#	Cited nodes	Nodes / Authors	GCS	LCS
101	7	262 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(23):17894-17899 Chen RH; Ding WV; McCormick F Wnt signaling to beta-catenin involves two interactive components - Glycogen synthase kinase-3 beta inhibition and activation of protein kinase C	45	12
102	7	373 2001 CANCER RESEARCH 61(11):4445-4449 Chen RH; McCormick F Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells	13	4
103	18	464 2001 JOURNAL OF CELL BIOLOGY 152(1):87-96 Chen SQ; Guttridge DC; You ZB; Zhang ZC; Fribley A; Mayo MW; Kitajewski J; Wang CY Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription	35	13
104	4	790 2003 CANCER RESEARCH 63(15):4368-4374 Chen TA; Yang I; Irby R; Shain KH; Wang HG; Quackenbush J; Coppola D; Cheng JQ; Yeatman TJ Regulation of caspase expression and apoptosis by adenomatous polyposis coli	0	0
105	1	822 2003 DEVELOPMENT 130(7):1367-1379 Chen W; Liang YQ; Deng WJ; Shimizu K; Ashique AM; Li E; Li YP The zinc-finger protein CNBP is required for forebrain formation in the mouse	1	1
106	1	858 2003 JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 85A(8):1544-1552 Cheng HW; Jiang W; Phillips FM; Haydon RC; Peng Y; Zhou L; Luu HH; An NL; Breyer B; Vanichakarn P; Szatkowski JP; Park JY; He TC Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)	1	0
107	17	728 2002 ONCOGENE 21(17):2679-2694 Chesire DR; Ewing CM; Gage WR; Isaacs WB In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis	10	3
108	11	324 2000 PROSTATE 45(4):323-334 Chesire DR; Ewing CM; Sauvageot J; Bova GS; Isaacs WB Detection and analysis of beta-catenin mutations in prostate cancer	20	8
109	21	745 2002 ONCOGENE 21(55):8453-8469 Chesire DR; Isaacs WB Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor	3	2
110	4	841 2003 IMMUNITY 19(2):169-182 Chi TH; Wan MM; Lee PP; Akashi K; Metzger D; Chambon P; Wilson CB; Crabtree GR Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development	1	0
111	9	578 2002 BRITISH JOURNAL OF CANCER 86(7):1124-1129 Chiang JM; Chou YHW; Chen TC; Ng KF; Lin JL Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma	0	0
112	6	663 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(7):5134-5144 Chong JM; Uren A; Rubin JS; Speicher DW Disulfide bond assignments of secreted frizzled-related protein-1 provide insights about frizzled homology and netrin modules	5	0
113	2	296 2000 MOLECULAR BRAIN RESEARCH 77(2):232-245 Chou AH; Zheng S; Itsukaichi T; Howard BD Wnt-1 inhibits nerve growth factor-induced differentiation of PC12 cells by preventing the induction of some but not all late-response genes	5	0
114	3	239 2000 GENOME RESEARCH 10(12):2006-2021 Chrast R; Scott HS; Papasavvas MP; Rossier C; Antonarakis ES; Barras C; Davisson MT; Schmidt C; Estivill X; Dierssen M; Pritchard M; Antonarakis SE The mouse brain transcriptome by SAGE: Differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals	18	0
115	9	697 2002 JOURNAL OF IMMUNOLOGY 169(2):758-769 Christian SL; Sims PV; Gold MR The B cell antigen receptor regulates the transcriptional activator beta-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3	4	1
116	11	569 2002 BIOCHEMICAL JOURNAL 367():723-728 Chtarbova S; Nimmrich I; Erdmann S; Herter P; Renner M; Kitajewski J; Muller O Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation	0	0
117	8	230 2000 GASTROENTEROLOGY 119(3):854-865 Chung DC The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis	78	10
118	17	576 2002 BLOOD 100(3):982-990 Chung EJ; Hwang SG; Nguyen P; Lee S; Kim JS; Kim JW; Henkart PA; Bottaro DP; Soon L; Bonvini P; Lee SJ; Karp JE; Oh HJ; Rubin JS; Trepel JB Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin	1	1
119	7	830 2003 EMBO REPORTS 4(2):166-171 Civenni G; Holbro T; Hynes NE Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells	1	0
120	8	485 2001 JOURNAL OF PATHOLOGY 194(1):20-26 Clavel CE; Nollet F; Berx G; Tejpar S; Naworcki-Raby B; Kaplan HH; van Roy FM; Birembaut PL Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours	10	1
121	1	81 1999 HUMAN MOLECULAR GENETICS 8(10):1821-1832 Claverie JM Computational methods for the identification of differential and coordinated gene expression	98	1
122	2	353 2001 BULLETIN DU CANCER 88(3):269-276 Claverie JM Bioinformatics of transcriptome analysis in cancer biology	2	0
123	11	595 2002 CANCER RESEARCH 62(12):3503-3506 Clements WM; Wang J; Sarnaik A; Kim OJ; MacDonald J; Fenoglio-Preiser C; Groden J; Lowy AM beta-catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer	8	5
124	4	723 2002 MOLECULAR CELL 10(6):1260-1261 Clevers H Inflating cell numbers by Wnt	1	1
125	4	171 2000 BRITISH JOURNAL OF CANCER 83(1):1-5 Compagni A; Christofori G Recent advances in research on multistage tumorigenesis	27	1
126	17	689 2002 JOURNAL OF CLINICAL INVESTIGATION 109(8):987-991 Conacci-Sorrell M; Zhurinsky J; Ben-Ze'ev A The cadherin-catenin adhesion system in signaling and cancer	38	0
127	21	630 2002 GENES & DEVELOPMENT 16(16):2058-2072 Conacci-Sorrell ME; Ben-Yedidia T; Shtutman M; Feinstein E; Einat P; Ben-Ze'ev A Nr-CAM is a target gene of the beta-catenin/LEF-1 in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis	11	0
128	12	774 2003 BMC MOLECULAR BIOLOGY 4():- Cong F; Zhang JX; Pao W; Zhou PB; Varmus H A protein knockdown strategy to study the function of beta-catenin in tumorigenesis	0	0
129	4	832 2003 EXPERIMENTAL CELL RESEARCH 285(1):131-145 Coppe JP; Smith AP; Desprez PY Id proteins in epithelial cells	1	0
130	3	583 2002 CANCER BIOLOGY & THERAPY 1(6):640-645 Coyle-Rink J; Del Valle L; Sweet T; Khalili K; Amini S Developmental expression of Wnt signaling factors in mouse brain	0	0
131	5	137 1999 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 72(3):299-328 Craig KL; Tyers M The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction	43	0
132	10	503 2001 MOLECULAR AND CELLULAR BIOLOGY 21(4):1370-1383 Crawford HC; Fingleton B; Gustavson MD; Kurpios N; Wagenaar RA; Hassell JA; Matrisian LM The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors	35	6
133	1	119 1999 ONCOGENE 18(18):2883-2891 Crawford HC; Fingleton BM; Rudolph-Owen LA; Goss KJH; Rubinfeld B; Polakis P; Matrisian LM The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors	206	146
134	7	621 2002 EXPERIMENTAL CELL RESEARCH 280(1):12-23 Cui HY; Dong M; Sadhu DN; Rosenberg DW Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells	2	1
135	1	463 2001 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 127(9):577-581 Cui J; Zhou XD; Liu YK; Tang ZY Mutation and overexpression of the beta-catenin gene may play an important role in primary hepatocellular carcinoma among Chinese people	3	0
136	3	731 2002 ONCOGENE 21(30):4696-4701 Cullingworth J; Hooper ML; Harrison DJ; Mason J; Sirard C; Patek CE; Clarke AR Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes	2	0
137	5	563 2002 ANTICANCER RESEARCH 22(6A):3409-3414 D'Orazio D; Muller PY; Heinimann K; Albrecht C; Bendik I; Herzog U; Tondelli P; Bauerfeind P; Muller H; Dobbie Z Overexpression of Wnt target genes in adenomas of familial adenomatous polyposis patients	0	0
138	1	124 1999 ONCOGENE 18(35):5010-5014 da Costa LT; He TC; Yu J; Sparks AB; Morin PJ; Polyak K; Laken S; Vogelstein B; Kinzler KW CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling	31	0
139	4	828 2003 EMBO JOURNAL 22(3):494-501 Dajani R; Fraser E; Roe SM; Yeo M; Good VM; Thompson V; Dale TC; Pearl LH Structural basis for recruitment of glycogen synthase kinase 3 beta to the axin-APC scaffold complex	3	0
140	5	391 2001 CELL 105(6):721-732 Dajani R; Fraser E; Roe SM; Young N; Good V; Dale TC; Pearl LH Crystal structure of glycogen synthase kinase 3 beta: Structural basis for phosphate-primed substrate specificity and autoinhibition	75	6
141	3	65 1999 EMBO JOURNAL 18(11):3054-3063 Damalas A; Ben-Ze'ev A; Simcha I; Shtutman N; Leal JFN; Zhurinsky J; Geiger B; Oren M Excess beta-catenin promotes accumulation of transcriptionally active p53	65	24
142	13	405 2001 EMBO JOURNAL 20(17):4912-4922 Damalas A; Kahan S; Shtutman M; Ben-Ze'ev A; Oren M Deregulated beta-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation	33	12
143	1	108 1999 MOLECULAR AND CELLULAR BIOLOGY 19(1):1-11 Dang CV c-myc target genes involved in cell growth, apoptosis, and metabolism	309	31
144	5	71 1999 EXPERIMENTAL CELL RESEARCH 253(1):63-77 Dang CV; Resar LMS; Emison E; Kim S; Li Q; Prescott JE; Wonsey D; Zeller K Function of the c-Myc oncogenic transcription factor	66	2
145	4	228 2000 FEBS LETTERS 476(3):203-207 Dang DT; Bachman KE; Mahatan CS; Dang LH; Giardiello FM; Yang VW Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients	17	1
146	7	528 2001 ONCOGENE 20(35):4884-4890 Dang DT; Mahatan CS; Dang LH; Agboola IA; Yang VW Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2	16	0
147	5	727 2002 NUCLEIC ACIDS RESEARCH 30(13):2911-2919 Daniel JM; Spring CM; Crawford HC; Reynolds AB; Baig A The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides	5	0
148	13	504 2001 MOLECULAR AND CELLULAR BIOLOGY 21(17):5857-5868 Danilkovitch-Miagkova A; Miagkov A; Skeel A; Nakaigawa N; Zbar B; Leonard EJ Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway	11	0
149	5	62 1999 DEVELOPMENT 126(20):4557-4568 DasGupta R; Fuchs E Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation	77	13
150	4	412 2001 EUROPEAN JOURNAL OF CANCER PREVENTION 10(2):139-145 Dashwood RH; Xu M; Orner GA; Horio DT Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidazo[4,5-f]quinoline and treated postinitiation with chlorophyllin	5	0
151	4	436 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(4):843-847 Davies G; Jiang WG; Mason MD The interaction between beta-catenin, GSM3 beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer	3	0
152	1	287 2000 JOURNAL OF MOLECULAR BIOLOGY 301(1):147-156 Day CL; Alber T Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor	12	1
153	3	754 2002 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 37(9):1048-1053 De Filippo C; Luceri C; Caderni G; Pacini M; Messerini L; Biggeri A; Mini E; Tonelli F; Cianchi F; Dolara P Mutations of the APC gene in human sporadic colorectal cancers	1	0
154	1	149 1999 UROLOGY 53(4):707-713 De Marzo AM; Knudsen B; Chan-Tack K; Epstein JI E-cadherin expression as a marker of tumor aggressiveness in routinely processed radical prostatectomy specimens	27	0
155	1	46 1999 CELL PROLIFERATION 32(2-3):79-84 Del Buono R; Pignatelli M The role of the E-cadherin complex in gastrointestinal cell differentiation	1	0
156	3	688 2002 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 87(7):3475-3485 Demeterco C; Itkin-Ansari P; Tyrberg B; Ford LP; Jarvis RA; Levine F c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells	1	0
157	11	587 2002 CANCER CELL 2(4):323-334 Deng JO; Miller SA; Wang HY; Xia WY; Wen Y; Zhou BHP; Li Y; Lin SY; Hung MC beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer	3	1
158	2	810 2003 CELLULAR SIGNALLING 15(3):327-338 Denoyelle C; Albanese P; Uzan G; Hong L; Vannier JP; Soria J; Soria C Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells	2	0
159	1	696 2002 JOURNAL OF IMMUNOLOGY 168(10):4837-4845 Denys A; Udalova IA; Smith C; Williams LM; Ciesielski CJ; Campbell J; Andrews C; Kwaitkowski D; Foxwell BMJ Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages	14	0
160	7	418 2001 FEBS LETTERS 490(3):179-189 DeSalle LM; Pagano M Regulation of the G1 to S transition by the ubiquitin pathway	25	0
161	3	638 2002 HEPATOLOGY 36(6):1528-1536 Desbois-Mouthon C; Eggelpoel MJBV; Beurel E; Boissan M; Delelo R; Cadoret A; Capeau J Dysregulation of glycogen synthase kinase-3 beta signaling in hepatocellular carcinoma cells	0	0
162	4	201 2000 CELLULAR AND MOLECULAR LIFE SCIENCES 57(8-9):1207-1219 Desterro JMP; Rodriguez MS; Hay RT Regulation of transcription factors by protein degradation	16	0
163	1	122 1999 ONCOGENE 18(33):4726-4733 Devereux TR; Anna CH; Foley JF; White CM; Sills RC; Barrett JC Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis	36	10
164	5	509 2001 MOLECULAR CARCINOGENESIS 31(2):68-73 Devereux TR; Stern MC; Flake GP; Yu MC; Zhang ZQ; London SJ; Taylor JA CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1	6	1
165	9	843 2003 INTERNATIONAL JOURNAL OF CANCER 103(4):435-439 Dietrich C; Faust D; Moskwa M; Kunz A; Bock KW; Oesch F TCDD-dependent downregulation of gamma-catenin in rat liver epithelial cells (WB-F344)	0	0
166	3	566 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 292(1):195-199 Dietrich C; Scherwat J; Faust D; Oesch F Subcellular localization of beta-catenin is regulated by cell density	4	3
167	11	524 2001 ONCOGENE 20(5):645-653 Dihlmann S; Siermann A; Doeberitz MV The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling	10	0
168	11	342 2001 ANTICANCER RESEARCH 21(2A):911-915 Dimberg J; Hugander A; Sirsjo A; Soderkvist P Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer	8	0
169	1	78 1999 GUT 45(5):730-732 Dimberg J; Samuelsson A; Hugander A; Soderkvist P Differential expression of cyclooxygenase 2 in human colorectal cancer	36	2
170	12	357 2001 CANCER LETTERS 166(2):185-191 Dimitriadis A; Vincan E; Mohammed IM; Roczo N; Phillips WA; Baindur-Hudson S Expression of Wnt genes in human colon cancers	1	0
171	9	783 2003 CANCER LETTERS 196(1):1-12 Dixelius J; Cross MJ; Matsumoto T; Claesson-Welsh L Endostatin action and intracellular signaling: beta-catenin as a potential target?	0	0
172	5	562 2002 ANTICANCER RESEARCH 22(4):2215-2220 Dobbie Z; Muller PY; Heinimann K; Albrecht C; D'Orazio D; Bendik I; Muller H; Bauerfeind P Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam	3	0
173	2	401 2001 CYTOGENETICS AND CELL GENETICS 93(1-2):26-28 Dong X; Seelan RS; Qian C; Mai M; Liu W Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene	1	0
174	3	231 2000 GENES & DEVELOPMENT 14(2):158-162 Dorsky RI; Raible DW; Moon RT Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway	34	3
175	6	397 2001 CURRENT OPINION IN GASTROENTEROLOGY 17(1):65-71 DuBois RN Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention	1	0
176	13	854 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(16):14274-14283 Duchesne C; Charland S; Asselin C; Nahmias C; Rivard N Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells	0	0
177	6	335 2001 ADVANCES IN CANCER RESEARCH, VOL 83 83():55-65 Dunbier A; Guilford P Hereditary diffuse gastric cancer	5	0
178	4	25 1999 BULLETIN DU CANCER 86(9):725-726 Durand M; Moles JP beta-catenin mutations in a common skin cancer: pilomatricoma	2	0
179	3	211 2000 CYTOGENETICS AND CELL GENETICS 88(3-4):264-265 Duval A; Busson-Leconiat M; Berger R; Hamelin R Assignment of the TCF-4 gene (TCF7L2) to human chromosome band 10q25.3	3	2
180	1	36 1999 CANCER RESEARCH 59(17):4213-4215 Duval A; Gayet J; Zhou XP; Iacopetta B; Thomas G; Hamelin R Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability	79	23
181	2	128 1999 ONCOGENE 18(48):6806-6809 Duval A; Iacopetta B; Ranzani GN; Lothe RA; Thomas G; Hamelin R Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability	23	8
182	5	182 2000 CANCER RESEARCH 60(14):3872-3879 Duval A; Rolland S; Tubacher E; Bui H; Thomas G; Hamelin R The human T-cell transcription factor-4 gene: Structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines	32	15
183	2	56 1999 CURRENT OPINION IN CELL BIOLOGY 11(2):233-240 Eastman Q; Grosschedl R Regulation of LEF-1/TCF transcription factors by Wnt and other signals	144	31
184	12	789 2003 CANCER RESEARCH 63(12):3145-3153 Easwaran V; Lee SH; Inge L; Guo L; Goldbeck C; Garrett E; Wiesmann M; Garcia PA; Fuller JH; Chan V; Randazzo F; Gundel R; Warren RS; Escobedo J; Aukerman SL; Taylor RN; Fantl WJ beta-catenin regulates vascular endothelial growth factor expression in colon cancer	0	0
185	1	89 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(23):16641-16645 Easwaran V; Song V; Polakis P; Byers S The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling	32	13
186	7	540 2001 PEDIATRIC AND DEVELOPMENTAL PATHOLOGY 4(4):351-357 Eberhart CG; Argani P Wnt signaling in human development: Beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage	5	1
187	5	288 2000 JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 59(4):333-337 Eberhart CG; Tihan T; Burger PC Nuclear localization and mutation of beta-catenin in medulloblastomas	23	9
188	2	274 2000 JOURNAL OF CELL BIOLOGY 148(1):173-187 Eger A; Stockinger A; Schaffhauser B; Beug H; Foisner R Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity	34	10
189	9	907 2003 PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 2(8):825-834 Ehrhart JC; Gosselet FP; Culerrier RM; Sarasin A UVB-induced mutations in human key gatekeeper genes governing signalling pathways and consequences for skin tumourigenesis	0	0
190	5	781 2003 BRITISH JOURNAL OF DERMATOLOGY 148(5):964-970 El-Bahrawy M; El-Masry N; Alison M; Poulsom R; Fallowfield M Expression of beta-catenin in basal cell carcinoma	0	0
191	9	452 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(28):25883-25888 Eleftheriou A; Yoshida M; Henderson BR Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor	15	4
192	6	415 2001 EXPERIMENTAL CELL RESEARCH 264(1):169-184 Elenbaas B; Weinberg RA Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation	38	1
193	1	39 1999 CARCINOGENESIS 20(9):1709-1713 Erdman SH; Ignatenko NA; Powell MB; Blohm-Mangone KA; Holubec H; Guillen-Rodriguez JM; Gerner EW APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse	14	4
194	5	313 2000 ONCOGENE 19(34):3894-3901 Erdmann KS; Kuhlmann J; Lessmann V; Herrmann L; Eulenburg V; Muller O; Heumann R The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain	19	5
195	1	76 1999 GENOME RESEARCH 9(10):950-959 Ewing RM; Ben Kahla A; Poirot O; Lopez F; Audic S; Claverie JM Large-scale statistical analyses of rice ESTs reveal correlated patterns of gene expression	47	0
196	3	831 2003 ENDOCRINOLOGY 144(8):3618-3624 Fagman H; Grande M; Edsbagge J; Semb H; Nilsson M Expression of classical cadherins in thyroid development: Maintenance of an epithelial phenotype throughout organogenesis	0	0
197	12	901 2003 ONCOGENE 22(38):6013-6022 Fagman H; Larsson F; Arvidsson Y; Meuller J; Nordling M; Martinson T; Helmbrecht K; Brabant G; Nilsson M Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation	0	0
198	23	429 2001 HUMAN MOLECULAR GENETICS 10(7):721-733 Fearnhead NS; Britton MP; Bodmer WF The ABC of APC	61	12
199	4	580 2002 BRITISH MEDICAL BULLETIN 64():27-43 Fearnhead NS; Wilding JL; Bodmer WF Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis	1	0
200	1	54 1999 CURRENT BIOLOGY 9(2):R62-R65 Fearon ER; Dang CV Cancer genetics: Tumor suppressor meets oncogene	11	0

#	Cited nodes	Nodes / Authors	GCS	LCS
201	4	599 2002 CARCINOGENESIS 23(6):1065-1070 Fenton JI; Wolff MS; Orth MW; Hord NG Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype	2	0
202	4	207 2000 CRITICAL REVIEWS IN ONCOGENESIS 11(1):19-62 Feo F; Pascale RM; Simile MM; De Miglio MR; Muroni MR; Calvisi D Genetic alterations in liver carcinogenesis: Implications for new preventive and therapeutic strategies	15	2
203	12	614 2002 EUROPEAN JOURNAL OF CANCER 38(7):867-871 Fodde R The APC gene in colorectal cancer	5	3
204	16	518 2001 NATURE REVIEWS CANCER 1(1):55-67 Fodde R; Smits R; Clevers H APC, signal transduction and genetic instability in colorectal cancer	46	5
205	8	187 2000 CANCER RESEARCH 60(22):6488-6495 Foster KW; Frost AR; McKie-Bell P; Lin CY; Engler JA; Grizzle WE; Ruppert JM Increase of GKLF messenger RNA and protein expression during progression of breast cancer	17	0
206	1	44 1999 CELL GROWTH & DIFFERENTIATION 10(6):423-434 Foster KW; Ren SR; Louro ID; Lobo-Ruppert SM; McKie-Bell P; Grizzle W; Hayes MR; Broker TR; Chow LT; Ruppert JM Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: Transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF	15	2
207	3	757 2002 SURGERY 131(4):384-392 Fransen K; Dimberg J; Osterstrom A; Olsson A; Soderkvist P; Sirsjo A Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas	0	0
208	4	846 2003 INTERNATIONAL JOURNAL OF CANCER 104(1):60-65 Fricke E; Keller G; Becker I; Rosivatz E; Schott C; Plaschke S; Rudelius M; Hermannstadter C; Busch R; Hofler H; Becker KF; Luber B Relationship between E-cadherin gene mutation and p53 gene mutation, p53 accumulation, Bcl-2 expression and Ki-67 staining in diffuse-type gastric carcinoma	0	0
209	1	93 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(42):29583-29586 Fry CJ; Farnham PJ Context-dependent transcriptional regulation	66	1
210	2	244 2000 HARVEY LECTURES, SERIES 94, 1998-1999 94():47-+ Fuchs E Beauty is skin deep: The fascinating biology of the epidermis and its appendages	0	0
211	4	195 2000 CELL 100(1):143-155 Fuchs E; Segre JA Stem cells: A new lease on life	182	5
212	7	629 2002 GENE THERAPY 9(4):270-281 Fuerer C; Iggo R Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway	10	1
213	5	425 2001 HEPATOLOGY RESEARCH 20(1):39-51 Fujie H; Moriya K; Shintani Y; Tsutsumi T; Takayama T; Makuuchi M; Kimura S; Koike K Frequent beta-catenin aberration in human hepatocellular carcinoma	3	1
214	4	379 2001 CANCER RESEARCH 61(18):6656-6659 Fujimori M; Ikeda S; Shimizu Y; Okajima M; Asahara T Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor	11	5
215	4	478 2001 JOURNAL OF GASTROENTEROLOGY 36(9):587-594 Fujimori T; Kawamata H; Kashida H Precancerous lesions of the colorectum	0	0
216	9	891 2003 NATURE MEDICINE 9(3):300-306 Fujimuro M; Wu FY; ApRhys C; Kajumbula H; Young DB; Hayward GS; Hayward SD A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency	2	0
217	10	189 2000 CANCER RESEARCH 60(23):6683-6687 Fujita M; Furukawa Y; Nagasawa Y; Ogawa M; Nakamura Y Down-regulation of monocyte chemotactic protein-3 by activated beta-catenin	4	4
218	8	381 2001 CANCER RESEARCH 61(21):7722-7726 Fujita M; Furukawa Y; Tsunoda T; Tanaka T; Ogawa M; Nakamura Y Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas	14	9
219	5	720 2002 MOLECULAR CARCINOGENESIS 34(1):10-18 Fultz KE; Gerner EW APC-dependent regulation of ornithine decarboxylase in human colon tumor cells	5	3
220	6	243 2000 GYNECOLOGIC ONCOLOGY 77(1):97-104 Furlong MT; Morin PJ Rare activation of the TCF/beta-catenin pathway in ovarian cancer	10	3
221	2	155 2000 AMERICAN JOURNAL OF PATHOLOGY 156(6):1997-2005 Furuuchi K; Tada M; Yamada H; Kataoka A; Furuuchi N; Hamada J; Takahashi M; Todo S; Moriuchi T Somatic mutations of the APC gene in primary breast cancers	19	8
222	2	895 2003 NUCLEIC ACIDS RESEARCH 31(19):5789-5804 Gadal F; Bozic C; Pillot-Brochet C; Malinge S; Wagner S; Le Cam A; Buffat L; Crepin M; Iris F Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line	0	0
223	4	213 2000 DEVELOPMENT 127(3):469-482 Galceran J; Miyashita-Lin EM; Devaney E; Rubenstein JLR; Grosschedl R Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1	44	3
224	8	461 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(49):45833-45839 Galea MA; Eleftheriou A; Henderson BR ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A	6	2
225	13	737 2002 ONCOGENE 21(42):6446-6457 Gallagher RCJ; Hay T; Meniel V; Naughton C; Anderson TJ; Shibata H; Ito M; Clevers H; Noda T; Sansom OJ; Mason JO; Clarke AR Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency	4	3
226	5	892 2003 NATURE REVIEWS NEUROSCIENCE 4(10):795-805 Gammill LS; Bronner-Fraser M Neural crest specification: Migrating into genomics	1	0
227	1	32 1999 CANCER RESEARCH 59(8):1811-1815 Garcia-Rostan G; Tallini G; Herrero A; D'Aquila TG; Carcangiu ML; Rimm DL Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma	90	0
228	8	701 2002 JOURNAL OF ORAL PATHOLOGY & MEDICINE 31(7):385-394 Gasparoni A; Chaves A; Fonzi L; Johnson GK; Schneider GB; Squier CA Subcellular localization of beta-catenin in malignant cell lines and squamous cell carcinomas of the oral cavity	0	0
229	1	4 1998 CELL 95(5):605-614 Gat U; DasGupta R; Degenstein L; Fuchs E De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin	239	71
230	3	797 2003 CANCER RESEARCH 63(19):6212-6220 Gatenby RA; Vincent TL An evolutionary model of carcinogenesis	0	0
231	2	126 1999 ONCOGENE 18(44):5959-5966 Gazit A; Yaniv A; Bafico A; Pramila T; Igarashi M; Kitajewski J; Aaronson SA Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response	8	4
232	2	49 1999 CHIRURGISCHE GASTROENTEROLOGIE 15(2):163-172 Gebert J; Doeberitz CV Hereditary tumors of the gastrointestinal tract (FAP/HNPCC)	3	0
233	1	64 1999 DIGESTION 60(6):544-548 Gerdes B; Ramaswamy A; Simon B; Pietsch T; Bastian D; Kersting M; Moll R; Bartsch D Analysis of beta-catenin gene mutations in pancreatic tumors	23	10
234	2	222 2000 EPITHELIAL TRANSPORT AND BARRIER FUNCTION 915():136-143 Gessner R; Tauber R Intestinal cell adhesion molecules - Liver-intestine cadherin	5	0
235	14	855 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(22):20259-20267 Ghiselli G; Coffee N; Munnery CE; Koratkar R; Siracusa LD The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway	0	0
236	2	344 2001 BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY 15(5):821-833 Giercksky KE COX-2 inhibition and prevention of cancer	6	0
237	70	773 2003 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1653(1):1-24 Giles RH; van Es JH; Clevers H Caught up in a Wnt storm: Wnt signaling in cancer	1	0
238	11	787 2003 CANCER RESEARCH 63(10):2658-2664 Gilles C; Polette M; Mestdagt M; Nawrocki-Raby B; Ruggeri P; Birembaut P; Foidart JM Transactivation of vimentin by beta-catenin in human breast cancer cells	0	0
239	7	473 2001 JOURNAL OF CELL SCIENCE 114(7):1309-1319 Goichberg P; Shtutman M; Ben-Ze'ev A; Geiger B Recruitment of beta-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction	7	0
240	3	249 2000 IMMUNOLOGICAL REVIEWS 176():47-68 Gold MR; Ingham RJ; McLeod SJ; Christian SL; Scheid MP; Duronio V; Santos L; Matsuuchi L Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap 1 GTPase	12	0
241	5	236 2000 GENES & DEVELOPMENT 14(13):1553-1577 Goodman RH; Smolik S CBP/p300 in cell growth, transformation, and development	286	4
242	8	502 2001 MOLECULAR AND CELLULAR BIOLOGY 21(3):902-915 Goruppi S; Chiaruttini C; Ruaro ME; Varnum B; Schneider C Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells	14	3
243	10	284 2000 JOURNAL OF CLINICAL ONCOLOGY 18(9):1967-1979 Goss KH; Groden J Biology of the adenomatous polyposis coli tumor suppressor	50	15
244	10	468 2001 JOURNAL OF CELL BIOLOGY 153(5):1049-1059 Gottardi CJ; Wong E; Gumbiner BM E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner	47	13
245	8	729 2002 ONCOGENE 21(26):4099-4107 Gounari F; Signoretti S; Bronson R; Klein L; Sellers WR; Kum J; Siermann A; Taketo MM; von Boehmer H; Khazaie K Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia	6	4
246	2	427 2001 HISTOPATHOLOGY 39(2):141-149 Grabsch H; Takeno S; Noguchi T; Hommel G; Gabbert HE; Mueller W Different patterns of beta-catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome	7	2
247	1	109 1999 MOLECULAR AND CELLULAR BIOLOGY 19(8):5576-5587 Gradl D; Kuhl M; Wedlich D The Wnt/Wg signal transducer beta-catenin controls fibronectin expression	83	49
248	11	561 2002 ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS 3():101-128 Grady WM; Markowitz SD Genetic and epigenetic alterations in colon cancer	9	0
249	14	722 2002 MOLECULAR CELL 10(3):563-571 Graham TA; Clements WK; Kimelman D; Xu WQ The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT	4	1
250	5	519 2001 NATURE STRUCTURAL BIOLOGY 8(12):1048-1052 Graham TA; Ferkey DM; Mao F; Kimelman D; Xu WQ Tcf4 can specifically recognize beta-catenin using alternative conformations	9	2
251	3	306 2000 NUCLEIC ACIDS RESEARCH 28(2):446-453 Greasley PJ; Bonnard C; Amati B Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis	31	3
252	5	489 2001 JOURNAL OF SURGICAL RESEARCH 101(1):16-20 Green DW; Roh H; Pippin JA; Drebin JA beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts	2	0
253	1	148 1999 TRENDS IN GENETICS 15(3):109-112 Greider CW Telomerase activation - one step on the road to cancer?	39	0
254	5	395 2001 CLINICAL CANCER RESEARCH 7(8):2425-2433 Grotzer MA; Hogarty MD; Janss AJ; Liu XY; Zhao HQ; Eggert A; Sutton LN; Rorke LB; Brodeur GM; Phillips PC MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma	17	1
255	13	883 2003 MOLECULAR AND CELLULAR BIOLOGY 23(11):3936-3950 Grueneberg DA; Pablo L; Hu KQ; August P; Weng ZG; Papkoff J A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway	0	0
256	1	111 1999 MOLECULAR MEDICINE TODAY 5(4):172-177 Guilford P E-cadherin downregulation in cancer: fuel on the fire?	33	2
257	2	240 2000 GLIA 32(2):146-154 Gunnersen JM; Spirkoska V; Smith PE; Danks RA; Tan SS Growth and migration markers of rat C6 glioma cells identified by serial analysis of gene expression	21	4
258	9	835 2003 GENES & DEVELOPMENT 17(4):488-501 Gunther EJ; Moody SE; Belka GK; Hahn KT; Innocent N; Dugan KD; Cardiff RD; Chodosh LA Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis	3	0
259	6	620 2002 EXPERIMENTAL CELL RESEARCH 278(1):19-30 Hackett L; Davies D; Helyer R; Kennedy H; Kros C; Lawlor P; Rivolta MN; Holley M E-cadherin and the differentiation of mammalian vestibular hair cells	1	0
260	4	271 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(41):32046-32051 Haertel-Wiesmann M; Liang YX; Fantl WJ; Williams LT Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells	21	0
261	21	632 2002 GENES CHROMOSOMES & CANCER 34(3):255-268 Hajra KM; Fearon ER Cadherin and catenin alterations in human cancer	19	4
262	5	259 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(15):10905-10911 Hakimelahi S; Parker HR; Gilchrist AJ; Barry M; Li Z; Bleackley RC; Pasdar M Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2	25	8
263	9	905 2003 ORGANIC LETTERS 5(16):2927-2930 Hale KJ; Domostoj MM; Tocher DA; Irving E; Scheinmann F Enantiospecific formal total synthesis of the tumor and GSK-3 beta inhibiting alkaloid, (-)-agelastatin A	1	0
264	3	326 2000 SCIENTIST 14(11):20-21 Halim NS Hot papers - Converging pathways - Comment	0	0
265	2	75 1999 GENES TO CELLS 4(8):465-474 Hamada F; Murata Y; Nishida A; Fujita F; Tomoyasu Y; Nakamura M; Toyoshima K; Tabata T; Ueno N; Akiyama T Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC	14	5
266	2	879 2003 M S-MEDECINE SCIENCES 19(8-9):788-790 Hamelin R; Duval A beta-catenin and cell proliferation in normal and transformed intestinal cells	0	0
267	3	250 2000 INTERNATIONAL JOURNAL OF CANCER 86(4):480-488 Hanada N; Makino K; Koga H; Morisaki T; Kuwahara H; Masuko N; Tabira Y; Hiraoka T; Kitamura N; Kikuchi A; Saya H NE-dlg, a mammalian homolog of Drosophila DLG tumor suppressor, induces growth suppression and impairment of cell adhesion: Possible involvement of down-regulation of beta-catenin by NE-dlg expression	2	0
268	3	668 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(19):16464-16469 Hanai J; Dhanabal M; Karumanchi SA; Albanese C; Waterman M; Chan B; Ramchandran R; Pestell R; Sukhatme VP Endostatin causes G(1) arrest of endothelial cells through inhibition of cyclin D1	20	2
269	10	682 2002 JOURNAL OF CELL BIOLOGY 158(3):529-539 Hanai J; Gloy J; Karumanchi SA; Kale S; Tang JA; Hu GA; Chan B; Ramchandran R; Jha V; Sukhatme VP; Sokol S Endostatin is a potential inhibitor of Wnt signaling	12	1
270	3	205 2000 COLORECTAL CANCER: NEW ASPECTS OF MOLECULAR BIOLOGY AND IMMUNOLOGY AND THEIR CLINICAL APPLICATIONS 910():1-9 Hanski C; Itzkowitz SH Translating the knowledge of molecular alterations that occur during colon carcinogenesis into clinically relevant solutions	2	0
271	3	760 2002 VIRCHOWS ARCHIV 440(4):362-366 Hao XP; Frayling IM; Willcocks TC; Han W; Tomlinson IPM; Pignatelli MN; Pretlow TP; Talbot IC beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis	4	0
272	7	383 2001 CANCER RESEARCH 61(22):8085-8088 Hao XP; Pretlow TG; Rao JS; Pretlow TP beta-catenin expression is altered in human colonic aberrant crypt foci	6	2
273	10	594 2002 CANCER RESEARCH 62(7):1971-1977 Harada N; Miyoshi H; Murai N; Oshima H; Tamai Y; Oshima M; Taketo MM Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin	7	6
274	4	703 2002 JOURNAL OF PATHOLOGY 197(2):194-200 Hardy RG; Brown RM; Miller SJ; Tselepis C; Morton DG; Jankowski JAZ; Sanders DSA Transient P-cadherin expression in radiation proctitis; a model of mucosal injury and repair	0	0
275	3	633 2002 GUT 50(4):513-519 Hardy RG; Tselepis C; Hoyland J; Wallis Y; Pretlow TP; Talbot I; Sanders DSA; Matthews G; Morton D; Jankowski JAZ Aberrant P-cadherin expression is an early event in hyperplastic and dlysplastic transformation in the colon	2	1
276	5	819 2003 CURRENT MOLECULAR MEDICINE 3(5):472-482 Harwood AJ Neurodevelopment and mood stabilizers	0	0
277	6	771 2003 BIOCHEMICAL PHARMACOLOGY 66(2):179-189 Harwood AJ; Agam G Search for a common mechanism of mood stabilizers	0	0
278	2	389 2001 CARCINOGENESIS 22(12):1965-1970 Hashimoto K; Nakagawa Y; Morikawa H; Niki M; Egashira Y; Hirata I; Katsu K; Akao Y Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines	3	0
279	3	170 2000 BLOOD 96(6):2206-2214 Hashimoto S; Suzuki T; Nagai S; Yamashita T; Toyoda N; Matsushima K Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression	57	2
280	1	176 2000 CANCER RESEARCH 60(4):1070-1076 Hassan AB; Howell JA Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice	17	2
281	23	864 2003 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 8(2):145-158 Hatsell S; Rowlands T; Hiremath M; Cowin P beta-catenin and Tcfs in mammary development and cancer	0	0
282	12	648 2002 INTERNATIONAL JOURNAL OF CANCER 102(4):338-342 Haydon RC; Deyrup A; Ishikawa A; Heck R; Jiang W; Zhou L; Feng T; King D; Chew HW; Breyer B; Peabody T; Simon MA; Montag AG; He TC Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma	2	1
283	4	41 1999 CELL 99(3):335-345 He TC; Chan TA; Vogelstein B; Kinzler KW PPAR delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs	351	104
284	0	8 1998 SCIENCE 281(5382):1509-1512 He TC; Sparks AB; Rago C; Hermeking H; Zawel L; da Costa LT; Morin PJ; Vogelstein B; Kinzler KW Identification of c-MYC as a target of the APC pathway	919	918
285	2	90 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(25):18017-18025 Hecht A; Litterst CM; Huber O; Kemler R Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro	70	35
286	4	627 2002 GASTROENTEROLOGY 123(3):751-763 Heinen CD; Goss KH; Cornelius JR; Babcock GF; Knudsen ES; Kowalik T; Groden J The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway	3	1
287	1	66 1999 ENDOCRINE 10(1):67-76 Heinrich CA; Lail-Trecker MR; Peluso JJ; White BA Negative regulation of N-cadherin-mediated cell-cell adhesion by the estrogen receptor signaling pathway in rat pituitary GH(3) cells	7	1
288	2	82 1999 IMMUNITY 11(4):433-442 Held W; Kunz B; Lowin-Kropf B; van de Wetering M; Clevers H Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1	31	2
289	9	410 2001 ENDOCRINOLOGY 142(12):5261-5266 Helmbrecht K; Kispert A; von Wasielewski R; Brabant G Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells	4	1
290	5	301 2000 NATURE CELL BIOLOGY 2(9):653-660 Henderson BR Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover	109	39
291	12	675 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(27):24258-24264 Henderson BR; Galea M; Schuechner S; Leung L Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin - Regulation by histone deacetylase 1	5	1
292	12	574 2002 BIOLOGICAL RESEARCH 35(2):277-286 Hendriks B; Reichmann E Wnt signaling: A complex issue	2	0
293	1	343 2001 APOPTOSIS 6(1-2):133-137 Henriksson M; Selivanova G; Lindstrom M; Wiman KG Inactivation of Myc-induced p53-dependent apoptosis in human tumors	11	0
294	6	821 2003 CURRENT OPINION IN ONCOLOGY 15(1):44-49 Hermeking H Serial analysis of gene expression and cancer	0	0
295	2	321 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(5):2229-2234 Hermeking H; Rago C; Schuhmacher M; Li Q; Barrett JF; Obaya AJ; O'Connell BC; Mateyak MK; Tam W; Kohlhuber F; Dang CV; Sedivy JM; Eick D; Vogelstein B; Kinzler KW Identification of CDK4 as a target of c-MYC	89	15
296	1	721 2002 MOLECULAR CELL 10(3):509-521 Herold S; Wanzel M; Beuger V; Frohme C; Beul D; Hillukkala T; Syvaoja J; Saluz HP; Haenel F; Eilers M Negative regulation of the mammalian UV response by Myc through association with Miz-1	9	2
297	3	125 1999 ONCOGENE 18(38):5325-5333 Heyer J; Yang K; Lipkin M; Edelmann W; Kucherlapati R Mouse models for colorectal cancer	25	6
298	10	499 2001 MOLECULAR AND CELLULAR BIOLOGY 21(1):330-342 Hino SI; Kishida S; Michiue T; Fukui A; Sakamoto I; Takada S; Asashima M; Kikuchi A Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein	14	3
299	14	272 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(44):34399-34406 Hinoi T; Yamamoto H; Kishida M; Takada S; Kishida S; Kikuchi A Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin	21	8
300	6	384 2001 CANCER RESEARCH 61(22):8089-8093 Hlubek F; Jung A; Kotzor N; Kirchner T; Brabletz T Expression of the invasion factor laminin gamma 2 in colorectal carcinomas is regulated by beta-catenin	17	6

#	Cited nodes	Nodes / Authors	GCS	LCS
301	3	837 2003 GUT 52(5):759-766 Ho GT; Moodie FM; Satsangi J Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?	0	0
302	6	829 2003 EMBO JOURNAL 22(12):3084-3094 Hocevar BA; Mou F; Rennolds JL; Morris SM; Cooper JA; Howe PH Regulation of the Wnt signaling pathway by disabled-2 (Dab2)	0	0
303	17	597 2002 CANCER RESEARCH 62(20):5939-5954 Hoglund M; Gisselsson D; Hansen GB; Sall T; Mitelman F; Nilbert M Dissecting karyotypic patterns in colorectal tumors: Two distinct but overlapping pathways in the adenoma-carcinoma transition	3	0
304	8	690 2002 JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY 55(4):220-226 Holcombe RF; Marsh JL; Waterman ML; Lin F; Milovanovic T; Truong T Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma	2	1
305	8	535 2001 ONCOGENE 20(52):7645-7657 Hollmann CA; Kittrell FS; Medina D; Butel JS Wnt-1 and int-2 mammary oncogene effects on the beta-catenin pathway in immortalized mouse mammary epithelial cells are not sufficient for tumorigenesis	0	0
306	16	680 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(48):45847-45853 Holnthoner W; Pillinger M; Groger M; Wolff K; Ashton AW; Albanese C; Neumeister P; Pestell RG; Petzelbauer P Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells	1	0
307	1	31 1999 CANCER RESEARCH 59(4):826-830 Horikawa I; Cable PL; Afshari C; Barrett JJ Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene	107	2
308	2	801 2003 CANCER SCIENCE 94(3):297-301 Hoshida Y; Hongyo T; Jia XS; He YJ; Hasui K; Dong ZM; Luo WJ; Ham MF; Nomura T; Aozasa K Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China	0	0
309	1	711 2002 LABORATORY INVESTIGATION 82(3):257-264 Hoshida Y; Hongyo T; Nakatsuka S; Nishiu M; Takakuwa T; Tomita Y; Nomura T; Aozasa K Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients	5	2
310	8	515 2001 NATURE GENETICS 28(1):53-57 Hovanes K; Li TWH; Munguia JE; Truong T; Milovanovic T; Marsh JL; Holcombe RF; Waterman ML beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer	55	26
311	8	450 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(23):20108-20115 Howe LR; Crawford HC; Subbaramaiah K; Hassell JA; Dannenberg AJ; Brown AMC PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2	26	5
312	14	786 2003 CANCER RESEARCH 63(8):1906-1913 Howe LR; Watanabe O; Leonard J; Brown AMC Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation	2	1
313	7	592 2002 CANCER LETTERS 183(1):95-101 Howng SL; Wu CH; Cheng TS; Sy WD; Lin PCK; Wang CH; Hong YR Differential expression of Wnt genes, beta-catenin and E-cadherin in human brain tumors	1	0
314	2	613 2002 ENDOCRINOLOGY 143(3):898-908 Hsieh M; Johnson MA; Greenberg NM; Richards JS Regulated expression of Wnts and frizzleds at specific stages of follicular development in the rodent ovary	7	0
315	16	472 2001 JOURNAL OF CELL BIOLOGY 155(6):1055-1064 Hsu W; Shakya R; Costantini F Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice	16	7
316	13	863 2003 JOURNAL OF INVESTIGATIVE DERMATOLOGY 121(2):242-251 Hu PQ; Berkowitz P; O'Keefe EJ; Rubenstein DS Keratinocyte adherens junctions initiate nuclear signaling by translocation of plakoglobin from the membrane to the nucleus	0	0
317	5	275 2000 JOURNAL OF CELL BIOLOGY 148(3):567-578 Huelsken J; Vogel R; Brinkmann V; Erdmann B; Birchmeier C; Birchmeier W Requirement for beta-catenin in anterior-posterior axis formation in mice	58	14
318	10	390 2001 CELL 105(4):533-545 Huelsken J; Vogel R; Erdmann B; Cotsarelis G; Birchmeier W beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin	110	20
319	20	611 2002 EMBO JOURNAL 21(10):2303-2311 Hurlstone A; Clevers H T-cell factors: turn-ons and turn-offs	14	3
320	6	554 2002 AMERICAN JOURNAL OF GASTROENTEROLOGY 97(3):542-553 Husain SS; Szabo IL; Tarnawski AS NSAID inhibition of GI cancer growth: Clinical implications and molecular mechanisms of action	8	0
321	4	806 2003 CARCINOGENESIS 24(4):643-650 Husoy T; Cruciani V; Knutsen HK; Mikalsen SO; Olstorn HB; Alexander J Cells heterozygous for the Apc(Min) mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization	0	0
322	2	712 2002 LEUKEMIA RESEARCH 26(9):863-871 Hwang SG; Lee HC; Trepel JB; Jeon BH Anticancer drugs-induced apoptotic cell death in leukemia cells is associated with proteolysis of beta-catenin	0	0
323	5	309 2000 ONCOGENE 19(4):537-545 Ikeda S; Kishida M; Matsuura Y; Usui H; Kikuchi A GSK-3 beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin	46	21
324	8	658 2002 JAPANESE JOURNAL OF CANCER RESEARCH 93(11):1213-1220 Ikenoue T; Ijichi H; Kato N; Kanai F; Masaki T; Rengifo W; Okamoto M; Matsumura M; Kawabe T; Shiratori Y; Omata M Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells	0	0
325	5	265 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(28):21435-21443 Ilan N; Cheung L; Pinter E; Madri JA Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation	30	1
326	1	68 1999 EUROPEAN JOURNAL OF CANCER 35(3):335-351 Ilyas M; Straub J; Tomlinson IPM; Bodmer WF Genetic pathways in colorectal and other cancers	52	8
327	2	69 1999 EUROPEAN JOURNAL OF CANCER 35(14):1986-2002 Ilyas M; Straub J; Tomlinson IPM; Bodmer WF Genetic pathways in colorectal and other cancers (Reprinted from Eur J Cancer, vol 35, pg 335-351, 1999)	22	2
328	11	467 2001 JOURNAL OF CELL BIOLOGY 153(3):555-568 Imbert A; Eelkema R; Jordan S; Feiner H; Cowin P Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland	28	12
329	6	517 2001 NATURE IMMUNOLOGY 2(8):691-697 Ioannidis V; Beermann F; Clevers H; Held W The beta-catenin-TCF-I pathway ensures CD4(+)CD8(+) thymocyte survival	22	6
330	8	862 2003 JOURNAL OF IMMUNOLOGY 171(2):769-775 Ioannidis V; Kunz A; Tanamachi DM; Scarpellino L; Held W Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1	0	0
331	1	308 2000 ONCOGENE 19(3):365-372 Ishidate T; Matsumine A; Toyoshima K; Akiyama T The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase	28	8
332	10	687 2002 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 87(7):3433-3440 Ishigaki K; Namba H; Nakashima M; Nakayama T; Mitsutake N; Hayashi T; Maeda S; Ichinose M; Kanematsu T Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer	4	2
333	3	256 2000 JAPANESE JOURNAL OF CANCER RESEARCH 91(6):597-603 Ishiguro H; Furukawa Y; Daigo Y; Miyoshi Y; Nagasawa Y; Nishiwaki T; Kawasoe T; Fujita M; Satoh S; Miwa N; Fujii Y; Nakamura Y Isolation and characterization of human NBL4, a gene involved in the beta-catenin/Tcf signaling pathway	7	7
334	13	736 2002 ONCOGENE 21(41):6387-6394 Ishiguro H; Shimokawa T; Tsunoda T; Tanaka T; Fujii Y; Nakamura Y; Furukawa Y Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas	1	0
335	11	529 2001 ONCOGENE 20(36):5062-5066 Ishiguro H; Tsunoda T; Tanaka T; Fujii Y; Nakamura Y; Furukawa Y Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney	4	3
336	3	129 1999 ONCOGENE 18(50):7080-7090 Ito K; Okamoto I; Araki N; Kawano Y; Nakao M; Fujiyama S; Tomita K; Mimori T; Saya H Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts	19	0
337	2	193 2000 CARCINOGENESIS 21(11):1935-1940 Iwamoto M; Ahnen DJ; Franklin WA; Maltzman TH Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues	15	9
338	4	812 2003 CLINICAL & EXPERIMENTAL METASTASIS 20(6):525-529 Iwaya K; Ogawa H; Kuroda M; Izumi M; Ishida T; Mukai K Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis	0	0
339	3	303 2000 NATURE GENETICS 26(3):291-299 Jacobs JJL; Keblusek P; Robanus-Maandag E; Kristel P; Lingbeek M; Nederlof PM; van Welsem T; van de Vijver MJ; Koh EY; Daley GQ; van Lohuizen M Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers	61	0
340	1	6 1998 GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE 22(12):1071-1080 Jais P; Laurent-Puig P; Olschwang S APC protein: protein interactions and cellular functions	0	0
341	1	131 1999 ONCOLOGY REPORTS 6(6):1253-1256 Jaiswal AS; Kennedy CH; Narayan S A correlation of APC and c-myc mRNA levels in lung cancer cell lines	3	3
342	11	744 2002 ONCOGENE 21(55):8414-8427 Jaiswal AS; Marlow BP; Gupta N; Narayan S beta-Catenin-mediated transactivation and cell - cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells	2	1
343	11	449 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(21):18193-18199 Jaiswal AS; Narayan S p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents	10	1
344	2	474 2001 JOURNAL OF CELLULAR BIOCHEMISTRY 81(2):262-277 Jaiswal AS; Narayan S Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the Adenomatous polyposis coli (APC) tumor suppressor gene	7	1
345	5	704 2002 JOURNAL OF PATHOLOGY 197(4):479-491 Janes SM; Lowell S; Hutter C Epidermal stem cells	6	0
346	1	10 1999 AMERICAN JOURNAL OF PATHOLOGY 154(4):965-973 Jankowski JA; Wright NA; Meltzer SJ; Triadafilopoulos G; Geboes K; Casson AG; Kerr D; Young LS Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus	91	1
347	8	809 2003 CELLULAR AND MOLECULAR LIFE SCIENCES 60(3):495-506 Janssen KP Murine models of colorectal cancer: studying the role of oncogenic K-ras	0	0
348	5	626 2002 GASTROENTEROLOGY 123(2):492-504 Janssen KP; El Marjou F; Pinto D; Sastre X; Rouillard D; Fouquet C; Soussi T; Louvard D; Robine S Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice	4	1
349	7	382 2001 CANCER RESEARCH 61(21):7978-7984 Jarrett CR; Blancato J; Cao T; Bressette DS; Cepeda M; Young PE; King CR; Byers SW Human APC2 localization and allelic imbalance	3	2
350	1	136 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(20):11566-11571 Jayachandra S; Low KG; Thlick AE; Yu J; Ling PD; Chang Y; Moore PS Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors (Retracted article. See vol 98, pg 12313, 2001)	55	2
351	1	3 1998 BULLETIN DU CANCER 85(11):925-928 Jeanteur P The role of APC in colon cancer: zeroing in on MYC	6	2
352	3	24 1999 BULLETIN DU CANCER 86(4):336-336 Jeanteur P beta-catenin, APC, C-MYC and the others...	0	0
353	9	699 2002 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 7(4):415-432 Jechlinger M; Grunert S; Beug H Mechanisms in epithelial plasticity and metastasis: Insights from 3D cultures and expression profiling	0	0
354	1	460 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):45168-45174 Jiang W; Zhou L; Breyer B; Feng T; Cheng HW; Haydon R; Ishikawa A; He TC Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cells	1	0
355	12	763 2002 WORLD JOURNAL OF GASTROENTEROLOGY 8(5):804-807 Jiang Y; Zhou XD; Liu YK; Wu X; Huang XW Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma	1	0
356	5	572 2002 BIOESSAYS 24(1):54-64 Johnston LA; Gallant P Control of growth and organ size in Drosophila	14	0
357	2	40 1999 CELL 98(6):779-790 Johnston LA; Prober DA; Edgar BA; Eisenman RN; Gallant P Drosophila myc regulates cellular growth during development	109	9
358	2	223 2000 EUROPEAN JOURNAL OF CANCER 36(2):242-248 Jonsson M; Borg A; Nilbert M; Andersson T Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer	19	6
359	4	164 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(3):1162-1169 Julius MA; Schelbert B; Hsu W; Fitzpatrick E; Jho E; Fagotto F; Costantini F; Kitajewski J Domains of Axin and disheveled required for interaction and function in Wnt signaling	7	3
360	10	338 2001 AMERICAN JOURNAL OF PATHOLOGY 159(5):1613-1617 Jung A; Schrauder M; Oswald U; Knoll C; Sellberg P; Palmqvist R; Niedobitek G; Brabletz T; Kirchner T The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D-1, and p16(INK4A) and is a region of low proliferation	16	4
361	4	852 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(14):11937-11944 Kahler RA; Westendorf JJ Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter	0	0
362	3	355 2001 CANCER 92(11):2786-2795 Kallakury BVS; Sheehan CE; Winn-Deen E; Oliver J; Fisher HAG; Kaufman RP; Ross JS Decreased expression of catenins (alpha and beta), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas	5	0
363	5	678 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(40):37479-37486 Karasawa T; Yokokura H; Kitajewski J; Lombroso PJ Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta-catenin signaling	1	0
364	4	825 2003 DEVELOPMENTAL BIOLOGY 261(1):165-182 Karsten SL; Kudo LC; Jackson R; Sabatti C; Kornblum HI; Geschwind DH Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks	0	0
365	8	520 2001 NEOPLASIA 3(1):4-9 Kato T; Satoh S; Okabe H; Kitahara O; Ono K; Kihara C; Tanaka T; Tsunoda T; Yamaoka Y; Nakamura Y; Furukawa Y Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis	5	0
366	17	652 2002 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(6):677-682 Katoh M Paradigm shift in gene-finding method: From bench-top approach to desk-top approach (review)	25	0
367	17	655 2002 INTERNATIONAL JOURNAL OF ONCOLOGY 21(6):1269-1273 Katoh M WNT and FGF gene clusters (Review)	20	0
368	1	258 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(12):8369-8374 Kawahara K; Morishita T; Nakamura T; Hamada F; Toyoshima K; Akiyama T Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with axin and beta-catenin	23	10
369	5	692 2002 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 21(1):23-27 Kawakami M; Kimura Y; Furuhata T; Zenbutsu H; Yanai Y; Mukaiya M; Satoh Y; Murata S; Hirata K beta-catenin alteration in cancer of the ampulla of Vater	1	1
370	1	153 2000 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 113(2):266-274 Kawanishi K; Doki Y; Shiozaki H; Yano M; Inoue M; Fukuchi N; Utsunomiya T; Watanabe H; Monden M Correlation between loss of E-cadherin expression and overexpression of autocrine motility factor receptor in association with progression of human gastric cancers	3	0
371	6	181 2000 CANCER RESEARCH 60(13):3354-3358 Kawasoe T; Furukawa Y; Daigo Y; Nishiwaki T; Ishiguro H; Fujita M; Satoh S; Miwa N; Nagasawa Y; Miyoshi Y; Ogawa M; Nakamura Y Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin	6	6
372	1	254 2000 INTERNATIONAL JOURNAL OF CANCER 90(4):175-185 Kennedy AS; Harrison GH; Mansfield CM; Zhou XJ; Xu JF; Balcer-Kubiczek EK Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: Effect of TP53 or hMLH1 deficiency	7	0
373	13	844 2003 INTERNATIONAL JOURNAL OF CANCER 103(5):652-656 Kielhorn E; Provost E; Olsen D; D'Aquila TG; Smith BL; Camp RL; Rimm DL Tissue microarray-based analysis shows phospho-beta-catenin expression in malignant melanoma is associated with poor outcome	3	1
374	7	48 1999 CELLULAR SIGNALLING 11(11):777-788 Kikuchi A Roles of axin in the Wnt signalling pathway	39	13
375	7	60 1999 CYTOKINE & GROWTH FACTOR REVIEWS 10(3-4):255-265 Kikuchi A Modulation of Wnt signaling by Axin and Axil	17	6
376	7	161 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(2):243-248 Kikuchi A Regulation of beta-catenin signaling in the Wnt pathway	42	15
377	1	318 2000 ONCOLOGY REPORTS 7(4):707-712 Kim HJ; Guo WT; Park NH HPV-16 E6 oncoprotein induces mutations via p53-dependent and -independent pathways	0	0
378	12	718 2002 MOLECULAR CANCER THERAPEUTICS 1(14):1355-1359 Kim JS; Crooks H; Foxworth A; Waldman T Proof-of-principle: Oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitors	2	1
379	6	392 2001 CELL BIOLOGY INTERNATIONAL 25(5):421-427 Kim K; Lee KY Tyrosine phosphorylation translocates beta-catenin from cell-cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function	5	1
380	11	295 2000 MOLECULAR BIOLOGY OF THE CELL 11(10):3509-3523 Kim K; Pang KM; Evans M; Hay ED Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators	34	17
381	1	42 1999 CELL 99(4):399-408 Kim L; Liu JC; Kimmel AR The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification	48	6
382	9	875 2003 LANCET 362(9379):205-209 Kim PJ; Plescia J; Clevers H; Fearon ER; Altieri DC Survivin and molecular pathogenesis of colorectal cancer	1	0
383	1	340 2001 ANALYTICAL BIOCHEMISTRY 288(2):141-148 Kim S; Zeller K; Dang CV; Sandgren EP; Lee LA A strategy to identify differentially expressed genes using representational difference analysis and cDNA arrays	8	0
384	2	141 1999 SCIENTIST 13(14):15-15 Kinzler KW Hot papers - Cancer - Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC by P.J. Morin, A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, K.W. Kinzler - Comments	0	0
385	7	156 2000 AMERICAN JOURNAL OF PATHOLOGY 157(4):1113-1121 Kirchner T; Brabletz T Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence - Analogies with embryonic gastrulation	22	11
386	6	346 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 283(4):798-805 Kirikoshi H; Sekihara H; Katoh M WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells	60	2
387	8	441 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):111-115 Kirikoshi H; Sekihara H; Katoh M Up-regulation of Frizzled-7 (FZD7) in human gastric cancer	66	3
388	11	887 2003 MOLECULAR CANCER THERAPEUTICS 2(1):113-121 Kirmizis A; Bartley SM; Farnham PJ Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy	1	0
389	14	456 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(35):33147-33155 Kishida M; Hino S; Michiue T; Yamamoto H; Kishida S; Fukui A; Asashima M; Kikuchi A Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase I epsilon	15	2
390	2	693 2002 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 21(2):203-211 Kishimoto Y; Morisawa T; Hosoda A; Shiota G; Kawasaki H; Hasegawa J Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane	0	0
391	1	241 2000 GUT 47(6):812-819 Kishimoto Y; Takata N; Jinnai T; Morisawa T; Shiota G; Kawasaki H; Hasegawa J Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane	9	5
392	4	694 2002 JOURNAL OF GASTROENTEROLOGY 37(3):186-193 Kishimoto Y; Yashima K; Morisawa T; Shiota G; Kawasaki H; Hasegawa J Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane	5	0
393	4	167 2000 BIOESSAYS 22(10):902-910 Kitajewski J; Sassoon D The emergence of molecular gynecology: homeobox and Wnt genes in the female reproductive tract	9	0
394	1	292 2000 MOLECULAR AND CELLULAR BIOLOGY 20(5):1733-1746 Kobayashi A; Yamagiwa H; Hoshino H; Muto A; Sato K; Morita M; Hayashi N; Yamamoto M; Igarashi K A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain	18	0
395	1	30 1999 CANCER RESEARCH 59(2):269-273 Koch A; Denkhaus D; Albrecht S; Leuschner I; von Schweinitz D; Pietsch T Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene	95	44
396	6	431 2001 INTERNATIONAL JOURNAL OF CANCER 93(3):445-449 Koch A; Waha A; Tonn JC; Sorensen N; Berthold F; Wolter M; Reifenberger J; Hartmann W; Friedl W; Reifenberger G; Wiestler OD; Pietsch T Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors	18	4
397	4	92 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(39):27682-27688 Kodama S; Ikeda S; Asahara T; Kishida M; Kikuchi A Axin directly interacts with plakoglobin and regulates its stability	28	20
398	3	813 2003 CLINICAL CANCER RESEARCH 9(1):1-9 Koeffler HP Peroxisome proliferator-activated receptor gamma and cancers	0	0
399	3	388 2001 CARCINOGENESIS 22(11):1885-1890 Koesters R; Hans MA; Benner A; Prosst R; Boehm J; Gahlen J; Doeberitz MVK Predominant mutation of codon 41 of the beta-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol	6	0
400	10	869 2003 JOURNAL OF PATHOLOGY 199(1):68-76 Koesters R; Niggli F; Doeberitz MV; Stallmach T Nuclear accumulation of beta-catenin protein in Wilms' tumours	1	0

#	Cited nodes	Nodes / Authors	GCS	LCS
401	2	35 1999 CANCER RESEARCH 59(16):3880-3882 Koesters R; Ridder R; Kopp-Schneider A; Betts D; Adams V; Niggli F; Briner J; Doeberitz MV Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors	43	17
402	6	677 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26031-26035 Koh SS; Li HW; Lee YH; Widelitz RB; Chuong CM; Stallcup MR Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators	5	1
403	4	283 2000 JOURNAL OF CLINICAL INVESTIGATION 106(4):533-539 Koh TJ; Bulitta CJ; Fleming JV; Dockray GJ; Varro A; Wang TC Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis	41	23
404	1	845 2003 INTERNATIONAL JOURNAL OF CANCER 104(1):44-53 Kohya N; Kitajima Y; Jiao W; Miyazaki K Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: Repression of MTS1/S100A4 gene expression	0	0
405	4	162 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(1):103-109 Koike J; Sagara N; Kirikoshi H; Takagi A; Miwa T; Hirai M; Katoh M Molecular cloning and genomic structure of the beta TRCP2 gene on chromosome 5q35.1	49	8
406	4	545 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(8):4646-4651 Kolli S; Buchmann AM; Williams J; Weitzman S; Thimmapaya B Antisense-mediated depletion of p300 in human cells leads to premature G(1) exit and up-regulation of c-MYC	8	1
407	59	609 2002 DIGESTION 66(3):131-144 Kolligs FT; Bommer G; Goke B Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis	1	0
408	5	110 1999 MOLECULAR AND CELLULAR BIOLOGY 19(8):5696-5706 Kolligs FT; Hu G; Dang CV; Fearon ER Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression	62	38
409	15	235 2000 GENES & DEVELOPMENT 14(11):1319-1331 Kolligs FT; Kolligs B; Hajra KM; Hu G; Tani M; Cho KR; Fearon ER gamma-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin	74	41
410	18	584 2002 CANCER CELL 1(2):145-155 Kolligs FT; Nieman MT; Winer I; Hu G; Van Mater D; Feng Y; Smith IM; Wu R; Zhai YL; Cho KR; Fearon ER ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation	11	8
411	3	87 1999 JAPANESE JOURNAL OF CANCER RESEARCH 90(12):1301-1309 Kondo Y; Kanai Y; Sakamoto M; Genda T; Mizokami M; Ueda R; Hirohashi S beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma	25	12
412	3	439 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(6):1271-1278 Kondoh N; Wakatsuki T; Hada A; Shuda M; Tanaka K; Arai M; Yamamoto M Genetic and epigenetic events in human hepatocarcinogenesis (Review)	14	0
413	3	165 2000 BIOCHEMISTRY-MOSCOW 65(1):2-27 Kopnin BP Targets of oncogenes and tumor suppressors: Key for understanding basic mechanisms of carcinogenesis	10	0
414	3	51 1999 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 64():141-147 Korswagen HC; Clevers HC Activation and repression of Wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors	8	0
415	6	698 2002 JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS 7(1):41-45 Koster MI; Huntzinger KA; Roop DR Epidermal differentiation: Transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation	2	0
416	5	659 2002 JAPANESE JOURNAL OF CLINICAL ONCOLOGY 32(9):358-362 Koyama T; Tago K; Nakamura T; Ohwada S; Morishita Y; Yokota J; Akiyama T Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors	0	0
417	1	73 1999 GENE 238(2):301-313 Krupnik VE; Sharp JD; Jiang C; Robison K; Chickering TW; Amaravadi L; Brown DE; Guyot D; Mays G; Leiby K; Chang B; Duong T; Goodearl ADJ; Gearing DP; Sokol SY; McCarthy SA Functional and structural diversity of the human Dickkopf gene family	35	1
418	5	358 2001 CANCER LETTERS 168(1):1-6 Kubozoe TO; Tsujiuchi T; Murata N; Sasaki Y; Tsunoda T; Konishi Y; Tsutsumi R Absence of beta-catenin gene mutations in pancreatic duct lesions induced by N-nitrosobis(2-oxopropyl)amine in hamsters	0	0
419	2	85 1999 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 4(5):541-544 Kucerova D; Sloncova E; Tuhackova Z; Uhlirova M; Kos M; Sovova V Changes of E-cadherin and beta-catenin levels during induced differentiation of colorectal carcinoma cells	6	0
420	5	551 2001 SEMINARS IN CANCER BIOLOGY 11(3):219-225 Kucherlapati R; Lin DP; Edelmann W Mouse models for human familial adenomatous polyposis	2	1
421	4	719 2002 MOLECULAR CARCINOGENESIS 33(3):131-136 Kugoh H; Kleymenova E; Walker CL Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin	3	0
422	2	542 2001 PHYSIOLOGICAL GENOMICS 7(2):105-114 Kuhn I; Bartholdi MF; Salamon H; Feldman RI; Roth RA; Johnson PH Identification of AKT-regulated genes in inducible MERAkt cells	3	0
423	5	872 2003 JOURNAL OF THE NATIONAL CANCER INSTITUTE 95(12):896-905 Kumagai T; O'Kelly J; Said JW; Koeffler HP Vitamin D-2 analog 19-nor-1,25-dihydroxyvitamin D-2: Antitumor activity against leukemia, myeloma, and colon cancer cells	0	0
424	1	232 2000 GENES & DEVELOPMENT 14(3):272-277 Kung AL; Rebel VI; Bronson RT; Ch'ng LE; Sieff CA; Livingston DM; Yao TP Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP	97	2
425	4	315 2000 ONCOGENE 19(50):5755-5763 Kuraguchi M; Edelmann W; Yang K; Lipkin M; Kucherlapati R; Brown AMC Tumor-associated Apc mutations in Mlh1(-/-) Apc(1638N) mice reveal a mutational signature of Mlh1 deficiency	10	0
426	9	651 2002 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(4):395-399 Kusafuka T; Miao J; Kuroda S; Udatsu Y; Yoneda A Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor	2	1
427	10	743 2002 ONCOGENE 21(54):8340-8346 Kwong KY; Zou YY; Day CP; Hung MC The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway	2	0
428	2	104 1999 M S-MEDECINE SCIENCES 15(3):427-428 L'Allemain G The WISP genes, a family of novel connective tissue growth factors, are dysregulated in Wnt-1-transformed cells and in human colon cancer.	0	0
429	5	808 2003 CELL DEATH AND DIFFERENTIATION 10(5):528-538 Lacher MD; Siegenthaler A; Jager R; Yan X; Hett S; Xuan L; Saurer S; Lareu R; Dharmarajan AM; Friis R Role of DDC-4/sFRP-4, a secreted Frizzled-related protein, at the onset of apoptosis in mammary involution	1	0
430	1	134 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(5):2322-2326 Laken SJ; Papadopoulos N; Petersen GM; Gruber SB; Hamilton SR; Giardiello FM; Brensinger JD; Vogelstein B; Kinzler KW Analysis of masked mutations in familial adenomatous polyposis	37	6
431	1	37 1999 CANCER RESEARCH 59(21):5403-5407 Lal A; Lash AE; Altschul SF; Velculescu V; Zhang L; McLendon RE; Marra MA; Prange C; Morin PJ; Polyak K; Papadopoulos N; Vogelstein B; Kinzler KW; Strausberg RL; Riggins GJ A public database for gene expression in human cancers	144	12
432	3	59 1999 CURRENT OPINION IN MOLECULAR THERAPEUTICS 1(6):720-726 Lal A; Siu IM; Riggins GJ Serial analysis of gene expression: Probing transcriptomes for molecular targets	4	2
433	6	457 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(45):42276-42286 Lamberti C; Lin KM; Yamamoto Y; Verma U; Verma IM; Byers S; Gaynor RB Regulation of beta-catenin function by the I kappa B kinases	10	5
434	3	526 2001 ONCOGENE 20(25):3247-3257 Landesman-Bollag E; Romieu-Mourez R; Song DH; Sonenshein GE; Cardiff RD; Seldin DC Protein kinase CK2 in mammary gland tumorigenesis	30	0
435	1	498 2001 MOLECULAR AND CELLULAR BIOCHEMISTRY 227(1-2):153-165 Landesman-Bollag E; Song DH; Romieu-Mourez R; Sussman DJ; Cardiff RD; Sonenshein GE; Seldin DC Protein kinase CK2: Signaling and tumorigenesis in the mammary gland	8	0
436	9	909 2003 PIGMENT CELL RESEARCH 16(3):312-317 Larue L; Kumasaka M; Goding CR beta-catenin in the melanocyte lineage	0	0
437	2	253 2000 INTERNATIONAL JOURNAL OF CANCER 89(2):172-176 Latil A; Vidaud D; Valeri A; Fournier G; Vidaud M; Lidereau R; Cussenot O; Bieche I htert expression correlates with myc over-expression in human prostate cancer	29	0
438	1	116 1999 ONCOGENE 18(4):849-854 Latres E; Chiaur DS; Pagano M The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin	81	22
439	1	70 1999 EUROPEAN JOURNAL OF CANCER PREVENTION 8():S39-S47 Laurent-Puig P; Blons H; Cugnenc PH Sequence of molecular genetic events in colorectal tumorigenesis	16	0
440	5	838 2003 GYNECOLOGIC ONCOLOGY 88(3):363-368 Lee CM; Shvartsman H; Deavers MT; Wang SC; Xia WY; Schmandt R; Bodurka DC; Atkinson EN; Malpica A; Gershenson DM; Hung MC; Lu KH beta-Catenin nuclear localization is associated with grade in ovarian serous carcinoma	1	0
441	3	83 1999 IMMUNOLOGY AND CELL BIOLOGY 77(5):460-467 Leenen PJM; Egeler RM Langerhans' cell histiocytosis is caused by dysregulation of the E-cadherin-beta-catenin cascade: A hypothesis	3	0
442	5	890 2003 MOLECULAR PSYCHIATRY 8(2):135-144 Lenox RH; Wang L Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks	3	1
443	1	579 2002 BRITISH JOURNAL OF SURGERY 89(7):845-860 Leslie A; Carey FA; Pratt NR; Steele RJC The colorectal adenoma-carcinoma sequence	6	1
444	23	673 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(24):21657-21665 Leung JY; Kolligs FT; Wu R; Zhai YL; Kuick R; Hanash S; Cho KR; Fearon ER Activation of AXIN2 expression by beta-catenin-T cell factor - A feedback repressor pathway regulating Wnt signaling	5	3
445	20	679 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):42386-42393 Levy L; Neuveut C; Renard CA; Charneau P; Branchereau S; Gauthier F; Van Nhieu JT; Cherqui D; Petit-Bertron AF; Mathieu D; Buendia MA Transcriptional activation of interleukin-8 by beta-catenin-Tcf4	3	1
446	7	639 2002 HORMONE-RELATED TUMORS: NOVEL APPROACHES TO PREVENTION AND TREATMENT 963():21-36 Levy L; Renard CA; Wei Y; Buendia MA Genetic alterations and oncogenic pathways in hepatocellular carcinoma	2	0
447	2	695 2002 JOURNAL OF GASTROINTESTINAL SURGERY 6(4):563-568 Lew JI; Guo Y; Kim RK; Vargish L; Michelassi F; Arenas RB Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive	2	0
448	2	184 2000 CANCER RESEARCH 60(21):6178-6183 Lewis BC; Prescott JE; Campbell SE; Shim H; Orlowski RZ; Dang CV Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A	3	0
449	13	750 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(9):6064-6069 Li BA; Mackay DR; Dai Q; Li TWH; Nair M; Fallahi M; Schonbaum CP; Fantes J; Mahowald AP; Waterma ML; Fuchs E; Dai X The LEF1/beta-catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation	6	3
450	15	570 2002 BIOCHEMICAL PHARMACOLOGY 64(9):1325-1336 Li H; Liu L; David ML; Whitehead CM; Chen M; Fetter JR; Sperl GJ; Pamukcu R; Thompson WJ Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation	5	1
451	6	310 2000 ONCOGENE 19(8):1002-1009 Li Y; Hively WP; Varmus HE Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer	26	9
452	10	214 2000 DEVELOPMENT 127(17):3805-3813 Lickert H; Domon C; Huls G; Wehrle C; Duluc I; Clevers H; Meyer BI; Freund JN; Kemler R Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine	43	6
453	4	446 2001 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 9(4):273-279 Lifschitz-Mercer B; Amitai R; Maymon BBS; Shechtman L; Czernobilsky B; Leider-Trejo L; Ben-Ze'ev A; Geiger B Nuclear localization of beta-catenin and plakoglobin in primary and metastatic human colonic carcinomas, colonic adenomas, and normal colon	0	0
454	3	568 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 299(5):806-812 Lim HW; Lee JE; Shin SJ; Lee YE; Oh SH; Park JY; Seong JK; Park JS Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display	1	0
455	8	714 2002 MECHANISMS OF AGEING AND DEVELOPMENT 123(12):1665-1680 Lim IK Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats	1	1
456	9	880 2003 MECHANISMS OF AGEING AND DEVELOPMENT 124(5):697-708 Lim IK Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats (vol 123, pg 1665, 2002)	0	0
457	1	202 2000 CHINESE SCIENCE BULLETIN 45(21):1973-1977 Lin GT; Zhang ZW; Zang T; Xin DQ; Chang ZJ; Guo YL Interaction of hTCF4 by yeast two-hybrid system	1	0
458	4	322 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(8):4262-4266 Lin SY; Xia WY; Wang JC; Kwong KY; Spohn B; Wen Y; Pestell RG; Hung MC beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression	85	39
459	6	377 2001 CANCER RESEARCH 61(17):6345-6349 Lin YM; Ono K; Satoh S; Ishiguro H; Fujita M; Miwa N; Tanaka T; Tsunoda T; Yang KC; Nakamura Y; Furukawa Y Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis	14	8
460	3	865 2003 JOURNAL OF MEDICAL GENETICS 40(4):- Lipton L; Sieber OM; Thomas HJW; Hodgson SV; Tomlinson IPM; Woodford-Richens K Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype	0	0
461	13	396 2001 CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE 12(2):152-165 Lo Muzio L A possible role for the WNT-1 pathway in oral carcinogenesis	1	0
462	5	747 2002 ORAL ONCOLOGY 38(1):64-72 Lo Muzio L; Pannone G; Staibano S; Mignogna MD; Serpico R; Fanali S; De Rosa G; Piattelli A; Mariggio MA p120(cat) delocalization in cell lines of oral cancer	1	0
463	5	755 2002 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 37(10):1184-1193 Lovig T; Meling GI; Diep CB; Thorstensen L; Andersen SN; Lothe RA; Rognum TO APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status	2	1
464	5	766 2003 ANNALS OF SURGICAL ONCOLOGY 10(3):284-290 Lowy AM; Fenoglio-Preiser C; Kim OJ; Kordich J; Gomez A; Knight J; James L; Groden J Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma	0	0
465	4	197 2000 CELL ADHESION AND COMMUNICATION 7(5):391-408 Luber B; Candidus S; Handschuh G; Mentele E; Hutzler P; Feller S; Voss J; Hofler H; Becker KF Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate	8	2
466	68	859 2003 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 129(4):199-221 Lustig B; Behrens J The Wnt signaling pathway and its role in tumor development	1	0
467	13	716 2002 MOLECULAR AND CELLULAR BIOLOGY 22(4):1184-1193 Lustig B; Jerchow B; Sachs M; Weiler S; Pietsch T; Karsten U; van de Wetering M; Clevers H; Schlag PM; Birchmeier W; Behrens J Negative feedback loop of Wnt signaling through upregulation of conductin/Axin2 in colorectal and liver tumors	22	10
468	31	637 2002 HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA 16(4):775-+ Lynch JP; Hoops TC The genetic pathogenesis of colorectal cancer	0	0
469	12	853 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(15):13487-13495 Lyu J; Costantini F; Jho EH; Joo CK Ectopic expression of axin blocks neuronal differentiation of embryonic carcinoma P19 cells	0	0
470	4	209 2000 CURRENT OPINION IN GENETICS & DEVELOPMENT 10(1):81-93 Macleod K Tumor suppressor genes	35	2
471	3	216 2000 DRUG DISCOVERY TODAY 5(9):415-425 Madden SL; Wang CJ; Landes G Serial analysis of gene expression: from gene discovery to target identification	21	2
472	10	818 2003 CLINICAL CANCER RESEARCH 9(9):3383-3388 Maelandsmo GM; Holm R; Nesland JM; Fodstad O; Florenes VA Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma	0	0
473	5	185 2000 CANCER RESEARCH 60(22):6288-6292 Maiti S; Alam R; Amos CI; Huff V Frequent association of beta-catenin and WT1 mutations in Wilms tumors	14	7
474	1	74 1999 GENES & DEVELOPMENT 13(5):505-510 Maniatis T A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways	180	15
475	1	133 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(4):1603-1608 Mann B; Gelos M; Siedow A; Hanski ML; Gratchev A; Ilyas M; Bodmer WF; Moyer MP; Riecken EO; Buhr HJ; Hanski C Target genes of beta-catenin-T cell-factor lymphoid-enhancer-factor signaling in human colorectal carcinomas	204	147
476	15	553 2002 ADVANCES IN CANCER RESEARCH, VOL 84 84():203-229 Manoukian AS; Woodgett JR Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways	11	0
477	10	453 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(28):26180-26188 Mao CD; Hoang P; DiCorleto PE Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells	9	2
478	4	622 2002 EXPERIMENTAL CELL RESEARCH 280(1):33-44 Marcelo P; Lefevre F Induction of the IFN-gamma gene and protein is linked to the establishment of cell polarity in a porcine epithelial cell line	1	0
479	15	908 2003 PHYSIOLOGICAL REVIEWS 83(2):337-376 Mareel M; Leroy A Clinical, cellular, and molecular aspects of cancer invasion	4	0
480	4	370 2001 CANCER RESEARCH 61(8):3465-3471 Mariadason JM; Bordonaro M; Aslam F; Shi L; Kuraguchi M; Velcich A; Augenlicht LH Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation	28	15
481	12	779 2003 BRITISH JOURNAL OF CANCER 88(11):1755-1762 Marotta A; Parhar K; Owen D; Dedhar S; Salh B Characterisation of integrin-linked kinase signalling in sporadic human colon cancer	0	0
482	9	534 2001 ONCOGENE 20(43):6250-6257 Marotta A; Tan C; Gray V; Malik S; Gallinger S; Sanghera J; Dupuis B; Owen D; Dedhar S; Salh B Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis	10	2
483	2	590 2002 CANCER LETTERS 181(2):125-164 Marsh DJ; Zori RT Genetic insights into familial cancers - update and recent discoveries	4	0
484	7	912 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(13):7859-7864 Martinez ME; O'Brien TG; Fultz KE; Babbar N; Yerushalmi H; Qu N; Guo YJ; Boorman D; Einspahr J; Alberts DS; Gerner EW Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene	1	0
485	3	316 2000 ONCOLOGY 59(4):302-309 Maruyama K; Ochiai A; Akimoto S; Nakamura S; Baba S; Moriya Y; Hirohashi S Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer	7	1
486	6	881 2003 MECHANISMS OF DEVELOPMENT 120(2):157-165 Marygold SJ; Vincent JP Armadillo levels are reduced during mitosis in Drosophila	0	0
487	10	604 2002 CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 41(1):11-28 Mason MD; Davies G; Jiang WG Cell adhesion molecules and adhesion abnormalities in prostate cancer	1	0
488	1	173 2000 CANCER GENETICS AND CYTOGENETICS 121(1):17-21 Masramon L; Ribas M; Cifuentes P; Arribas R; Garcia F; Egozcue J; Peinado MA; Miro R Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting	12	0
489	4	650 2002 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 9(5):489-493 Masui O; Ueda Y; Tsumura A; Koyanagi M; Hijikata M; Shimotohno K RelA suppresses the Wnt/beta-catenin pathway without exerting trans-acting transcriptional ability	0	0
490	2	512 2001 MOLECULAR CELL 7(5):915-926 Matsuzawa S; Reed JC Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses	84	20
491	6	145 1999 TRENDS IN BIOCHEMICAL SCIENCES 24(12):M53-M56 McCormick F Signalling networks that cause cancer	6	0
492	6	146 1999 TRENDS IN CELL BIOLOGY 9(12):M53-M56 McCormick F Signalling networks that cause cancer (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999)	26	0
493	6	147 1999 TRENDS IN GENETICS 15(12):M53-M56 McCormick F Signalling networks that cause cancer (Reprinted from Trends in Biochemical Sciences, vol 12, Dec., 1999)	1	0
494	1	38 1999 CARCINOGENESIS 20(4):635-640 McEntee MF; Chiu CH; Whelan J Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice	29	9
495	9	916 2003 THYROID 13(6):537-545 Meirmanov S; Nakashima M; Kondo H; Matsufuji R; Takamura N; Ishigaki K; Ito M; Prouglo Y; Yamashita S; Sekine I Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site	0	0
496	2	647 2002 INTERNATIONAL JOURNAL OF CANCER 102(1):60-69 Melkoumian ZK; Martirosyan AR; Strobl JS Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines	0	0
497	5	567 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 299(5):744-750 Meredith JE; Wang Q; Mitchell TJ; Olson RE; Zaczek R; Stern AM; Seiffert D gamma-Secretase activity is not involved in presenilin-mediated regulation of beta-catenin	0	0
498	1	50 1999 CLINICAL CANCER RESEARCH 5(5):945-951 Meyskens FL; Gerner EW Development of difluoromethylornithine (DFMO) as a chemoprevention agent	71	4
499	9	848 2003 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 11(4):461-464 Miao JY; Kusafuka T; Kuroda S; Yoneda A; Zhou ZW; Okada A Mutation of beta-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis	0	0
500	12	530 2001 ONCOGENE 20(37):5093-5099 Michaelson JS; Leder P beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland	23	12

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