#	Cited nodes	Nodes / Authors	GCS	LCS
601	5	585 2002 CANCER CELL 1(4):355-368 Philipp-Staheli J; Kim KH; Payne SR; Gurley KE; Liggitt D; Longton G; Kemp CJ Pathway-specific tumor suppression: Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice	7	0
602	2	616 2002 EUROPEAN JOURNAL OF CANCER PREVENTION 11(1):85-97 Piard F; Chapusot C; Ecarnot-Laubriet A; Ponnelle T; Martin L Molecular markers of heterogeneity in colorectal cancers and adenomas	0	0
603	2	560 2002 ANNALES DE PATHOLOGIE 22(4):277-288 Piard F; Martin L; Chapusot C; Ponnelle T; Faivre J Genetic pathways in colorectal cancer: interest for the pathologist	0	0
604	13	451 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(23):20436-20443 Piedra J; Martinez D; Castano J; Miravet S; Dunach M; de Herreros AG Regulation of beta-catenin structure and activity by tyrosine phosphorylation	27	9
605	9	475 2001 JOURNAL OF CELLULAR PHYSIOLOGY 189(2):121-132 Pla P; Moore R; Morali OG; Grille S; Martinozzi S; Delmas V; Larue L Cadherins in neural crest cell development and transformation	7	1
606	3	323 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(22):12103-12108 Playford MP; Bicknell D; Bodmer WF; Macaulay VM Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin	39	9
607	1	58 1999 CURRENT OPINION IN GENETICS & DEVELOPMENT 9(1):15-21 Polakis P The oncogenic activation of beta-catenin	207	100
608	24	237 2000 GENES & DEVELOPMENT 14(15):1837-1851 Polakis P Wnt signaling and cancer	448	140
609	1	53 1999 COLON CANCER PREVENTION 470():23-32 Polakis P; Hart M; Rubinfeld B Defects in the regulation of beta-catenin in colorectal cancer	22	8
610	7	476 2001 JOURNAL OF CLINICAL ONCOLOGY 19(11):2948-2958 Polyak K; Riggins GJ Gene discovery using the serial analysis of gene expression technique: Implications for cancer research	24	2
611	18	686 2002 JOURNAL OF CELL SCIENCE 115(23):4587-4595 Posthaus H; Williamson L; Baumann D; Kemler R; Caldelari R; Suter MM; Schwarz H; Muller E beta-catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes	3	0
612	1	67 1999 ENDOCRINE REVIEWS 20(2):207-239 Potter E; Bergwitz C; Brabant G The cadherin-catenin system: Implications for growth and differentiation of endocrine tissues	42	7
613	1	102 1999 JOURNAL OF THE NATIONAL CANCER INSTITUTE 91(11):916-932 Potter JD Colorectal cancer: Molecules and populations	193	6
614	15	871 2003 JOURNAL OF PATHOLOGY 201(2):250-259 Prange W; Breuhahn K; Fischer F; Zilkens C; Pietsch T; Petmecky K; Eilers R; Dienes HP; Schirmacher P Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes	0	0
615	2	120 1999 ONCOGENE 18(19):2967-2987 Prendergast GC Mechanisms of apoptosis by c-Myc	152	8
616	6	462 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(51):48276-48284 Prescott JE; Osthus RC; Lee LA; Lewis BC; Shim H; Barrett JF; Guo QB; Hawkins AL; Griffin CA; Dang CV A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation	5	0
617	3	707 2002 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13(5):1152-1161 Price VR; Reed CA; Lieberthal W; Schwartz JH ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of beta-catenin and LEF-1	3	1
618	8	398 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(1):19-26 Prober DA; Edgar BA Growth regulation by oncogenes - new insights from model organisms	23	1
619	10	642 2002 INFECTION AND IMMUNITY 70(5):2605-2613 Prozialeck WC; Fay MJ; Lamar PC; Pearson CA; Sigar I; Ramsey KH Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells	0	0
620	6	758 2002 TOXICOLOGY AND APPLIED PHARMACOLOGY 182(3):255-265 Prozialeck WC; Grunwald GB; Dey PM; Reuhl KR; Parrish AR Cadherins and NCAM as potential targets in metal toxicity	1	0
621	7	448 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(12):8968-8978 Pukrop T; Gradl D; Henningfeld KA; Knochel W; Wedlich D; Kuhl M Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4	8	1
622	4	770 2003 BIOCHEMICAL JOURNAL 375():465-470 Qu N; Ignatenko NA; Yamauchi P; Stringer DE; Levenson C; Shannon P; Perrin S; Gerner EW Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine	0	0
623	7	868 2003 JOURNAL OF NUTRITION 133(6):1943-1948 Rajakangas J; Basu S; Salminen I; Mutanen M Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappa B and cyclin D1 protein levels in the Min mouse	0	0
624	3	884 2003 MOLECULAR AND CELLULAR BIOLOGY 23(18):6694-6701 Rao P; Kadesch T The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells	0	0
625	3	496 2001 MODERN PATHOLOGY 14(3):236-245 Redston M Carcinogenesis in the GI tract: From morphology to genetics and back again	5	0
626	3	421 2001 GENE 277(1-2):63-81 Reeves R Molecular biology of HMGA proteins: hubs of nuclear function	21	0
627	2	349 2001 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1519(1-2):13-29 Reeves R; Beckerbauer L HMGI/Y proteins: flexible regulators of transcription and chromatin structure	32	1
628	1	501 2001 MOLECULAR AND CELLULAR BIOLOGY 21(2):575-594 Reeves R; Edberg DD; Li Y Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells	23	2
629	14	645 2002 INTERNATIONAL JOURNAL OF CANCER 100(5):549-556 Reifenberger J; Knobbe CB; Wolter M; Blaschke B; Schulte KW; Pietsch T; Ruzicka T; Reifenberger G Molecular genetic analysis of malignant melanomas for aberrations of the Wnt signaling pathway genes CTNNB1, APC, ICAT and BTRC	8	4
630	5	866 2003 JOURNAL OF MOLECULAR BIOLOGY 330(5):955-966 Reimer T; Weiwad M; Schierhorn A; Ruecknagel PK; Rahfeld JU; Bayer P; Fischer G Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14	0	0
631	6	465 2001 JOURNAL OF CELL BIOLOGY 152(3):491-502 Reinacher-Schick A; Gumbiner BM Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells	22	0
632	5	902 2003 ONCOGENE 22(42):6517-6523 Reiss K; Khalili K Viruses and cancer: lessons from the human polyomavirus, JCV	0	0
633	7	684 2002 JOURNAL OF CELL SCIENCE 115(13):2639-2650 Relchelt J; Magin TM Hyperproliferation, induction of c-Myc and 14-3-3 sigma, but no cell fragility in keratin-10-null mice	0	0
634	5	247 2000 IMMUNITY 13(1):15-24 Reya T; O'Riordan M; Okamura R; Devaney E; Willert K; Nusse R; Grosschedl R Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism	49	11
635	1	194 2000 CARDIOVASCULAR RESEARCH 45(3):621-629 Rezvani M; Barrans JD; Dai KS; Liew CC Apoptosis-related genes expressed in cardiovascular development and disease: an EST approach	7	0
636	1	263 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(24):18470-18475 Rezvani M; Liew CC Role of the adenomatous polyposis coli gene product in human cardiac development and disease	7	0
637	4	210 2000 CURRENT OPINION IN MOLECULAR THERAPEUTICS 2(6):682-690 Ricci MS; El-Deiry WS Novel strategies for therapeutic design in molecular oncology using gene expression profiles	5	0
638	13	888 2003 MOLECULAR CANCER THERAPEUTICS 2(9):885-892 Rice PL; Kelloff J; Sullivan H; Driggers LJ; Beard KS; Kuwada S; Piazza G; Ahnen DJ Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells	0	0
639	2	753 2002 RECENT PROGRESS IN HORMONE RESEARCH, VOL 57 57():195-220 Richards JS; Russell DL; Ochsner S; Hsieh M; Doyle KH; Falender AE; Lo YK; Sharma SC Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization	11	0
640	10	491 2001 MECHANISMS OF DEVELOPMENT 109(2):173-181 Ridanpaa M; Fodde R; Kielman M Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures	2	0
641	8	403 2001 DISEASE MARKERS 17(2):41-48 Riggins GJ Using Serial Analysis of Gene Expression to identify tumor markers and antigens	3	1
642	4	260 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(19):14736-14742 Rimerman RA; Gellert-Randleman A; Diehl JA Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation	25	3
643	1	618 2002 EUROPEAN JOURNAL OF HUMAN GENETICS 10(10):631-637 Ripa R; Bisgaard ML; Bulow S; Nielsen FC De novo mutations in familial adenomatous polyposis (FAP)	0	0
644	1	234 2000 GENES & DEVELOPMENT 14(8):889-894 Robinson GW; Hennighausen L; Johnson PF Side-branching in the mammary gland: the progesterone-Wnt connection	17	2
645	5	459 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):45113-45119 Rockman SP; Currie SA; Ciavarella M; Vincan E; Dow C; Thomas RJS; Phillips WA Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma	18	9
646	11	378 2001 CANCER RESEARCH 61(17):6563-6568 Roh H; Green DW; Boswell CB; Pippin JA; Drebin JA Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells	15	8
647	2	199 2000 CELL PROLIFERATION 33(1):1-18 Roncucci L; Pedroni M; Vaccina F; Benatti P; Marzona L; De Pol A Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics	22	1
648	5	21 1999 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1424(2-3):M23-M37 Roose J; Clevers H TCF transcription factors: molecular switches in carcinogenesis	53	0
649	3	139 1999 SCIENCE 285(5435):1923-1926 Roose J; Huls G; van Beest M; Moerer P; van der Horn K; Goldschmeding R; Logtenberg T; Cleavers H Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1	124	82
650	1	118 1999 ONCOGENE 18(15):2507-2517 Rosenwald IB; Chen JJ; Wang ST; Savas L; London IM; Pullman J Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis	36	2
651	8	577 2002 BREAST CANCER RESEARCH 5(1):16-22 Rossi S; Loda M The role of the ubiquitination-proteasome pathway in breast cancer - Use of mouse models for analyzing ubiquitination processes	0	0
652	4	325 2000 REVIEWS OF REPRODUCTION 5(1):53-61 Rowlands TM; Symonds JM; Farookhi R; Blaschuk OW Cadherins: crucial regulators of structure and function in reproductive tissues	10	0
653	1	510 2001 MOLECULAR CARCINOGENESIS 31(4):192-203 Roy D; Calaf G; Hei TK Profiling of differentially expressed genes induced by high linear energy transfer radiation in breast epithelial cells	3	0
654	16	860 2003 JOURNAL OF CELL SCIENCE 116(5):773-783 Ryo A; Liou YC; Lu KP; Wulf G Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer	2	0
655	13	514 2001 NATURE CELL BIOLOGY 3(9):793-801 Ryo A; Nakamura M; Wulf G; Liou YC; Lu KP Pin 1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC	31	9
656	6	533 2001 ONCOGENE 20(42):5972-5981 Saadi-Kheddouci S; Berrebi D; Romagnolo B; Cluzeaud F; Peuchmaur M; Kahn A; Vandewalle A; Perret C Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene	13	0
657	12	685 2002 JOURNAL OF CELL SCIENCE 115(13):2771-2780 Sadot E; Conacci-Sorrell M; Zhurinsky J; Shnizer D; Lando Z; Zharhary D; Kam Z; Ben-Ze'ev A; Geiger B Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells	1	0
658	23	506 2001 MOLECULAR AND CELLULAR BIOLOGY 21(20):6768-6781 Sadot E; Geiger B; Oren M; Ben-Ze'ev A Down-regulation of beta-catenin by activated p53	26	8
659	11	312 2000 ONCOGENE 19(16):1992-2001 Sadot E; Simcha I; Iwai K; Ciechanover A; Geiger B; Ben-Ze'ev A Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system	17	10
660	9	800 2003 CANCER SCIENCE 94(1):103-111 Saegusa M; Hamano M; Kuwata T; Yoshida T; Hashimura M; Akino F; Watanabe J; Kuramoto H; Okayasu I Up-regulation and nuclear localization of beta-catenin in endometrial carcinoma in response to progestrone therapy	0	0
661	5	486 2001 JOURNAL OF PATHOLOGY 194(1):59-67 Saegusa M; Okayasu I Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation	12	7
662	8	610 2002 DIGESTIVE DISEASES AND SCIENCES 47(12):2738-2742 Saeki H; Tanaka S; Sugimachi K; Kimura Y; Miyazaki M; Ohga T; Sugimachi K Interrelation between expression of matrix metalloproteinase 7 and beta-catenin in esophageal cancer	0	0
663	6	536 2001 ONCOLOGY 61(2):156-161 Saeki H; Tanaka S; Tokunaga E; Kawaguchi H; Ikeda Y; Maehara Y; Sugimachi K Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability	2	1
664	1	2 1998 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 252(1):117-122 Sagara N; Toda G; Hirai M; Terada M; Katoh M Molecular cloning, differential expression, and chromosomal localization of human Frizzled-1, Frizzled-2 and Frizzled-7	94	11
665	8	710 2002 LABORATORY INVESTIGATION 82(1):97-103 Saito T; Oda Y; Kawaguchi K; Tanaka K; Matsuda S; Tamiya S; Iwamoto Y; Tsuneyoshi M Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: Real-time semiquantitative assay by TaqMan polymerase chain reaction	2	1
666	7	487 2001 JOURNAL OF PATHOLOGY 195(2):222-228 Saito T; Oda Y; Tanaka K; Matsuda S; Tamiya S; Iwamoto Y; Tsuneyoshi M beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours	7	2
667	9	347 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284(5):1168-1175 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region	61	2
668	7	438 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(5):991-996 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2	67	7
669	6	440 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):105-110 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region	62	2
670	5	437 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(5):959-964 Saitoh T; Katoh M Expression profiles of beta TRCP1 and beta TRCP2, and mutation analysis of beta TRCP2 in gastric cancer	46	6
671	9	442 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):123-127 Saitoh T; Katoh M Molecular cloning and characterization of human WNT8A	59	2
672	8	443 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(2):311-315 Saitoh T; Katoh M FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer	41	2
673	4	345 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 281(3):815-820 Saitoh T; Moriwaki J; Koike J; Takagi A; Miwa T; Shiokawa K; Katoh M Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway	54	4
674	6	564 2002 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 126(9):1071-1078 Sakamoto A; Oda Y; Adachi T; Saito T; Tamiya S; Iwamoto Y; Tsuneyoshi M beta-Catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma	1	1
675	5	660 2002 JOURNAL OF BIOCHEMISTRY 132(5):697-703 Sakanaka C Phosphorylation and regulation of beta-catenin by casein kinase I epsilon	3	0
676	5	483 2001 JOURNAL OF PATHOLOGY 193(4):427-432 Saldanha G The Hedgehog signalling pathway and cancer	7	0
677	1	636 2002 GUT 51(1):56-59 Salovaara R; Roth S; Loukola A; Launonen V; Sistonen P; Avizienyte E; Kristo P; Jarvinen H; Souchelnytskyi S; Sarlomo-Rikala M; Aaltonen LA Frequent loss of SMAD4/DPC4 protein in colorectal cancers	4	1
678	2	691 2002 JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY 55(6):385-388 Salovaara R; Roth S; Loukola A; Launonen V; Sistonen P; Avizienyte E; Kristo P; Jarvinen H; Souchelnytskyi S; Sarlomo-Rikala M; Aaltonen LA Frequent loss of SMAD4/DPC4 protein in colorectal cancers (Reprinted from Gut, vol 51, pg 56-59, 2002)	0	0
679	15	404 2001 EMBO JOURNAL 20(16):4500-4511 Sampson EM; Haque ZK; Ku MC; Tevosian SG; Albanese C; Pestell RG; Paulson KE; Yee AS Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1	11	3
680	2	878 2003 LUNG CANCER 40(2):111-121 Sanchez-Cespedes M Dissecting the genetic alterations involved in lung carcinogenesis	0	0
681	1	298 2000 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 453(2):129-181 Sankaranarayanan K; Chakraborty R Ionizing radiation and genetic risks XII. The concept of "potential recoverability correction factor" (PRCF) and its use for predicting the risk of radiation-inducible genetic disease in human live births	2	0
682	3	293 2000 MOLECULAR AND CELLULAR BIOLOGY 20(10):3497-3509 Santoni-Rugiu E; Falck J; Mailand N; Bartek J; Lukas J Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway	53	0
683	5	336 2001 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 115(6):835-840 Sarbia M; Arjumand J; Wolter M; Reifenberger G; Heep H; Gabbert HE Frequent c-myc amplification in high-grade dysplasia and adenocarcinoma in Barrett esophagus	9	1
684	1	12 1999 AMERICAN JOURNAL OF PATHOLOGY 155(4):1027-1032 Sarbia M; Loberg C; Wolter M; Arjumand J; Heep H; Reifenberger G; Gabbert HE Expression of Bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus	10	2
685	5	190 2000 CANCER RESEARCH 60(24):7057-7065 Sasaki CY; Lin HC; Morin PJ; Longo DL Truncation of the extracellular region abrogrates cell contact but retains the growth-suppressive activity of E-cadherin	9	0
686	2	300 2000 NATURE 406(6798):897-902 Sasaki T; Irie-Sasaki J; Horie Y; Bachmaier K; Fata JE; Li M; Suzuki A; Bouchard D; Ho A; Redston M; Gallinger S; Khokha R; Mak TW; Hawkins PT; Stephens L; Scherer SW; Tsao M; Penninger JM Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma	46	4
687	8	785 2003 CANCER RESEARCH 63(4):801-806 Sasaki T; Suzuki H; Yagi K; Furuhashi M; Yao R; Susa S; Noda T; Arai Y; Miyazono K; Kato M Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc	2	0
688	7	748 2002 ORAL ONCOLOGY 38(8):772-778 Sato K; Okazaki Y; Tonogi M; Tanaka Y; Yamane G Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide	0	0
689	4	302 2000 NATURE GENETICS 24(3):245-250 Satoh S; Daigo Y; Furukawa Y; Kato T; Miwa N; Nishiwaki T; Kawasoe T; Ishiguro H; Fujita M; Tokino T; Sasaki Y; Imaoka S; Murata M; Shimano T; Yamaoka Y; Nakamura Y AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1	257	122
690	1	870 2003 JOURNAL OF PATHOLOGY 200(1):59-64 Sawyer EJ; Poulsom R; Hunt FT; Jeffery R; Elia G; Ellis IO; Ellis P; Tomlinson IPM; Hanby AM Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit	0	0
691	11	715 2002 MODERN PATHOLOGY 15(10):1032-1037 Schlosshauer PW; Ellenson LH; Soslow RA beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype	2	0
692	3	291 2000 MODERN PATHOLOGY 13(10):1066-1071 Schlosshauer PW; Pirog EC; Levine RL; Ellenson LH Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma	17	6
693	9	674 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(25):22692-22698 Schroeder JA; Adriance MC; McConnell EJ; Thompson MC; Pockaj B; Gendler SJ ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu Transgenic carcinomas	7	5
694	7	896 2003 ONCOGENE 22(9):1324-1332 Schroeder JA; Adriance MC; Thompson MC; Camenisch TD; Gendler SJ MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion	1	0
695	21	788 2003 CANCER RESEARCH 63(11):2913-2922 Schwartz DR; Wu R; Kardia SLR; Levin AM; Huang CC; Shedden KA; Kuick R; Misek DE; Hanash SM; Taylor JMG; Reed H; Hendrix N; Zhai Y; Fearon ER; Cho KR Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas	0	0
696	1	138 1999 SCIENCE 283(5410):2089-2091 Seeling JM; Miller JR; Gil R; Moon RT; White R; Virshup DM Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A	117	44
697	16	166 2000 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1495(2):168-182 Seidensticker MJ; Behrens J Biochemical interactions in the wnt pathway	67	11
698	6	792 2003 CANCER RESEARCH 63(15):4641-4647 Seike M; Kondo T; Mori Y; Gemma A; Kudoh S; Sakamoto M; Yamada T; Hirohashi S Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin	0	0
699	12	735 2002 ONCOGENE 21(38):5906-5911 Sekine S; Shibata T; Sakamoto M; Hirohashi S Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype	3	1
700	8	761 2002 VIRCHOWS ARCHIV 440(4):381-386 Sekine S; Shibata T; Yamauchi Y; Nakanishi Y; Shimoda T; Sakamoto M; Hirohashi S beta-catenin mutations in sporadic fundic gland polyps	10	4

#	Cited nodes	Nodes / Authors	GCS	LCS
701	4	368 2001 CANCER RESEARCH 61(7):2899-2906 Sellin JH; Umar S; Xiao JG; Morris AP Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo	13	4
702	1	1 1998 AMERICAN JOURNAL OF HUMAN GENETICS 63(6):1588-1593 Semb H; Christofori G The tumor-suppressor function of E-cadherin	20	3
703	2	354 2001 CANCER 91(1):42-48 Semba S; Han SY; Ikeda H; Horii A Frequent nuclear accumulation of beta-catenin in pituitary adenoma	0	2
704	2	221 2000 ENDOCRINE PATHOLOGY 11(3):243-250 Semba S; Kusumi R; Moriya T; Sasano H Nuclear accumulation of beta-catenin in human endocrine tumors: Association with Ki-67 (MIB-1) proliferative activity	4	1
705	4	409 2001 ENDOCRINE PATHOLOGY 12(1):1-13 Semba S; Yamakawa M; Sasano H The cadherin-catenin superfamily in endocrine tumors	0	0
706	3	411 2001 EUROPEAN JOURNAL OF CANCER 37(1):12-22 Sharma RA; Manson MM; Gescher A; Steward WP Colorectal cancer chemoprevention: biochemical targets and clinical development of promising agents	18	0
707	1	57 1999 CURRENT OPINION IN GASTROENTEROLOGY 15(1):3-8 Shattuck-Brandt RL; DuBois RN The molecular basis of colorectal carcinogenesis	0	0
708	4	612 2002 EMBO REPORTS 3(6):521-526 Shaw PE Peptidyl-prolyl isomerases: a new twist to transcription	8	2
709	4	527 2001 ONCOGENE 20(30):4007-4018 Shi YJ; Simmons MN; Seki T; Oh SP; Sugrue SP Change in gene expression subsequent to induction of Pnn/DRS/memA: increase in p21(cip1/waf1)	6	0
710	1	334 2001 ADVANCES IN CANCER RESEARCH, VOL 80 80():83-114 Shibata D; Aaltonen LA Genetic predisposition and somatic diversification in tumor development and progression	8	0
711	10	840 2003 HEPATOLOGY 38(1):178-186 Shibata T; Chuma M; Kokubu A; Sakamoto N; Hirohashi S EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma	0	0
712	1	307 2000 NUCLEIC ACIDS RESEARCH 28(15):2969-2976 Shie JL; Chen ZY; Fu MF; Pestell RG; Tseng CC Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif	33	3
713	4	177 2000 CANCER RESEARCH 60(6):1671-1676 Shih IM; Tu J; He TC; Vogelstein B; Kinzler KW The beta-catenin binding domain of adenomatous polyposis coil is sufficient for tumor suppression	42	23
714	13	816 2003 CLINICAL CANCER RESEARCH 9(6):2121-2132 Shiina H; Igawa M; Breault J; Ribeiro L; Pookot D; Urakami S; Terashima M; Deguchi M; Yamanaka M; Shirai M; Kaneuchi M; Kane CJ; Dahiya R The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma	0	0
715	5	709 2002 JOURNAL OF UROLOGY 168(5):2220-2226 Shiina H; Igawa M; Shigeno K; Terashima M; Deguchi M; Yamanaka M; Ribeiro L; Kane CJ; Dahiya R beta-catenin mutations correlate with over expression of c-myc and cyclin D1 genes in bladder cancer	0	0
716	6	380 2001 CANCER RESEARCH 61(19):7101-7109 Shiina H; Igawa M; Urakami S; Shigeno K; Yoneda T; Terashima M; Deguchi M; Ribeiro L; Dahiya R Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer	2	0
717	5	634 2002 GUT 50(5):658-664 Shimada T; Kojima K; Yoshiura K; Hiraishi H; Terano A Characteristics of the peroxisome proliferator activated receptor gamma (PPAR gamma) ligand induced apoptosis in colon cancer cells	9	0
718	2	252 2000 INTERNATIONAL JOURNAL OF CANCER 87(1):5-11 Shimakage M; Kawahara K; Kikkawa N; Sasagawa T; Yutsudo M; Inoue H Down-regulation of drs mRNA in human colon adenocarcinomas	6	0
719	1	834 2003 GENE 307():51-62 Shimizu K; Chen W; Ashique AM; Moroi R; Li YP Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene	1	0
720	11	631 2002 GENES CHROMOSOMES & CANCER 33(1):73-81 Shimizu Y; Ikeda S; Fujimori M; Kodama S; Nakahara M; Okajima M; Asahara T Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability	2	0
721	6	796 2003 CANCER RESEARCH 63(19):6116-6120 Shimokawa T; Furukawa Y; Sakai M; Li MH; Miwa N; Lin YM; Nakamura Y Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex	0	0
722	4	619 2002 EXPERIMENTAL AND MOLECULAR MEDICINE 34(6):444-450 Shin SY; Yoon SC; Kim YH; Kim YS; Lee YH Phosphorylation of glycogen synthase kinase-3 beta at serine-9 by phospholipase C gamma 1 through protein kinase C in rat 3Y1 fibroblasts	0	0
723	1	329 2000 SURGERY 127(5):552-561 Shiozaki H; Doki Y; Kawanishi K; Shamma A; Yano M; Inoue M; Monden M Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers	11	0
724	1	135 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(10):5522-5527 Shtutman M; Zhurinsky J; Simcha I; Albanese C; D'Amico M; Pestell R; Ben-Ze'ev A The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway	351	229
725	1	752 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(18):11593-11598 Siddiqui-Jain A; Grand CL; Bearss DJ; Hurley LH Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription	22	0
726	7	297 2000 MOLECULAR MEDICINE TODAY 6(12):462-469 Sieber OM; Tomlinson IP; Lamlum H The adenomatous polyposis coli (APC) tumour suppressor - genetics, function and disease	13	3
727	4	793 2003 CANCER RESEARCH 63(16):4773-4776 Siu IM; Lal A; Blankenship JR; Aldosari N; Riggins GJ c-myc promoter activation in medulloblastoma	0	0
728	11	26 1999 CANCER AND METASTASIS REVIEWS 18(2):215-230 Smalley MJ; Dale TC Wnt signalling in mammalian development and cancer	33	13
729	22	482 2001 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 6(1):37-52 Smalley MJ; Dale TC Wnt signaling and mammary tumorigenesis	11	2
730	1	152 2000 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 14(10):1231-1247 Smith AM; Watson SA Review article: gastrin and colorectal cancer	16	0
731	1	242 2000 GUT 47(6):820-824 Smith AM; Watson SA Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence	26	1
732	1	80 1999 HUMAN MOLECULAR GENETICS 8(8):1479-1485 Smith DP; Spicer J; Smith A; Swift S; Ashworth A The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase	23	0
733	5	670 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(20):18191-18197 Smith E; Coetzee GA; Frenkel B Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3 beta	2	0
734	3	224 2000 EUROPEAN JOURNAL OF CANCER 36(5):664-674 Smith ML; Hawcroft G; Hull MA The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action	60	4
735	7	827 2003 DIAGNOSTIC MOLECULAR PATHOLOGY 12(1):44-49 Smyth P; Finn S; O'Leary J; Sheils O Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues	0	0
736	5	330 2000 SURGICAL ONCOLOGY-OXFORD 9(3):95-101 Sohn TA; Yeo CJ The molecular genetics of pancreatic ductal carcinoma: a review	3	0
737	9	765 2003 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 285(1):G217-G222 Song DH; Rana B; Wolfe JR; Crimmins G; Choi C; Albanese C; Wang TC; Pestell RG; Wolfe MM Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1	0	0
738	4	267 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(31):23790-23797 Song DH; Sussman DJ; Seldin DC Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells	51	8
739	7	466 2001 JOURNAL OF CELL BIOLOGY 152(4):785-794 Soriano S; Kang DE; Fu MF; Pestell R; Chevallier N; Zheng H; Koo EH Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and Notch processing	39	4
740	6	407 2001 EMBO JOURNAL 20(22):6203-6212 Spink KE; Fridman SG; Weis WI Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex	8	0
741	8	217 2000 EMBO JOURNAL 19(10):2270-2279 Spink KE; Polakis P; Weis WI Structural basis of the Axin-adenomatous polyposis coli interaction	27	5
742	1	91 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(32):22705-22712 Spychala J; Zimmermann AG; Mitchell BS Tissue-specific regulation of the ecto-5 '-nucleotidase promoter - Role of the cAMP response element site in mediating repression by the upstream regulatory region	11	0
743	3	413 2001 EUROPEAN JOURNAL OF IMMUNOLOGY 31(1):285-293 Staal FJT; Meeldijk J; Moerer P; Jay P; van de Weerdt BCM; Vainio S; Nolan GP; Clevers H Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription	20	2
744	2	910 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(3):1004-1009 Stappenbeck TS; Mills JC; Gordon JI Molecular features of adult mouse small intestinal epithelial progenitors	2	0
745	1	5 1998 CURRENT OPINION IN CELL BIOLOGY 10(6):702-709 Stappenbeck TS; Wong MH; Saam JR; Mysorekar IU; Gordon JI Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium	28	3
746	5	261 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(21):16345-16353 Steinhusen U; Badock V; Bauer A; Behrens J; Wittman-Liebold B; Dorken B; Bommert K Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential	22	6
747	2	311 2000 ONCOGENE 19(8):1102-1113 Sternlicht MD; Bissell MJ; Werb Z The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter	49	0
748	6	264 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(27):20707-20716 Stewart DB; Barth AIM; Nelson WJ Differential regulation of endogenous cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and activation of beta-catenin signaling	12	1
749	21	471 2001 JOURNAL OF CELL BIOLOGY 154(6):1185-1196 Stockinger A; Eger A; Wolf J; Beug H; Foisner R E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity	31	5
750	9	653 2002 INTERNATIONAL JOURNAL OF ONCOLOGY 20(5):905-911 Stoehr R; Krieg RC; Knuechel R; Hofstaedter F; Pilarsky C; Zaak D; Schmitt R; Hartmann A No evidence for involvement of beta-catenin and APC in urothelial carcinomas	4	1
751	3	624 2002 FEBS LETTERS 530(1-3):147-152 Stone CD; Chen ZY; Tseng CC Gut-enriched Kruppel-like factor regulates colonic cell growth through APC/beta-catenin pathway	0	0
752	1	494 2001 MICROSCOPY RESEARCH AND TECHNIQUE 52(2):171-181 Strange R; Metcalfe T; Thackray L; Dang M Apoptosis in normal and neoplastic mammary gland development	9	0
753	1	99 1999 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(4):1491-1492 Stratakis CA Carney complex and related syndromes and their genetic loci - Response	0	0
754	3	589 2002 CANCER LETTERS 180(2):107-119 Strieder V; Lutz W Regulation of N-myc expression in development and disease	2	0
755	2	824 2003 DEVELOPMENTAL BIOLOGY 259(1):48-61 Stump RJW; Ang S; Chen YJ; von Bahr T; Lovicu FJ; Pinson K; de Iongh RU; Yamaguchi TP; Sassoon DA; McAvoy JW A role for Wnt/beta-catenin signaling in lens epithelial differentiation	0	0
756	5	208 2000 CURRENT OPINION IN GASTROENTEROLOGY 16(5):419-425 Su GH; Kern SE Molecular genetics of ductal pancreatic neoplasia	2	0
757	6	497 2001 MODERN PATHOLOGY 14(9):900-905 Sugimachi K; Taguchi K; Aishima S; Tanaka S; Shimada M; Kajiyama K; Sugimachi K; Tsuneyoshi M Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma	7	5
758	1	341 2001 ANTICANCER RESEARCH 21(1A):65-70 Sundfeldt K; Ivarsson K; Rask K; Haeger M; Hedin L; Brannstrom M Higher levels of soluble E-cadherin in cyst fluid from malignant ovarian tumours than in benign cysts	1	0
759	2	591 2002 CANCER LETTERS 183(1):31-41 Suzui M; Okuno M; Tanaka T; Nakagama H; Moriwaki H Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation	1	0
760	11	372 2001 CANCER RESEARCH 61(10):4197-4205 Szeto W; Jiang W; Tice DA; Rubinfeld B; Hollingshead PG; Fong SE; Dugger DL; Pham T; Yansura DG; Wong TA; Grimaldi JC; Corpuz RT; Singh JS; Frantz GD; Devaux B; Crowley CW; Schwall RH; Eberhard DA; Rastelli L; Polakis P; Pennica D Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid	7	2
761	1	550 2001 PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 69 69():47-79 Szyf M; Detich N Regulation of the DNA methylation machinery and its role in cellular transformation	7	0
762	6	513 2001 NATURE 411(6835):349-354 Taipale J; Beachy PA The Hedgehog and Wnt signaling pathways in cancer	98	11
763	13	734 2002 ONCOGENE 21(38):5861-5867 Takahashi M; Tsunoda T; Seiki M; Nakamura Y; Furukawa Y Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers	10	1
764	1	101 1999 JOURNAL OF INVESTIGATIVE DERMATOLOGY 113(2):258-262 Takata M; Fujimoto A; Aoki H; Hatta N; Ooi A; Takehara K erbB-2 overexpression but no activation of beta-catenin gene in extramammary Paget's disease	7	0
765	9	394 2001 CLINICAL CANCER RESEARCH 7(4):901-908 Takayasu H; Horie H; Hiyama E; Matsunaga T; Hayashi Y; Watanabe Y; Suita S; Kaneko M; Sasaki F; Hashizume K; Ozaki T; Furuuchi K; Tada M; Ohnuma N; Nakagawara A Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma	19	9
766	6	641 2002 HUMAN PATHOLOGY 33(8):852-855 Takayasu H; Motoi T; Kanamori Y; Kitano Y; Nakanishi H; Tange T; Nakagawara A; Hashizume K Two case reports of childhood liver cell adenomas harboring beta-catenin abnormalities	1	0
767	5	276 2000 JOURNAL OF CELL BIOLOGY 149(2):249-254 Takemaru KI; Moon RT The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression	85	43
768	2	876 2003 LEUKEMIA RESEARCH 27(4):359-361 Takeuchi S; Takeuchi N; Fermin AC; Taguchi H; Koeffler HP Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability	0	0
769	5	522 2001 ONCOGENE 20(1):133-140 Tan C; Costello P; Sanghera J; Dominguez D; Baulida J; de Herreros AG; Dedhar S Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells	35	7
770	2	649 2002 INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 46(4):653-660 Tan SS; Gunnersen J; Job C Global gene expression analysis of developing neocortex using SAGE	0	0
771	12	422 2001 GENES & DEVELOPMENT 15(14):1796-1807 Tao WK; Pennica D; Xu LF; Kalejta RF; Levine AJ Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1	27	2
772	6	305 2000 NEUROSURGERY 47(4):888-901 Taylor MD; Mainprize TG; Rutka JT Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: A review	10	1
773	6	416 2001 FASEB JOURNAL 15(12):2057-2072 Tegeder I; Pfeilschifter J; Geisslinger G Cyclooxygenase-independent actions of cyclooxygenase inhibitors	70	0
774	1	16 1999 ANTICANCER RESEARCH 19(6A):4715-4728 Teh BT; Larsson C; Nordenskjold M Tumor suppressor genes (TSG)	7	0
775	4	333 2001 ACTA GASTRO-ENTEROLOGICA BELGICA 64(3):249-254 Tejpar S; Cassiman JJ; Van Cutsem E The molecular basis of colorectal cancer	0	0
776	5	565 2002 BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY 16(2):171-185 Tejpar S; Van Cutsem E Molecular and genetic defects in colorectal tumorigenesis	0	0
777	2	582 2002 CANCER BIOLOGY & THERAPY 1(1):58-63 Termuhlen PM; Sweeney-Gotsch BM; Berman RS; Ellis LM; Bucana C; Shen Y; Cleary KR; McConkey DJ Increased apoptosis in metastatic human colonic adenocarcinomas	0	0
778	2	127 1999 ONCOGENE 18(47):6583-6588 Terris B; Pineau P; Bregeaud L; Valla D; Belghiti J; Tiollais P; Degott C; Dejean A Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas	32	13
779	1	112 1999 NATURE 398(6726):422-426 Tetsu O; McCormick F beta-catenin regulates expression of cyclin D1 in colon carcinoma cells	698	498
780	17	480 2001 JOURNAL OF IMMUNOLOGY 167(12):6786-6793 Thiele A; Wasner M; Muller C; Engeland K; Hauschildt S Regulation and possible function of beta-catenin in human monocytes	0	0
781	7	180 2000 CANCER RESEARCH 60(13):3338-3342 Thompson WJ; Piazza GA; Li H; Liu L; Fetter J; Zhu B; Sperl G; Ahnen D; Pamukcu R Exisulind induction of apoptosis involves guanosine 3 ',5 '-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin	49	3
782	2	708 2002 JOURNAL OF THE NATIONAL CANCER INSTITUTE 94(4):252-266 Thun MJ; Henley SJ; Patrono C Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues	83	1
783	13	664 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(8):6118-6123 Tice DA; Soloviev I; Polakis P Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes	6	0
784	9	666 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(16):14329-14335 Tice DA; Szeto W; Soloviev I; Rubinfeld B; Fong SE; Dugger DL; Winer J; Williams PM; Wieand D; Smith V; Schwall RH; Pennica D; Polakis P Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling	9	1
785	6	278 2000 JOURNAL OF CELL BIOLOGY 149(4):761-766 Tirnauer JS; Bierer BE EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability	44	3
786	5	477 2001 JOURNAL OF DERMATOLOGICAL SCIENCE 27(3):170-177 Tsuji H; Ishida-Yamamoto A; Takahashi H; Iizuka H Nuclear localization of beta-catenin in the hair matrix cells and differentiated keratinocytes	2	1
787	3	160 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(1):20-24 Tsuji T; Miyazaki M; Sakaguchi M; Inoue Y; Namba M A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines	9	0
788	2	188 2000 CANCER RESEARCH 60(23):6611-6616 Tsujiuchi T; Tsutsumi M; Sasaki Y; Murata N; Konishi Y Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats	14	5
789	1	245 2000 HISTOLOGY AND HISTOPATHOLOGY 15(1):251-260 Tucker EL; Pignatelli M Catenins and their associated proteins in colorectal cancer	11	2
790	4	541 2001 PEDIATRIC SURGERY INTERNATIONAL 17(7):508-512 Udatsu Y; Kusafuka T; Kuroda S; Miao J; Okada A High frequency of beta-catenin mutations in hepatoblastoma	5	2
791	5	898 2003 ONCOGENE 22(24):3821-3826 Udtha M; Lee SJ; Alam R; Coombes K; Huff V Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors	0	0
792	15	644 2002 INTERNATIONAL JOURNAL OF CANCER 99(5):681-688 Ueda Y; Hijikata M; Takagi S; Takada R; Takada S; Chiba T; Shimotohno K Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts	3	1
793	6	791 2003 CANCER RESEARCH 63(15):4547-4551 Uematsu K; Kanazawa S; You L; He B; Xu ZD; Li K; Peterlin BM; McCormick F; Jablons DM Wnt pathway activation in mesothelioma: Evidence of dishevelled overexpression and transcriptional activity of beta-catenin	0	0
794	6	867 2003 JOURNAL OF NEUROSCIENCE RESEARCH 73(2):166-175 Uemura K; Kitagawa N; Kohno R; Kuzuya A; Kageyama T; Shibasaki H; Shimohama S Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling	0	0
795	9	746 2002 ONCOLOGY REPORTS 9(6):1197-1203 Ueta T; Ikeguchi M; Hirooka Y; Kaibara N; Terada T beta-catenin and cyclin D1 expression in human hepatocellular carcinoma	0	0
796	1	117 1999 ONCOGENE 18(10):1903-1910 Ugolini F; Adelaide J; Charafe-Jauffret E; Nguyen C; Jacquemier J; Jordan B; Birnbaum D; Pebusque MJ Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes	33	7
797	6	532 2001 ONCOGENE 20(41):5810-5817 Ugolini F; Charafe-Jauffret E; Bardou VJ; Geneix J; Adelaide J; Labat-Moleur F; Penault-Llorca F; Longy M; Jacquemier J; Birnbaum D; Pebusque MJ WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type	14	4
798	1	317 2000 ONCOLOGY REPORTS 7(2):427-431 Uhrhammer N; Bay JO; Gosse-Brun S; Kwiatkowski F; Rio P; Daver A; Bignon YJ Allelic imbalance at NBS1 is frequent in both proximal and distal colorectal carcinoma	3	0
799	5	257 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(6):4374-4382 Uren A; Reichsman F; Anest V; Taylor WG; Muraiso K; Bottaro DP; Cumberledge S; Rubin JS Secreted frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of Wnt signaling	37	7
800	5	900 2003 ONCOGENE 22(39):5978-5986 Usami N; Sekido Y; Maeda O; Yamamoto K; Minna JD; Hasegawa Y; Yoshioka H; Imaizumi M; Ueda Y; Takahashi M; Shimokata K beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
801	7	444 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(4):803-810 Uthoff SMS; Eichenberger MR; Lewis RK; Fox MP; Hamilton CJ; McAuliffe TL; Grimes HL; Galandiuk S Identification of candidate genes in ulcerative colitis and Crohn's disease using cDNA array technology	2	0
802	10	508 2001 MOLECULAR CARCINOGENESIS 31(1):56-62 Uthoff SMS; Eichenberger MR; McAuliffe TL; Hamilton CJ; Galandiuk S Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer	6	3
803	10	537 2001 ONCOLOGY 61(3):226-233 Utsunomiya T; Doki Y; Takemoto H; Shiozaki H; Yano M; Sekimoto M; Tamura S; Yasuda T; Fujiwara Y; Monden M Correlation of beta-catenin and cyclin D1 expression in colon cancers	4	3
804	1	72 1999 EXPERIMENTAL CELL RESEARCH 253(2):336-348 Uusitalo M; Heikkila M; Vainio S Molecular genetic studies of Wnt signaling in the mouse	23	0
805	12	894 2003 NUCLEIC ACIDS RESEARCH 31(9):2369-2380 Valenta T; Lukas J; Korinek V HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells	0	0
806	3	304 2000 NEPHROLOGY DIALYSIS TRANSPLANTATION 15(1):1-2 van Adelsberg J Polycystin-1 interacts with E-cadherin and the catenins - clues to the pathogenesis of cyst formation in ADPKD?	2	0
807	15	552 2001 VIRCHOWS ARCHIV 439(6):725-751 Van Aken E; De Wever O; da Rocha ASC; Mareel M Defective E-cadherin/catenin complexes in human cancer	29	0
808	3	270 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(35):27266-27273 van Beest M; Dooijes D; van de Wetering M; Kjaerulff S; Bonvin A; Nielsen O; Clevers H Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs	6	0
809	2	269 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(33):25805-25813 van de Water B; Tijdens IB; Verbrugge A; Huigsloot M; Dihal AA; Stevens JL; Jaken S; Mulder GJ Cleavage of the actin-capping protein alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells	18	0
810	9	360 2001 CANCER RESEARCH 61(1):278-284 van de Wetering M; Barker N; Harkes IC; van der Heyden M; Dijk NJ; Hollestelle A; Klijn JGM; Clevers H; Schutte M Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling	19	0
811	13	600 2002 CELL 111(2):241-250 van de Wetering M; Sancho E; Verweij C; de Lau W; Oving I; Hurlstone A; van der Horn K; Batlle E; Coudreuse D; Haramis AP; Tion-Pon-Fong M; Moerer P; van den Born M; Soete G; Pals S; Eilers M; Medema R; Clevers H The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells	59	0
812	6	820 2003 CURRENT OPINION IN GENETICS & DEVELOPMENT 13(1):28-33 van Es JH; Barker N; Clevers H You Wnt some, you lose some: oncogenes in the Wnt signaling pathway	2	0
813	10	414 2001 EXPERIMENTAL CELL RESEARCH 264(1):126-134 van Es JH; Giles RH; Clevers HC The many faces of the tumor suppressor gene APC	27	0
814	1	55 1999 CURRENT BIOLOGY 9(2):105-108 van Es JH; Kirkpatrick C; van de Wetering M; Molenaar M; Miles A; Kuipers J; Destree O; Peifer M; Clevers H Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor	37	0
815	4	11 1999 AMERICAN JOURNAL OF PATHOLOGY 155(3):703-710 Van Nhieu JT; Renard CA; Wei Y; Cherqui D; Zafrani ES; Buendia MA Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation	20	0
816	15	608 2002 DEVELOPMENTAL BIOLOGY 244(1):1-8 van Noort M; Clevers H TCF transcription factors, mediators of Wnt-signaling in development and cancer	27	0
817	10	730 2002 ONCOGENE 21(30):4646-4662 Vecsey-Semjen B; Becker KT; Sinski A; Blennow E; Vietor I; Zatlouka K; Beug H; Wagner E; Huber LA Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers	4	0
818	2	756 2002 SCIENCE 295(5560):1726-1729 Velcich A; Yang WC; Heyer J; Fragale A; Nicholas C; Viani S; Kucherlapati R; Lipkin M; Yang K; Augenlicht L Colorectal cancer in mice genetically deficient in the mucin Muc2	30	3
819	1	140 1999 SCIENCE 286(5444):1491-1492 Velculescu VE Essay: Amersham Pharmacia Biotech & Science Prize - Tantalizing transcriptomes - SAGE and its use in global gene expression analysis	18	1
820	1	115 1999 NATURE GENETICS 23(4):387-388 Velculescu VE; Madden SL; Zhang L; Lash AE; Yu J; Rago C; Lal A; Wang CJ; Beaudry GA; Ciriello KM; Cook BP; Dufault MR; Ferguson AT; Gao YH; He TC; Hermeking H; Hiraldo SK; Hwang PM; Lopez MA; Luderer HF; Mathews B; Petroziello JM; Polyak K; Zawel L; Zhang W; Zhang XM; Zhou W; Haluska FG; Jen J; Sukumar S; Landes GM; Riggins GJ; Vogelstein B; Kinzler KW Analysis of human transcriptomes	159	11
821	3	332 2000 TRENDS IN GENETICS 16(10):423-425 Velculescu VE; Vogelstein B; Kinzler KW Analysing uncharted transcriptomes with SAGE	53	3
822	7	882 2003 MODERN PATHOLOGY 16(1):57-65 Venesio T; Balsamo A; Scordamaglia A; Bertolaso M; Arrigoni A; Sprujevnik T; Rossini FP; Risio M Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas	0	0
823	13	559 2002 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283(3):C811-C821 Venkiteswaran K; Xiao KY; Summers S; Calkins CC; Vincent PA; Pumiglia K; Kowalczyk AP Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin	7	0
824	11	815 2003 CLINICAL CANCER RESEARCH 9(4):1291-1300 Verma UN; Surabhi RM; Schmaltieg A; Becerra C; Gaynor RB Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells	3	0
825	1	408 2001 EMBO REPORTS 2(4):306-312 Vietor I; Bader T; Paiha K; Huber LA Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription	10	3
826	2	656 2002 INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 219 219():157-198 Vikhanskaya F; Broggini M Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients	0	0
827	5	319 2000 ONCOLOGY RESEARCH 12(4):193-201 Vincan E; Leet CSF; Reyes NI; Dilley RJ; Thomas RJS; Phillips WA Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3 beta activity and increases levels of both membrane-bound and APC/Axin/GSK-3 beta complex-associated pools of beta-catenin	2	0
828	6	842 2003 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 35(7):1034-1051 Visvader JE; Lindeman GJ Transcriptional regulators in mammary gland development and cancer	0	0
829	3	654 2002 INTERNATIONAL JOURNAL OF ONCOLOGY 21(1):135-144 Vizirianakis IS; Chen YQ; Kantak SS; Tsiftsoglou AS; Kramer RH Dominant-negative E-cadherin alters adhesion and reverses contact inhibition of growth in breast carcinoma cells	3	0
830	1	106 1999 MECHANISMS OF DEVELOPMENT 81(1-2):65-74 Vleminckx K; Kemler R; Hecht A The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis	22	8
831	8	726 2002 NEUROSURGERY 51(1):227-233 von Koch CS; Gulati M; Aldape K; Berger MS Familial medulloblastoma: Case report of one family and review of the literature	0	0
832	13	366 2001 CANCER RESEARCH 61(5):2097-2104 Wagenaar RA; Crawford HC; Matrisian LM Stabilized beta-catenin immortalizes colonic epithelial cells	7	2
833	2	204 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65():511-520 Wahl G; Vafa O Genetic instability, oncogenes, and the p53 pathway	0	0
834	1	516 2001 NATURE GENETICS 28(2):165-168 Waikel RL; Kawachi Y; Waikel PA; Wang XJ; Roop DR Deregulated expression of c-Myc depletes epidermal stem cells	24	5
835	3	362 2001 CANCER RESEARCH 61(3):854-858 Wakita K; Tetsu O; McCormick F A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics	1	0
836	12	27 1999 CANCER AND METASTASIS REVIEWS 18(2):231-246 Waltzer L; Bienz M The control of beta-catenin and TCF during embryonic development and cancer	15	4
837	2	20 1999 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1450(3):331-340 Wang B; Kishihara K; Zhang DL; Sakamoto T; Nomoto K Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells	1	0
838	14	646 2002 INTERNATIONAL JOURNAL OF CANCER 101(4):301-310 Wang HLL; Wang J; Xiao SY; Haydon R; Stoiber D; He TC; Bissonnette M; Hart J Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin	6	2
839	3	897 2003 ONCOGENE 22(21):3297-3306 Wang WS; Chen PM; Hsiao HL; Ju SY; Su Y Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells	0	0
840	1	77 1999 GENOMICS 57(2):235-248 Wang YK; Sporle R; Paperna T; Schughart K; Francke U Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome	20	2
841	2	918 2003 TRENDS IN CELL BIOLOGY 13(3):146-150 Wanzel M; Herold S; Eilers M Transcriptional repression by Myc	1	0
842	18	605 2002 CURRENT OPINION IN GASTROENTEROLOGY 18(1):53-59 Waterman ML Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer	0	0
843	6	490 2001 LANCET 357(9256):572-573 Watson SA Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis	3	0
844	3	246 2000 HUMAN GENE THERAPY 11(16):2261-2266 Watt FM Epidermal stem cells as targets for gene transfer	6	0
845	4	238 2000 GENES CHROMOSOMES & CANCER 28(4):443-453 Webster MT; Rozycka M; Sara E; Davis E; Smalley M; Young N; Dale TC; Wooster R Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding	43	20
846	14	851 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(7):5188-5194 Wei Y; Renard CA; Labalette C; Wu YF; Levy L; Neuveut C; Prieur X; Flajolet M; Prigent S; Buendia MA Identification of the LIM protein FHL2 as a coactivator of beta-catenin	3	1
847	11	857 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(39):38029-38039 Wen YF; Caffrey TC; Wheelock MJ; Johnson KR; Hollingsworth MA Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin	0	0
848	14	671 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(21):18677-18686 Weng ZG; Xin M; Pablo L; Grueneberg D; Hagel M; Bain G; Muller T; Papkoff J Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein	2	1
849	6	215 2000 DEVELOPMENTAL BIOLOGY 219(1):98-114 Widelitz RB; Jiang TX; Lu JF; Chuong CM beta-catenin in epithelial morphogenesis: Conversion of part of avian foot scales into feather buds with a mutated beta-catenin	33	2
850	7	683 2002 JOURNAL OF CELL BIOLOGY 158(6):1079-1087 Widlund HR; Horstmann MA; Price ER; Cui JI; Lessnick SL; Wu M; He X; Fisher DE beta-Catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor	8	4
851	1	9 1999 AMERICAN JOURNAL OF PATHOLOGY 154(2):515-523 Wielenga VJM; Smits R; Korinek V; Smit L; Kielman M; Fodde R; Clevers H; Pals ST Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway	37	21
852	2	157 2000 AMERICAN JOURNAL OF PATHOLOGY 157(5):1563-1573 Wielenga VJM; van der Voort R; Taher TEI; Smit L; Beuling EA; van Krimpen C; Spaargaren M; Pals ST Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer	12	1
853	12	172 2000 BRITISH JOURNAL OF SURGERY 87(8):992-1005 Wijnhoven BPL; Dinjens WNM; Pignatelli M E-cadherin-catenin cell-cell adhesion complex and human cancer	48	5
854	4	251 2000 INTERNATIONAL JOURNAL OF CANCER 86(4):533-537 Wijnhoven BPL; Nollet F; De Both NJ; Tilanus HW; Dinjens WNM Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus	8	3
855	4	596 2002 CANCER RESEARCH 62(16):4562-4565 Wilding J; Straub J; Bee J; Churchman M; Bodmer W; Dickson C; Tomlinson I; Ilyas M Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice	3	1
856	18	314 2000 ONCOGENE 19(50):5720-5728 Williams BO; Barish GD; Klymkowsky MW; Varmus HE A comparative evaluation of beta-catenin and plakoglobin signaling activity	13	6
857	14	445 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(6):1227-1233 Williams CL; Noti JD Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha	1	0
858	7	814 2003 CLINICAL CANCER RESEARCH 9(3):931-946 Williams NS; Gaynor RB; Scoggin S; Verma U; Gokaslan T; Simmang C; Fleming J; Tavana D; Frenkel E; Becerra C Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference	1	0
859	5	598 2002 CANCER RESEARCH 62(21):6006-6010 Wilson AJ; Velcich A; Arango D; Kurland AR; Shenoy SM; Pezo RC; Levsky JM; Singer RH; Augenlicht LH Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention	4	0
860	9	739 2002 ONCOGENE 21(49):7497-7506 Winn RA; Bremnes RM; Bemis L; Franklin WA; Miller YE; Cool C; Heasley LE gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth	1	0
861	6	676 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(28):25562-25567 Wolf D; Rodova M; Miska EA; Calvet JP; Kouzarides T Acetylation of beta-catenin by CREB-binding protein (CBP)	6	3
862	11	667 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(18):15843-15850 Wong MH; Huelsken J; Birchmeier W; Gordon JI Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling	8	1
863	26	555 2002 AMERICAN JOURNAL OF PATHOLOGY 160(2):389-401 Wong NACS; Pignatelli M beta-catenin - A linchpin in colorectal carcinogenesis?	33	5
864	6	702 2002 JOURNAL OF PATHOLOGY 196(2):145-153 Wong SCC; Lo SFE; Lee KC; Yam JWP; Chan JKC; Hsiao WLW Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours	9	4
865	3	433 2001 INTERNATIONAL JOURNAL OF CANCER 95(2):108-113 Woo DK; Kim HS; Lee HS; Kang YH; Yang HK; Kim WH Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines	18	4
866	1	84 1999 INTERNATIONAL JOURNAL OF CANCER 82(5):625-629 Wright K; Wilson P; Morland S; Campbell I; Walsh M; Hurst T; Ward B; Cummings M; Chenevix-Trench G beta-catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours	29	15
867	2	18 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 263(2):384-388 Wright M; Aikawa M; Szeto W; Papkoff J Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells	19	8
868	1	255 2000 INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 81(2):117-143 Wright NA Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer	19	1
869	21	385 2001 CANCER RESEARCH 61(22):8247-8255 Wu R; Zhai Y; Fearon ER; Cho KR Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas	21	14
870	8	547 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(19):10863-10868 Xia XF; Qian S; Soriano S; Wu Y; Fletcher AM; Wang XJ; Koo EH; Wu XW; Zheng H Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis	26	7
871	5	233 2000 GENES & DEVELOPMENT 14(5):585-595 Xu LF; Corcoran RB; Welsh JW; Pennica D; Levine AJ WISP-1 is a Wnt-1-and beta-catenin-responsive oncogene	67	38
872	2	661 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(1):854-861 Yagi K; Furuhashi M; Aoki H; Goto D; Kuwano H; Sugamura K; Miyazono K; Kato M c-myc is a downstream target of the Smad pathway	26	3
873	11	899 2003 ONCOGENE 22(25):3901-3910 Yam JWP; Chan KW; Hsiao WLW Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB	0	0
874	5	348 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 286(1):94-100 Yam JWP; Chan KW; Wong VKW; Hsiao WLW Transcriptional activity of the promoter region of rat frizzled-related protein gene	4	1
875	7	807 2003 CARCINOGENESIS 24(6):1015-1019 Yamada Y; Mori H Pre-cancerous lesions for colorectal cancers in rodents: a new concept	0	0
876	5	805 2003 CARCINOGENESIS 24(1):91-97 Yamada Y; Oyama T; Hirose Y; Hara A; Sugie S; Yoshida K; Yoshimi N; Mori H beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis	2	2
877	4	447 2001 JAPANESE JOURNAL OF CANCER RESEARCH 92(6):617-623 Yamada Y; Yoshimi N; Hirose Y; Hara A; Shimizu M; Kuno T; Katayama M; Qiao Z; Mori H Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib	8	1
878	4	179 2000 CANCER RESEARCH 60(13):3323-3327 Yamada Y; Yoshimi N; Hirose Y; Kawabata K; Matsunaga K; Shimizu M; Hara A; Mori H Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis	35	8
879	4	365 2001 CANCER RESEARCH 61(5):1874-1878 Yamada Y; Yoshimi N; Hirose Y; Matsunaga K; Katayama M; Sakata K; Shimizu M; Kuno T; Mori H Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis	25	7
880	1	86 1999 JAPANESE JOURNAL OF CANCER RESEARCH 90(8):824-828 Yamada Y; Yoshimi N; Sugie S; Suzui M; Matsunaga K; Kawabata K; Hara A; Mori H beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats	8	1
881	1	601 2002 CELL DEATH AND DIFFERENTIATION 9(5):513-526 Yamakawa-Karakida N; Sugita K; Inukai T; Goi K; Nakamura M; Uno K; Sato H; Kagami K; Barker N; Nakazawa S Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity	8	0
882	16	454 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(29):26875-26882 Yamamoto H; Hinoi T; Michiue T; Fukui A; Usui H; Janssens V; Van Hoof C; Goris J; Asashima M; Kikuchi A Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A	10	2
883	1	88 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(16):10681-10684 Yamamoto H; Kishida S; Kishida M; Ikeda S; Takada S; Kikuchi A Phosphorylation of Axin, a Wnt signal negative regulator, by glycogen synthase kinase-3 beta regulates its stability	87	40
884	3	780 2003 BRITISH JOURNAL OF CANCER 89(1):152-157 Yamamoto T; Konishi K; Yamochi T; Makino R; Kaneko K; Shimamura T; Ota H; Mitamura K No major tumorigenic role for beta-catenin in serrated as opposed to conventional colorectal adenomas	0	0
885	5	839 2003 HEPATOLOGY 37(3):528-533 Yamamoto Y; Sakamoto M; Fujii G; Tsuiji H; Kanetaka K; Asaka M; Hirohashi S Overexpression of orphan G-Protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations	1	0
886	1	123 1999 ONCOGENE 18(34):4777-4787 Yamashita A; Hakura A; Inoue H Suppression of anchorage-independent growth of human cancer cell lines by the drs gene	8	1
887	4	548 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(26):14973-14978 Yan D; Wiesmann M; Rohan M; Chan V; Jefferson AB; Guo LD; Sakamoto D; Caothien RH; Fuller JH; Reinhard C; Garcia PD; Randazzo FM; Escobedo J; Fantl WJ; Williams LT Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta-catenin signaling is activated in human colon tumors	13	7
888	4	435 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(3):541-548 Yang SZ; Kohno N; Yokoyama A; Kondo K; Hamada H; Hiwada K Decreased E-cadherin augments beta-catenin nuclear localization: Studies in breast cancer cell lines	8	1
889	7	628 2002 GASTROENTEROLOGY 123(3):935-939 Yang VW APC as a checkpoint gene: The beginning or the end?	1	0
890	7	795 2003 CANCER RESEARCH 63(16):4990-4996 Yang WC; Bancroft L; Nicholas C; Lozonschi I; Augenlicht LH Targeted inactivation of p27(kip1) is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a western-style high-risk diet	0	0
891	2	361 2001 CANCER RESEARCH 61(2):565-569 Yang WC; Mathew J; Velcich A; Edelmann W; Kucherlapati R; Lipkin M; Yang K; Augenlicht LH Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a western-style high-risk diet by altering cell maturation in the intestinal mucosa	15	4
892	5	376 2001 CANCER RESEARCH 61(16):6297-6302 Yang WC; Velcich A; Mariadason J; Nicholas C; Corner G; Houston M; Edelmann W; Kucherlapati R; Holt PR; Augenlicht LH p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo	6	2
893	12	769 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 308(2):227-233 Yasuda J; Tsuchiya A; Yamada T; Sakamoto M; Sekiya T; Hirohashi S Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells	0	0
894	3	811 2003 CLINICAL & EXPERIMENTAL METASTASIS 20(1):85-90 Yeatman TJ; Chambers AF Osteopontin and colon cancer progression	1	0
895	21	681 2002 JOURNAL OF CELL BIOLOGY 157(3):429-440 You ZB; Saims D; Chen SQ; Zhang ZC; Guttridge DC; Guan KL; MacDougald OA; Brown AMC; Evan G; Kitajewski J; Wang CY Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis	10	1
896	2	777 2003 BRITISH JOURNAL OF CANCER 88(10):1560-1565 Yu J; Leung WK; Ebert MPA; Leong RWL; Tse PCH; Chan MWY; Bai AHC; To KF; Malfertheiner P; Sung JJY Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer	0	0
897	1	511 2001 MOLECULAR CELL 7(3):673-682 Yu J; Zhang L; Hwang PM; Kinzler KW; Vogelstein B PUMA induces the rapid apoptosis of colorectal cancer cells	137	2
898	2	113 1999 NATURE CELL BIOLOGY 1(3):144-151 Yu X; Waltzer L; Bienz M A new Drosophila APC homologue associated with adhesive zones of epithelial cells	46	13
899	27	556 2002 AMERICAN JOURNAL OF PATHOLOGY 160(4):1229-1238 Zhai Y; Wu R; Schwartz DR; Darrah D; Reed H; Kolligs FT; Nieman MT; Fearon ER; Cho KR Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas	7	1
900	9	817 2003 CLINICAL CANCER RESEARCH 9(8):3073-3079 Zhang B; Ougolkov A; Yamashita K; Takahashi Y; Mai M; Minamoto T beta-catenin and ras oncogenes detect most human colorectal cancer	0	0

#	Cited nodes	Nodes / Authors	GCS	LCS
901	7	507 2001 MOLECULAR AND CELLULAR BIOLOGY 21(23):8143-8156 Zhang F; White RL; Neufeld KL Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein	13	5
902	1	150 1999 WORLD JOURNAL OF GASTROENTEROLOGY 5(5):451-454 Zhang J; Lai MD; Chen J Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa	7	0
903	4	386 2001 CANCER RESEARCH 61(24):8664-8667 Zhang T; Otevrel T; Gao ZQ; Gao ZP; Ehrlich SM; Fields JZ; Boman BM Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer	15	7
904	5	375 2001 CANCER RESEARCH 61(16):6050-6054 Zhang XB; Gaspard JP; Chung DC Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia	13	6
905	3	268 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(32):25008-25014 Zhang Y; Neo SY; Han JH; Lin SC Dimerization choices control the ability of axin and dishevelled to activate c-jun N-terminal kinase/stress-activated protein kinase	11	3
906	2	95 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(49):35247-35254 Zhang Y; Neo SY; Wang XH; Han JH; Lin SC Axin forms a complex with MEKK1 and activates c-Jun NH2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling	28	8
907	11	669 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(20):17706-17712 Zhang Y; Qiu WJ; Chan SC; Han JH; He X; Lin SC Casein kinase I and casein kinase II differentially regulate Axin function in Wnt and JNK pathways	4	0
908	12	455 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(34):32152-32159 Zhang Y; Qiu WJ; Liu DX; Neo SY; He X; Lin SC Differential molecular assemblies underlie the dual function of axin in modulating the Wnt and JNK pathways	8	2
909	11	575 2002 BIOTECHNIQUES 33(5):1126-+ Zhou L; An N; Jiang W; Haydon R; Cheng H; Zhou Q; Breyer B; Feng T; He TC Fluorescence-based functional assay for Wnt/beta-catenin signaling activity	1	1
910	17	782 2003 CANCER LETTERS 193(2):161-170 Zhou L; An NL; Haydon RC; Zhou QX; Cheng HW; Peng Y; Jiang W; Luu HH; Vanichakarn P; Szatkowski JP; Park JY; Breyer B; He TC Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity	0	0
911	2	61 1999 DEVELOPMENT 126(10):2285-2298 Zhu AJ; Watt FM beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion	56	20
912	4	320 2000 PATHOLOGY INTERNATIONAL 50(12):945-952 Zhu XD; Kanai Y; Saito A; Kondo Y; Hirohashi S Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas	2	0
913	8	733 2002 ONCOGENE 21(36):5643-5648 Zhuang SM; Wiseman RW; Soderkvist P Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice	0	0
914	29	281 2000 JOURNAL OF CELL SCIENCE 113(18):3127-3139 Zhurinsky J; Shtutman M; Ben-Ze'ev A Plakoglobin and beta-catenin: protein interactions, regulation and biological roles	57	18
915	14	294 2000 MOLECULAR AND CELLULAR BIOLOGY 20(12):4238-4252 Zhurinsky J; Shtutman M; Ben-Ze'ev A Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin	35	18
916	10	500 2001 MOLECULAR AND CELLULAR BIOLOGY 21(2):562-574 Ziemer LT; Pennica D; Levine AJ Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene	13	5
917	1	79 1999 HEPATOLOGY 29(4):1208-1214 Zimonjic DB; Keck CL; Thorgeirsson SS; Popescu NC Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization	47	1
918	3	523 2001 ONCOGENE 20(5):626-633 Zwerner JP; May WA PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors	20	0
919	1	143 1999 SCIENTIST 13(2):24-24 [Anon] Serial analysis of gene expression: An alternative to chip arrays	0	0

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