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#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
1	265	391	4546 2002 NUCLEIC ACIDS RESEARCH 30 (4): 839-865 Mergny JL; Riou JF; Mailliet P; Teulade-Fichou MP; Gilson E Natural and pharmacological regulation of telomerase	65	100
2	221	324	2563 1998 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 33 (4): 297-336 Muniyappa K; Kironmai KM Telomere structure, replication and length maintenance	14	22
3	215	368	6325 2006 CURRENT CANCER DRUG TARGETS 6 (2): 147-180 Pendino F; Tarkanyi I; Dudognon C; Hillion J; Lanotte M; et al. Telomeres and telomerase: Pharmacological targets for new anticancer strategies?	0	1
4	194	235	4732 2003 CANCER LETTERS 194 (2): 139-154 Harrington L Biochemical aspects of telomerase function	39	41
5	185	314	6467 2006 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 612 (3): 189-214 Bolzan AD; Bianchi MS Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations	0	0
6	178	342	5843 2005 CURRENT MEDICINAL CHEMISTRY 12 (26): 3091-3102 Colangelo D; Osella D Telomerase inhibition and cancer: Might platinum based drugs have a future as anti-telomerase pharmacological approach?	0	0
7	177	244	2223 1997 EUROPEAN JOURNAL OF CANCER 33 (5): 735-749 Wellinger RJ; Sen D The DNA structures at the ends of eukaryotic chromosomes	89	121
8	172	246	3385 2000 CELLULAR AND MOLECULAR LIFE SCIENCES 57 (3): 464-486 Krupp G; Klapper W; Parwaresch R Cell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation	9	16
9	164	306	1068 1992 ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE 30: 185-249 BIESSMANN H; MASON JM GENETICS AND MOLECULAR-BIOLOGY OF TELOMERES	69	97
10	164	270	6321 2006 CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 57 (3): 191-214 Olaussen KA; Dubrana K; Dornont J; Spano JP; Sabatier L; et al. Telomeres and telomerase as targets for anticancer drug development	0	0
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
11	154	211	5169 2004 ANNUAL REVIEW OF BIOCHEMISTRY 73: 177-208 Smogorzewska A; de Lange T Regulation of telomerase by telomeric proteins	96	144
12	154	185	6246 2006 ANNUAL REVIEW OF BIOCHEMISTRY 75: 493-517 Autexier C; Lue NF The structure and function of telomerase reverse transcriptase	2	2
13	143	274	4480 2002 MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS 66 (3): 407-+ Cong YS; Wright WE; Shay JW Human telomerase and its regulation	62	108
14	140	179	2468 1998 ANNALS OF MEDICINE 30 (5): 419-430 Urquidi V; Tarin D; Goodison S Telomerase in cancer: clinical applications	11	21
15	138	178	3304 2000 ANNUAL REVIEW OF GENETICS 34: 331-358 McEachern MJ; Krauskopf A; Blackburn EH Telomeres and their control	272	272
16	138	224	5939 2005 GENOME INSTABILITY IN CANCER DEVELOPMENT 570: 311-341 Greenberg RA; Rudolph KL Telomere structural dynamics in genome integrity control and carcinogenesis	0	0
17	136	160	6476 2006 NATURE REVIEWS MOLECULAR CELL BIOLOGY 7 (7): 484-494 Collins K The biogenesis and regulation of telomerase holoenzymes	0	0
18	133	181	3038 1999 FASEB JOURNAL 13 (15): 2091-2104 Liu JP Studies of the molecular mechanisms in the regulation of telomerase activity	49	107
19	132	244	6511 2006 PATHOLOGY 38 (2): 103-113 Shin JS; Hong A; Solomon MJ; Lee CS The role of telomeres and telomerase in the pathology of human cancer and aging	0	0
20	129	230	3418 2000 CURRENT PHARMACEUTICAL DESIGN 6 (4): 441-471 Kerwin SM G-quadruplex DNA as a target for drug design	52	99
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
21	127	180	6026 2005 JOURNAL OF MOLECULAR MEDICINE-JMM 83 (4): 244-257 Brunori M; Luciano P; Gilson E; Geli V The telomerase cycle: normal and pathological aspects	3	3
22	121	183	1821 1996 ANNUAL REVIEW OF BIOCHEMISTRY 65: 337-365 Greider CW Telomere length regulation	403	545
23	120	147	1799 1995 SCIENCE 270 (5242): 1601-1607 ZAKIAN VA TELOMERES - BEGINNING TO UNDERSTAND THE END	373	497
24	119	159	5051 2003 NATURE REVIEWS MOLECULAR CELL BIOLOGY 4 (12): 948-959 Vega LR; Mateyak MK; Zakian VA Getting to the end: Telomerase access in yeast and humans	22	28
25	114	381	1518 1994 MICROBIOLOGICAL REVIEWS 58 (2): 233-267 PRESCOTT DM THE DNA OF CILIATED PROTOZOA	107	287
26	114	168	3910 2001 HUMAN MOLECULAR GENETICS 10 (7): 677-685 Shay JW; Zou Y; Hiyama E; Wright WE Telomerase and cancer	37	84
27	114	170	4938 2003 JOURNAL OF CLINICAL ONCOLOGY 21 (10): 2034-2043 Hahn WC Role of telomeres and telomerase in the pathogenesis of human cancer	8	23
28	112	212	5260 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61 (6): 641-656 Mathieu N; Pirzio L; Freulet-Marriere MA; Desmaze C; Sabatier L Telomeres and chromosomal instability	8	14
29	112	187	6056 2005 LEUKEMIA & LYMPHOMA 46 (8): 1121-1135 Ram R; Uziel O; Lahav M The importance of the telomere and telomerase system in hematological malignancies	0	0
30	110	194	5256 2004 CELL CYCLE 3 (9): 1138-1150 Satyanarayana A; Manns MP; Rudolph KL Telomeres, telomerase and cancer - An endless search to target the ends	1	4
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
31	110	195	5386 2004 GENES & DEVELOPMENT 18 (15): 1781-1799 di Fagagna FD; Teo SH; Jackson SP Functional links between telomeres and proteins of the DNA-damage response	23	37
32	106	159	4010 2001 JOURNAL OF UROLOGY 166 (2): 666-673 Orlando C; Gelmini S; Selli C; Pazzagli M Telomerase in urological malignancy	9	30
33	106	176	4601 2002 PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B- BIOLOGICAL SCIENCES 357 (1420): 545-562 Fajkus J; Simickoval M; Malaska J Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology	3	6
34	103	178	2010 1996 MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY 366 (1): 45-63 Counter CM The roles of telomeres and telomerase in cell life span	23	51
35	103	138	5314 2004 CYTOTECHNOLOGY 45 (1-2): 75-90 Guittat L; Alberti P; Gomez D; De Cian A; Pennarun G; et al. Targeting human telomerase for cancer therapeutics	2	3
36	101	230	3587 2000 METHODS IN CELL BIOLOGY, VOL 62 62: 127-+ Karrer KM Tetrahymena genetics: Two nuclei are better than one	15	31
37	101	155	6320 2006 CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION 16 (2): 103-118 Zhou SY; Liu D Inside the mammalian telomere interactome: Regulation and regulatory activities of telomeres	0	0
38	100	1517	4337 2002 FRONTIERS IN BIOSCIENCE 7: D1056-D1183 Pawelec G; Barnett Y; Forsey R; Frasca D; Globerson A; et al. T cells and aging, January 2002 update	2	54
39	99	167	3998 2001 JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 78 (3): 201-214 Orlando C; Gelmini S Telomerase in endocrine and endocrine-dependent tumors	3	18
40	99	351	5167 2004 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 43 (6): 668-698 Davis JT G-quartets 40 years later: From 5 '-GMP to molecular biology and supramolecular chemistry	11	108
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
41	99	159	6332 2006 CURRENT PHARMACEUTICAL BIOTECHNOLOGY 7 (3): 171-183 Deville L; Hillion J; Lanotte M; Rousselot P; Segal-Bendirdjian E Diagnostics, prognostic and therapeutic exploitation of telomeres and telomerase in leukemias	0	0
42	96	235	5569 2004 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 567 (1): 85-104 Callen E; Surralles J Telomere dysfunction in genome instability syndromes	7	10
43	94	141	6201 2005 REPRODUCTION FERTILITY AND DEVELOPMENT 17 (1-2): 85-96 Schaetzlein S; Rudolph KL Telomere length regulation during cloning, embryogenesis and ageing	2	4
44	93	158	1813 1995 YEAST 11 (16): 1553-1573 Louis EJ The chromosome ends of Saccharomyces cerevisiae	42	89
45	92	143	5821 2005 CHROMOSOME RESEARCH 13 (5): 493-504 Harrington L Making the most of a little: dosage effects in eukaryotic telomere length maintenance	3	3
46	91	108	2466 1998 ANNALES DE PATHOLOGIE 18 (5): 391-403 Soria JC; Ducray C; Vielh P Telomerase and cancer	0	1
47	91	116	5736 2005 BIOESSAYS 27 (7): 685-697 Louis EJ; Vershinin AV Chromosome ends: different sequences may provide conserved functions	2	4
48	90	139	3637 2000 MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 462 (1): 31-47 Cerni C Telomeres, telomerase, and myc. An update	23	46
49	90	141	4573 2002 ONCOGENE 21 (4): 564-579 Collins K; Mitchell JR Telomerase in the human organism	90	129
50	90	142	5319 2004 DEVELOPMENTAL BIOLOGY 274 (1): 15-30 Bekaert S; Derradji H; Baatout S Telomere biology in mammalian germ cells and during development	6	8
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
51	90	137	6245 2006 ANNUAL REVIEW OF BIOCHEMISTRY 75: 111-135 McEachern MJ; Haber JE Break-induced replication and recombinational telomere elongation in yeast	0	1
52	89	151	670 1989 ANNUAL REVIEW OF GENETICS 23: 579-604 ZAKIAN VA STRUCTURE AND FUNCTION OF TELOMERES	430	557
53	89	113	2142 1997 BIOCHEMISTRY-MOSCOW 62 (11): 1323-1331 Meeker AK; Coffey DS Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review	24	42
54	89	112	2621 1998 GENES & DEVELOPMENT 12 (8): 1073-1085 Nugent CI; Lundblad V The telomerase reverse transcriptase: components and regulation	219	272
55	89	113	3306 2000 ANTI-CANCER DRUGS 11 (7): 503-513 Kelland LR Telomerase inhibitors: targeting the vulnerable end of cancer?	15	30
56	88	2563	2457 1998 ADVANCES IN GENETICS, VOL. 37 37: 1-555 Zhimulev IF Polytene chromosomes, heterochromatin, and position effect variegation	1	41
57	88	106	2894 1999 ANTI-CANCER DRUG DESIGN 14 (4): 327-339 Mergny JL; Mailliet P; Lavelle F; Riou JF; Laoui A; et al. The development of telomerase inhibitors: the G-quartet approach	34	65
58	88	125	3716 2000 VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY 437 (1): 1-16 Dhaene K; Van Marck E; Parwaresch R Telomeres, telomerase and cancer: an up-date	30	67
59	88	95	5198 2004 BIOESSAYS 26 (9): 955-962 Lue NF Adding to the ends: what makes telomerase processive and how important is it?	13	14
60	88	93	6453 2006 MOLECULAR BIOLOGY 40 (4): 580-594 Shcherbakova DM; Zvereva ME; Shpanchenko OV; Dontsova OA Telomerase: Structure and properties of the enzyme, the peculiarities of the yeast telomerase	0	0
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
61	86	273	3336 2000 BIOGERONTOLOGY 1 (2): 103-121 Duncan EL; Wadhwa R; Kaul SC Senescence and immortalization of human cells	4	12
62	86	121	3676 2000 ONCOGENE 19 (56): 6632-6641 Bearss DJ; Hurley LH; Von Hoff DD Telomere maintenance mechanisms as a target for drug development	19	38
63	85	128	2527 1998 CANCER JOURNAL 4: S26-S34 Shay JW Telomerase in cancer: Diagnostic, prognostic, and therapeutic implications	16	25
64	85	135	4237 2002 CANCER INVESTIGATION 20 (1): 82-101 Helder MN; Wisman GBA; van der Zee AGJ Telomerase and telomeres: From basic biology to cancer treatment	11	20
65	85	144	5788 2005 CARCINOGENESIS 26 (5): 867-874 Shay JW; Wright WE Senescence and immortalization: role of telomeres and telomerase	13	25
66	85	132	5837 2005 CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 54 (2): 85-93 Dong CK; Masutomi K; Hahn WC Telomerase: regulation, function and transformation	7	9
67	84	149	1822 1996 ANNUAL REVIEW OF GENETICS 30: 141-172 Zakian VA Structure, function, and replication of Saccharomyces cerevisiae telomeres	91	120
68	84	128	5042 2003 MOLECULES AND CELLS 15 (2): 164-175 Djojosubroto MW; Choi YS; Lee HW; Rudolph KL Telomeres and telomerase in aging, regeneration and cancer	17	26
69	83	120	1865 1996 CANCER SURVEYS 28: 197-216 Bacchetti S Telomere maintenance in tumour cells	17	30
70	83	114	3530 2000 JOURNAL OF CLINICAL ONCOLOGY 18 (13): 2626-2634 Meyerson M Role of telomerase in normal and cancer cells	26	63
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
71	82	144	4577 2002 ONCOGENE 21 (4): 598-610 Henson JD; Neumann AA; Yeager TR; Reddel RR Alternative lengthening of telomeres in mammalian cells	115	164
72	82	152	5975 2005 INTERNATIONAL JOURNAL OF ONCOLOGY 27 (6): 1583-1596 Sebastian S; Grammatica L; Paradiso A Telomeres, telomerase and oral cancer (Review)	0	0
73	81	108	3800 2001 CELL 106 (6): 661-673 Blackburn EH Switching and signaling at the telomere	429	429
74	80	116	2101 1997 ANNALS OF ONCOLOGY 8 (11): 1063-1074 Sharma S; Raymond E; Soda H; Sun D; Hilsenbeck SG; et al. Preclinical and clinical strategies for development of telomerase and telomere inhibitors	41	61
75	80	125	5844 2005 CURRENT MOLECULAR MEDICINE 5 (2): 135-143 Crabbe L; Karlseder J In the end, it's all structure	1	1
76	80	118	5878 2005 EMBO JOURNAL 24 (6): 1095-1103 Blasco MA Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging	7	11
77	79	109	2814 1998 ONCOLOGY REPORTS 5 (5): 1043-1052 Engelhardt M; Martens UM The implication of telomerase activity and telomere stability for replicative aging and cellular immortality (Review)	9	21
78	79	123	4830 2003 EUROPEAN JOURNAL OF BIOCHEMISTRY 270 (3): 389-403 Saldanha SN; Andrews LG; Tollefsbol TO Assessment of telomere length and factors that contribute to its stability	10	17
79	78	173	1592 1995 ADVANCES IN GENETICS, VOL 32 32: 273-315 ROYLE NJ THE PROTERMINAL REGIONS AND TELOMERES OF HUMAN-CHROMOSOMES	4	6
80	78	116	3843 2001 DRUG-NUCLEIC ACID INTERACTIONS 340: 573-+ Sun DY; Hurley LH Targeting telomeres and telomerase	6	9
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
81	78	124	4652 2003 ADVANCES IN CANCER RESEARCH, VOL 87 87: 31-58 Chen Z; Corey DR Telomerase inhibitors: A new option for chemotherapy	6	9
82	77	157	2544 1998 CELLULAR AND MOLECULAR LIFE SCIENCES 54 (1): 32-49 Lowell JE; Pillus L Telomere tales: chromatin, telomerase and telomere function in Saccharomyces cerevisiae	9	19
83	77	111	3768 2001 BIOLOGICHESKIE MEMBRANY 18 (3): 249-256 Yegorov YE Telomeres, telomeric DNA, chromosomes	0	0
84	77	115	5709 2005 ANTICANCER RESEARCH 25 (4): 3011-3021 Bekaert S; De Meyer T; Van Oostveldt P Telomere attrition as ageing biomarker	0	1
85	76	257	1591 1995 ACTA PROTOZOOLOGICA 34 (3): 151-171 RAIKOV IB STRUCTURE AND GENETIC ORGANIZATION OF THE POLYPLOID MACRONUCLEUS OF CILIATES - A COMPARATIVE REVIEW	8	21
86	76	156	5738 2005 BIOGERONTOLOGY 6 (6): 371-385 Davis T; Kipling D Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing	0	0
87	76	156	6491 2006 NUCLEIC ACIDS RESEARCH 34 (8): 2408-2417 Bailey SM; Murnane JP Telomeres, chromosome instability and cancer	0	1
88	75	95	1403 1994 ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE 23: 703-730 WILLIAMSON JR G-QUARTET STRUCTURES IN TELOMERIC DNA	142	339
89	75	88	2608 1998 EXPERT OPINION ON THERAPEUTIC PATENTS 8 (12): 1567-1586 Perry PJ; Kelland LR Telomeres and telomerase: targets for cancer chemotherapy?	15	23
90	75	101	2881 1999 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 112 (1): S68-S75 Vasef MA; Ross JS; Cohen MB Telomerase activity in human solid tumors - Diagnostic utility and clinical applications	6	13
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
91	75	82	2892 1999 ANNUAL REVIEW OF BIOCHEMISTRY 68: 187-218 Collins K Ciliate telomerase biochemistry	43	45
92	75	100	3005 1999 CURRENT OPINION IN GENETICS & DEVELOPMENT 9 (1): 97-103 Colgin LM; Reddel RR Telomere maintenance mechanisms and cellular immortalization	49	79
93	75	100	3312 2000 ANTICANCER RESEARCH 20 (6B): 4419-4429 Rowley PT; Tabler M Telomerase inhibitors	8	11
94	75	133	4394 2002 INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 218 218: 37-67 Zalenskaya IA; Zalensky AO Telomeres in mammalian male germline cells	4	6
95	75	147	5193 2004 BIOCHEMISTRY-MOSCOW 69 (2): 117-129 Kuimov AN Polypeptide components of telomere nueleoprotein complex	1	2
96	74	99	2903 1999 ANTICANCER RESEARCH 19 (6A): 4823-4830 Klingelhutz AJ The roles of telomeres and telomerase in cellular immortalization and the development of cancer	6	15
97	74	104	3114 1999 JOURNAL OF CELLULAR PHYSIOLOGY 180 (1): 10-18 Holt SE; Shay JW Role of telomerase in cellular proliferation and cancer	53	118
98	74	155	4935 2003 JOURNAL OF CELLULAR BIOCHEMISTRY 89 (1): 19-37 Zhou XZ; Perrem K; Lu KP Role of Pin2/TRF1 in telomere maintenance and cell cycle control	5	7
99	74	127	5961 2005 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 37 (5): 1000-1013 Gilley D; Tanaka H; Herbert BS Telomere dysfunction in aging and cancer	4	5
100	74	108	6466 2006 MOLECULAR MICROBIOLOGY 59 (5): 1357-1368 Pennaneach V; Putnam CD; Kolodner RD Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae	2	2

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