| Author(s) | LING WH; KORPELA R; MYKKANEN H; SALMINEN S; HANNINEN O
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| Title | LACTOBACILLUS STRAIN GG SUPPLEMENTATION DECREASES COLONIC HYDROLYTIC AND REDUCTIVE ENZYME-ACTIVITIES IN HEALTHY FEMALE-ADULTS
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| Source | JOURNAL OF NUTRITION 124 (1): 18-23
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| Date | 1994 JAN
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| Type | Journal : Article
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| LCR: 0 NCR: 30 LCS: 0 GCS: 64
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| Address | UNIV KUOPIO,DEPT CLIN NUTR,SF-70211 KUOPIO,FINLAND.
UNIV KUOPIO,DEPT PHYSIOL,SF-70211 KUOPIO,FINLAND.
FDN NUTR RES,SF-00101 HELSINKI,FINLAND.
UNIV TURKU,DEPT BIOCHEM & FOOD CHEM,SF-20500 TURKU,FINLAND.
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| Abstract | The effects of yogurt containing viable Lactobacillus strain GG (L. GG) and/or fiber supplements on fecal enzyme activities (beta-glucuronidase, nitroreductase, beta-glucosidase, glycocholic acid hydrolase, urease) and on bacterial metabolites in urine (phenol, p-cresol) were studied in 64 females, 20-41 y old. The subjects were randomly divided into three groups: the first group received L. GG yogurt (2 x 150 mL/d, containing 10(11) colony-forming units (cfu)/L of L. GG), the second group received L. GG yogurt and a rye fiber product (30 g/d, equivalent to 9 g fiber/d), and the third group received placebo yogurt (pasteurized) and fiber. The supplementation period lasted 4 wk, with a preceding 2-wk baseline period and a 2-wk follow-up period. The mean fecal count of L. GG was similar to 10(6) cfu/g feces during the supplementation, and L. GG persisted in the fecal samples of 28% of the subjects for 2 wk after supplementation. L. GG yogurt alone or with fiber significantly decreased fecal beta-glucuronidase, nitroreductase and glycocholic acid hydrolase activities. These enzyme activities returned to baseline levels during the follow-up period. beta-Glucosidase and urease activities were not altered significantly during the study. The addition of fiber to L. GG and placebo yogurt had no effect on the enzymic activities. Urinary excretion of p-cresol decreased significantly in groups receiving L. GG. These data demonstrate that L. GG can modify the colonic environment with possible health effects.
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ADLERCREUTZ H, 1990, SCAND J CLIN LAB INV, V50, P3
ASP NG, 1983, J AGR FOOD CHEM, V31, P476
BONE E, 1976, AM J CLIN NUTR, V29, P1448
CHIPMAN JK, 1982, TOXICOLOGY, V25, P99
COLE CB, 1985, J APPL BACTERIOL, V59, P549
DRASAR BS, 1976, J MED MICROBIOL, V9, P423
FREEMAN HJ, 1986, CANCER RES, V46, P5529
GADELLE D, 1985, APPL ENVIRON MICROB, V49, P682
GOLDIN BR, 1980, J NATL CANCER I, V64, P255
GOLDIN BR, 1984, AM J CLIN NUTR, V39, P756
GOLDIN BR, 1990, ANN MED, V22, P43
GOLDIN BR, 1992, DIGEST DIS SCI, V37, P121
HAWKESWORTH GB, 1971, J MED MICROBIOL, V4, P451
KOCK RL, 1979, J PHARMACOL EXP THER, V208, P406
KORPELA JT, 1992, GASTROENTEROLOGY, V103, P1246
KRITCHEVSKY D, 1986, DIETARY FIBER BASIC, P427
LOWRY OH, 1951, J BIOL CHEM, V193, P265
MARTEAU P, 1990, AM J CLIN NUTR, V52, P685
MOORE WEC, 1975, CANCER RES, V35, P3418
NAIR PP, 1967, J BIOL CHEM, V242, P7
RASTAS M, 1989, NUTRIENT COMPOSITION
SALMINEN S, 1992, DIGEST DIS, V10, P227
SAVAGE DC, 1986, ANNU REV NUTR, V6, P155
SAXELIN M, 1992, MICROB ECOL HEALTH D, V4, P209
SILVA M, 1987, ANTIMICROB AGENTS CH, V31, P1231
SIMON GL, 1984, GASTROENTEROLOGY, V86, P174
TAKADA H, 1982, CANCER RES, V42, P331
WILLIAMS RT, 1972, TOXICOL APPL PHARM, V23, P769
YOSHIKAWA M, 1986, J CHROMATOGR, V362, P425
ZHANG LX, 1989, LABORATORY METHOD TE, P160
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