICA SINICA 25 (12): 1613-1618 Lu HM; Deng H; Xiao F; Gao Q; Weng W; et al. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA | 0 | 0 |
| 127 | 3 | 14 | 105 2004 SEIKAGAKU 76 (7): 666-670 Tomita T; Iwatsubo T Recent advances in Alzheimer's disease-related gamma-secretase complex | 0 | 0 |
| 128 | 3 | 13 | 89 2004 MOLECULAR PSYCHIATRY 9 (1): 8-10 Iwatsubo T Assembly and activation of the gamma-secretase complex: roles of presenilin cofactors | 1 | 2 |
| 129 | 1 | 11 | 26 2003 NATURE 422 (6930): 385-387 Mattson MP Neurobiology - Ballads of a protein quartet | 0 | 3 |
| 130 | 1 | 10 | 97 2004 NEUROLOGY 63 (9): 1702-1704 Godbolt AK; Beck JA; Collinge J; Garrard P; Warren JD; et al. A presenilin 1 R278I mutation presenting with language impairment | 1 | 1 |
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