| Author(s) | ROSENBERG CL; KIM HG; SHOWS TB; KRONENBERG HM; ARNOLD A
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| Title | REARRANGEMENT AND OVEREXPRESSION OF D11S287E, A CANDIDATE ONCOGENE ON CHROMOSOME 11Q13 IN BENIGN PARATHYROID TUMORS
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| Source | ONCOGENE 6 (3): 449-453
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| Date | 1991 MAR
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| Type | Journal : Article
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| LCR: 5 NCR: 41 LCS: 6 GCS: 214
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| Address | MASSACHUSETTS GEN HOSP,ENDOCRINE UNIT,BOSTON,MA 02114.
MASSACHUSETTS GEN HOSP,HEMATOL ONCOL UNIT,BOSTON,MA 02114.
HARVARD UNIV,SCH MED,BOSTON,MA 02115.
NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,DEPT HUMAN GENET,BUFFALO,NY 14263.
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| Abstract | We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement. This rearrangement is similar to one we characterized recently in an independent adenoma. In these two, plus a third partially characterized adenoma, one allele of the PTH gene, on 11p15, is rearranged with DNA from the D11S287 region on 11q13. This region contains a transcribed sequence, D11S287E, distinct from known 11q13 oncogenes, that is expressed in all parathyroid tissues examined, but is overexpressed dramatically in all three tumors with PTH gene-D11S287 rearrangements. These findings suggest that overexpression of D11S287E, perhaps driven by the misplaced PTH gene's regulatory elements, contributed to the development of these benign tumors. D11S287E is a new candidate oncogene with potential importance in parathyroid adenomas and perhaps other tumors with 11q13 abnormalities.
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