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Nodes: 130,
Authors: 480,
Journals: 60,
Outer References: 3273,
Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by first author.
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| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
|---|---|---|---|---|---|
| 101 | 10 | 42 | 81 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527 Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 | 7 | 8 |
| 102 | 5 | 58 | 98 2004 NEUROSCIENCE 129 (3): 615-628 Siman R; Salidas S Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain | 0 | 0 |
| 103 | 1 | 36 | 55 2004 HUMAN MOLECULAR GENETICS 13: R123-R126 Singleton A; Myers A; Hardy J The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases | 0 | 12 |
| 104 | 3 | 204 | 31 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341 Stein TD; Johnson JA Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity | 0 | 4 |
| 105 | 3 | 91 | 36 2004 BIOCHEMICAL JOURNAL 381: 619-628 Suga K; Tomiyama T; Mori H; Akagawa K Syntaxin 5 interacts with presenilin holoproteins, but not with their N-or C-terminal fragments, and affects beta-amyloid peptide production | 0 | 0 |
| 106 | 1 | 46 | 11 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (20): 18664-18670 Takahashi Y; Hayashi I; Tominari Y; Rikimaru K; Morohashi Y; et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces A beta 42 generation | 11 | 28 |
| 107 | 0 | 28 | 27 2003 NATURE 422 (6930): 438-441 Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; et al. The role of presenilin cofactors in the gamma-secretase complex | 129 | 130 |
| 108 | 5 | 48 | 102 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (49): 17050-17055 Tarassishin L; Yin YI; Bassit L; Li YM Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct | 0 | 1 |
| 109 | 1 | 105 | 100 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418 Thinakaran G; Parent AT Identification of the role of presenilins beyond Alzheimer's disease | 2 | 4 |
| 110 | 3 | 33 | 48 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325 Tomita T; Iwatsubo T The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease | 1 | 2 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 111 | 3 | 14 | 105 2004 SEIKAGAKU 76 (7): 666-670 Tomita T; Iwatsubo T Recent advances in Alzheimer's disease-related gamma-secretase complex | 0 | 0 |
| 112 | 7 | 50 | 122 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912 Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al. Association of active gamma-secretase complex with lipid rafts | 0 | 0 |
| 113 | 3 | 34 | 129 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888 Urban S; Wolfe MS Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity | 0 | 1 |
| 114 | 9 | 76 | 74 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954 Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al. Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes | 4 | 10 |
| 115 | 1 | 60 | 5 2003 BIOCHEMISTRY 42 (47): 13977-13986 Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al. gamma-secretase activity is present in rafts but is not cholesterol-dependent | 3 | 8 |
| 116 | 9 | 75 | 70 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566 Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components | 2 | 3 |
| 117 | 1 | 41 | 94 2004 NEUROBIOLOGY OF DISEASE 15 (3): 654-666 Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes | 3 | 7 |
| 118 | 2 | 59 | 13 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754 Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al. A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain | 2 | 10 |
| 119 | 4 | 103 | 43 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178 Westlund B; Stilwell G; Sluder A Invertebrate disease models in neurotherapeutic discovery | 0 | 0 |
| 120 | 1 | 50 | 107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20 Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation | 0 | 0 |
| # | LCR | NCR | Node / Date / Journal / Author | LCS | GCS |
| 121 | 5 | 58 | 47 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588 Wilquet V; De Strooper B Amyloid-beta precursor protein processing in neurodegeneration | 0 | 1 |
| 122 | 11 | 73 | 104 2004 SCIENCE 305 (5687): 1119-1123 Wolfe MS; Kopan R Intramembrane proteotysis: Theme and variations | 3 | 11 |
| 123 | 3 | 37 | 83 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320 Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding | 5 | 5 |
| 124 | 15 | 77 | 117 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535 Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity | 0 | 0 |
| 125 | 4 | 108 | 119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832 Xie J; Guo Q PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein | 0 | 0 |
| 126 | 3 | 47 | 67 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34130-34137 Xie ZC; Romano DM; Kovacs DM; Tanzi RE Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation | 1 | 1 |
| 127 | 8 | 31 | 123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77 Xie ZC; Romano DM; Tanzi RE Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1 | 0 | 0 |
| 128 | 3 | 36 | 111 2005 BIOCHEMISTRY 44 (11): 4450-4457 Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2 | 0 | 0 |
| 129 | 13 | 44 | 120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026 Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components | 0 | 0 |
| 130 | 1 | 25 | 103 2004 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31 (3): 198-203 Zhou QJ; Hu RZ; Shao JZ; Xiang LX Notch signal transduction and regulation | 0 | 0 |
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