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Papers by DE Koshland
and the papers citing DE Koshland

Nodes: 18789, Authors: 32142, Journals: 2179, Outer References: 517928, Words: 22058
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Collection span: 1949 - 2006
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Page 139 of 188:  1  |  101   111   121  [  131  132  133  134  135  136  137  138  139  140 ]  141   151   161   171   181 

#LCRNCRNode / Date / Journal / AuthorLCSGCS
138012213801 1996 BIOPHYSICAL JOURNAL 70 (2): SU473-SU473
Balazs YS; DelFederico E; Wang J; Thompson LK
Probing the ligand-binding site of the transmembrane serine receptor using solid-state NMR
00
1380225213802 1996 BIOPHYSICAL JOURNAL 71 (3): 1596-1604
Ghelichkhani E; Goldbeck RA; Lewis JW; Kliger DS
Nanosecond time-resolved absorption studies of human oxyhemoglobin photolysis intermediates
410
1380333313803 1996 BIOPHYSICAL JOURNAL 71 (4): 2040-2048
Baxa U; Steinbacher S; Miller S; Weintraub A; Huber R; et al.
Interactions of phage P22 tails with their cellular receptor, Salmonella O-antigen polysaccharide
229
1380473413804 1996 BIOPHYSICAL JOURNAL 71 (4): 2106-2116
Huang YW; Koestner ML; Ackers GK
Heterotropic effects of chloride on the ligation microstates of hemoglobin at constant water activity
413
13805173213805 1996 BIOPHYSICAL JOURNAL 71 (4): 2227-2233
Tumer L; Caplan SR; Berg HC
Temperature-induced switching of the bacterial flagellar motor
00
1380652913806 1996 BIOPHYSICAL JOURNAL 71 (6): 3083-3090
Zhang HJ; Liu Y; Zuhlke RD; Joho RH
Oxidation of an engineered pore cysteine locks a voltage-gated K+ channel in a nonconducting state
15
1380713513807 1996 BIOPOLYMERS 39 (5): 737-751
Andre G; Buleon A; Tran V; Vallee F; Juy M; et al.
Amylose chain behavior in an interacting context .1. Influence of a nonchair ring on the maltose conformations
15
1380824913808 1996 BIOSCIENCE 46 (1): 42-51
Berkowitz A
Our genes, ourselves?
04
1380912013809 1996 BIOSCIENCE REPORTS 16 (6): 453-458
Basu PS; Datta PK; Datta TK
Possible mechanism for the inhibition of lectin-erythrocyte interaction in presence of endogenous lectin receptor
00
1381031113810 1996 BIOSYSTEMS 39 (2): 109-116
Acerenza L
Sensitivity constraints in a chemical/biochemical highly responsive system
47
#LCRNCRNode / Date / Journal / AuthorLCSGCS
13811112913811 1996 BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 24: 13-18
Chang CT; Liou HY; Tang HL; Sung HY
Activation, purification and properties of beta-amylase from sweet potatoes (Ipomoea batatas)
04
13812116513812 1996 BIOTECHNOLOGY AND BIOENGINEERING 49 (2): 111-129
Marx A; deGraaf AA; Wiechert W; Eggeling L; Sahm H
Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
19159
13813183913813 1996 BIOTECHNOLOGY AND BIOENGINEERING 51 (1): 120-125
Liu ZW; Papadopoulos KD
A method for measuring bacterial chemotaxis parameters in a microcapillary
28
1381432613814 1996 BIOTECHNOLOGY AND BIOENGINEERING 51 (6): 624-635
Hartbrich A; Schmitz G; WeusterBotz D; deGraaf AA; Wandrey C
Development and application of a membrane cyclone reactor for in vivo NMR spectroscopy with high microbial cell densities
023
1381557313815 1996 BIOTECHNOLOGY PROGRESS 12 (4): 423-433
Sears P; Wong CH
Engineering enzymes for bioorganic synthesis: Peptide bond formation
327
1381615313816 1996 BLOOD 87 (6): 2486-2495
Tos AG; Cignetti A; Rovera G; Foa R
Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect
113
1381713813817 1996 BLOOD 88 (11): 4296-4303
BenYehuda D; Krichevsky S; Caspi O; Rund D; Polliack A; et al.
Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype
0113
1381822213818 1996 BRAIN RESEARCH 706 (1): 169-172
Gillardon F; Skutella T; Uhlmann E; Holsboer F; Zimmermann M
Activation of c-Fos contributes to amyloid beta-peptide-induced neurotoxicity
034
1381915513819 1996 BRAIN RESEARCH 710 (1-2): 1-10
Zhang C; Bachoo M; Polosa C
Long-term depression of a sympathetic ganglionic response to opioids by prolonged synaptic activity and by phorbol esters
05
1382035513820 1996 BRAIN RESEARCH 715 (1-2): 145-154
Wiklund P; Ekstrom PAR; Edbladh M; Tonge D; Edstrom A
Protein kinase C and mouse sciatic nerve regeneration
015
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1382115113821 1996 BRAIN RESEARCH 742 (1-2): 129-140
Stuenkel EL; Dayanithi G; Nordmann JJ
Arachidonic acid regulation of vasopressin release and intracellular Ca2+ in neurohypophysial nerve endings
01
1382212813822 1996 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 69 (6): 1639-1643
Fett R; Brighente IMC; Yunes RA
Influence of calcium ions on the mechanism of oxime formation from acetoin
12
1382311713823 1996 CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS 5 (2): 300-306
Biesecker LG
Orphan tests
03
1382411513824 1996 CANADIAN JOURNAL OF CARDIOLOGY 12 (10): 1007-1011
Olley PM
Basic research: A continuing imperative for clinical practice
00
1382544713825 1996 CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE 74 (1): 38-48
LeonLai CH; Gresser MJ; Tracey AS
Influence of vanadium(V) complexes on the catalytic activity of ribonuclease A. The role of vanadate complexes as transition state analogues to reactions at phosphate
016
13826112213826 1996 CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE 74 (7): 1283-1296
Guthrie JP
1995 Syntex Award Lecture - Correlation and prediction of rate constants for organic reactions
09
1382736813827 1996 CANCER JOURNAL 9 (1): 47-53
Zusman I; Korol D; Zusman R; Gurevich P; Smirnoff P
Effects of heat shock and a carcinogen (1,2-dimethylhydrazine) on the time-dependent p53 protein concentration in the rat serum
27
138283019213828 1996 CANCER SURVEYS 27: 213-248
Blobe GC; Stribling S; Obeid LM; Hannun YA
Protein kinase C isoenzymes: Regulation and function
8116
13829127013829 1996 CELL 84 (3): 401-410
Hyman AA; Karsenti E
Morphogenetic properties of microtubules and mitotic spindle assembly
8192
1383054313830 1996 CELL BIOCHEMISTRY AND FUNCTION 14 (4): 269-276
Brindle KM
Analysis of metabolic control in vivo using molecular genetics
00
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1383193113831 1996 CELL MOTILITY AND THE CYTOSKELETON 35 (2): 121-133
Thrower DA; Jordan MA; Wilson L
Modulation of CENP-E organization at kinetochores by spindle microtubule attachment
022
1383282013832 1996 CELL STRUCTURE AND FUNCTION 21 (5): 375-379
Inoue S
Mitotic organization and force generation by assembly/disassembly of microtubules
03
13833910713833 1996 CELLULAR AND MOLECULAR BIOLOGY 42 (7): 1065-1096
Salhany JM
Allosteric effects in stilbenedisulfonate binding to band 3 protein (AE1)
120
1383406713834 1996 CHEMICAL COMMUNICATIONS (3): 281-288
James TD; Linnane P; Shinkai S
Fluorescent saccharide receptors: A sweet solution to the design, assembly and evaluation of boronic acid derived PET sensors
0123
1383536913835 1996 CHEMICAL COMMUNICATIONS (14): 1595-1602
Helliwell JR; Helliwell M
X-ray crystallography in structural chemistry and molecular biology
15
1383611213836 1996 CHEMICAL COMMUNICATIONS (20): 2313-2314
Morrison DL; Hoger S
Shape-persistent macrocyclic amphiphiles: Molecular reversible coats
417
1383711213837 1996 CHEMICAL COMMUNICATIONS (22): 2541-2542
Bornaghi L; Utille JP; Penninga D; Schmidt AK; Dijkhuizen L; et al.
Enzymic synthesis of cyclothiomaltins
12
138381613838 1996 CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 17 (3): 392-395
Yu K; Sun Y; Zhang BS; Zhou XZ
Synthesis of diacetylenic lipids and studies on the preparation and stability of polymerized liposomes
01
13839885413839 1996 CHEMICAL REVIEWS 96 (7): 2659-2756
Kappock TJ; Caradonna JP
Pterin-dependent amino acid hydroxylases
4137
13840313513840 1996 CHEMICAL REVIEWS 96 (7): 2951-2964
Averill BA
Dissimilatory nitrite and nitric oxide reductases
5155
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1384123413841 1996 CHEMICO-BIOLOGICAL INTERACTIONS 100 (2): 177-185
Mistry KJ; Krishna M; Pasupathy K; Murthy V; Bhattacharya RK
Signal transduction mechanism in response to anatoxin B-1 exposure: Protein kinase C activity
08
1384212313842 1996 CHEMISTRY & BIOLOGY 3 (1): 31-36
Rochel N; Cowan JA
Negative cooperativity exhibited by the lytic amino-terminal domain of human perforin: Implications for perforin-mediated cell lysis
02
1384324913843 1996 CHEMISTRY & BIOLOGY 3 (3): 151-156
Shoichet BK; Kuntz ID
Predicting the structure of protein complexes: A step in the right direction
229
1384431813844 1996 CHEMISTRY & BIOLOGY 3 (3): 207-215
Cho YR; Maguire AJ; Try AC; Westwell MS; Groves P; et al.
Cooperativity and anti cooperativity between ligand binding and the dimerization of ristocetin A: Asymmetry of a homodimer complex and implications for signal transduction
215
1384502613845 1996 CHEMISTRY & BIOLOGY 3 (12): 1011-1019
Ghosh A; Ghosh M; Niu C; Malouin F; Moellmann U; et al.
Iron transport-mediated drug delivery using mixed-ligand siderophore-beta-lactam conjugates
019
13846613913846 1996 CHEMISTRY OF MATERIALS 8 (8): 1820-1839
Davis ME; Katz A; Ahmad WR
Rational catalyst design via imprinted nanostructured materials
3129
1384724413847 1996 CHEMISTRY-A EUROPEAN JOURNAL 2 (4): 403-411
Kazmierski WM; McDermed J; Aulabaugh A
A new experimental method to determine the mutual orientation of helices in coiled-coil proteins: Structural information about the dimeric interface of cJun, cFos, GCN4, and gp41
05
1384816813848 1996 CHIMIA 50 (4): 144-153
Piguet C
Toward programmed molecular lanthanide probes and sensors
731
138491913849 1996 CHINESE SCIENCE BULLETIN 41 (15): 1297-1302
Sun M; Lu YY
Inhibition of tumorigenicity in human gastric cancer cells by introduction of exogenous g53 gene
11
1385034413850 1996 CIRCULATION RESEARCH 79 (2): 153-161
RouetBenzineb P; Mohammadi K; Perennec J; Poyard M; Bouanani NE; et al.
Protein kinase C isoform expression in normal and failing rabbit hearts
038
#LCRNCRNode / Date / Journal / AuthorLCSGCS
13851216813851 1996 CLINICAL CHEMISTRY 42 (6): 858-868
Velculescu VE; ElDeiry WS
Biological and clinical importance of the p53 tumor suppressor gene
0105
1385212513852 1996 COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE- LIFE SCIENCES 319 (5): 401-404
ThomasVaslin V; Coltey M; Salaun J
On the mechanisms of thymic epithelium induced tolerance
03
1385311513853 1996 CONTEMPORARY PSYCHOLOGY 41 (4): 398-399
Dorfman DD
The Bell Curve is factually incorrect - Reply
00
13854317713854 1996 CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 31 (3): 201-236
Beguin P; Lemaire M
The cellulosome: An exocellular, multiprotein complex specialized in cellulose degradation
1103
13855131813855 1996 CURRENT BIOLOGY 6 (7): 825-827
Stock J
Receptor signaling: Dimerization and beyond
618
13856104113856 1996 CURRENT BIOLOGY 6 (9): 1114-1123
Bornancin F; Parker PJ
Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase C alpha
2582
13857312313857 1996 CURRENT MEDICINAL CHEMISTRY 3 (6): 419-436
Martin JL
Protein crystallography and examples of its applications in medicinal chemistry
09
13858174713858 1996 CURRENT OPINION IN CELL BIOLOGY 8 (3): 381-388
Yen TJ; Schaar BT
Kinetochore function: Molecular motors, switches and gates
218
13859610213859 1996 CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE 1 (3): 412-424
Gittes F; Schmidt CF
Microscopic approaches to dynamics and structure of biological motors
04
1386044613860 1996 CURRENT OPINION IN STRUCTURAL BIOLOGY 6 (3): 402-406
Lengauer T; Rarey M
Computational methods for biomolecular docking
785
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1386131213861 1996 CURRENT OPINION IN STRUCTURAL BIOLOGY 6 (6): 733-735
Stubbe J; Johnson LN
Catalysis and regulation - Editorial overview
00
13862152413862 1996 CURRENT OPINION IN STRUCTURAL BIOLOGY 6 (6): 757-761
Koshland DE
The structural basis of negative cooperativity: Receptors and enzymes
2525
13863103613863 1996 CURRENT OPINION IN STRUCTURAL BIOLOGY 6 (6): 762-769
Johnson LN; OReilly M
Control by phosphorylation
956
1386443513864 1996 CURRENT OPINION IN STRUCTURAL BIOLOGY 6 (6): 824-829
Mattevi A; Rizzi M; Bolognesi M
New structures of allosteric proteins revealing remarkable conformational changes
423
1386511316213865 1996 CURRENT TOPICS IN CELLULAR REGULATION, VOL 34 34: 137-158
Barak R; Eisenbach M
Regulation of interaction between signaling protein CheY and flagellar motor during bacterial chemotaxis
1016
13866212213866 1996 CURRENT TOPICS IN CELLULAR REGULATION, VOL 34 34: 159-187
Wink DA; Hanbauer I; Grisham MB; Laval F; Nims RW; et al.
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms
9166
138671451113867 1996 CURRENT TOPICS IN CELLULAR REGULATION, VOL 34 34: 209-314
Jaenicke R
Protein folding and association: In vitro studies for self-organization and targeting in the cell
260
138682023913868 1996 CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 34 34: 207-257
Roberts RC; Mohr CD; Shapiro L
Developmental programs in bacteria
09
1386974713869 1996 DIABETES 45 (10): 1396-1404
Avignon A; Yamada K; Zhou XP; Spencer B; Cardona O; et al.
Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats - A mechanism for inhibiting glycogen synthesis
1680
1387041313870 1996 DOKLADY AKADEMII NAUK 351 (4): 561-564
Tsyganov MA; Kresteva IB; Lysochenko IV; Medvinskii AB; Ivanitskii GR
Fractal self organization in bacterial populations of Escherichia coli: Computer modeling
03
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1387112713871 1996 DRUG METABOLISM REVIEWS 28 (1-2): 29-52
Rozman KK; Kerecsen L; Viluksela MK; Osterle D; Deml E; et al.
A toxicologist's view of cancer risk assessment
033
1387227513872 1996 ELECTROPHORESIS 17 (11): 1655-1670
Epstein LB; Smith DM; Matsui NM; Tran HM; Sullivan C; et al.
Identification of cytokine-regulated proteins in normal and malignant cells by the combination of two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, Edman degradation and immunoblotting and approaches to the analysis of their functional roles
019
1387326713873 1996 ELECTROPHORESIS 17 (11): 1671-1676
Liao J; Ku NO; Omary MB
Two-dimensional gel analysis of glandular keratin intermediate filament phosphorylation
018
13874175513874 1996 EMBO JOURNAL 15 (5): 1028-1036
Uhl MA; Miller JF
Integration of multiple domains in a two-component sensor protein: The Bordetella pertussis BVgAS phosphorelay
11119
1387545613875 1996 EMBO JOURNAL 15 (9): 2313-2321
Garner J; Crooke E
Membrane regulation of the chromosomal replication activity of E-coli DnaA requires a discrete site on the protein
121
1387655713876 1996 EMBO JOURNAL 15 (13): 3477-3485
Garner J; Crooke E
Membrane regulation of the chromosomal replication activity of E-coli DnaA requires a discrete site on the protein (vol 15, pg 2313, 1996)
043
1387756713877 1996 EMBO JOURNAL 15 (22): 6075-6083
Smith JL; Silveira LA; Spudich JA
Activation of Dictyostelium myosin light chain kinase a by phosphorylation of Thr166
023
1387845013878 1996 EMBO JOURNAL 15 (22): 6213-6219
Elling CE; Schwartz TW
Connectivity and orientation of the seven helical bundle in the tachykinin NK-1 receptor probed by zinc site engineering
467
1387913613879 1996 EMBO JOURNAL 15 (23): 6541-6551
Alessi DR; Andjelkovic M; Caudwell B; Cron P; Morrice N; et al.
Mechanism of activation of protein kinase B by insulin and IGF-1
101005
13880230413880 1996 ENDOCRINE REVIEWS 17 (3): 269-288
Feuilloley M; Vaudry H
Role of the cytoskeleton in adrenocortical cells
029
#LCRNCRNode / Date / Journal / AuthorLCSGCS
13881312313881 1996 ENDOCRINOLOGIST 6 (4): 307-321
Legro RS; Dunaif A
The role of insulin resistance in polycystic ovary syndrome
09
13882117013882 1996 ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS-PART C OF JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH 14 (2): 105-137
Kakkar P; Jaffery F; Viswanathan PN
Specific molecular probes for mechanistic studies in toxicology and molecular epidemiology for risk assessment
05
138833924213883 1996 ENZYME & PROTEIN 49 (5-6): 231-261
Quest AFG
Regulation of protein kinase C: A tale of lipids and proteins
248
1388456613884 1996 ENZYME AND MICROBIAL TECHNOLOGY 19 (1): 74-79
Daniel RM
The upper limits of enzyme thermal stability
435
1388531113885 1996 ENZYME ENGINEERING XIII 799: 19-25
Nikolova PV; Duff S; MacLeod A; Haynes DA
Transglycosylation by wild type and mutants of a beta-1,4-glycosidase from Cellulomonas fimi (Cex) for synthesis of oligosaccharides
04
1388631913886 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 236 (2): 706-713
Armand S; Vieille C; Gey C; Heyraud A; Zeikus JG; et al.
Stereochemical course and reaction products of the action of beta-xylosidase from Thermoanaerobacterium saccharolyticum strain B6A-RI
320
13887163913887 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 237 (1): 247-254
Rittinger K; Negre D; Divita G; Scarabel M; BonodBidaud C; et al.
Escherichia coli isocitrate dehydrogenase kinase phosphatase - Overproduction and kinetics of interaction with its substrates by using intrinsic fluorescence and fluorescent nucleotide analogues
48
1388814113888 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 239 (1): 229-234
Bzowska A; Kulikowska E; Poopeiko NE; Shugar D
Kinetics of phosphorolysis of 3-(beta-D-ribofuranosyl) adenine and 3- (beta-D-ribofuranosyl)hypoxanthine, non-conventional substrates of purine-nucleoside phosphorylase
15
1388924813889 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 240 (3): 637-645
Jensen KF; Mygind B
Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli
016
1389072513890 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 240 (3): 747-750
Gysin S; Imber R
Replacement of Ser657 of protein kinase C-alpha by alanine leads to premature down regulation after phorbol-ester-induced translocation to the membrane
517
#LCRNCRNode / Date / Journal / AuthorLCSGCS
1389131813891 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 242 (2): 428-432
Rennecke J; Johannes FJ; Richter KH; Kittstein W; Marks F; et al.
Immunological demonstration of protein kinase C mu in murine tissues and various cell lines - Differential recognition of phosphorylated forms and lack of down-regulation upon 12-O-tetradecanoylphorphol-13-acetate treatment of cells
136
1389225813892 1996 EUROPEAN JOURNAL OF BIOCHEMISTRY 242 (3): 592-600
DeBoer APN; VanderOost J; Reijnders WNM; Westerhoff HV; Stouthamer AH; et al.
Mutational analysis of the nor gene cluster which encodes nitric-oxide reductase from Paracoccus denitrificans
052
13893111513893 1996 EUROPEAN JOURNAL OF CANCER 32A (1): 30-38
Dreher D; Junod AF
Role of oxygen free radicals in cancer development
0245
1389433713894 1996 EUROPEAN JOURNAL OF PHARMACOLOGY 299 (1-3): 221-228
Szallasi A; Acs G; Cravotto G; Blumberg PM; Lundberg JM; et al.
A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor
112
1389523113895 1996 EUROPEAN JOURNAL OF PHARMACOLOGY 314 (1-2): 243-248
Yakushi Y; Watanabe A; Murayama T; Nomura Y
P-2 purinoceptor-mediated stimulation of adenylyl cyclase in PC12 cells
115
1389667613896 1996 EUROPEAN JOURNAL OF PROTISTOLOGY 32 (4): 459-480
HankeBucker G; Hauser M
Nuclear phenomena during conjugation of the suctorian Heliophrya erhardi .1. EM-observations of micronuclear meiosis
01
1389713513897 1996 EUROPEAN JOURNAL OF SURGICAL ONCOLOGY 22 (5): 469-473
Rew DA
Heterogeneity, biodiversity and bioperversity in solid neoplasms
214
13898166713898 1996 EXPERIENTIA 52 (12): 1083-1090
Edelstein SJ; Changeux JP
Allosteric proteins after thirty years: The binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptors
721
1389912013899 1996 FAMILY PRACTICE 13 (5): 445-449
Windak A; Tomasik T; Jacobs HM; deMelker RA
Are antibiotics over-prescribed in Poland? Management of upper respiratory tract infections in primary health care region of Warszawa, Wola
05
139000013900 1996 FASEB JOURNAL 10 (6): 544-544
LeMoual H; Koshland DE
Bacterial receptors involved in taxis: Molecular evolution of the C-terminal cytoplasmic domain.
00

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