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Wed Jun 1 16:44:12 2005

The role of presenilin cofactors in the gamma-secretase complex
TAKASUGI N, TOMITA T, HAYASHI I, et al.
NATURE 422: 438-441 2003
and the citing papers

Nodes: 130, Authors: 480, Journals: 60, Outer References: 3273, Words: 549
Collection span: 2003 - 2005
View: Overview. Sorted by year, source, volume, issue, page.
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#LCRNCRNode / Date / Journal / AuthorLCSGCS
101153101 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (17): 6623-6628
Iijima K; Liu HP; Chiang AS; Hearn SA; Konsolaki M; et al.
Dissecting the pathological effects of human A beta 40 and A beta 42 in Drosophila: A potential model for Alzheimer's disease
010
102548102 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (49): 17050-17055
Tarassishin L; Yin YI; Bassit L; Li YM
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
01
103125103 2004 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 31 (3): 198-203
Zhou QJ; Hu RZ; Shao JZ; Xiang LX
Notch signal transduction and regulation
00
1041173104 2004 SCIENCE 305 (5687): 1119-1123
Wolfe MS; Kopan R
Intramembrane proteotysis: Theme and variations
311
105314105 2004 SEIKAGAKU 76 (7): 666-670
Tomita T; Iwatsubo T
Recent advances in Alzheimer's disease-related gamma-secretase complex
00
106227106 2004 TETRAHEDRON LETTERS 45 (11): 2323-2326
Fuwa H; Okamura Y; Morohashi Y; Tomita T; Iwatsubo T; et al.
Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of omega-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues
03
107150107 2005 AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 132B (1): 14-20
Wijsman EM; Daw EW; Yu XS; Steinbart EJ; Nochlin D; et al.
APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation
00
108722108 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 (1): 18-22
Salto S; Araki W
Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes
00
1091125109 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 (4): 1068-1072
Saito S; Takahashi-Sasaki N; Araki W
Identification and characterization of a novel human APH-1b splice variant lacking exon 4
00
110753110 2005 BIOCHEMISTRY 44 (11): 4332-4341
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; et al.
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
111336111 2005 BIOCHEMISTRY 44 (11): 4450-4457
Zhang LL; Lee JL; Song LX; Sun XY; Shen J; et al.
Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2
00
112170112 2005 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739 (2-3): 260-267
King ME
Can tau filaments be both physiologically beneficial and toxic?
00
1139178113 2005 GENES BRAIN AND BEHAVIOR 4 (3): 134-146
Marambaud P; Robakis NK
Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation
00
1141125114 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (3): 1992-2001
Kim SH; Sisodia SS
A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
00
115654115 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (6): 4383-4392
Chyung JH; Raper DM; Selkoe DJ
gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage
01
1161553116 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (8): 6471-6478
Capell A; Beher D; Prokop S; Steiner H; Kaether C; et al.
gamma-secretase complex assembly within the early secretory pathway
00
1171577117 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12523-12535
Wrigley JDJ; Schurov I; Nunn EJ; Martin ACL; Clarke EE; et al.
Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity
00
1182168118 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12967-12975
Niimura M; Isoo N; Takasugi N; Tsuruoka M; Ui- Tei K; et al.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
00
1194108119 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (14): 13824-13832
Xie J; Guo Q
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein
00
1201344120 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (17): 17020-17026
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; et al.
Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
121952121 2005 JOURNAL OF BIOLOGICAL CHEMISTRY 280 (19): 19070-19077
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; et al.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
00
122750122 2005 JOURNAL OF LIPID RESEARCH 46 (5): 904-912
Urano Y; Hayashi I; Isoo N; Reid PC; Shibasaki Y; et al.
Association of active gamma-secretase complex with lipid rafts
00
123831123 2005 JOURNAL OF MOLECULAR NEUROSCIENCE 25 (1): 67-77
Xie ZC; Romano DM; Tanzi RE
Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
00
124735124 2005 JOURNAL OF NEUROCHEMISTRY 92 (5): 1010-1020
Hansson EM; Stromberg K; Bergstedt S; Yu G; Naslund J; et al.
Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch
00
12520282125 2005 JOURNAL OF NEUROCHEMISTRY 93 (4): 769-792
Brunkan AL; Goate AM
Presenilin function and gamma-secretase activity
00
1261436126 2005 JOURNAL OF NEUROSCIENCE 25 (1): 192-198
Ma GJ; Li T; Price DL; Wong PC
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
11
127768127 2005 MOLECULAR AND CELLULAR NEUROSCIENCE 29 (1): 65-73
Brunkan AL; Martinez M; Walker ES; Goate AM
Presenilin endoproteolysis is an intrarnolecular cleavage
00
128628128 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (5): 1719-1724
Serneels L; Dejaegere T; Craessaerts K; Horre K; Jorissen E; et al.
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoi
22
129334129 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (6): 1883-1888
Urban S; Wolfe MS
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity
01
130331130 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 (9): 3230-3235
Kornilova AY; Bihel F; Das C; Wolfe MS
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
00

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