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#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
601	31	95	5362 2004 EXPERIMENTAL CELL RESEARCH 301 (2): 189-200 Li GZ; Eller MS; Hanna K; Gilchrest BA Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotides	0	2
602	48	95	5664 2004 REJUVENATION RESEARCH 7 (2): 126-133 de Magalhaes JP; Toussaint O Telomeres and telomerase: A modern fountain of youth?	2	5
603	14	94	1673 1995 GENETICS 141 (3): 873-888 SUSSEL L; VANNIER D; SHORE D SUPPRESSORS OF DEFECTIVE SILENCING IN YEAST - EFFECTS ON TRANSCRIPTIONAL REPRESSION AT THE HMR LOCUS, CELL-GROWTH AND TELOMERE STRUCTURE	1	25
604	26	94	2048 1996 ONCOLOGY RESEARCH 8 (10-11): 387-398 WynfordThomas D Telomeres, p53 and cellular senescence	7	17
605	4	94	3428 2000 DRUG SAFETY 23 (6): 467-481 Moyle G Toxicity of antiretroviral nucleoside and nucleotide analogues - Is mitochondrial toxicity the only mechanism?	1	33
606	61	94	4025 2001 MECHANISMS OF AGEING AND DEVELOPMENT 122 (7): 695-712 Klapper W; Parwaresch R; Krupp G Telomere biology in human aging and aging syndromes	16	30
607	10	94	4453 2002 JOURNAL OF RADIATION RESEARCH 43 (3): 223-236 Koike M Dimerization, translocation and localization of Ku70 and Ku80 proteins	2	19
608	47	94	5101 2003 POULTRY SCIENCE 82 (6): 917-926 Delany ME; Daniels LM; Swanberg SE; Taylor HA Telomeres in the chicken: Genome stability and chromosome ends	7	10
609	20	94	5440 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279 (23): 24323-24333 Van Dyke MW; Nelson LD; Weilbaecher RG; Mehta DV Stm1p, a G(4) quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y ' DNA in Saccharomyces cerevisiae	1	2
610	7	94	5536 2004 MOLECULAR AND CELLULAR BIOLOGY 24 (10): 4151-4165 Baroni E; Viscardi V; Cartagena-Lirola H; Lucchini G; Longhese MP The functions of budding yeast Sae2 in the DNA damage response require Mec1-and Tel1-dependent phosphorylation	1	7
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
611	8	93	986 1991 JAPANESE JOURNAL OF GENETICS 66 (5): 635-661 IMAI HT MUTABILITY OF CONSTITUTIVE HETEROCHROMATIN (C-BANDS) DURING EUKARYOTIC CHROMOSOMAL EVOLUTION AND THEIR CYTOLOGICAL MEANING	4	36
612	4	93	1139 1992 GENETICA 86 (1-3): 99-111 SHAPIRO JA NATURAL GENETIC-ENGINEERING IN EVOLUTION	4	63
613	14	93	1428 1994 CHROMOSOMA 103 (2): 73-81 WINTERSBERGER E DNA AMPLIFICATION - NEW INSIGHTS INTO ITS MECHANISM	0	23
614	65	93	1683 1995 INTERNATIONAL JOURNAL OF ONCOLOGY 7 (3): 423-432 BACCHETTI S; COUNTER CM TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW)	80	113
615	8	93	2390 1997 NUCLEIC ACIDS RESEARCH 25 (12): 2245-2253 Mitas M Trinucleotide repeats associated with human disease	6	154
616	3	93	2470 1998 ANNUAL REVIEW OF GENETICS 32: 185-225 Karlin S; Campbell AM; Mrazek J Comparative DNA analysis across diverse genomes	1	96
617	71	93	3017 1999 DRUG RESISTANCE UPDATES 2 (2): 104-115 Helder MN; de Jong S; de Vries EGE; van der Zee AGJ Telomerase targeting in cancer treatment: new developments	6	7
618	9	93	3187 1999 MOLECULAR AND CELLULAR BIOLOGY 19 (12): 8660-8672 Tanaka K; Nishide J; Okazaki K; Kato H; Niwa O; et al. Characterization of a fission yeast SUMO-1 homologue, Pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation	5	66
619	1	93	3207 1999 MUTATION RESEARCH-DNA REPAIR 435 (1): 13-21 Shinohara A; Ogawa T Rad51/RecA protein families and the associated proteins in eukaryotes	1	43
620	70	93	3401 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65: 253-263 Blackburn EH; Chan S; Chang J; Fulton TB; Krauskopf A; et al. Molecular manifestations and molecular determinants of telomere capping	11	11
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
621	47	93	4582 2002 ONCOGENE 21 (4): 688-697 Kyo S; Inoue M Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy?	26	52
622	46	93	4627 2002 SCIENCE 297 (5581): 565-569 Maser RS; DePinho RA Connecting chromosomes, crisis, and cancer	79	166
623	59	93	4838 2003 EXPERIMENTAL AND MOLECULAR MEDICINE 35 (3): 141-153 Cheong C; Hong KU; Lee HW Mouse models for telomere and telomerase biology	4	7
624	31	93	4850 2003 EXPERIMENTAL GERONTOLOGY 38 (11-12): 1231-1241 Hayflick L Living forever and dying in the attempt	2	9
625	8	93	5302 2004 CYTOGENETIC AND GENOME RESEARCH 105 (2-4): 285-291 Tamada H; Kikyo N Nuclear reprogramming in mammalian somatic cell nuclear cloning	0	6
626	15	93	5565 2004 MOLECULAR MICROBIOLOGY 53 (4): 1177-1194 Ciudad T; Andaluz E; Steinberg-Neifach O; Lue NF; Gow NAR; et al. Homologous recombination in Candida albicans: role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere length	4	7
627	6	93	5795 2005 CELL 120 (4): 557-567 Hadley EC; Lakatta EG; Morrison-Bogorad M; Warner HR; Hodes RJ The future of aging therapies	0	11
628	7	93	5920 2005 GENE 345 (1): 91-100 Shapiro JA A 21st century view of evolution: genome system architecture, repetitive DNA, and natural genetic engineering	0	2
629	18	93	5959 2005 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 37 (5): 961-976 Ben-Porath I; Weinberg RA The signals and pathways activating cellular senescence	2	19
630	88	93	6453 2006 MOLECULAR BIOLOGY 40 (4): 580-594 Shcherbakova DM; Zvereva ME; Shpanchenko OV; Dontsova OA Telomerase: Structure and properties of the enzyme, the peculiarities of the yeast telomerase	0	0
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
631	51	92	1429 1994 CHROMOSOMA 103 (3): 154-161 BIESSMANN H; MASON JM TELOMERIC REPEAT SEQUENCES	26	50
632	30	92	1647 1995 ELECTROPHORESIS 16 (9): 1705-1714 BRAHMACHARI SK; MEERA G; SARKAR PS; BALAGURUMOORTHY P; TRIPATHI J; et al. SIMPLE REPETITIVE SEQUENCES IN THE GENOME - STRUCTURE AND FUNCTIONAL-SIGNIFICANCE	6	44
633	23	92	1761 1995 NUCLEIC ACIDS RESEARCH 23 (10): 1766-1774 DU CY; SANZGIRI RP; SHAIU WL; CHOI JK; HOU Z; et al. MODULAR STRUCTURAL ELEMENTS IN THE REPLICATION ORIGIN REGION OF TETRAHYMENA RDNA	3	11
634	2	92	2282 1997 IMMUNOLOGY AND CELL BIOLOGY 75 (1): 82-95 Steele EJ; Rothenfluh HS; Blanden RV Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse	4	24
635	5	92	3576 2000 LEUKEMIA & LYMPHOMA 38 (5-6): 489-497 Xiao M; Douglas DC Cellular and molecular aspects of human CD34+CD38-precursors: Analysis of a primitive hematopoietic population	0	7
636	11	92	3868 2001 EUROPEAN UROLOGY 39 (6): 619-633 Saad A; Hanbury DC; McNicholas TA; Boustead GB; Woodman AC The early detection and diagnosis of bladder cancer: A critical review of the options	1	17
637	49	92	4274 2002 CRITICAL REVIEWS IN PLANT SCIENCES 21 (2): 127-141 Osborne DJ; Boubriak I Telomeres and their relevance to the life and death of seeds	1	1
638	45	92	4770 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60 (11): 2295-2302 Kanoh J; Ishikawa F Composition and conservation of the telomeric complex	5	10
639	2	92	5696 2005 ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH 30 (3-4): 219-261 Omura Y Beneficial effects & side effects of DHEA: True anti-aging & age-promoting effects, as well as anti-cancer & cancer-promoting effects of DHEA evaluated from the effects on the normal & cancer cell telomeres & other parameters	0	0
640	55	92	5879 2005 EMBO JOURNAL 24 (17): 3117-3127 Pardo B; Marcand P Rap1 prevents telomere fusions by nonhomologous end joining	2	4
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
641	29	92	5900 2005 EXPERIMENTAL GERONTOLOGY 40 (8-9): 634-642 Erusalimsky JD; Kurz DJ Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease	0	1
642	1	91	514 1987 METHODS IN CELL BIOLOGY 28: 261-279 ROOS UP PROBING THE MECHANISMS OF MITOSIS WITH DICTYOSTELIUM-DISCOIDEUM	0	19
643	5	91	928 1991 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 621: 401-417 MARTIN GM GENETIC AND ENVIRONMENTAL MODULATIONS OF CHROMOSOMAL STABILITY - THEIR ROLES IN AGING AND ONCOGENESIS	1	21
644	3	91	1298 1993 EUROPEAN JOURNAL OF BIOCHEMISTRY 212 (1): 1-11 WILLIS IM RNA POLYMERASE-III - GENES, FACTORS AND TRANSCRIPTIONAL SPECIFICITY	1	164
645	7	91	1512 1994 JOURNAL OF PHYCOLOGY 30 (2): 316-329 MCNALLY KL; GOVIND NS; THOME PE; TRENCH RK SMALL-SUBUNIT RIBOSOMAL DNA-SEQUENCE ANALYSES AND A RECONSTRUCTION OF THE INFERRED PHYLOGENY AMONG SYMBIOTIC DINOFLAGELLATES (PYRROPHYTA)	0	74
646	52	91	2744 1998 MOLECULAR AND CELLULAR BIOLOGY 18 (9): 5600-5608 Bourns BD; Alexander MK; Smith AM; Zakian VA Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo	47	72
647	71	91	3128 1999 JOURNAL OF HEPATOLOGY 31 (5): 939-945 Erlitzki R; Minuk GY Telomeres, telomerase and HCC: the long and the short of it	3	6
648	7	91	4599 2002 PHARMACOGENOMICS 3 (4): 469-484 Perls T; Puca A The genetics of aging - implications for pharmacogenomics	0	2
649	70	91	4778 2003 CHROMOSOME RESEARCH 11 (3): 263-275 Riha K; Shippen DE Telomere structure, function and maintenance in Arabidopsis	19	21
650	50	91	5813 2005 CHROMOSOMA 114 (4): 275-285 Slijepcevic P; Al-Wahiby S Telomere biology: integrating protection with DNA damage chromosomal end response	1	1
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
651	24	91	6300 2006 CELL CYCLE 5 (6): 630-634 Heeg S; Doebele M; von Werder A; Opitz OG In vitro transformation models - Modeling human cancer	0	0
652	2	90	164 1983 BIOCHIMIE 65 (6): R3-R11 BRISON O GENE AMPLIFICATION IN EUCARYOTE CELLS	0	0
653	2	90	291 1985 INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY 94: 107-126 CHAPMAN GP THE EVOLVED CHROMOSOMES OF HIGHER-PLANTS	1	2
654	19	90	1725 1995 MOLECULAR AND BIOCHEMICAL PARASITOLOGY 70 (1-2): 1-8 LANZER M; FISCHER K; LEBLANCQ SM PARASITISM AND CHROMOSOME DYNAMICS IN PROTOZOAN PARASITES - IS THERE A CONNECTION	8	59
655	67	90	2981 1999 CHROMOSOMA 108 (2): 73-82 Pardue ML; DeBaryshe PG Telomeres and telomerase: more than the end of the line	35	59
656	67	90	3016 1999 DRUG DISCOVERY TODAY 4 (4): 155-161 Pitts AE; Corey DR The telomerase challenge - an unusual problem in drug discovery	17	23
657	58	90	3767 2001 BIOLOGICAL CHEMISTRY 382 (4): 621-628 Simonsson T G-quadruplex DNA structures - Variations on a theme	34	115
658	3	90	3859 2001 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 38 (2-3): 122-131 Cleaver JE Richard B. Setlow, a commentary on seminal contributions and scientific controversies	0	2
659	6	90	4336 2002 FROM EPIGENESIS TO EPIGENETICS: THE GENOME IN CONTEXT 981: 111-134 Shapiro JA Genome organization and reorganization in evolution formatting for computation and function	2	9
660	27	90	5230 2004 CANCER CELL 6 (3): 215-222 Hahn WC Cancer: Surviving on the edge	2	6
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
661	65	90	5310 2004 CYTOTECHNOLOGY 45 (1-2): 3-12 Broccoli D Function, replication and structure of the mammalian telomere	3	3
662	40	90	5552 2004 MOLECULAR BIOLOGY OF THE CELL 15 (1): 81-90 Zhu YS; Tomlinson RL; Lukowiak AA; Terns RM; Terns MP Telomerase RNA accumulates in Cajal bodies in human cancer cells	9	26
663	3	90	5644 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 (19): 7287-7292 Mathews DH; Disney MD; Childs JL; Schroeder SJ; Zuker M; et al. Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure	1	54
664	39	90	5859 2005 CURRENT PHARMACEUTICAL DESIGN 11 (9): 1105-1117 Folini M; Zaffaroni N Targeting telomerase by antisense-based approaches: Perspectives for new anti-cancer therapies	0	2
665	10	90	6338 2006 ELECTROPHORESIS 27 (8): 1669-1682 Eman MR; Regan-Klapisz E; Pinkse MWH; Koop IM; Haverkamp J; et al. Protein expression dynamics during replicative senescence of endothelial cells studied by 2-D difference in-gel electrophoresis	0	0
666	7	89	256 1985 ANNUAL REVIEW OF GENETICS 19: 29-56 CLARKE L; CARBON J THE STRUCTURE AND FUNCTION OF YEAST CENTROMERES	14	104
667	2	89	536 1987 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B- BIOLOGICAL SCIENCES 317 (1187): 395-420 ALBERTS BM PROKARYOTIC DNA-REPLICATION MECHANISMS	1	65
668	6	89	624 1988 MOLECULAR AND CELLULAR BIOLOGY 8 (1): 210-225 BUCHMAN AR; KIMMERLY WJ; RINE J; KORNBERG RD 2 DNA-BINDING FACTORS RECOGNIZE SPECIFIC SEQUENCES AT SILENCERS, UPSTREAM ACTIVATING SEQUENCES, AUTONOMOUSLY REPLICATING SEQUENCES, AND TELOMERES IN SACCHAROMYCES-CEREVISIAE	74	414
669	4	89	840 1990 INTERCIENCIA 15 (1): 15-25 GOLDSTEIN DJ AN IMPENDING DISASTER FOR LATIN-AMERICA - X-RAY CRYSTALLOGRAPHY AND PROTEIN ENGINEERING	0	1
670	5	89	1604 1995 BIOCHIMIE 77 (1-2): 113-124 MARQUET R; ISEL C; EHRESMANN C; EHRESMANN B TRANSFER-RNAS AS PRIMER OF REVERSE TRANSCRIPTASES	4	100
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
671	24	89	1751 1995 NUCLEAR MAGNETIC RESONANCE AND NUCLEIC ACIDS 261: 225-255 Feigon J; Koshlap KM; Smith FW H-1 NMR spectroscopy of DNA triplexes and quadruplexes	15	56
672	66	89	3305 2000 ANNUAL REVIEW OF MEDICINE 51: 65-79 Urquidi V; Tarin D; Goodison S Role of telomerase in cell senescence and oncogenesis	14	41
673	4	89	3748 2001 ARCHIVES OF GERONTOLOGY AND GERIATRICS 32 (1): 1-14 Malaguarnera L; Ferlito L; Imbesi RM; Gulizia GS; Di Mauro S; et al. Immunosenescence: a review	1	27
674	27	89	4004 2001 JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 49 (8): 1105-1109 Ahmed A; Tollefsbol T Telomeres and telomerase: Basic science implications for aging	9	18
675	26	89	4767 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60 (3): 507-517 Marrone A; Mason PJ Dyskeratosis congenita	15	23
676	58	89	5149 2004 ADVANCES IN ANATOMIC PATHOLOGY 11 (5): 262-268 Baykal A; Rosen D; Zhou CY; Liu JS; Sahin AA Telomerase in breast cancer	1	4
677	64	89	5634 2004 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 359 (1441): 109-121 Chan SRWL; Blackburn EH Telomeres and telomerase	39	36
678	17	89	5697 2005 AGEING RESEARCH REVIEWS 4 (1): 67-82 Smelick C; Ahmed S Achieving immortality in the C-elegans germline	0	0
679	42	89	5845 2005 CURRENT MOLECULAR MEDICINE 5 (2): 145-152 Hezel AF; Bardeesy N; Maser RS Telomere induced senescence: End game signaling	0	1
680	52	89	6037 2005 JOURNAL OF STRUCTURAL BIOLOGY 152 (3): 169-184 Wojciechowski M; Fogolari F; Baginski M Thermodynamic and electrostatic properties of ternary Oxytricha nova TEBP-DNA complex	0	0
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
681	2	89	6065 2005 MEDICAL SCIENCE MONITOR 11 (5): MS54-MS65 Fricchione G; Stefano GB Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries	0	5
682	6	89	6168 2005 PHARMACOGENOMICS 6 (1): 27-36 Fischel-Ghodsian N Genetic factors in aminoglycoside toxicity	1	8
683	43	89	6474 2006 NATURE REVIEWS DRUG DISCOVERY 5 (7): 577-584 Shay JW; Wright WE Telomerase therapeutics for cancer: challenges and new directions	0	0
684	5	88	255 1985 ANNUAL REVIEW OF CELL BIOLOGY 1: 289-315 MURRAY AW; SZOSTAK JW CHROMOSOME SEGREGATION IN MITOSIS AND MEIOSIS	12	135
685	4	88	918 1990 SCIENCE 249 (4973): 1129-1133 GOLDSTEIN S REPLICATIVE SENESCENCE - THE HUMAN FIBROBLAST COMES OF AGE	78	506
686	54	88	1888 1996 CURRENT OPINION IN BIOTECHNOLOGY 7 (6): 583-591 Raymond E; Sun D; Chen SF; Windle B; VonHoff DD Agents that target telomerase and telomeres	55	73
687	54	88	2281 1997 IMMUNOLOGICAL REVIEWS 160: 43-54 Weng NP; Palmer LD; Levine BL; Lane HC; June CH; et al. Tales of tails: Regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging	46	91
688	75	88	2608 1998 EXPERT OPINION ON THERAPEUTIC PATENTS 8 (12): 1567-1586 Perry PJ; Kelland LR Telomeres and telomerase: targets for cancer chemotherapy?	15	23
689	22	88	2745 1998 MOLECULAR AND CELLULAR BIOLOGY 18 (10): 6121-6130 Lew JE; Enomoto S; Berman J Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway	4	29
690	7	88	3203 1999 MOLECULAR STRATEGIES IN BIOLOGICAL EVOLUTION 870: 23-35 Shapiro JA Genome system architecture and natural genetic engineering in evolution	3	25
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
691	69	88	3477 2000 HISTOLOGY AND HISTOPATHOLOGY 15 (3): 813-824 Kyo S; Takakura M; Inoue M Telomerase activity in cancer as a diagnostic and therapeutic target	1	7
692	19	88	3877 2001 EXPERIMENTAL GERONTOLOGY 36 (7): 1049-1062 von Zglinicki T; Burkle A; Kirkwood TBL Stress, DNA damage and ageing - an integrative approach	7	42
693	3	88	4218 2002 BMC BIOINFORMATICS 3: Art. No. 2 Cannone JJ; Subramanian S; Schnare MN; Collett JR; D'Souza LM; et al. The Comparative RNA Web (CRW) Site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs	1	204
694	47	88	4965 2003 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125 (16): 4732-4740 Teulade-Fichou MP; Carrasco C; Guittat L; Bailly C; Alberti P; et al. Selective recognition of G-quadruplex telomeric DNA by a bis(quinacridine) macrocycle	5	21
695	40	88	5387 2004 GENES & DEVELOPMENT 18 (15): 1850-1861 Oikemus SR; McGinnis N; Queiroz-Machado J; Tukachinsky H; Takada S; et al. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect	8	23
696	10	88	5558 2004 MOLECULAR CANCER RESEARCH 2 (8): 427-432 Liberti SE; Rasmussen LJ Is hEXO1 a cancer predisposing gene?	0	1
697	64	88	5618 2004 ONCOGENE 23 (43): 7283-7289 Harrington L Does the reservoir for self-renewal stem from the ends?	5	11
698	14	88	6211 2005 SEMINARS IN LIVER DISEASE 25 (1): 84-92 Tillmann HL; Manns MP; Rudolph KL Merging models of hepatitis C virus pathogenesis	0	9
699	16	87	850 1990 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 8 (3): 491-511 GUSCHLBAUER W; CHANTOT JF; THIELE D 4-STRANDED NUCLEIC-ACID STRUCTURES 25 YEARS LATER - FROM GUANOSINE GELS TO TELOMER DNA	101	257
700	3	87	961 1991 EXPERIMENTAL CELL RESEARCH 192 (2): 325-332 HAAF T; SCHMID M CHROMOSOME TOPOLOGY IN MAMMALIAN INTERPHASE NUCLEI	9	145

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