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Wed Jun 1 16:44:12 2005

The role of presenilin cofactors in the gamma-secretase complex
TAKASUGI N, TOMITA T, HAYASHI I, et al.
NATURE 422: 438-441 2003
and the citing papers

Nodes: 130, Authors: 480, Journals: 60, Outer References: 3273, Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by first author.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
101104281 2004 JOURNAL OF NEUROCHEMISTRY 89 (6): 1520-1527
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
78
10255898 2004 NEUROSCIENCE 129 (3): 615-628
Siman R; Salidas S
Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain
00
10313655 2004 HUMAN MOLECULAR GENETICS 13: R123-R126
Singleton A; Myers A; Hardy J
The law of mass action applied to neurodegenerative disease: a hypothesis concerning the etiology and pathogenesis of complex diseases
012
104320431 2003 REVIEWS IN THE NEUROSCIENCES 14 (4): 317-341
Stein TD; Johnson JA
Genetic programming by the proteolytic fragments of the amyloid precursor protein: Somewhere between confusion and clarity
04
10539136 2004 BIOCHEMICAL JOURNAL 381: 619-628
Suga K; Tomiyama T; Mori H; Akagawa K
Syntaxin 5 interacts with presenilin holoproteins, but not with their N-or C-terminal fragments, and affects beta-amyloid peptide production
00
10614611 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (20): 18664-18670
Takahashi Y; Hayashi I; Tominari Y; Rikimaru K; Morohashi Y; et al.
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces A beta 42 generation
1128
10702827 2003 NATURE 422 (6930): 438-441
Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; et al.
The role of presenilin cofactors in the gamma-secretase complex
129130
108548102 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (49): 17050-17055
Tarassishin L; Yin YI; Bassit L; Li YM
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
01
1091105100 2004 PHARMACOLOGICAL RESEARCH 50 (4): 411-418
Thinakaran G; Parent AT
Identification of the role of presenilins beyond Alzheimer's disease
24
11033348 2004 DRUG NEWS & PERSPECTIVES 17 (5): 321-325
Tomita T; Iwatsubo T
The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
12
#LCRNCRNode / Date / Journal / AuthorLCSGCS
111314105 2004 SEIKAGAKU 76 (7): 666-670
Tomita T; Iwatsubo T
Recent advances in Alzheimer's disease-related gamma-secretase complex
00
112750122 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
113334129 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888
Urban S; Wolfe MS
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity
01
11497674 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (43): 44945-44954
Vetrivel KS; Cheng HP; Lin W; Sakurai T; Li T; et al.
Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes
410
1151605 2003 BIOCHEMISTRY 42 (47): 13977-13986
Wada S; Morishima-Kawashima M; Qi Y; Misono H; Shimada Y; et al.
gamma-secretase activity is present in rafts but is not cholesterol-dependent
38
11697570 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (39): 40560-40566
Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; et al.
Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components
23
11714194 2004 NEUROBIOLOGY OF DISEASE 15 (3): 654-666
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes
37
11825913 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278 (33): 30748-30754
Weggen S; Eriksen JL; Sagi SA; Pietrzik CU; Golde TE; et al.
A beta 42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain
210
119410343 2004 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 7 (2): 169-178
Westlund B; Stilwell G; Sluder A
Invertebrate disease models in neurotherapeutic discovery
00
120150107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20
Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
12155847 2004 CURRENT OPINION IN NEUROBIOLOGY 14 (5): 582-588
Wilquet V; De Strooper B
Amyloid-beta precursor protein processing in neurodegeneration
01
1221173104 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
311
12333783 2004 JOURNAL OF NEUROCHEMISTRY 90 (6): 1312-1320
Wrigley JDJ; Nunn EJ; Nyabi O; Clarke EE; Hunt P; et al.
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding
55
1241577117 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
1254108119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832
Xie J; Guo Q
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
00
12634767 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (33): 34130-34137
Xie ZC; Romano DM; Kovacs DM; Tanzi RE
Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation
11
127831123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
128336111 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
1291344120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
130125103 2004 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31 (3): 198-203
Zhou QJ; Hu RZ; Shao JZ; Xiang LX
Notch signal transduction and regulation
00

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