#	Cited nodes	Nodes / Authors	GCS	LCS
601	6	416 2001 FASEB JOURNAL 15(12):2057-2072 Tegeder I; Pfeilschifter J; Geisslinger G Cyclooxygenase-independent actions of cyclooxygenase inhibitors	70	0
602	7	417 2001 FEBS LETTERS 490(3):153-162 Nasi S; Ciarapica R; Jucker R; Rosati J; Soucek L Making decisions through Myc	32	0
603	7	418 2001 FEBS LETTERS 490(3):179-189 DeSalle LM; Pagano M Regulation of the G1 to S transition by the ubiquitin pathway	25	0
604	3	419 2001 GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE 25(11):967-978 Buecher B; Heymann MF; Blottiere HM Rationale and prospects for the use of cyclooxygenase-2 (COX-2) inhibitors in colorectal cancer	1	0
605	3	420 2001 GASTROENTEROLOGY 120(7):1680-1688 Bartkova J; Thullberg M; Slezak P; Jaramillo E; Rubio C; Thomassen LH; Bartek J Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon	9	0
606	3	421 2001 GENE 277(1-2):63-81 Reeves R Molecular biology of HMGA proteins: hubs of nuclear function	21	0
607	3	432 2001 INTERNATIONAL JOURNAL OF CANCER 94(1):148-149 Bukholm IRK; Bukholm G; Nesland JM Coexpression of cyclin A and beta-catenin and survival in breast cancer patients	3	0
608	1	434 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(2):233-239 Obara K; Yokoyama M; Asano G; Tanaka S Evaluation of myc and chromosome 8 copy number in colorectal cancer using interphase cytogenetics	3	0
609	4	436 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(4):843-847 Davies G; Jiang WG; Mason MD The interaction between beta-catenin, GSM3 beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer	3	0
610	3	439 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(6):1271-1278 Kondoh N; Wakatsuki T; Hada A; Shuda M; Tanaka K; Arai M; Yamamoto M Genetic and epigenetic events in human hepatocarcinogenesis (Review)	14	0
611	7	444 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(4):803-810 Uthoff SMS; Eichenberger MR; Lewis RK; Fox MP; Hamilton CJ; McAuliffe TL; Grimes HL; Galandiuk S Identification of candidate genes in ulcerative colitis and Crohn's disease using cDNA array technology	2	0
612	14	445 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(6):1227-1233 Williams CL; Noti JD Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha	1	0
613	4	446 2001 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 9(4):273-279 Lifschitz-Mercer B; Amitai R; Maymon BBS; Shechtman L; Czernobilsky B; Leider-Trejo L; Ben-Ze'ev A; Geiger B Nuclear localization of beta-catenin and plakoglobin in primary and metastatic human colonic carcinomas, colonic adenomas, and normal colon	0	0
614	1	460 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):45168-45174 Jiang W; Zhou L; Breyer B; Feng T; Cheng HW; Haydon R; Ishikawa A; He TC Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cells	1	0
615	6	462 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(51):48276-48284 Prescott JE; Osthus RC; Lee LA; Lewis BC; Shim H; Barrett JF; Guo QB; Hawkins AL; Griffin CA; Dang CV A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation	5	0
616	1	463 2001 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 127(9):577-581 Cui J; Zhou XD; Liu YK; Tang ZY Mutation and overexpression of the beta-catenin gene may play an important role in primary hepatocellular carcinoma among Chinese people	3	0
617	6	465 2001 JOURNAL OF CELL BIOLOGY 152(3):491-502 Reinacher-Schick A; Gumbiner BM Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells	22	0
618	7	473 2001 JOURNAL OF CELL SCIENCE 114(7):1309-1319 Goichberg P; Shtutman M; Ben-Ze'ev A; Geiger B Recruitment of beta-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction	7	0
619	4	478 2001 JOURNAL OF GASTROENTEROLOGY 36(9):587-594 Fujimori T; Kawamata H; Kashida H Precancerous lesions of the colorectum	0	0
620	17	480 2001 JOURNAL OF IMMUNOLOGY 167(12):6786-6793 Thiele A; Wasner M; Muller C; Engeland K; Hauschildt S Regulation and possible function of beta-catenin in human monocytes	0	0
621	5	483 2001 JOURNAL OF PATHOLOGY 193(4):427-432 Saldanha G The Hedgehog signalling pathway and cancer	7	0
622	7	488 2001 JOURNAL OF PEPTIDE RESEARCH 58(6):493-503 Catimel B; Faux MC; Nerrie M; Rothacker J; Otvos L; Wade JD; Nice EC; Burgess AW The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes	1	0
623	5	489 2001 JOURNAL OF SURGICAL RESEARCH 101(1):16-20 Green DW; Roh H; Pippin JA; Drebin JA beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts	2	0
624	6	490 2001 LANCET 357(9256):572-573 Watson SA Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis	3	0
625	10	491 2001 MECHANISMS OF DEVELOPMENT 109(2):173-181 Ridanpaa M; Fodde R; Kielman M Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures	2	0
626	4	493 2001 MEDICINAL RESEARCH REVIEWS 21(4):245-273 Myung J; Kim KB; Crews CM The ubiquitin-proteasome pathway and proteasome inhibitors	34	0
627	1	494 2001 MICROSCOPY RESEARCH AND TECHNIQUE 52(2):171-181 Strange R; Metcalfe T; Thackray L; Dang M Apoptosis in normal and neoplastic mammary gland development	9	0
628	3	496 2001 MODERN PATHOLOGY 14(3):236-245 Redston M Carcinogenesis in the GI tract: From morphology to genetics and back again	5	0
629	1	498 2001 MOLECULAR AND CELLULAR BIOCHEMISTRY 227(1-2):153-165 Landesman-Bollag E; Song DH; Romieu-Mourez R; Sussman DJ; Cardiff RD; Sonenshein GE; Seldin DC Protein kinase CK2: Signaling and tumorigenesis in the mammary gland	8	0
630	13	504 2001 MOLECULAR AND CELLULAR BIOLOGY 21(17):5857-5868 Danilkovitch-Miagkova A; Miagkov A; Skeel A; Nakaigawa N; Zbar B; Leonard EJ Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway	11	0
631	5	505 2001 MOLECULAR AND CELLULAR BIOLOGY 21(19):6626-6639 Miller LD; Park KS; Guo QBM; Alkharouf NW; Malek RL; Lee NH; Liu ET; Cheng SY Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation	11	0
632	1	510 2001 MOLECULAR CARCINOGENESIS 31(4):192-203 Roy D; Calaf G; Hei TK Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells	3	0
633	8	520 2001 NEOPLASIA 3(1):4-9 Kato T; Satoh S; Okabe H; Kitahara O; Ono K; Kihara C; Tanaka T; Tsunoda T; Yamaoka Y; Nakamura Y; Furukawa Y Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis	5	0
634	3	523 2001 ONCOGENE 20(5):626-633 Zwerner JP; May WA PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors	20	0
635	11	524 2001 ONCOGENE 20(5):645-653 Dihlmann S; Siermann A; Doeberitz MV The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling	10	0
636	2	525 2001 ONCOGENE 20(22):2727-2736 Baba M; Hirai S; Kawakami S; Kishida T; Sakai N; Kaneko S; Yao M; Shuin T; Kubota Y; Hosaka M; Ohno S Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth	14	0
637	3	526 2001 ONCOGENE 20(25):3247-3257 Landesman-Bollag E; Romieu-Mourez R; Song DH; Sonenshein GE; Cardiff RD; Seldin DC Protein kinase CK2 in mammary gland tumorigenesis	30	0
638	4	527 2001 ONCOGENE 20(30):4007-4018 Shi YJ; Simmons MN; Seki T; Oh SP; Sugrue SP Change in gene expression subsequent to induction of Pnn/DRS/memA: increase in p21(cip1/waf1)	6	0
639	7	528 2001 ONCOGENE 20(35):4884-4890 Dang DT; Mahatan CS; Dang LH; Agboola IA; Yang VW Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2	16	0
640	6	533 2001 ONCOGENE 20(42):5972-5981 Saadi-Kheddouci S; Berrebi D; Romagnolo B; Cluzeaud F; Peuchmaur M; Kahn A; Vandewalle A; Perret C Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene	13	0
641	8	535 2001 ONCOGENE 20(52):7645-7657 Hollmann CA; Kittrell FS; Medina D; Butel JS Wnt-1 and int-2 mammary oncogene effects on the beta-catenin pathway in immortalized mouse mammary epithelial cells are not sufficient for tumorigenesis	0	0
642	2	542 2001 PHYSIOLOGICAL GENOMICS 7(2):105-114 Kuhn I; Bartholdi MF; Salamon H; Feldman RI; Roth RA; Johnson PH Identification of AKT-regulated genes in inducible MERAkt cells	3	0
643	1	550 2001 PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 69 69():47-79 Szyf M; Detich N Regulation of the DNA methylation machinery and its role in cellular transformation	7	0
644	15	552 2001 VIRCHOWS ARCHIV 439(6):725-751 Van Aken E; De Wever O; da Rocha ASC; Mareel M Defective E-cadherin/catenin complexes in human cancer	29	0
645	15	553 2002 ADVANCES IN CANCER RESEARCH, VOL 84 84():203-229 Manoukian AS; Woodgett JR Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways	11	0
646	6	554 2002 AMERICAN JOURNAL OF GASTROENTEROLOGY 97(3):542-553 Husain SS; Szabo IL; Tarnawski AS NSAID inhibition of GI cancer growth: Clinical implications and molecular mechanisms of action	8	0
647	4	558 2002 AMERICAN JOURNAL OF PATHOLOGY 161(5):1735-1742 Abraham SC; Park SJ; Mugartegui L; Hamilton SR; Wu TT Sporadic fundic gland polyps with epithelial dysplasia - Evidence for preferential targeting for mutations in the adenomatous polyposis coli gene	1	0
648	13	559 2002 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283(3):C811-C821 Venkiteswaran K; Xiao KY; Summers S; Calkins CC; Vincent PA; Pumiglia K; Kowalczyk AP Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin	7	0
649	2	560 2002 ANNALES DE PATHOLOGIE 22(4):277-288 Piard F; Martin L; Chapusot C; Ponnelle T; Faivre J Genetic pathways in colorectal cancer: interest for the pathologist	0	0
650	11	561 2002 ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS 3():101-128 Grady WM; Markowitz SD Genetic and epigenetic alterations in colon cancer	9	0
651	5	562 2002 ANTICANCER RESEARCH 22(4):2215-2220 Dobbie Z; Muller PY; Heinimann K; Albrecht C; D'Orazio D; Bendik I; Muller H; Bauerfeind P Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam	3	0
652	5	563 2002 ANTICANCER RESEARCH 22(6A):3409-3414 D'Orazio D; Muller PY; Heinimann K; Albrecht C; Bendik I; Herzog U; Tondelli P; Bauerfeind P; Muller H; Dobbie Z Overexpression of Wnt target genes in adenomas of familial adenomatous polyposis patients	0	0
653	5	565 2002 BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY 16(2):171-185 Tejpar S; Van Cutsem E Molecular and genetic defects in colorectal tumorigenesis	0	0
654	5	567 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 299(5):744-750 Meredith JE; Wang Q; Mitchell TJ; Olson RE; Zaczek R; Stern AM; Seiffert D gamma-Secretase activity is not involved in presenilin-mediated regulation of beta-catenin	0	0
655	3	568 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 299(5):806-812 Lim HW; Lee JE; Shin SJ; Lee YE; Oh SH; Park JY; Seong JK; Park JS Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display	1	0
656	11	569 2002 BIOCHEMICAL JOURNAL 367():723-728 Chtarbova S; Nimmrich I; Erdmann S; Herter P; Renner M; Kitajewski J; Muller O Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation	0	0
657	6	571 2002 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1577(1):81-92 Ballarino M; Marchioni M; Carnevali F The Xenopus laevis beta TrCP gene: genomic organization, alternative splicing, 5 ' and 3 ' region characterization and comparison of its structure with that of human beta TrCP genes	2	0
658	5	572 2002 BIOESSAYS 24(1):54-64 Johnston LA; Gallant P Control of growth and organ size in Drosophila	14	0
659	12	574 2002 BIOLOGICAL RESEARCH 35(2):277-286 Hendriks B; Reichmann E Wnt signaling: A complex issue	2	0
660	8	577 2002 BREAST CANCER RESEARCH 5(1):16-22 Rossi S; Loda M The role of the ubiquitination-proteasome pathway in breast cancer - Use of mouse models for analyzing ubiquitination processes	0	0
661	9	578 2002 BRITISH JOURNAL OF CANCER 86(7):1124-1129 Chiang JM; Chou YHW; Chen TC; Ng KF; Lin JL Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma	0	0
662	4	580 2002 BRITISH MEDICAL BULLETIN 64():27-43 Fearnhead NS; Wilding JL; Bodmer WF Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis	1	0
663	10	581 2002 CANCER 95(12):2479-2486 Cheah PY; Choo PH; Yao J; Eu KW; Seow-Choen F A survival-stratification model of human colorectal carcinomas with beta-catenin and p27(kip1)	0	0
664	2	582 2002 CANCER BIOLOGY & THERAPY 1(1):58-63 Termuhlen PM; Sweeney-Gotsch BM; Berman RS; Ellis LM; Bucana C; Shen Y; Cleary KR; McConkey DJ Increased apoptosis in metastatic human colonic adenocarcinomas	0	0
665	3	583 2002 CANCER BIOLOGY & THERAPY 1(6):640-645 Coyle-Rink J; Del Valle L; Sweet T; Khalili K; Amini S Developmental expression of Wnt signaling factors in mouse brain	0	0
666	5	585 2002 CANCER CELL 1(4):355-368 Philipp-Staheli J; Kim KH; Payne SR; Gurley KE; Liggitt D; Longton G; Kemp CJ Pathway-specific tumor suppression: Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice	7	0
667	1	588 2002 CANCER GENETICS AND CYTOGENETICS 135(1):48-56 Moritake H; Sugimoto T; Asada Y; Yoshida MA; Maehara Y; Epstein AL; Kuroda H Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene	1	0
668	3	589 2002 CANCER LETTERS 180(2):107-119 Strieder V; Lutz W Regulation of N-myc expression in development and disease	2	0
669	2	590 2002 CANCER LETTERS 181(2):125-164 Marsh DJ; Zori RT Genetic insights into familial cancers - update and recent discoveries	4	0
670	2	591 2002 CANCER LETTERS 183(1):31-41 Suzui M; Okuno M; Tanaka T; Nakagama H; Moriwaki H Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation	1	0
671	7	592 2002 CANCER LETTERS 183(1):95-101 Howng SL; Wu CH; Cheng TS; Sy WD; Lin PCK; Wang CH; Hong YR Differential expression of Wnt genes, beta-catenin and E-cadherin in human brain tumors	1	0
672	17	597 2002 CANCER RESEARCH 62(20):5939-5954 Hoglund M; Gisselsson D; Hansen GB; Sall T; Mitelman F; Nilbert M Dissecting karyotypic patterns in colorectal tumors: Two distinct but overlapping pathways in the adenoma-carcinoma transition	3	0
673	5	598 2002 CANCER RESEARCH 62(21):6006-6010 Wilson AJ; Velcich A; Arango D; Kurland AR; Shenoy SM; Pezo RC; Levsky JM; Singer RH; Augenlicht LH Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention	4	0
674	4	599 2002 CARCINOGENESIS 23(6):1065-1070 Fenton JI; Wolff MS; Orth MW; Hord NG Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype	2	0
675	13	600 2002 CELL 111(2):241-250 van de Wetering M; Sancho E; Verweij C; de Lau W; Oving I; Hurlstone A; van der Horn K; Batlle E; Coudreuse D; Haramis AP; Tion-Pon-Fong M; Moerer P; van den Born M; Soete G; Pals S; Eilers M; Medema R; Clevers H The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells	59	0
676	1	601 2002 CELL DEATH AND DIFFERENTIATION 9(5):513-526 Yamakawa-Karakida N; Sugita K; Inukai T; Goi K; Nakamura M; Uno K; Sato H; Kagami K; Barker N; Nakazawa S Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity	8	0
677	1	602 2002 CELLULAR SIGNALLING 14(4):351-358 Pauley CJ; Ledwith BJ; Kaplanski C Peroxisome proliferators activate growth regulatory pathways largely via peroxisome proliferator-activated receptor alpha-independent mechanisms	2	0
678	4	603 2002 CIRCULATION RESEARCH 91(7):565-569 Patino WD; Mian OY; Hwang PM Serial analysis of gene expression - Technical considerations and applications to cardiovascular biology	7	0
679	10	604 2002 CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 41(1):11-28 Mason MD; Davies G; Jiang WG Cell adhesion molecules and adhesion abnormalities in prostate cancer	1	0
680	18	605 2002 CURRENT OPINION IN GASTROENTEROLOGY 18(1):53-59 Waterman ML Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer	0	0
681	4	606 2002 CURRENT OPINION IN STRUCTURAL BIOLOGY 12(6):761-767 Pearl LH; Barford D Regulation of protein kinases in insulin, growth factor and Wnt signalling	2	0
682	15	608 2002 DEVELOPMENTAL BIOLOGY 244(1):1-8 van Noort M; Clevers H TCF transcription factors, mediators of Wnt-signaling in development and cancer	27	0
683	59	609 2002 DIGESTION 66(3):131-144 Kolligs FT; Bommer G; Goke B Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis	1	0
684	8	610 2002 DIGESTIVE DISEASES AND SCIENCES 47(12):2738-2742 Saeki H; Tanaka S; Sugimachi K; Kimura Y; Miyazaki M; Ohga T; Sugimachi K Interrelation between expression of matrix metalloproteinase 7 and beta-catenin in esophageal cancer	0	0
685	2	613 2002 ENDOCRINOLOGY 143(3):898-908 Hsieh M; Johnson MA; Greenberg NM; Richards JS Regulated expression of Wnts and frizzleds at specific stages of follicular development in the rodent ovary	7	0
686	6	615 2002 EUROPEAN JOURNAL OF CANCER PREVENTION 11():S12-S17 Augenlicht LH; Heerdt BG; Mariadason JM; Yang WC; Wilson AJ; Fragale A; Velcich A Environment-gene interactions in intestinal cancer	0	0
687	2	616 2002 EUROPEAN JOURNAL OF CANCER PREVENTION 11(1):85-97 Piard F; Chapusot C; Ecarnot-Laubriet A; Ponnelle T; Martin L Molecular markers of heterogeneity in colorectal cancers and adenomas	0	0
688	1	618 2002 EUROPEAN JOURNAL OF HUMAN GENETICS 10(10):631-637 Ripa R; Bisgaard ML; Bulow S; Nielsen FC De novo mutations in familial adenomatous polyposis (FAP)	0	0
689	4	619 2002 EXPERIMENTAL AND MOLECULAR MEDICINE 34(6):444-450 Shin SY; Yoon SC; Kim YH; Kim YS; Lee YH Phosphorylation of glycogen synthase kinase-3 beta at serine-9 by phospholipase C gamma 1 through protein kinase C in rat 3Y1 fibroblasts	0	0
690	6	620 2002 EXPERIMENTAL CELL RESEARCH 278(1):19-30 Hackett L; Davies D; Helyer R; Kennedy H; Kros C; Lawlor P; Rivolta MN; Holley M E-cadherin and the differentiation of mammalian vestibular hair cells	1	0
691	4	622 2002 EXPERIMENTAL CELL RESEARCH 280(1):33-44 Marcelo P; Lefevre F Induction of the IFN-gamma gene and protein is linked to the establishment of cell polarity in a porcine epithelial cell line	1	0
692	3	624 2002 FEBS LETTERS 530(1-3):147-152 Stone CD; Chen ZY; Tseng CC Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway	0	0
693	7	628 2002 GASTROENTEROLOGY 123(3):935-939 Yang VW APC as a checkpoint gene: The beginning or the end?	1	0
694	21	630 2002 GENES & DEVELOPMENT 16(16):2058-2072 Conacci-Sorrell ME; Ben-Yedidia T; Shtutman M; Feinstein E; Einat P; Ben-Ze'ev A Nr-CAM is a target gene of the beta-catenin/LEF-1 in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis	11	0
695	11	631 2002 GENES CHROMOSOMES & CANCER 33(1):73-81 Shimizu Y; Ikeda S; Fujimori M; Kodama S; Nakahara M; Okajima M; Asahara T Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability	2	0
696	5	634 2002 GUT 50(5):658-664 Shimada T; Kojima K; Yoshiura K; Hiraishi H; Terano A Characteristics of the peroxisome proliferator activated receptor gamma (PPAR gamma) ligand induced apoptosis in colon cancer cells	9	0
697	3	635 2002 GUT 50(6):845-850 Moisio AL; Jarvinen H; Peltomaki P Genetic and clinical characterisation of familial adenomatous polyposis: a population based study	0	0
698	31	637 2002 HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA 16(4):775-+ Lynch JP; Hoops TC The genetic pathogenesis of colorectal cancer	0	0
699	3	638 2002 HEPATOLOGY 36(6):1528-1536 Desbois-Mouthon C; Eggelpoel MJBV; Beurel E; Boissan M; Delelo R; Cadoret A; Capeau J Dysregulation of glycogen synthase kinase-3 beta signaling in hepatocellular carcinoma cells	0	0
700	7	639 2002 HORMONE-RELATED TUMORS: NOVEL APPROACHES TO PREVENTION AND TREATMENT 963():21-36 Levy L; Renard CA; Wei Y; Buendia MA Genetic alterations and oncogenic pathways in hepatocellular carcinoma	2	0

#	Cited nodes	Nodes / Authors	GCS	LCS
701	2	640 2002 HUMAN MOLECULAR GENETICS 11(15):1731-1742 Muto S; Aiba A; Saito Y; Nakao K; Nakamura K; Tomita K; Kitamura T; Kurabayashi M; Nagai R; Higashihara E; Harris PC; Katsuki M; Horie S Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant	5	0
702	6	641 2002 HUMAN PATHOLOGY 33(8):852-855 Takayasu H; Motoi T; Kanamori Y; Kitano Y; Nakanishi H; Tange T; Nakagawara A; Hashizume K Two case reports of childhood liver cell adenomas harboring beta-catenin abnormalities	1	0
703	10	642 2002 INFECTION AND IMMUNITY 70(5):2605-2613 Prozialeck WC; Fay MJ; Lamar PC; Pearson CA; Sigar I; Ramsey KH Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells	0	0
704	10	643 2002 INTERNATIONAL JOURNAL OF CANCER 97(1):42-51 Bordonaro M; Lazarova DL; Augenlicht LH; Sartorelli AC Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate	6	0
705	2	647 2002 INTERNATIONAL JOURNAL OF CANCER 102(1):60-69 Melkoumian ZK; Martirosyan AR; Strobl JS Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines	0	0
706	2	649 2002 INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 46(4):653-660 Tan SS; Gunnersen J; Job C Global gene expression analysis of developing neocortex using SAGE	0	0
707	4	650 2002 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 9(5):489-493 Masui O; Ueda Y; Tsumura A; Koyanagi M; Hijikata M; Shimotohno K RelA suppresses the Wnt/beta-catenin pathway without exerting trans-acting transcriptional ability	0	0
708	17	652 2002 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(6):677-682 Katoh M Paradigm shift in gene-finding method: From bench-top approach to desk-top approach (review)	25	0
709	3	654 2002 INTERNATIONAL JOURNAL OF ONCOLOGY 21(1):135-144 Vizirianakis IS; Chen YQ; Kantak SS; Tsiftsoglou AS; Kramer RH Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells	3	0
710	17	655 2002 INTERNATIONAL JOURNAL OF ONCOLOGY 21(6):1269-1273 Katoh M WNT and FGF gene clusters (Review)	20	0
711	2	656 2002 INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 219 219():157-198 Vikhanskaya F; Broggini M Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients	0	0
712	1	657 2002 JAPANESE JOURNAL OF CANCER RESEARCH 93(3):267-274 Nakatsuka S; Hongyo T; Syaifudin M; Nomura T; Shingu N; Aozasa K Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland	0	0
713	8	658 2002 JAPANESE JOURNAL OF CANCER RESEARCH 93(11):1213-1220 Ikenoue T; Ijichi H; Kato N; Kanai F; Masaki T; Rengifo W; Okamoto M; Matsumura M; Kawabe T; Shiratori Y; Omata M Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells	0	0
714	5	659 2002 JAPANESE JOURNAL OF CLINICAL ONCOLOGY 32(9):358-362 Koyama T; Tago K; Nakamura T; Ohwada S; Morishita Y; Yokota J; Akiyama T Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors	0	0
715	5	660 2002 JOURNAL OF BIOCHEMISTRY 132(5):697-703 Sakanaka C Phosphorylation and regulation of beta-catenin by casein kinase I epsilon	3	0
716	6	663 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(7):5134-5144 Chong JM; Uren A; Rubin JS; Speicher DW Disulfide bond assignments of secreted frizzled-related protein-1 provide insights about frizzled homology and netrin modules	5	0
717	13	664 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):6118-6123 Tice DA; Soloviev I; Polakis P Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes	6	0
718	8	665 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(9):7453-7465 Briggs MW; Li ZG; Sacks DB IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin	9	0
719	11	669 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(20):17706-17712 Zhang Y; Qiu WJ; Chan SC; Han JH; He X; Lin SC Casein kinase I and casein kinase II differentially regulate Axin function in Wnt and JNK pathways	4	0
720	5	670 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(20):18191-18197 Smith E; Coetzee GA; Frenkel B Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3 beta	2	0
721	5	678 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(40):37479-37486 Karasawa T; Yokokura H; Kitajewski J; Lombroso PJ Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta-catenin signaling	1	0
722	16	680 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(48):45847-45853 Holnthoner W; Pillinger M; Groger M; Wolff K; Ashton AW; Albanese C; Neumeister P; Pestell RG; Petzelbauer P Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells	1	0
723	7	684 2002 JOURNAL OF CELL SCIENCE 115(13):2639-2650 Relchelt J; Magin TM Hyperproliferation, induction of c-Myc and 14-3-3 sigma, but no cell fragility in keratin-10-null mice	0	0
724	12	685 2002 JOURNAL OF CELL SCIENCE 115(13):2771-2780 Sadot E; Conacci-Sorrell M; Zhurinsky J; Shnizer D; Lando Z; Zharhary D; Kam Z; Ben-Ze'ev A; Geiger B Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells	1	0
725	18	686 2002 JOURNAL OF CELL SCIENCE 115(23):4587-4595 Posthaus H; Williamson L; Baumann D; Kemler R; Caldelari R; Suter MM; Schwarz H; Muller E beta-catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes	3	0
726	3	688 2002 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 87(7):3475-3485 Demeterco C; Itkin-Ansari P; Tyrberg B; Ford LP; Jarvis RA; Levine F c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells	1	0
727	17	689 2002 JOURNAL OF CLINICAL INVESTIGATION 109(8):987-991 Conacci-Sorrell M; Zhurinsky J; Ben-Ze'ev A The cadherin-catenin adhesion system in signaling and cancer	38	0
728	2	691 2002 JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY 55(6):385-388 Salovaara R; Roth S; Loukola A; Launonen V; Sistonen P; Avizienyte E; Kristo P; Jarvinen H; Souchelnytskyi S; Sarlomo-Rikala M; Aaltonen LA Frequent loss of SMAD4/DPC4 protein in colorectal cancers (Reprinted from Gut, vol 51, pg 56-59, 2002)	0	0
729	2	693 2002 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 21(2):203-211 Kishimoto Y; Morisawa T; Hosoda A; Shiota G; Kawasaki H; Hasegawa J Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane	0	0
730	4	694 2002 JOURNAL OF GASTROENTEROLOGY 37(3):186-193 Kishimoto Y; Yashima K; Morisawa T; Shiota G; Kawasaki H; Hasegawa J Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane	5	0
731	2	695 2002 JOURNAL OF GASTROINTESTINAL SURGERY 6(4):563-568 Lew JI; Guo Y; Kim RK; Vargish L; Michelassi F; Arenas RB Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive	2	0
732	1	696 2002 JOURNAL OF IMMUNOLOGY 168(10):4837-4845 Denys A; Udalova IA; Smith C; Williams LM; Ciesielski CJ; Campbell J; Andrews C; Kwaitkowski D; Foxwell BMJ Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages	14	0
733	6	698 2002 JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS 7(1):41-45 Koster MI; Huntzinger KA; Roop DR Epidermal differentiation: Transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation	2	0
734	9	699 2002 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 7(4):415-432 Jechlinger M; Grunert S; Beug H Mechanisms in epithelial plasticity and metastasis: Insights from 3D cultures and expression profiling	0	0
735	8	700 2002 JOURNAL OF NUTRITION 132(12):3804S-3808S Augenlicht LH; Mariadason JM; Wilson A; Arango D; Yang WC; Heerdt BG; Velcich A Short chain fatty acids and colon cancer	2	0
736	8	701 2002 JOURNAL OF ORAL PATHOLOGY & MEDICINE 31(7):385-394 Gasparoni A; Chaves A; Fonzi L; Johnson GK; Schneider GB; Squier CA Subcellular localization of beta-catenin in malignant cell lines and squamous cell carcinomas of the oral cavity	0	0
737	4	703 2002 JOURNAL OF PATHOLOGY 197(2):194-200 Hardy RG; Brown RM; Miller SJ; Tselepis C; Morton DG; Jankowski JAZ; Sanders DSA Transient P-cadherin expression in radiation proctitis; a model of mucosal injury and repair	0	0
738	5	704 2002 JOURNAL OF PATHOLOGY 197(4):479-491 Janes SM; Lowell S; Hutter C Epidermal stem cells	6	0
739	10	705 2002 JOURNAL OF PATHOLOGY 197(4):492-509 Brittan M; Wright NA Gastrointestinal stem cells	14	0
740	5	706 2002 JOURNAL OF SURGICAL ONCOLOGY 80(4):204-213 Neibergs HL; Hein DW; Spratt JS Genetic profiling of colon cancer	3	0
741	5	709 2002 JOURNAL OF UROLOGY 168(5):2220-2226 Shiina H; Igawa M; Shigeno K; Terashima M; Deguchi M; Yamanaka M; Ribeiro L; Kane CJ; Dahiya R beta-catenin mutations correlate with over expression of c-myc and cyclin D1 genes in bladder cancer	0	0
742	2	712 2002 LEUKEMIA RESEARCH 26(9):863-871 Hwang SG; Lee HC; Trepel JB; Jeon BH Anticancer drugs-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin	0	0
743	11	715 2002 MODERN PATHOLOGY 15(10):1032-1037 Schlosshauer PW; Ellenson LH; Soslow RA beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype	2	0
744	1	717 2002 MOLECULAR AND CELLULAR BIOLOGY 22(15):5467-5478 Boudreau F; Rings EHHM; Swain GP; Sinclair AM; Suh ER; Silberg DG; Scheuermann RH; Traber PG A novel colonic repressor element regulates intestinal gene expression by interacting with Cux/CDP	1	0
745	4	719 2002 MOLECULAR CARCINOGENESIS 33(3):131-136 Kugoh H; Kleymenova E; Walker CL Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin	3	0
746	7	724 2002 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 506():137-144 Nakagama H; Ochiai M; Ubagai T; Tajima R; Fujiwara K; Sugimura T; Nagao M A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP	1	0
747	4	725 2002 NATURE 420(6913):274-277 Peifer M Developmental biology - Colon construction	0	0
748	8	726 2002 NEUROSURGERY 51(1):227-233 von Koch CS; Gulati M; Aldape K; Berger MS Familial medulloblastoma: Case report of one family and review of the literature	0	0
749	5	727 2002 NUCLEIC ACIDS RESEARCH 30(13):2911-2919 Daniel JM; Spring CM; Crawford HC; Reynolds AB; Baig A The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides	5	0
750	10	730 2002 ONCOGENE 21(30):4646-4662 Vecsey-Semjen B; Becker KT; Sinski A; Blennow E; Vietor I; Zatlouka K; Beug H; Wagner E; Huber LA Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers	4	0
751	3	731 2002 ONCOGENE 21(30):4696-4701 Cullingworth J; Hooper ML; Harrison DJ; Mason J; Sirard C; Patek CE; Clarke AR Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes	2	0
752	8	733 2002 ONCOGENE 21(36):5643-5648 Zhuang SM; Wiseman RW; Soderkvist P Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice	0	0
753	13	736 2002 ONCOGENE 21(41):6387-6394 Ishiguro H; Shimokawa T; Tsunoda T; Tanaka T; Fujii Y; Nakamura Y; Furukawa Y Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas	1	0
754	9	739 2002 ONCOGENE 21(49):7497-7506 Winn RA; Bremnes RM; Bemis L; Franklin WA; Miller YE; Cool C; Heasley LE gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth	1	0
755	20	740 2002 ONCOGENE 21(52):7971-7980 Cagatay T; Ozturk M p53 mutation as a source of aberrant beta-catenin accumulation in cancer cells	1	0
756	12	741 2002 ONCOGENE 21(52):7981-7990 Moreno-Bueno G; Hardisson D; Sanchez C; Sarrio D; Cassia R; Garcia-Rostan G; Prat J; Guo MZ; Herman JG; Matias-Guiu X; Esteller M; Palacios J Abnormalities of the APC/beta-catenin pathway in endometrial cancer	3	0
757	8	742 2002 ONCOGENE 21(54):8293-8301 Cadoret A; Ovejero C; Terris B; Souil E; Levy L; Lamers WH; Kitajewski J; Kahn A; Perret C New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism	0	0
758	10	743 2002 ONCOGENE 21(54):8340-8346 Kwong KY; Zou YY; Day CP; Hung MC The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway	2	0
759	9	746 2002 ONCOLOGY REPORTS 9(6):1197-1203 Ueta T; Ikeguchi M; Hirooka Y; Kaibara N; Terada T beta-catenin and cyclin D1 expression in human hepatocellular carcinoma	0	0
760	5	747 2002 ORAL ONCOLOGY 38(1):64-72 Lo Muzio L; Pannone G; Staibano S; Mignogna MD; Serpico R; Fanali S; De Rosa G; Piattelli A; Mariggio MA p120(cat) delocalization in cell lines of oral cancer	1	0
761	7	748 2002 ORAL ONCOLOGY 38(8):772-778 Sato K; Okazaki Y; Tonogi M; Tanaka Y; Yamane G Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide	0	0
762	2	749 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(6):3830-3835 Berg T; Cohen SB; Desharnais J; Sonderegger C; Maslyar DJ; Goldberg J; Boger DL; Vogt PK Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts	15	0
763	1	752 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11593-11598 Siddiqui-Jain A; Grand CL; Bearss DJ; Hurley LH Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription	22	0
764	2	753 2002 RECENT PROGRESS IN HORMONE RESEARCH, VOL 57 57():195-220 Richards JS; Russell DL; Ochsner S; Hsieh M; Doyle KH; Falender AE; Lo YK; Sharma SC Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization	11	0
765	3	754 2002 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 37(9):1048-1053 De Filippo C; Luceri C; Caderni G; Pacini M; Messerini L; Biggeri A; Mini E; Tonelli F; Cianchi F; Dolara P Mutations of the APC gene in human sporadic colorectal cancers	1	0
766	3	757 2002 SURGERY 131(4):384-392 Fransen K; Dimberg J; Osterstrom A; Olsson A; Soderkvist P; Sirsjo A Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas	0	0
767	6	758 2002 TOXICOLOGY AND APPLIED PHARMACOLOGY 182(3):255-265 Prozialeck WC; Grunwald GB; Dey PM; Reuhl KR; Parrish AR Cadherins and NCAM as potential targets in metal toxicity	1	0
768	6	759 2002 TUMOR BIOLOGY 23(1):45-53 Pereira-Suarez AL; Meraz MA; Lizanoc M; Estrada-Chavez C; Hernandez F; Olivera P; Perez E; Padilla P; Yaniv M; Thierry F; Garcia-Carranca A Frequent alterations of the beta-catenin protein in cancer of the uterine cervix	2	0
769	3	760 2002 VIRCHOWS ARCHIV 440(4):362-366 Hao XP; Frayling IM; Willcocks TC; Han W; Tomlinson IPM; Pignatelli MN; Pretlow TP; Talbot IC beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis	4	0
770	12	763 2002 WORLD JOURNAL OF GASTROENTEROLOGY 8(5):804-807 Jiang Y; Zhou XD; Liu YK; Wu X; Huang XW Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma	1	0
771	12	764 2003 AMERICAN JOURNAL OF PATHOLOGY 163(2):653-661 Nawrocki-Raby B; Gilles C; Polette M; Martinella-Catusse C; Bonnet N; Puchelle E; Foidart JM; van Roy F; Birembaut P E-cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells	0	0
772	9	765 2003 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 285(1):G217-G222 Song DH; Rana B; Wolfe JR; Crimmins G; Choi C; Albanese C; Wang TC; Pestell RG; Wolfe MM Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1	0	0
773	5	766 2003 ANNALS OF SURGICAL ONCOLOGY 10(3):284-290 Lowy AM; Fenoglio-Preiser C; Kim OJ; Kordich J; Gomez A; Knight J; James L; Groden J Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma	0	0
774	5	767 2003 ANTICANCER RESEARCH 23(2B):1489-1493 Bitzer M; Stahl M; Arjumand J; Rees M; Klump B; Heep H; Gabbert HE; Sarbia M C-MYC gene amplification in different stages of oesophageal squamous cell carcinoma: Prognostic value in relation to treatment modality	0	0
775	8	768 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303(1):212-218 Biswas P; Canosa S; Schoenfeld J; Schoenfeld D; Tucker A; Madri JA PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation	1	0
776	12	769 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 308(2):227-233 Yasuda J; Tsuchiya A; Yamada T; Sakamoto M; Sekiya T; Hirohashi S Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells	0	0
777	4	770 2003 BIOCHEMICAL JOURNAL 375():465-470 Qu N; Ignatenko NA; Yamauchi P; Stringer DE; Levenson C; Shannon P; Perrin S; Gerner EW Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine	0	0
778	6	771 2003 BIOCHEMICAL PHARMACOLOGY 66(2):179-189 Harwood AJ; Agam G Search for a common mechanism of mood stabilizers	0	0
779	8	772 2003 BIOCHEMICAL SOCIETY TRANSACTIONS 31():388-392 Babbar N; Gerner EW Polyamines as modifiers of genetic risk factors in human intestinal cancers	0	0
780	70	773 2003 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1653(1):1-24 Giles RH; van Es JH; Clevers H Caught up in a Wnt storm: Wnt signaling in cancer	1	0
781	12	774 2003 BMC MOLECULAR BIOLOGY 4():- Cong F; Zhang JX; Pao W; Zhou PB; Varmus H A protein knockdown strategy to study the function of beta-catenin in tumorigenesis	0	0
782	2	775 2003 BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 36(8):975-985 Cerutti JM; Riggins GJ; de Souza SJ What can digital transcript profiling reveal about human cancers?	0	0
783	19	776 2003 BREAST CANCER RESEARCH 5(2):63-68 Miyoshi K; Hennighausen L beta-catenin: a transforming actor on many stages	1	0
784	2	777 2003 BRITISH JOURNAL OF CANCER 88(10):1560-1565 Yu J; Leung WK; Ebert MPA; Leong RWL; Tse PCH; Chan MWY; Bai AHC; To KF; Malfertheiner P; Sung JJY Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer	0	0
785	11	778 2003 BRITISH JOURNAL OF CANCER 88(11):1734-1739 Nakajima M; Fukuchi M; Miyazaki T; Masuda N; Kato H; Kuwano H Reduced expression of Axin correlates with tumour progression of oesophageal squamous cell carcinoma	0	0
786	12	779 2003 BRITISH JOURNAL OF CANCER 88(11):1755-1762 Marotta A; Parhar K; Owen D; Dedhar S; Salh B Characterisation of integrin-linked kinase signalling in sporadic human colon cancer	0	0
787	3	780 2003 BRITISH JOURNAL OF CANCER 89(1):152-157 Yamamoto T; Konishi K; Yamochi T; Makino R; Kaneko K; Shimamura T; Ota H; Mitamura K No major tumorigenic role for beta-catenin in serrated as opposed to conventional colorectal adenomas	0	0
788	5	781 2003 BRITISH JOURNAL OF DERMATOLOGY 148(5):964-970 El-Bahrawy M; El-Masry N; Alison M; Poulsom R; Fallowfield M Expression of beta-catenin in basal cell carcinoma	0	0
789	17	782 2003 CANCER LETTERS 193(2):161-170 Zhou L; An NL; Haydon RC; Zhou QX; Cheng HW; Peng Y; Jiang W; Luu HH; Vanichakarn P; Szatkowski JP; Park JY; Breyer B; He TC Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity	0	0
790	9	783 2003 CANCER LETTERS 196(1):1-12 Dixelius J; Cross MJ; Matsumoto T; Claesson-Welsh L Endostatin action and intracellular signaling: beta-catenin as a potential target?	0	0
791	10	784 2003 CANCER RESEARCH 63(3):728-734 Araki Y; Okamura S; Hussain SP; Nagashima M; He PJ; Shiseki M; Miura K; Harris CC Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways	4	0
792	8	785 2003 CANCER RESEARCH 63(4):801-806 Sasaki T; Suzuki H; Yagi K; Furuhashi M; Yao R; Susa S; Noda T; Arai Y; Miyazono K; Kato M Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc	2	0
793	11	787 2003 CANCER RESEARCH 63(10):2658-2664 Gilles C; Polette M; Mestdagt M; Nawrocki-Raby B; Ruggeri P; Birembaut P; Foidart JM Transactivation of vimentin by beta-catenin in human breast cancer cells	0	0
794	21	788 2003 CANCER RESEARCH 63(11):2913-2922 Schwartz DR; Wu R; Kardia SLR; Levin AM; Huang CC; Shedden KA; Kuick R; Misek DE; Hanash SM; Taylor JMG; Reed H; Hendrix N; Zhai Y; Fearon ER; Cho KR Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas	0	0
795	12	789 2003 CANCER RESEARCH 63(12):3145-3153 Easwaran V; Lee SH; Inge L; Guo L; Goldbeck C; Garrett E; Wiesmann M; Garcia PA; Fuller JH; Chan V; Randazzo F; Gundel R; Warren RS; Escobedo J; Aukerman SL; Taylor RN; Fantl WJ beta-catenin regulates vascular endothelial growth factor expression in colon cancer	0	0
796	4	790 2003 CANCER RESEARCH 63(15):4368-4374 Chen TA; Yang I; Irby R; Shain KH; Wang HG; Quackenbush J; Coppola D; Cheng JQ; Yeatman TJ Regulation of caspase expression and apoptosis by adenomatous polyposis coli	0	0
797	6	791 2003 CANCER RESEARCH 63(15):4547-4551 Uematsu K; Kanazawa S; You L; He B; Xu ZD; Li K; Peterlin BM; McCormick F; Jablons DM Wnt pathway activation in mesothelioma: Evidence of dishevelled overexpression and transcriptional activity of beta-catenin	0	0
798	6	792 2003 CANCER RESEARCH 63(15):4641-4647 Seike M; Kondo T; Mori Y; Gemma A; Kudoh S; Sakamoto M; Yamada T; Hirohashi S Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin	0	0
799	4	793 2003 CANCER RESEARCH 63(16):4773-4776 Siu IM; Lal A; Blankenship JR; Aldosari N; Riggins GJ c-myc promoter activation in medulloblastoma	0	0
800	2	794 2003 CANCER RESEARCH 63(16):4836-4841 Bertolino P; Tong WM; Herrera PL; Casse H; Zhang CX; Wang ZQ Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
801	7	795 2003 CANCER RESEARCH 63(16):4990-4996 Yang WC; Bancroft L; Nicholas C; Lozonschi I; Augenlicht LH Targeted inactivation of p27(kip1) is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a western-style high-risk diet	0	0
802	6	796 2003 CANCER RESEARCH 63(19):6116-6120 Shimokawa T; Furukawa Y; Sakai M; Li MH; Miwa N; Lin YM; Nakamura Y Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex	0	0
803	3	797 2003 CANCER RESEARCH 63(19):6212-6220 Gatenby RA; Vincent TL An evolutionary model of carcinogenesis	0	0
804	3	798 2003 CANCER RESEARCH 63(19):6244-6251 Ayala G; Wang DG; Wulf G; Frolov A; Li R; Sowadski J; Wheeler TM; Lu KP; Bao L The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer	0	0
805	5	799 2003 CANCER RESEARCH 63(20):6626-6634 Chen DH; Xu WD; Bales E; Colmenares C; Conacci-Sorrell M; Ishii S; Stavnezer E; Campisi J; Fisher DE; Ben-Ze'ev A; Medrano EE SKI activates Wnt/beta-catenin signaling in human melanoma	0	0
806	9	800 2003 CANCER SCIENCE 94(1):103-111 Saegusa M; Hamano M; Kuwata T; Yoshida T; Hashimura M; Akino F; Watanabe J; Kuramoto H; Okayasu I Up-regulation and nuclear localization of beta-catenin in endometrial carcinoma in response to progestrone therapy	0	0
807	2	801 2003 CANCER SCIENCE 94(3):297-301 Hoshida Y; Hongyo T; Jia XS; He YJ; Hasui K; Dong ZM; Luo WJ; Ham MF; Nomura T; Aozasa K Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China	0	0
808	7	802 2003 CANCER SCIENCE 94(6):515-518 Nagahata T; Shimada T; Harada A; Nagai H; Onda M; Yokoyama S; Shiba T; Jin EJ; Kawanami O; Emi M Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers	0	0
809	1	803 2003 CANCER TREATMENT REVIEWS 29():49-57 Nalepa G; Harper JW Therapeutic anti-cancer targets upstream of the proteasome	0	0
810	6	804 2003 CARCINOGENESIS 24(1):17-24 Campbell PM; Szyf M Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway	0	0
811	4	806 2003 CARCINOGENESIS 24(4):643-650 Husoy T; Cruciani V; Knutsen HK; Mikalsen SO; Olstorn HB; Alexander J Cells heterozygous for the Apc(Min) mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization	0	0
812	7	807 2003 CARCINOGENESIS 24(6):1015-1019 Yamada Y; Mori H Pre-cancerous lesions for colorectal cancers in rodents: a new concept	0	0
813	5	808 2003 CELL DEATH AND DIFFERENTIATION 10(5):528-538 Lacher MD; Siegenthaler A; Jager R; Yan X; Hett S; Xuan L; Saurer S; Lareu R; Dharmarajan AM; Friis R Role of DDC-4/sFRP-4, a secreted Frizzled-related protein, at the onset of apoptosis in mammary involution	1	0
814	8	809 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(3):495-506 Janssen KP Murine models of colorectal cancer: studying the role of oncogenic K-ras	0	0
815	2	810 2003 CELLULAR SIGNALLING 15(3):327-338 Denoyelle C; Albanese P; Uzan G; Hong L; Vannier JP; Soria J; Soria C Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells	2	0
816	3	811 2003 CLINICAL & EXPERIMENTAL METASTASIS 20(1):85-90 Yeatman TJ; Chambers AF Osteopontin and colon cancer progression	1	0
817	4	812 2003 CLINICAL & EXPERIMENTAL METASTASIS 20(6):525-529 Iwaya K; Ogawa H; Kuroda M; Izumi M; Ishida T; Mukai K Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis	0	0
818	3	813 2003 CLINICAL CANCER RESEARCH 9(1):1-9 Koeffler HP Peroxisome proliferator-activated receptor gamma and cancers	0	0
819	7	814 2003 CLINICAL CANCER RESEARCH 9(3):931-946 Williams NS; Gaynor RB; Scoggin S; Verma U; Gokaslan T; Simmang C; Fleming J; Tavana D; Frenkel E; Becerra C Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference	1	0
820	11	815 2003 CLINICAL CANCER RESEARCH 9(4):1291-1300 Verma UN; Surabhi RM; Schmaltieg A; Becerra C; Gaynor RB Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells	3	0
821	13	816 2003 CLINICAL CANCER RESEARCH 9(6):2121-2132 Shiina H; Igawa M; Breault J; Ribeiro L; Pookot D; Urakami S; Terashima M; Deguchi M; Yamanaka M; Shirai M; Kaneuchi M; Kane CJ; Dahiya R The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma	0	0
822	9	817 2003 CLINICAL CANCER RESEARCH 9(8):3073-3079 Zhang B; Ougolkov A; Yamashita K; Takahashi Y; Mai M; Minamoto T beta-catenin and ras oncogenes detect most human colorectal cancer	0	0
823	10	818 2003 CLINICAL CANCER RESEARCH 9(9):3383-3388 Maelandsmo GM; Holm R; Nesland JM; Fodstad O; Florenes VA Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma	0	0
824	5	819 2003 CURRENT MOLECULAR MEDICINE 3(5):472-482 Harwood AJ Neurodevelopment and mood stabilizers	0	0
825	6	820 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(1):28-33 van Es JH; Barker N; Clevers H You Wnt some, you lose some: oncogenes in the Wnt signaling pathway	2	0
826	6	821 2003 CURRENT OPINION IN ONCOLOGY 15(1):44-49 Hermeking H Serial analysis of gene expression and cancer	0	0
827	3	823 2003 DEVELOPMENT GROWTH & DIFFERENTIATION 45(2):121-128 Miyawaki K; Yamamoto M; Saito K; Saito S; Kobayashi N; Matsuda S Nuclear localization of beta-catenin in vegetal pole cells during early embryogenesis of the starfish Asterina pectinifera	0	0
828	2	824 2003 DEVELOPMENTAL BIOLOGY 259(1):48-61 Stump RJW; Ang S; Chen YJ; von Bahr T; Lovicu FJ; Pinson K; de Iongh RU; Yamaguchi TP; Sassoon DA; McAvoy JW A role for Wnt/beta-catenin signaling in lens epithelial differentiation	0	0
829	4	825 2003 DEVELOPMENTAL BIOLOGY 261(1):165-182 Karsten SL; Kudo LC; Jackson R; Sabatti C; Kornblum HI; Geschwind DH Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks	0	0
830	7	827 2003 DIAGNOSTIC MOLECULAR PATHOLOGY 12(1):44-49 Smyth P; Finn S; O'Leary J; Sheils O Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues	0	0
831	4	828 2003 EMBO JOURNAL 22(3):494-501 Dajani R; Fraser E; Roe SM; Yeo M; Good VM; Thompson V; Dale TC; Pearl LH Structural basis for recruitment of glycogen synthase kinase 3 beta to the axin-APC scaffold complex	3	0
832	6	829 2003 EMBO JOURNAL 22(12):3084-3094 Hocevar BA; Mou F; Rennolds JL; Morris SM; Cooper JA; Howe PH Regulation of the Wnt signaling pathway by disabled-2 (Dab2)	0	0
833	7	830 2003 EMBO REPORTS 4(2):166-171 Civenni G; Holbro T; Hynes NE Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells	1	0
834	3	831 2003 ENDOCRINOLOGY 144(8):3618-3624 Fagman H; Grande M; Edsbagge J; Semb H; Nilsson M Expression of classical cadherins in thyroid development: Maintenance of an epithelial phenotype throughout organogenesis	0	0
835	4	832 2003 EXPERIMENTAL CELL RESEARCH 285(1):131-145 Coppe JP; Smith AP; Desprez PY Id proteins in epithelial cells	1	0
836	14	833 2003 GASTROENTEROLOGY 124(1):202-216 Monga SPS; Monga HK; Tan XP; Mule K; Pediaditakis P; Michalopoulos GK beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification	0	0
837	1	834 2003 GENE 307():51-62 Shimizu K; Chen W; Ashique AM; Moroi R; Li YP Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene	1	0
838	9	835 2003 GENES & DEVELOPMENT 17(4):488-501 Gunther EJ; Moody SE; Belka GK; Hahn KT; Innocent N; Dugan KD; Cardiff RD; Chodosh LA Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis	3	0
839	11	836 2003 GENES & DEVELOPMENT 17(10):1189-1200 Alonso L; Fuchs E Stem cells in the skin: waste not, Wnt not	1	0
840	3	837 2003 GUT 52(5):759-766 Ho GT; Moodie FM; Satsangi J Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?	0	0
841	5	838 2003 GYNECOLOGIC ONCOLOGY 88(3):363-368 Lee CM; Shvartsman H; Deavers MT; Wang SC; Xia WY; Schmandt R; Bodurka DC; Atkinson EN; Malpica A; Gershenson DM; Hung MC; Lu KH beta-Catenin nuclear localization is associated with grade in ovarian serous carcinoma	1	0
842	5	839 2003 HEPATOLOGY 37(3):528-533 Yamamoto Y; Sakamoto M; Fujii G; Tsuiji H; Kanetaka K; Asaka M; Hirohashi S Overexpression of orphan G-Protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations	1	0
843	10	840 2003 HEPATOLOGY 38(1):178-186 Shibata T; Chuma M; Kokubu A; Sakamoto N; Hirohashi S EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma	0	0
844	4	841 2003 IMMUNITY 19(2):169-182 Chi TH; Wan MM; Lee PP; Akashi K; Metzger D; Chambon P; Wilson CB; Crabtree GR Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development	1	0
845	6	842 2003 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 35(7):1034-1051 Visvader JE; Lindeman GJ Transcriptional regulators in mammary gland development and cancer	0	0
846	9	843 2003 INTERNATIONAL JOURNAL OF CANCER 103(4):435-439 Dietrich C; Faust D; Moskwa M; Kunz A; Bock KW; Oesch F TCDD-dependent downregulation of gamma-catenin in rat liver epithelial cells (WB-F344)	0	0
847	1	845 2003 INTERNATIONAL JOURNAL OF CANCER 104(1):44-53 Kohya N; Kitajima Y; Jiao W; Miyazaki K Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: Repression of MTS1/S100A4 gene expression	0	0
848	4	846 2003 INTERNATIONAL JOURNAL OF CANCER 104(1):60-65 Fricke E; Keller G; Becker I; Rosivatz E; Schott C; Plaschke S; Rudelius M; Hermannstadter C; Busch R; Hofler H; Becker KF; Luber B Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma	0	0
849	20	847 2003 INTERNATIONAL JOURNAL OF CANCER 106(5):653-660 Pajari AM; Rajakangas J; Paivarinta E; Kosma VM; Rafter J; Mutanen M Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic beta-catenin in Min mice	0	0
850	9	848 2003 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 11(4):461-464 Miao JY; Kusafuka T; Kuroda S; Yoneda A; Zhou ZW; Okada A Mutation of beta-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis	0	0
851	9	849 2003 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 11(1):1-9 Nabais S; Machado JC; Lopes C; Seruca R; Carneiro F; Sobrinho-Simoes M Patterns of beta-catenin expression in gastric carcinoma: Clinicopathological relevance and mutation analysis	0	0
852	3	850 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(2):1380-1387 Ni ZY; Anini Y; Fang XJ; Mills G; Brubakers PL; Jin TR Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells	2	0
853	4	852 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(14):11937-11944 Kahler RA; Westendorf JJ Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter	0	0
854	12	853 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(15):13487-13495 Lyu J; Costantini F; Jho EH; Joo CK Ectopic expression of axin blocks neuronal differentiation of embryonic carcinoma P19 cells	0	0
855	13	854 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(16):14274-14283 Duchesne C; Charland S; Asselin C; Nahmias C; Rivard N Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells	0	0
856	14	855 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20259-20267 Ghiselli G; Coffee N; Munnery CE; Koratkar R; Siracusa LD The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway	0	0
857	13	856 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(33):30828-30834 Amir AL; Barua M; McKnight NC; Cheng ST; Yuan X; Balk SP A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4	0	0
858	11	857 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(39):38029-38039 Wen YF; Caffrey TC; Wheelock MJ; Johnson KR; Hollingsworth MA Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin	0	0
859	1	858 2003 JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 85A(8):1544-1552 Cheng HW; Jiang W; Phillips FM; Haydon RC; Peng Y; Zhou L; Luu HH; An NL; Breyer B; Vanichakarn P; Szatkowski JP; Park JY; He TC Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)	1	0
860	68	859 2003 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 129(4):199-221 Lustig B; Behrens J The Wnt signaling pathway and its role in tumor development	1	0
861	16	860 2003 JOURNAL OF CELL SCIENCE 116(5):773-783 Ryo A; Liou YC; Lu KP; Wulf G Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer	2	0
862	9	861 2003 JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY 56(5):280-285 Pham K; Milovanovic T; Barr RJ; Truong T; Holcombe RF Wnt ligand expression in malignant melanoma: pilot study indicating correlation with histopathological features	0	0
863	8	862 2003 JOURNAL OF IMMUNOLOGY 171(2):769-775 Ioannidis V; Kunz A; Tanamachi DM; Scarpellino L; Held W Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1	0	0
864	13	863 2003 JOURNAL OF INVESTIGATIVE DERMATOLOGY 121(2):242-251 Hu PQ; Berkowitz P; O'Keefe EJ; Rubenstein DS Keratinocyte adherens junctions initiate nuclear signaling by translocation of plakoglobin from the membrane to the nucleus	0	0
865	23	864 2003 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 8(2):145-158 Hatsell S; Rowlands T; Hiremath M; Cowin P beta-catenin and Tcfs in mammary development and cancer	0	0
866	3	865 2003 JOURNAL OF MEDICAL GENETICS 40(4):- Lipton L; Sieber OM; Thomas HJW; Hodgson SV; Tomlinson IPM; Woodford-Richens K Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype	0	0
867	5	866 2003 JOURNAL OF MOLECULAR BIOLOGY 330(5):955-966 Reimer T; Weiwad M; Schierhorn A; Ruecknagel PK; Rahfeld JU; Bayer P; Fischer G Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14	0	0
868	6	867 2003 JOURNAL OF NEUROSCIENCE RESEARCH 73(2):166-175 Uemura K; Kitagawa N; Kohno R; Kuzuya A; Kageyama T; Shibasaki H; Shimohama S Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling	0	0
869	7	868 2003 JOURNAL OF NUTRITION 133(6):1943-1948 Rajakangas J; Basu S; Salminen I; Mutanen M Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappa B and cyclin D1 protein levels in the Min mouse	0	0
870	10	869 2003 JOURNAL OF PATHOLOGY 199(1):68-76 Koesters R; Niggli F; Doeberitz MV; Stallmach T Nuclear accumulation of beta-catenin protein in Wilms' tumours	1	0
871	1	870 2003 JOURNAL OF PATHOLOGY 200(1):59-64 Sawyer EJ; Poulsom R; Hunt FT; Jeffery R; Elia G; Ellis IO; Ellis P; Tomlinson IPM; Hanby AM Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit	0	0
872	15	871 2003 JOURNAL OF PATHOLOGY 201(2):250-259 Prange W; Breuhahn K; Fischer F; Zilkens C; Pietsch T; Petmecky K; Eilers R; Dienes HP; Schirmacher P Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes	0	0
873	5	872 2003 JOURNAL OF THE NATIONAL CANCER INSTITUTE 95(12):896-905 Kumagai T; O'Kelly J; Said JW; Koeffler HP Vitamin D-2 analog 19-nor-1,25-dihydroxyvitamin D-2: Antitumor activity against leukemia, myeloma, and colon cancer cells	0	0
874	3	873 2003 JOURNAL OF UROLOGY 170(5):1892-1896 Bryan RT; Nicholls JH; Harrison RF; Jankowski JA; Wallace DMA The role of beta-catenin signaling in the malignant potential of cystitis glandularis	0	0
875	3	874 2003 JOURNAL OF VETERINARY MEDICAL SCIENCE 65(8):853-856 Nakamuta N; Kobayashi S Expression of p63 in the testis of mouse embryos	0	0
876	9	875 2003 LANCET 362(9379):205-209 Kim PJ; Plescia J; Clevers H; Fearon ER; Altieri DC Survivin and molecular pathogenesis of colorectal cancer	1	0
877	2	876 2003 LEUKEMIA RESEARCH 27(4):359-361 Takeuchi S; Takeuchi N; Fermin AC; Taguchi H; Koeffler HP Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability	0	0
878	7	877 2003 LIFE SCIENCES 72(11):1303-1320 Pearson CA; Lamar PC; Prozialeck WC Effects of cadmium on E-cadherin and VE-cadherin in mouse lung	1	0
879	2	878 2003 LUNG CANCER 40(2):111-121 Sanchez-Cespedes M Dissecting the genetic alterations involved in lung carcinogenesis	0	0
880	2	879 2003 M S-MEDECINE SCIENCES 19(8-9):788-790 Hamelin R; Duval A beta-catenin and cell proliferation in normal and transformed intestinal cells	0	0
881	9	880 2003 MECHANISMS OF AGEING AND DEVELOPMENT 124(5):697-708 Lim IK Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats (vol 123, pg 1665, 2002)	0	0
882	6	881 2003 MECHANISMS OF DEVELOPMENT 120(2):157-165 Marygold SJ; Vincent JP Armadillo levels are reduced during mitosis in Drosophila	0	0
883	7	882 2003 MODERN PATHOLOGY 16(1):57-65 Venesio T; Balsamo A; Scordamaglia A; Bertolaso M; Arrigoni A; Sprujevnik T; Rossini FP; Risio M Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas	0	0
884	13	883 2003 MOLECULAR AND CELLULAR BIOLOGY 23(11):3936-3950 Grueneberg DA; Pablo L; Hu KQ; August P; Weng ZG; Papkoff J A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway	0	0
885	3	884 2003 MOLECULAR AND CELLULAR BIOLOGY 23(18):6694-6701 Rao P; Kadesch T The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells	0	0
886	12	885 2003 MOLECULAR BIOLOGY OF THE CELL 14(2):585-599 Albanese C; Wu KM; D'Amico M; Jarrett C; Joyce D; Hughes J; Hulit J; Sakamaki T; Fu MF; Ben-Ze'ev A; Bromberg JF; Lamberti C; Verma U; Gaynor RB; Byers SW; Pestell RG IKK alpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf	1	0
887	19	886 2003 MOLECULAR BIOLOGY OF THE CELL 14(7):2844-2860 Olmeda D; Castel S; Vilaro S; Cano A beta-catenin regulation during the cell cycle: Implications in G2/M and apoptosis	0	0
888	11	887 2003 MOLECULAR CANCER THERAPEUTICS 2(1):113-121 Kirmizis A; Bartley SM; Farnham PJ Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy	1	0
889	13	888 2003 MOLECULAR CANCER THERAPEUTICS 2(9):885-892 Rice PL; Kelloff J; Sullivan H; Driggers LJ; Beard KS; Kuwada S; Piazza G; Ahnen DJ Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells	0	0
890	9	889 2003 MOLECULAR CARCINOGENESIS 36(4):195-203 Blum CA; Tanaka T; Zhong XY; Li QJ; Dashwood WM; Pereira C; Xu MR; Dashwood RH Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: Mutational 'hotspots' and the relative expression of beta-catenin and c-jun	0	0
891	9	891 2003 NATURE MEDICINE 9(3):300-306 Fujimuro M; Wu FY; ApRhys C; Kajumbula H; Young DB; Hayward GS; Hayward SD A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency	2	0
892	5	892 2003 NATURE REVIEWS NEUROSCIENCE 4(10):795-805 Gammill LS; Bronner-Fraser M Neural crest specification: Migrating into genomics	1	0
893	1	893 2003 NEOPLASIA 5(4):347-361 Nightingale J; Chaudhary KS; Abel PD; Stubbs AP; Romanska HM; Mitchell SE; Stamp GWH; Lalani EN Ligand activation of the androgen receptor downregulates E-cadherin-mediated cell adhesion and promotes apoptosis of prostatic cancer cells	0	0
894	12	894 2003 NUCLEIC ACIDS RESEARCH 31(9):2369-2380 Valenta T; Lukas J; Korinek V HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells	0	0
895	2	895 2003 NUCLEIC ACIDS RESEARCH 31(19):5789-5804 Gadal F; Bozic C; Pillot-Brochet C; Malinge S; Wagner S; Le Cam A; Buffat L; Crepin M; Iris F Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line	0	0
896	7	896 2003 ONCOGENE 22(9):1324-1332 Schroeder JA; Adriance MC; Thompson MC; Camenisch TD; Gendler SJ MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion	1	0
897	3	897 2003 ONCOGENE 22(21):3297-3306 Wang WS; Chen PM; Hsiao HL; Ju SY; Su Y Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells	0	0
898	5	898 2003 ONCOGENE 22(24):3821-3826 Udtha M; Lee SJ; Alam R; Coombes K; Huff V Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors	0	0
899	11	899 2003 ONCOGENE 22(25):3901-3910 Yam JWP; Chan KW; Hsiao WLW Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB	0	0
900	5	900 2003 ONCOGENE 22(39):5978-5986 Usami N; Sekido Y; Maeda O; Yamamoto K; Minna JD; Hasegawa Y; Yoshioka H; Imaizumi M; Ueda Y; Takahashi M; Shimokata K beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
901	12	901 2003 ONCOGENE 22(38):6013-6022 Fagman H; Larsson F; Arvidsson Y; Meuller J; Nordling M; Martinson T; Helmbrecht K; Brabant G; Nilsson M Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation	0	0
902	5	902 2003 ONCOGENE 22(42):6517-6523 Reiss K; Khalili K Viruses and cancer: lessons from the human polyomavirus, JCV	0	0
903	9	903 2003 ONCOLOGY REPORTS 10(2):455-461 Miyashita H; Mori S; Motegi K; Fukumoto M; Uchida T Pin1 is overexpressed in oral squamous cell carcinoma and its levels correlate with cyclin D1 overexpression	0	0
904	5	904 2003 ONCOLOGY REPORTS 10(5):1219-1223 Okino K; Nagai H; Hatta M; Nagahata T; Yoneyama K; Ohta Y; Jin EJ; Kawanami O; Araki T; Emi M Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma	0	0
905	9	905 2003 ORGANIC LETTERS 5(16):2927-2930 Hale KJ; Domostoj MM; Tocher DA; Irving E; Scheinmann F Enantiospecific formal total synthesis of the tumor and GSK-3 beta inhibiting alkaloid, (-)-agelastatin A	1	0
906	6	906 2003 PATHOLOGE 24(1):49-60 Baldus SE Clinical, pathological and molecular prognostic factors in colorectal carcinomas	0	0
907	9	907 2003 PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 2(8):825-834 Ehrhart JC; Gosselet FP; Culerrier RM; Sarasin A UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis	0	0
908	15	908 2003 PHYSIOLOGICAL REVIEWS 83(2):337-376 Mareel M; Leroy A Clinical, cellular, and molecular aspects of cancer invasion	4	0
909	9	909 2003 PIGMENT CELL RESEARCH 16(3):312-317 Larue L; Kumasaka M; Goding CR beta-catenin in the melanocyte lineage	0	0
910	2	910 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(3):1004-1009 Stappenbeck TS; Mills JC; Gordon JI Molecular features of adult mouse small intestinal epithelial progenitors	2	0
911	4	911 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(6):3245-3250 Baek SH; Kioussi C; Briata P; Wang DG; Nguyen HD; Ohgi KA; Glass CK; Wynshaw-Boris A; Rose DW; Rosenfeld MG Regulated subset of G(1) growth-control genes in response to derepression by the Wnt pathway	4	0
912	7	912 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(13):7859-7864 Martinez ME; O'Brien TG; Fultz KE; Babbar N; Yerushalmi H; Qu N; Guo YJ; Boorman D; Einspahr J; Alberts DS; Gerner EW Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene	1	0
913	5	913 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(15):8752-8757 Nakayama K; Hatakeyama S; Maruyama S; Kikuchi A; Onoe K; Good RA; Nakayama KI Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene	1	0
914	6	914 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(16):9524-9529 Baluchamy S; Rajabi HN; Thimmapaya R; Navaraj A; Thimmapaya B Repression of c-Myc and inhibition of G(1) exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity	1	0
915	9	915 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(18):10429-10434 Ohira T; Gemmill RM; Ferguson K; Kusy S; Roche J; Brambilla E; Zeng C; Baron A; Bemis L; Erickson P; Wilder E; Rustgi A; Kitajewski J; Gabrielson E; Bremnes R; Franklin W; Drabkin HA WNT7a induces E-cadherin in lung cancer cells	0	0
916	9	916 2003 THYROID 13(6):537-545 Meirmanov S; Nakashima M; Kondo H; Matsufuji R; Takamura N; Ishigaki K; Ito M; Prouglo Y; Yamashita S; Sekine I Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site	0	0
917	9	917 2003 TOXICOLOGY AND APPLIED PHARMACOLOGY 190(2):135-145 Anna CH; Iida M; Sills RC; Devereux TR Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice	0	0
918	2	918 2003 TRENDS IN CELL BIOLOGY 13(3):146-150 Wanzel M; Herold S; Eilers M Transcriptional repression by Myc	1	0
919	12	919 2003 TRENDS IN CELL BIOLOGY 13(6):310-318 Balda MS; Matter K Epithelial cell adhesion and the regulation of gene expression	0	0

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