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Wed Mar 30 12:22:19 2005
Transcription start regions in the human
genome are favored targets for MLV integration

WU XL, LI Y, CRISE B, et al.
SCIENCE 300: 1749-1751 2003
and the citing papers

Nodes: 99, Authors: 417, Journals: 56, Outer References: 4520, Words: 467
Collection span: 2003 - 2005
View: Overview. Sorted by first author.
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
11598 2003 DEVELOPMENTAL DYNAMICS 228(3):523-534
Amsterdam A
Insertional mutagenesis in zebrafish
06
2110541 2004 GENETICS 168(3):1159-1176
Aye M; Irwin B; Beliakova-Bethell N; Chen E; Garrus J; et al.
Host factors that affect Ty3 retrotransposition in Saccharomyces cerevisiae
00
315044 2004 HUMAN GENE THERAPY 15(5):445-456
Bao LL; Jaligam V; Zhang XY; Kutner RH; Kantrow SP; et al.
Stable transgene expression in tumors and metastases after transduction with lentiviral vectors based on human immunodeficiency virus type 1
01
4312635 2004 EXPERT OPINION ON BIOLOGICAL THERAPY 4(9):1423-1434
Barese CN; Goebel WS; Dinauer MC
Gene therapy for chronic granulomatous disease
00
535438 2004 GENE THERAPY 11:S3-S9
Barquinero J; Eixarch H; Perez-Melgosa M
Retroviral vectors: new applications for an old tool
00
61375 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):458-462
Baum C; Fehse B
Mutagenesis by retroviral transgene insertion: Risk assessment and potential alternatives
12
725461 2004 MOLECULAR THERAPY 9(1):5-13
Baum C; von Kalle C; Staal FJT; Li ZX; Fehse B; et al.
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
59
81312 2003 QJM-AN INTERNATIONAL JOURNAL OF MEDICINE 96(11):873-874
Berry C
Misplaced
00
919731 2004 CURRENT GENOMICS 5(1):19-35
Buchschacher GL
Safety considerations associated with development and clinical application of lentiviral vector systems for gene transfer
00
101991 2003 ARCHIVES OF MEDICAL RESEARCH 34(6):589-599
Bueren JA; Guenechea G; Casado JA; Lamana ML; Segovia JC
Genetic modification of hematopoietic stem cells: recent advances in the gene therapy of inherited diseases
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
111183 2003 CELL 115(2):135-138
Bushman FD
Targeting survival: Integration site selection by retroviruses and LTR-retrotransposons
1320
1236417 2004 AIDS REVIEWS 6(1):13-21
Cereseto A; Giacca M
Integration site selection by retroviruses
00
1316783 2004 WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE 16(1):23-33
Chandler LA; Sosnowski BA
Gene therapy for cutaneous wound repair
02
1414270 2004 NATURE GENETICS 36(3):304-312
Chen WSV; Delrow J; Corrin PD; Frazier JP; Soriano P
Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis
14
1534384 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 329(2):646-652
Chen ZYJ; Kren BT; Wong PYP; Low WC; Steer CJ
Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference
00
1665947 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(47):48883-48892
Cherepanov P; Devroe E; Silver PA; Engelman A
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
00
1738546 2004 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 113(4):595-603
Chinen J; Puck JM
Successes and risks of gene therapy in primary immunodeficiencies
05
1825045 2004 HUMAN GENE THERAPY 15(8):758-769
Chinnasamy D; Fairbairn LJ; Neuenfeldt J; Treisman JS; Hanson JP; et al.
Lentivirus-mediated expression of mutant MGMT(P140K) protects human CD34(+) cells against the combined toxicity of O-6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide
00
1962098 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(5):1275-1276
Engelman A
The ups and downs of gene expression and retroviral DNA integration
00
2021097 2005 PLOS MEDICINE 2(1):22-24
Fischer A; Cavazzana-Calvo M
Integration of retroviruses: A fine balance between efficiency and danger
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
2121059 2004 M S-MEDECINE SCIENCES 20(1):115-117
Fischer A; Hacein-Bey-Abina S; Cavazzana-Calvo M
Gene therapy of children with X-linked severe combined immune deficiency : efficiency and comlications
01
2228877 2004 SEMINARS IN HEMATOLOGY 41(4):272-278
Fischer A; Hacein-Bey-Abina S; Cavazzana-Calvo M
Gene therapy for immunodeficiency diseases
01
2323324 2004 BLOOD 104(12):3543-3549
Frank O; Rudolph C; Heberlein C; von Neuhoff N; Schrock E; et al.
Tumor cells escape suicide gene therapy by genetic and epigenetic instability
00
241939 2003 EXPERT OPINION ON BIOLOGICAL THERAPY 3(8):1241-1251
Fruehauf S; Veldwijk MR; Zeller WJ; Laufs S
Prospects and RISC score of viral gene therapy for sarcoma
00
2513210 2003 GENE THERAPY 10(24):1999-2004
Gaspar HB; Howe S; Thrasher AJ
Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency
15
2613816 2003 SCIENCE 302(5644):415-419
Hacein-Bey-Abina S; Von Kalle C; Schmidt M; McCcormack MP; Wulffraat N; et al.
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
43174
2723953 2004 JOURNAL OF VIROLOGICAL METHODS 121(2):127-136
Hahm SH; Yi YS; Lee DK; Noh MJ; Yun L; et al.
Construction of retroviral vectors with enhanced efficiency of transgene expression
00
2817155 2004 JOURNAL OF VIROLOGY 78(12):6122-6133
Han YF; Lassen K; Monie D; Sedaghat AR; Shimoji S; et al.
Resting CD4(+) T cells from human immunodeficiency virus type I (HIV-1)-infected individuals carry integrated HIV-1 Genomes within actively transcribed host genes
24
2933822 2004 BLOOD 104(8):2281-2290
Hanawa H; Hargrove PW; Kepes S; Srivastava DK; Nienhuis AW; et al.
Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia
00
3038021 2004 BLOOD 103(11):4062-4069
Hanawa H; Hematti P; Keyvanfar K; Metzger ME; Krouse A; et al.
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system
46
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
31212830 2004 CURRENT GENE THERAPY 4(3):263-276
Haviernik P; Bunting KD
Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors
00
3235374 2004 PLOS BIOLOGY 2(12):2183-2190
Hematti P; Hong BK; Ferguson C; Adler R; Hanawa H; et al.
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
00
3328789 2005 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 8(2):199-206
Herzog RW
Recent advances in hepatic gene transfer: More efficacy and less immunogenicity
00
3425860 2004 MOLECULAR CELL 13(3):403-414
Hickman AB; Ronning DR; Perez ZN; Kotin RM; Dyda F
The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces
04
3532420 2004 BIOLOGY OF REPRODUCTION 71(2):405-409
Hofmann A; Zakhartchenko V; Weppert M; Sebald H; Wenigerkind H; et al.
Generation of transgenic cattle by lentiviral gene transfer into oocytes
13
36519567 2004 MOLECULAR THERAPY 10(3):417-431
Horn PA; Morris JC; Neff T; Kiem HP
Stem cell gene transfer-efficacy and safety in large animal studies
00
3724536 2004 FOLIA BIOLOGICA 50(3-4):107-119
Hughes SH
The RCAS vector system
00
3827351 2004 JOURNAL OF CLINICAL INVESTIGATION 114(7):953-962
Imren S; Fabry ME; Westerman KA; Pawliuk R; Tang P; et al.
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells
11
392425 2004 CANADIAN MEDICAL ASSOCIATION JOURNAL 170(12):1785-1786
Johnston J; Baylis F
Gene therapy: two steps forward, one step back
00
4024263 2004 MOLECULAR THERAPY 9(4):548-556
Kankkonen HM; Vahakangas E; Marr RA; Pakkanen T; Laurema A; et al.
Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
4113633 2004 DEVELOPMENTAL CELL 7(1):133-144
Kawakami K; Takeda H; Kawakami N; Kobayashi M; Matsuda N; et al.
A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
05
4228476 2004 SCIENCE 303(5664):1626-1632
Kazazian HH
Mobile elements: Drivers of genome evolution
036
4323562 2004 MOLECULAR THERAPY 9(3):389-395
Kiem HP; Sellers S; Thomasson B; Morris JC; Tisdale JF; et al.
Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: No progression to clonal hematopoiesis or leukemia
48
44133129 2004 CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 14(1-2):89-136
Klamut HJ; Chen ST; Lau KHW; Baylink DJ
Progress toward skeletal gene therapy
00
45129488 2005 CURRENT GENOMICS 6(1):13-37
Kremer EJ
Gene transfer to the central nervous system: Current state of the art of the viral vectors
00
4627982 2004 TRENDS IN MOLECULAR MEDICINE 10(11):525-531
Lassen K; Han YF; Zhou Y; Siliciano J; Siliciano RF
The multifactorial nature of HIV-1 latency
11
4724569 2004 MOLECULAR THERAPY 10(5):874-881
Laufs S; Nagy KZ; Giordano FA; Hotz-Wagenblatt A; Zeller WJ; et al.
Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns
00
48610818 2004 AIDS REVIEWS 6(4):199-207
Lehmann-Che J; Saib A
Early stages of HIV replication: How to hijack cellular functions for a successful infection
00
49214549 2004 JOURNAL OF BIOMEDICAL SCIENCE 11(4):439-449
Lever AML; Strappe PM; Zhao J
Lentiviral vectors
00
5064919 2004 BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY 17(3):493-503
Li ZX; Modlich U; Baum C
Safety and efficacy in retrovirally modified haematopoietic cell therapy
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
5134848 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(53):55570-55577
Llano M; Delgado S; Vanegas M; Poeschla EM
Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase
00
5217957 2004 JOURNAL OF VIROLOGY 78(17):9524-9537
Llano M; Vanegas M; Fregoso O; Saenz D; Chung S; et al.
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
44
5331999 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(5):1436-1441
Maxfield LF; Fraize CD; Coffin JM
Relationship between retroviral DNA-integration-site selection and host cell transcription
11
5429071 2004 NEW ENGLAND JOURNAL OF MEDICINE 350(9):913-922
McCormack MP; Rabbitts TH
Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency
420
5523973 2004 PLOS BIOLOGY 2(8):1127-1137
Mitchell RS; Beitzel BF; Schroder ARW; Shinn P; Chen HM; et al.
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
00
5618332 2004 CURRENT HIV RESEARCH 2(2):185-191
Morris KV; Rossi JJ
Anti-HIV-1 gene expressing lentiviral vectors as an adjunctive therapy for HIV-1 infection
02
5723292 2005 JOURNAL OF VIROLOGY 79(6):3606-3614
Nakai H; Wu XL; Fuess S; Storm TA; Munroe D; et al.
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver
00
5844358 2004 JOURNAL OF VIROLOGY 78(21):11656-11663
Narezkina A; Taganov KD; Litwin S; Stoyanova R; Hayashi J; et al.
Genome-wide analyses of avian sarcoma virus integration sites
33
5944186 2005 BLOOD 105(3):997-1002
Neff T; Beard BC; Peterson LJ; Anandakumar P; Thompson J; et al.
Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy
00
6027791 2005 JOURNAL OF VIROLOGY 79(1):67-78
Nielsen AA; Sorensen AB; Schmidt J; Pedersen FS
Analysis of wild-type and mutant SL3-3 murine leukemia virus insertions in the c-myc promoter during lymphomagenesis reveals target site hot spots, virus-dependent patterns, and frequent error-prone gap repair
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
6114666 2004 MOLECULAR THERAPY 10(2):260-268
Ohlfest JR; Lobitz PD; Perkinson SG; Largaespada DA
Integration and long-term expression in xenografted human glioblastoma cells using a plasmid-based transposon system
22
62216552 2004 JOURNAL OF GENE MEDICINE 6:S67-S82
Pages JC; Bru T
Toolbox for retrovectorologists
02
6314434 2004 EXPERT OPINION ON BIOLOGICAL THERAPY 4(7):1103-1113
Pardridge WM
Intravenous, non-viral RNAi gene therapy of brain cancer
01
641966 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):508-516
Persons DA
Update on gene therapy for hemoglobin disorders
23
6525642 2004 GENOME BIOLOGY 5(10)
Peterson-Burch BD; Nettleton D; Voytas DF
Genomic neighborhoods for Arabidopsis retrotransposons: a role for targeted integration in the distribution of the Metaviridae
00
6645881 2004 TRANSGENIC RESEARCH 13(6):513-522
Pfeifer A
Lentiviral transgenesis
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6711447 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):529-540
Poeschla EM
Non-primate lentiviral vectors
14
6839894 2005 NATURE REVIEWS DRUG DISCOVERY 4(3):236-248
Pommier Y; Johnson AA; Marchand C
Integrase inhibitors to treat HIV/AIDS
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691524 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(4):376-382
Portlock JL; Calos MP
Site-specific genomic strategies for gene therapy
01
7034123 2004 BLOOD 104(12):3445-3453
Puthenveetil G; Scholes J; Carbonell D; Oureshi N; Xia P; et al.
Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector
00
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7123468 2004 MOLECULAR THERAPY 10(4):660-670
Recchia A; Perani L; Sartori D; Olgiati C; Mavilio F
Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors
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7215356 2004 JOURNAL OF VIROLOGY 78(12):6190-6199
Serhan F; Penaud M; Petit C; Leste-Lasserre T; Trajcevski S; et al.
Early detection of a two-long-terminal-repeat junction molecule in the cytoplasm of recombinant murine leukemia virus-infected cells
01
7313285 2005 BIOESSAYS 27(2):122-125
Shapiro JA
Retrotransposons and regulatory suites
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7419390 2005 GENE 345(1):91-100
Shapiro JA
A 21st century view of evolution: genome system architecture, repetitive DNA, and natural genetic engineering
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7523195 2005 NUCLEIC ACIDS RESEARCH 33(2)
Shigeoka T; Kawaichi M; Ishida Y
Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells
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7618172 2004 ONCOGENE 23(24):4297-4307
Shigesada K; van de Sluis B; Liu PP
Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11
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High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas
01
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Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae
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Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro
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8011513 2003 SCIENCE 300(5626):1670-1671
Trono D
Picking the right spot
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#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
8112227 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61(6):721-726
Tsyba L; Rynditch AV; Boeri E; Jabbari K; Bernardi G
Distribution of HIV-1 in the genomes of AIDS patients
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82321637 2004 FRONTIERS IN BIOSCIENCE 9:3187-3208
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Human cell proteins and human immunodeficiency virus DNA integration
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8329579 2004 SEMINARS IN THROMBOSIS AND HEMOSTASIS 30(2):185-195
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Onco-Retroviral and lentiviral vector-based gene therapy for hemophilia: Preclinical studies
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Novel integrase-defective lentiviral episomal vectors for gene transfer
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The human Polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1
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Lenti in red: progress in gene therapy for human hemoglobinopathies
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Stem cell clonality and genotoxicity in hematopoietic cells: Gene activation side effects should be avoidable
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Fetal and neonatal gene therapy: benefits and pitfalls
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Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation
04
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Gene therapy - New challenges ahead
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9246996 2005 PEDIATRIC NEPHROLOGY 20(2):118-124
Worgall S
A realistic chance for gene therapy in the near future
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9336628 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61(19-20):2588-2596
Wu X; Burgess SM
Integration target site selection for retroviruses and transposable elements
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9401814 2003 SCIENCE 300(5626):1749-1751
Wu XL; Li Y; Crise B; Burgess SM
Transcription start regions in the human genome are favored targets for MLV integration
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Yant SR; Wu XL; Huang Y; Garrison B; Burgess SM; et al.
High-resolution genome-wide mapping of transposon integration in mammals
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Yao AQ; Chiu R; Vora A; Brown DB; Grandgenett D; et al.
Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo
01
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Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications
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98111487 2005 CURRENT GENE THERAPY 5(1):25-35
Yi Y; Hahm SH; Lee KH
Retroviral gene therapy: Safety issues and possible solutions
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9912764 2004 MOLECULAR THERAPY 9(6):923-931
Zielske SP; Lingas KT; Li Y; Gerson SL
Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: Lack of copy number selection by drug treatment
00

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