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Control of regulatory T cell development
by the transcription factor Foxp3

HORI S, NOMURA T, SAKAGUCHI S
SCIENCE 299: 1057-1061 2003
and the citing papers

Nodes: 305, Authors: 1256, Journals: 99, Outer References: 8888, Words: 933
Collection span: 2003 - 2005
View: Overview. Sorted by GCS.
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#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
103149 2003 SCIENCE 299(5609):1057-1061
Hori S; Nomura T; Sakaguchi S
Control of regulatory T cell development by the transcription factor Foxp3
304304
224034 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(12):1875-1886
Chen WJ; Jin WW; Hardegen N; Lei KJ; Li L; et al.
Conversion of peripheral CD4(+)CD25(-) naive T cells to CD4(+)CD25(+) regulatory T cells by TGF-beta induction of transcription factor Foxp3
4683
3113846 2003 NATURE REVIEWS IMMUNOLOGY 3(7):521-533
Bouma G; Strober W
The immunological and genetic basis of inflammatory bowel disease
575
415230 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(2):235-247
Yamazaki S; Iyoda T; Tarbell K; Olson K; Velinzon K; et al.
Direct expansion of functional CD25(+) CD4(+) regulatory T cells by antigen-processing dendritic cells
3171
513229 2003 JOURNAL OF CLINICAL INVESTIGATION 112(9):1437-1443
Walker MR; Kasprowicz DJ; Gersuk VH; Benard A; Van Landeghen M; et al.
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4(+)CD25(-) T cells
4262
6313666 2004 ANNUAL REVIEW OF IMMUNOLOGY 22:531-562
Sakaguchi S
Naturally arising CD4(+) regulatory T cells for immunologic self-tolerance and negative control of immune responses
1861
715631 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(5):737-746
Fisson S; Darrasse-Jeze G; Litvinova E; Septier F; Klatzmann D; et al.
Continuous activation of autoreactive CD4(+) CD25(+) regulatory T cells in the steady state
2142
812217 2003 IMMUNITY 19(2):165-168
Ramsdell F
Foxp3 and natural regulatory T cells: Key to a cell lineage?
2036
914613 2003 CURRENT OPINION IN RHEUMATOLOGY 15(4):430-435
Gambineri E; Torgerson TR; Ochs HD
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
2635
10128161 2004 JOURNAL OF IMMUNOLOGY 172(2):834-842
Nakamura K; Kitani A; Fuss I; Pedersen A; Harada N; et al.
TGF-beta 1 plays an important role in the mechanism of CD4(+)CD25(+) regulatory T cell activity in both humans and mice
1434
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
1126038 2003 JOURNAL OF IMMUNOLOGY 171(12):6323-6327
Jonuleit H; Schmitt E
The regulatory T cell family: Distinct subsets and their interrelations
726
1211248 2003 SCIENCE 299(5609):1030-1031
Powrie F; Maloy KJ
Regulating the regulators
1025
13252172 2004 JOURNAL OF IMMUNOLOGY 172(10):5986-5993
Vieira PL; Christensen JR; Minaee S; O'Neill EJ; Barrat FJ; et al.
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4(+)CD25(+) regulatory T cells
1725
1414918 2003 IMMUNITY 19(4):503-514
Zheng XX; Sanchez-Fueyo A; Sho M; Domenig C; Sayegh MH; et al.
Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
324
1518324 2003 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 112(3):480-487
Umetsu DT; Akbari O; DeKruyff RH
Regulatory T cells control the development of allergic disease and asthma
624
16542151 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(10):1401-1408
Apostolou I; von Boehmer H
In vivo instruction of suppressor commitment in naive T cells
1823
17253152 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(11):1455-1465
Tang QZ; Henriksen KJ; Bi MY; Finger EB; Szot G; et al.
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
1022
1836212 2003 CURRENT OPINION IN IMMUNOLOGY 15(6):690-696
Gavin M; Rudensky A
Control of immune homeostasis by naturally arising regulatory CD4(+) T cells
921
191422 2003 BLOOD 102(12):4107-4114
Cosmi L; Liotta F; Lazzeri E; Francalanci M; Angeli R; et al.
Human CD8(+)CD25(+) thymocytes share phenotypic and functional features with CD4(+)CD25(+) re latory thyrnocytes
920
2012150 2003 SCIENCE 302(5647):1041-1043
Pearce EL; Mullen AC; Martins GA; Krawczyk CM; Hutchins AS; et al.
Control of effector CD8(+) T cell function by the transcription factor Eomesodermin
120
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
21121103 2004 EUROPEAN JOURNAL OF IMMUNOLOGY 34(3):623-630
Bruder D; Probst-Kepper M; Westendorf AM; Geffers R; Beissert S; et al.
Neuropilin-1: a surface marker of regulatory T cells
1320
22114167 2004 JOURNAL OF IMMUNOLOGY 172(9):5149-5153
Fantini MC; Becker C; Monteleone G; Pallone F; Galle PR; et al.
Cutting edge: TGF-beta induces a regulatory phenotype in CD4(+)CD25(-) T cells through Foxp3 induction and down-regulation of Smad7
1120
23237220 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(13):4572-4577
Peng YF; Laouar Y; Li MO; Green EA; Flavell RA
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4(+)CD25(+) regulatory T cells responsible for protection against diabetes
1220
24133201 2004 NATURE IMMUNOLOGY 5(3):266-271
Aluvihare VR; Kallikourdis M; Betz AG
Regulatory T cells mediate maternal tolerance to the fetus
119
2518740 2003 JOURNAL OF LEUKOCYTE BIOLOGY 74(4):471-478
Horwitz DA; Zheng SG; Gray JD
The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4(+) CD25(+) and CD8(+) regulatory T cell subsets
818
261117203 2004 NATURE IMMUNOLOGY 5(10):987-995
Iwasaki A; Medzhitov R
Toll-like receptor control of the adaptive immune responses
117
27122226 2004 SCIENCE 303(5660):1017-1020
Lin L; Spoor MS; Gerth AJ; Brody SL; Peng SL
Modulation of Th1 activation and inflammation by the NF-kappa B repressor Foxj1
317
2811644 2003 NATURE IMMUNOLOGY 4(4):304-306
O'Garra A; Vieira P
Twenty-first century Foxp3
016
29354153 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(11):1467-1477
Tarbell KV; Yamazaki S; Olson K; Toy P; Steinman RM
CD25(+) CD4(+) T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
816
30125227 2004 SCIENCE 304(5667):104-107
Traggiai E; Chicha L; Mazzucchelli L; Bronz L; Piffaretti JC; et al.
Development of a human adaptive immune system in cord blood cell-transplanted mice
016
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
3115811 2003 CURRENT OPINION IN IMMUNOLOGY 15(6):677-682
Pasare C; Medzhitov R
Toll-like receptors: balancing host resistance with immune tolerance
215
32243163 2004 JOURNAL OF IMMUNOLOGY 172(2):923-928
Karim M; Kingsley CI; Bushell AR; Sawitzki BS; Wood KJ
Alloantigen-induced CD25(+)CD4(+) regulatory T cells can develop in vivo from CD25(-)CD4(+) precursors in a thymus-independent process
415
33457173 2004 JOURNAL OF IMMUNOLOGY 172(10):6003-6010
Cobbold SP; Castejon R; Adams E; Zelenika D; Graca L; et al.
Induction of foxP3(+) regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
715
3418153 2003 TRANSPLANT IMMUNOLOGY 11(3-4):235-244
Suciu-Foca N; Manavalan JS; Cortesini R
Generation and function of antigen-specific suppressor and regulatory T cells
214
35129195 2004 LANCET 363(9409):608-615
Ling EM; Smith T; Nguyen XD; Pridgeon C; Dallman M; et al.
Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
314
3627610 2003 CURRENT OPINION IN IMMUNOLOGY 15(6):627-633
Akbari O; Stock P; DeKruyff RH; Umetsu DT
Role of regulatory T cells in allergy and asthma
213
3717322 2003 IMMUNOLOGY 109(3):319-325
Akbar AN; Taams LS; Salmon M; Vukmanovic-Stejic M
The peripheral generation of CD4(+) CD25(+) regulatory T cells
313
3815054 2003 TRENDS IN IMMUNOLOGY 24(7):380-386
Yusuf I; Fruman DA
Regulation of quiescence in lymphocytes
313
39153149 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(3):303-313
Huehn J; Siegmund K; Lehmann JCU; Siewert C; Haubold U; et al.
Developmental stage, phenotype, and migration distinguish naive-and effector/memory-like CD4(+) regulatory T cells
213
40765206 2004 NATURE MEDICINE 10(8):801-805
O'Garra A; Vieira P
Regulatory T cells and mechanisms of immune system control
013
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
41229150 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(9):1285-1291
Kriegel MA; Lohmann T; Gabler C; Blank N; Kalden JR; et al.
Defective suppressor function of human CD4(+) CD25(+) regulatory T cells in autoimmune polyglandular syndrome type II
712
42433230 2004 SEMINARS IN IMMUNOLOGY 16(2):89-97
Baecher-Allan C; Viglietta V; Hafler DA
Human CD4+CD25+ regulatory T cells
312
431364 2003 CANCER 98(5):1089-1099
Sasada T; Kimura M; Yoshida Y; Kanai M; Takabayashi A
CD4(+)CD25(+) regulatory T cells in patients with gastrointestinal malignancies - Possible involvement of regulatory T cells in disease progression
311
4413226 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(27):24259-24268
Wang B; Lin DJ; Li C; Tucker P
Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional Repressors
211
4532128 2003 JOURNAL OF CLINICAL INVESTIGATION 112(9):1310-1312
Sakaguchi S
The origin of FOXP3-expressing CD4(+) regulatory T cells: thymus or periphery
811
46458154 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(11):1479-1489
Herman AE; Freeman GJ; Mathis D; Benoist C
CD4(+)CD25(+) T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
411
4718421 2003 IMMUNOLOGICAL REVIEWS 196(1):109-124
Cobbold SP; Nolan KF; Graca L; Castejon R; Le Moine A; et al.
Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms
710
48143138 2004 JOURNAL OF CLINICAL INVESTIGATION 113(2):310-317
Dai ZH; Li Q; Wang YN; Gao G; Diggs LS; et al.
CD4(+)CD25(+) regulatory T cells suppress allograft rejection mediated by memory CD8(+) T cells via a CD30-dependent mechanism
110
49157139 2004 JOURNAL OF CLINICAL INVESTIGATION 113(7):963-972
Accapezzato D; Francavilla V; Paroli M; Casciaro M; Chircu LV; et al.
Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection
110
50113170 2004 JOURNAL OF IMMUNOLOGY 172(10):5823-5827
Ji HB; Liao GX; Faubion WA; Abadia-Molina AC; Cozzo C; et al.
Cutting edge: The natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression
210
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
51149207 2004 NATURE MEDICINE 10(9):942-949
Curiel TJ; Coukos G; Zou LH; Alvarez X; Cheng P; et al.
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
310
52140218 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(12):4228-4233
Prakken BJ; Samodal R; Le TD; Giannoni F; Yung GP; et al.
Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
510
5317137 2003 JOURNAL OF IMMUNOLOGY 171(11):5853-5864
Burchill MA; Goetz CA; Prlic M; O'Neil JJ; Harmon IR; et al.
Distinct effects of STAT5 activation on CD4(+) and CD8(+) T cell homeostasis: Development of CD4(+)CD25(+) regulatory T cells versus CD8(+) memory T cells
29
5416862 2004 AMERICAN JOURNAL OF TRANSPLANTATION 4(1):65-78
Fu S; Yopp AC; Mao X; Chen DM; Zhang N; et al.
CD4(+) CD25(+) CD62(+) T-regulatory cell subset has optimal suppressive and proliferative potential
49
5514675 2004 BLOOD 103(3):1140-1146
Stanzani M; Martins SLR; Saliba RM; John LSS; Bryan S; et al.
CD25 expression on donor CD4(+) or CD8(+) T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans
39
5637494 2004 CURRENT OPINION IN IMMUNOLOGY 16(2):157-162
Terabe M; Berzofsky JA
Immunoregulatory T cells in tumor immunity
19
5724695 2004 CURRENT OPINION IN IMMUNOLOGY 16(2):203-208
Fehervari Z; Sakaguchi S
Development and function of CD25(+)CD4(+) regulatory T cells
49
5834832 2003 JOURNAL OF EXPERIMENTAL MEDICINE 198(6):845-849
von Boehmer H
Dynamics of suppressor T cells: In vivo veritas
58
59253126 2004 INTERNATIONAL IMMUNOLOGY 16(8):1055-1068
Manavalan JS; Kim-Schulze S; Scotto L; Naiyer AJ; Vlad G; et al.
Alloantigen specific CD8(+)CD28(-) FOXP3(+) T suppressor cells induce ILT3(+) ILT4(+) tolerogenic endothelial cells, inhibiting alloreactivity
48
60226168 2004 JOURNAL OF IMMUNOLOGY 172(9):5213-5221
Zheng SG; Wang JH; Gray JD; Soucier H; Horwitz DA
Natural and induced CD4(+)CD25(+) cells educate CD4(+)D25(-)cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10
68
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61291210 2004 NATURE REVIEWS IMMUNOLOGY 4(6):478-485
Macpherson AJ; Harris NL
Interactions between commensal intestinal bacteria and the immune system
08
6219914 2003 EXPERT OPINION ON BIOLOGICAL THERAPY 3(6):875-885
Belkaid Y
The role of CD4+CD25+ regulatory T cells in Leishmania infection
27
6313377 2004 BLOOD 103(12):4594-4601
Mamura M; Lee W; Sullivan TJ; Felici A; Sowers AL; et al.
CD28 disruption exacerbates inflammation in Tgf-beta 1(-/-) mice: in vivo suppression by CD4(+)CD25(+) regulatory T cells independent of autocrine TGF-beta 1
67
6445378 2004 BLOOD 104(3):895-903
Hoffmann P; Eder R; Kunz-Schughart LA; Andreesen R; Edinger M
Large-scale in vitro expansion of polyclonal human CD4(+)CD25(high) regulatory T cells
27
65778157 2004 JOURNAL OF EXPERIMENTAL MEDICINE 200(3):331-343
Kinter AL; Hennessey M; Bell A; Kern S; Lin Y; et al.
CD25(+) CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
57
66234165 2004 JOURNAL OF IMMUNOLOGY 172(7):4123-4132
Suvas S; Azkur AK; Kim BS; Kumaraguru U; Rouse BT
CD4(+) CD25(+) regulatory T cells control the severity of viral immunoinflammatory lesions
37
67653231 2004 SEMINARS IN IMMUNOLOGY 16(2):119-126
Waldmann H; Graca L; Cobbold S; Adams E; Tone M; et al.
Regulatory T cells and organ transplantation
17
681899 2003 CURRENT OPINION IN IMMUNOLOGY 15(5):499-506
Graca L; Le Moine A; Cobbold SP; Waldmann H
Dominant transplantation tolerance - Opinion
46
6914019 2003 IMMUNOGENETICS 55(3):149-156
Bassuny WM; Ihara K; Sasaki Y; Kuromaru R; Kohno H; et al.
A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes
66
7016183 2004 CANCER IMMUNOLOGY IMMUNOTHERAPY 53(2):73-78
Wei WZ; Morris GP; Kong YCM
Anti-tumor immunity and autoimmunity: a balancing act of regulatory T cells
36
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
71443117 2004 IMMUNITY 21(2):203-213
Lin L; Hron JD; Peng SL
Regulation of NF-kappa B, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
26
72565180 2004 JOURNAL OF IMMUNOLOGY 173(2):1444-1453
Viguier M; Lemaitre F; Verola O; Cho MS; Gorochov G; et al.
Foxp3 expressing CD4(+)CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
26
733102200 2004 NATURE IMMUNOLOGY 5(1):23-30
Fischer A
Human primary immunodeficiency diseases: a perspective
06
74132222 2004 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(28):10398-10403
Paust S; Lu LR; McCarty N; Cantor H
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
46
75153229 2004 SEMINARS IN IMMUNOLOGY 16(2):81-88
Piccirillo CA; Shevach EM
Naturally-occurring CD4(+)CD25(+) immunoregulatory T cells: central players in the arena of peripheral tolerance
36
761315 2003 CLINICAL AND EXPERIMENTAL IMMUNOLOGY 133(2):193-199
Smyk-Pearson SK; Bakke AC; Held PK; Wildin RS
Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes
35
7713635 2003 JOURNAL OF IMMUNOLOGY 171(5):2279-2286
Denning TL; Qi H; Konig R; Scott KG; Naganuma M; et al.
CD4(+) Th cells resembling regulatory T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and class II MHC
35
78559127 2004 INTERNATIONAL IMMUNOLOGY 16(8):1189-1201
Nishimura E; Sakihama T; Setoguchi R; Tanaka K; Sakaguchi S
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3(+)CD25(+)CD4(+) regulatory T cells
45
79860155 2004 JOURNAL OF EXPERIMENTAL MEDICINE 199(12):1679-1688
Karlsson MR; Rugtveit J; Brandtzaeg P
Allergen-responsive CD4(+)CD25(+) regulatory T cells in children who have outgrown cow's milk allergy
25
80356179 2004 JOURNAL OF IMMUNOLOGY 173(2):1224-1231
McKee AS; Pearce EJ
CD25(+)CD4(+) cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development
15
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815128189 2004 JOURNAL OF LEUKOCYTE BIOLOGY 76(1):15-24
Wahl SM; Swisher J; McCartney-Francis N; Chen WJ
TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells
25
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Malek TR; Bayer AL
Tolerance, not immunity, crucially depends on IL-2
15
83199215 2004 NEW ENGLAND JOURNAL OF MEDICINE 350(20):2068-2079
Eisenbarth GS; Gottlieb PA
Medical progress - Autoimmune polyendocrine syndromes
05
841183 2003 BLOOD 102(13):4326-4328
Gross DA; Leboeuf M; Gjata B; Danos O; Davoust J
CD4(+)CD25(+) regulatory T cells inhibit immune-mediated transgene rejection
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Schramm C; Huber S; Protschka M; Czochra P; Burg J; et al.
TGF beta regulates the CD4+CD25+T-cell pool and the expression of Foxp3 in vivo
14
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T regulatory cells in atopic dermatitis and subversion of their activity by superantigens
14
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Ostroukhova M; Seguin-Devaux C; Oriss TB; Dixon-McCarthy B; Yang LY; et al.
Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3
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Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
34
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Mayerova D; Hogquist KA
Central tolerance to self-antigen expressed by cortical epithelial cells
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de Kleer IM; Wedderburn LR; Taams LS; Patel A; Varsani H; et al.
CD4(+)CD25(bright) regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
14
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Hori S; Sakaguchi S
Foxp3: a critical regulator of the development and function of regulatory T cells
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Regulatory T cells
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Mycobacterium vaccae induces a population of pulmonary CD11c(+) cells with regulatory potential in allergic mice
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CD25(+)CD4(+) T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene
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Chen TC; Cobbold SP; Fairchild PJ; Waldmann H
Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen
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Makita S; Kanai T; Oshima S; Uraushihara K; Totsuka T; et al.
CD4(+)CD25(bright) T cells in human intestinal lamina propria as regulatory cells
13
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de Lafaille MAC; Lino AC; Kutchukhidze N; Lafaille JJ
CD25(-) T cells generate CD25(+)Foxp3(+) regulatory T cells by peripheral expansion
23
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Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
23
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Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen
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Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders
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Schmidt-Weber CB; Blaser K
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