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#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
401	6	118	441 1986 PROCESS BIOCHEMISTRY 21 (3): 69-76 ESSER K; KEMPKEN F STRUCTURE AND FUNCTION OF LINEAR EXTRACHROMOSOMAL DNA IN EUKARYOTES	1	5
402	49	118	2175 1997 CANCER SURVEYS 29: 263-284 Harley CB; Sherwood SW Telomerase, checkpoints and cancer	14	49
403	5	118	5576 2004 NATURE MEDICINE 10 (8): 789-799 Vogelstein B; Kinzler KW Cancer genes and the pathways they control	6	237
404	80	118	5878 2005 EMBO JOURNAL 24 (6): 1095-1103 Blasco MA Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging	7	11
405	5	117	446 1987 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 503: 17-54 CAVALIERSMITH T THE ORIGIN OF EUKARYOTE AND ARCHAEBACTERIAL CELLS	1	124
406	62	117	3889 2001 GENE 269 (1-2): 1-12 Poole JC; Andrews LG; Tollefsbol TO Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)	39	85
407	42	117	4150 2001 SEMINARS IN CANCER BIOLOGY 11 (3): 227-238 Chang S; Khoo C; DePinho RA Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse	16	38
408	36	117	4205 2002 BIOGERONTOLOGY 3 (4): 195-206 Bree RT; Stenson-Cox C; Grealy M; Byrnes L; Gorman AM; et al. Cellular longevity: role of apoptosis and replicative senescence	0	10
409	6	117	4236 2002 CANCER INVESTIGATION 20 (1): 71-81 Munger K Disruption of oncogene/tumor suppressor networks during human carcinogenesis	0	16
410	56	117	4518 2002 MUTAGENESIS 17 (6): 539-550 Newbold RF The significance of telomerase activation and cellular immortalization in human cancer	4	15
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
411	32	117	4709 2003 BIOPHYSICAL JOURNAL 85 (3): 1787-1804 Stefl R; Cheatham TE; Spackova N; Fadrna E; Berger I; et al. Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates	3	13
412	4	117	5461 2004 JOURNAL OF CELL SCIENCE 117 (6): 815-825 Rouleau M; Aubin RA; Poirier GG Poly(ADP-ribosyl)ated chromatin domains: access granted	0	35
413	13	117	5719 2005 BASIC RESEARCH IN CARDIOLOGY 100 (6): 482-493 Anversa P; Rota M; Urbanek K; Hosoda T; Sonnenblick EH; et al. Myocardial aging - A stem cell problem	0	1
414	66	117	5904 2005 EXPERT OPINION ON THERAPEUTIC TARGETS 9 (3): 457-469 Fletcher TM Telomerase: a potential therapeutic target for cancer	0	1
415	69	117	6112 2005 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 576 (1-2): 39-53 Chang S Modeling aging and cancer in the telomerase knockout mouse	1	1
416	1	116	1230 1992 SCIENCE 257 (5066): 39-49 KARLIN S; BRENDEL V CHANCE AND STATISTICAL SIGNIFICANCE IN PROTEIN AND DNA-SEQUENCE ANALYSIS	5	103
417	2	116	1971 1996 JOURNAL OF PATHOLOGY 179 (2): 129-137 Goldstone AR; Quirke P; Dixon MF Helicobacter pylori infection and gastric cancer	0	55
418	80	116	2101 1997 ANNALS OF ONCOLOGY 8 (11): 1063-1074 Sharma S; Raymond E; Soda H; Sun D; Hilsenbeck SG; et al. Preclinical and clinical strategies for development of telomerase and telomere inhibitors	41	61
419	78	116	3843 2001 DRUG-NUCLEIC ACID INTERACTIONS 340: 573-+ Sun DY; Hurley LH Targeting telomeres and telomerase	6	9
420	37	116	3989 2001 JOURNAL OF NEUROSURGERY 94 (6): 961-969 Pallini R; Pierconti F; Falchetti ML; D'Arcangelo D; Fernandez E; et al. Evidence for telomerase involvement in the angiogenesis of astrocytic tumors: expression of human telomerase reverse transcriptase messenger RNA by vascular endothelial cells	8	12
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
421	91	116	5736 2005 BIOESSAYS 27 (7): 685-697 Louis EJ; Vershinin AV Chromosome ends: different sequences may provide conserved functions	2	4
422	3	116	5891 2005 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 32 (3): 351-368 Bourguignon MH; Gisone PA; Perez MR; Michelin S; Dubner D; et al. Genetic and epigenetic features in radiation sensitivity - Part II: implications for clinical practice and radiation protection	0	1
423	8	116	5953 2005 IMMUNOLOGY LETTERS 97 (1): 19-29 van Baarle D; Tsegaye A; Miedema F; Akbar A Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system	1	2
424	4	115	1934 1996 INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 6 (6): 425-438 Jeyarajah A; Oram D; Jacobs I Molecular events in endometrial carcinogenesis	1	17
425	3	115	2437 1997 SEMINARS IN SURGICAL ONCOLOGY 13 (5): 376-388 See WA; Berman CJ Future therapies for the treatment of bladder neoplasms	0	1
426	69	115	4815 2003 DRUGS OF TODAY 39 (4): 265-276 Saretzki G; von Zglinicki T Telomerase as a promising target for human cancer gene therapy	0	0
427	77	115	5709 2005 ANTICANCER RESEARCH 25 (4): 3011-3021 Bekaert S; De Meyer T; Van Oostveldt P Telomere attrition as ageing biomarker	0	1
428	12	114	1550 1994 NUCLEIC ACIDS RESEARCH 22 (13): 2479-2489 DOBBS DL; SHAIU WL; BENBOW RM MODULAR SEQUENCE ELEMENTS ASSOCIATED WITH ORIGIN REGIONS IN EUKARYOTIC CHROMOSOMAL DNA	5	64
429	24	114	1840 1996 BIOCHEMISTRY-MOSCOW 61 (11): 1465-1476 Golubev AG Biochemistry of space and time (telomeres, telomerases and lifetimes of cell populations and multicellular organisms): A review	1	1
430	16	114	2072 1996 SCIENCE 273 (5271): 63-67 Smith JR; PereiraSmith OM Replicative senescence: Implications for in vivo aging and tumor suppression	43	303
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
431	83	114	3530 2000 JOURNAL OF CLINICAL ONCOLOGY 18 (13): 2626-2634 Meyerson M Role of telomerase in normal and cancer cells	26	63
432	6	114	3840 2001 DIFFERENTIATION 68 (2-3): 67-83 Di Berardino MA Animal Cloning - the route to new genomics in agriculture and medicine	0	13
433	52	114	4668 2003 ANNUAL REVIEW OF GENETICS 37: 485-511 Pardue ML; DeBaryshe PG Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres	23	48
434	31	114	5678 2004 STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE 1019: 147-170 De Grey ADNJ; Campbell C; Dokal I; Fairbairn LJ; Graham GJ; et al. Total deletion of in vivo telomere elongation capacity - An ambitious but possibly ultimate cure for all age-related human cancers	1	3
435	27	114	6304 2006 CELL RESEARCH 16 (1): 45-54 Zhang Y; Zhou JQ; Lim CUK The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control	0	0
436	2	113	1404 1994 ANNUAL REVIEW OF MICROBIOLOGY 48: 619-654 KARLIN S; CARDON LR COMPUTATIONAL DNA-SEQUENCE ANALYSIS	1	58
437	17	113	1595 1995 ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY 11: 519-548 Loo S; Rine J Silencing and heritable domains of gene expression	6	136
438	89	113	2142 1997 BIOCHEMISTRY-MOSCOW 62 (11): 1323-1331 Meeker AK; Coffey DS Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review	24	42
439	89	113	3306 2000 ANTI-CANCER DRUGS 11 (7): 503-513 Kelland LR Telomerase inhibitors: targeting the vulnerable end of cancer?	15	30
440	62	113	3508 2000 JOURNAL OF ANTI-AGING MEDICINE 3 (4): 397-409 Brummendorf TH; Lansdorp PM; Rufer N Telomere length dynamics in normal and malignant hematopoiesis	0	0
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
441	9	113	4889 2003 HISTOLOGY AND HISTOPATHOLOGY 18 (2): 541-550 Chen W; Hahn WC SV40 early region oncoproteins and human cell transformation	0	9
442	14	113	5049 2003 NATURE REVIEWS CANCER 3 (3): 169-178 Hickson ID RecQ helicases: Caretakers of the genome	10	197
443	38	113	5510 2004 JOURNAL OF VIROLOGY 78 (11): 5698-5706 McMurray HR; McCance DJ Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7	0	4
444	89	112	2621 1998 GENES & DEVELOPMENT 12 (8): 1073-1085 Nugent CI; Lundblad V The telomerase reverse transcriptase: components and regulation	219	272
445	2	112	3552 2000 JOURNAL OF MOLECULAR BIOLOGY 298 (2): 167-185 Giedroc DP; Theimer CA; Nixon PL Structure, stability and function of RNA pseudoknots involved in stimulating ribosomal frameshifting	3	55
446	65	112	4077 2001 NATURE REVIEWS CANCER 1 (3): 203-213 Mathon NE; Lloyd AC Cell senescence and cancer	9	60
447	72	112	4106 2001 ORAL ONCOLOGY 37 (4): 333-340 Sumida T; Hamakawa H Telomerase and oral cancer	1	4
448	32	112	4447 2002 JOURNAL OF MOLECULAR MEDICINE-JMM 80 (11): 689-695 Aviv A Telomeres, sex, reactive oxygen species, and human cardiovascular aging	3	6
449	22	112	5492 2004 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 36 (2): 175-183 Minamino T; Miyauchi H; Yoshida T; Tateno K; Kunieda T; et al. Vascular cell senescence and vascular aging	2	15
450	4	111	511 1987 JOURNAL OF THEORETICAL BIOLOGY 125 (2): 219-235 NUSSINOV R THEORETICAL MOLECULAR-BIOLOGY - PROSPECTIVES AND PERSPECTIVES	1	35
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
451	2	111	590 1988 GENES & DEVELOPMENT 2 (12B): 1745-1763 KARPEN GH; SCHAEFER JE; LAIRD CD A DROSOPHILA RIBOSOMAL-RNA GENE LOCATED IN EUCHROMATIN IS ACTIVE IN TRANSCRIPTION AND NUCLEOLUS FORMATION	1	86
452	4	111	1087 1992 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 70 (10-11): 856-866 CLARKE HJ NUCLEAR AND CHROMATIN COMPOSITION OF MAMMALIAN GAMETES AND EARLY EMBRYOS	0	10
453	77	111	3768 2001 BIOLOGICHESKIE MEMBRANY 18 (3): 249-256 Yegorov YE Telomeres, telomeric DNA, chromosomes	0	0
454	72	111	4734 2003 CANCER LETTERS 194 (2): 163-172 Masutomi K; Hahn WC Telomerase and tumorigenesis	8	16
455	35	110	3842 2001 DRUG-NUCLEIC ACID INTERACTIONS 340: 109-149 Haq I; Chowdhry BZ; Jenkins TC Calorimetric techniques in the study of high-order DNA-drug interactions	0	11
456	5	110	4061 2001 MOLECULAR CELL 8 (3): 489-498 Moazed D Common themes in mechanisms of gene silencing	2	120
457	70	110	4572 2002 ONCOGENE 21 (4): 553-563 Chan SWL; Blackburn EH New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin	86	86
458	70	110	6124 2005 NATURE REVIEWS GENETICS 6 (8): 611-622 Blasco MA Telomeres and human disease: Ageing, cancer and beyond	16	25
459	50	109	1823 1996 ANNUAL REVIEW OF GENETICS 30: 557-578 Coyne RS; Chalker DL; Yao MC Genome downsizing during ciliate development: Nuclear Division of Labor through chromosome restructuring	51	85
460	79	109	2814 1998 ONCOLOGY REPORTS 5 (5): 1043-1052 Engelhardt M; Martens UM The implication of telomerase activity and telomere stability for replicative aging and cellular immortality (Review)	9	21
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
461	44	109	3708 2000 SEIKAGAKU 72 (10): 1231-1244 Ishikawa T Telomere heterochromatin in yeast	0	0
462	5	109	4055 2001 MOLECULAR BIOTECHNOLOGY 19 (1): 45-57 Andersen JK Genetically engineered mice and their use in aging research	1	2
463	58	109	4662 2003 ANALYTICAL BIOCHEMISTRY 315 (1): 1-21 Saldanha SN; Andrews LG; Tollefsbol TO Analysis of telomerase activity and detection of its catalytic subunit, hTERT	9	14
464	57	109	4933 2003 JOURNAL OF CELL SCIENCE 116 (20): 4057-4065 Lydall D Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways	16	24
465	42	109	5847 2005 CURRENT MOLECULAR MEDICINE 5 (2): 159-170 Mason PJ; Wilson DB; Bessler M Dyskeratosis congenita - A disease of dysfunctional telomere maintenance	5	8
466	5	109	6291 2006 CANCER IMMUNOLOGY IMMUNOTHERAPY 55 (1): 85-95 Baxevanis CN; Sotiriadou NN; Gritzapis AD; Sotiropoulou PA; Perez SA; et al. Immunogenic HER-2/neu peptides as tumor vaccines	0	1
467	24	108	821 1990 CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 163: 71-92 DELANGE AM; MCFADDEN G THE ROLE OF TELOMERES IN POXVIRUS DNA-REPLICATION	3	33
468	5	108	2106 1997 APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 47 (4): 329-336 Meinhardt F; Schaffrath R; Larsen M Microbial linear plasmids	1	34
469	91	108	2466 1998 ANNALES DE PATHOLOGIE 18 (5): 391-403 Soria JC; Ducray C; Vielh P Telomerase and cancer	0	1
470	81	108	3800 2001 CELL 106 (6): 661-673 Blackburn EH Switching and signaling at the telomere	429	429
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
471	3	108	3820 2001 CLINICS IN LABORATORY MEDICINE 21 (4): 811-+ Miller DT; Stelzer GT Contributions of flow cytometry to the analysis of the myelodysplastic syndrome	0	2
472	45	108	4515 2002 MOLECULES AND CELLS 13 (3): 351-361 Hahn WC Immortalization and transformation of human cells	0	6
473	5	108	5046 2003 NATURE GENETICS 33: 238-244 Balmain A; Gray J; Ponder B The genetics and genomics of cancer	1	112
474	74	108	6466 2006 MOLECULAR MICROBIOLOGY 59 (5): 1357-1368 Pennaneach V; Putnam CD; Kolodner RD Chromosome healing by de novo telomere addition in Saccharomyces cerevisiae	2	2
475	27	107	381 1986 INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY 99: 1-28 KRAUT H; LIPPS HJ; PRESCOTT DM THE GENOME OF HYPOTRICHOUS CILIATES	21	46
476	22	107	2489 1998 BIOCHEMISTRY 37 (46): 16325-16337 Brown BA; Li YQ; Brown JC; Hardin CC; Roberts JF; et al. Isolation and characterization of a monoclonal anti-quadruplex DNA antibody from autoimmune "viable motheaten" mice	7	13
477	30	107	2835 1998 PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 59 59: 55-94 Shafer RH Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands	18	55
478	68	107	5192 2004 BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 82 (4): 498-507 Mondello C; Scovassi AI Telomeres, telomerase, and apoptosis	2	8
479	56	107	5199 2004 BIOESSAYS 26 (11): 1164-1174 Murnane JP; Sabatier L Chromosome rearrangements resulting from telomere dysfunction and their role in cancer	7	16
480	64	107	5849 2005 CURRENT MOLECULAR MEDICINE 5 (2): 179-185 Zimmermann S; Martens UM Telomere dynamics in hematopoietic stem cells	1	2
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
481	64	107	5906 2005 EXPERT REVIEW OF MOLECULAR DIAGNOSTICS 5 (6): 907-916 Mabruk MJEMF; O'Flatharta C Telomerase: is it the future diagnostic and prognostic tool in human cancer?	0	1
482	53	106	2135 1997 BIOCHEMISTRY-MOSCOW 62 (11): 1232-1241 Pryde FE; Louis EJ Saccharomyces cerevisiae telomeres. A review	13	32
483	88	106	2894 1999 ANTI-CANCER DRUG DESIGN 14 (4): 327-339 Mergny JL; Mailliet P; Lavelle F; Riou JF; Laoui A; et al. The development of telomerase inhibitors: the G-quartet approach	34	65
484	62	106	4575 2002 ONCOGENE 21 (4): 584-591 Goytisolo FA; Blasco MA Many ways to telomere dysfunction: in vivo studies using mouse models	42	53
485	18	106	4911 2003 JOURNAL OF APPLIED PHYSIOLOGY 95 (4): 1706-1716 Weinert BT; Timiras PS Theories of aging	1	18
486	6	106	5564 2004 MOLECULAR HUMAN REPRODUCTION 10 (9): 685-695 Soloff MS; Jeng YJ; Ilies M; Soloff SL; Izban MG; et al. Immortalization and characterization of human myometrial cells from term-pregnant patients using a telomerase expression vector	0	3
487	14	106	5757 2005 BMC NEUROSCIENCE 6: Art. No. 59 Santillano DR; Kumar LS; Prock TL; Camarillo C; Tingling JD; et al. Ethanol induces cell-cycle activity and reduces stem cell diversity to alter both regenerative capacity and differentiation potential of cerebral cortical neuroepithelial precursors	0	0
488	62	106	6378 2006 HISTOLOGY AND HISTOPATHOLOGY 21 (11): 1249-1261 Weise JM; Gunes C Telomeres and telomerase. A survey about methods and recent advances in cancer diagnostic and therapy	0	0
489	20	105	4007 2001 JOURNAL OF THEORETICAL BIOLOGY 210 (4): 475-497 Imai HT; Satta Y; Takahata N Integrative study on chromosome evolution of mammals, ants and wasps based on the minimum interaction theory	0	8
490	66	105	4283 2002 CURRENT PHARMACEUTICAL DESIGN 8 (27): 2491-2504 Cairns D; Anderson RJ; Perry PJ; Jenkins TC Design of telomerase inhibitors for the treatment of cancer	1	3
#	LCR	NCR	Node / Date / Journal / Author	LCS	GCS
491	4	105	4313 2002 EXPERIMENTAL BIOLOGY AND MEDICINE 227 (8): 579-586 Miturski R; Bogusiewicz M; Ciotta C; Bignami M; Gogacz M; et al. Mismatch repair genes and microsatellite instability as molecular markers for gynecological cancer detection	0	6
492	54	105	4347 2002 GENETICS 161 (3): 995-1013 DuBois ML; Haimberger ZW; McIntosh MW; Gottschling DE A quantitative assay for telomere protection in Saccharomyces cerevisiae	27	30
493	39	105	4526 2002 NATURE BIOTECHNOLOGY 20 (7): 682-688 Wright WE; Shay JW Historical claims and current interpretations of replicative aging	45	107
494	58	105	4568 2002 ONCOGENE 21 (4): 503-511 Kim S; Kaminker P; Campisi J Telomeres, aging and cancer: In search of a happy ending	48	87
495	40	105	4569 2002 ONCOGENE 21 (4): 512-521 Tham WH; Zakian VA Transcriptional silencing at Saccharomyces telomeres: implications for other organisms	17	38
496	67	105	4771 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60 (11): 2325-2333 Biessmann H; Mason JM Telomerase-independent mechanisms of telomere elongation	4	9
497	2	104	930 1991 ANNUAL REVIEW OF BIOPHYSICS AND BIOPHYSICAL CHEMISTRY 20: 175-203 KARLIN S; BUCHER P; BRENDEL V; ALTSCHUL SF STATISTICAL-METHODS AND INSIGHTS FOR PROTEIN AND DNA-SEQUENCES	0	51
498	8	104	1951 1996 JOURNAL OF CELL BIOLOGY 134 (5): 1109-1125 Scherthan H; Weich S; Schwegler H; Heyting C; Harle M; et al. Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing	32	172
499	41	104	2182 1997 CELLULAR AND MOLECULAR LIFE SCIENCES 53 (7): 568-575 Crompton NEA Telomeres, senescence and cellular radiation response	4	21
500	8	104	2904 1999 ANTICANCER RESEARCH 19 (6A): 4877-4886 Rubin H Cell damage, aging and transformation: A multilevel analysis of carcinogenesis	0	11

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