#	Cited nodes	Nodes / Authors	GCS	LCS
101	1	101 1999 JOURNAL OF INVESTIGATIVE DERMATOLOGY 113(2):258-262 Takata M; Fujimoto A; Aoki H; Hatta N; Ooi A; Takehara K erbB-2 overexpression but no activation of beta-catenin gene in extramammary Paget's disease	7	0
102	1	102 1999 JOURNAL OF THE NATIONAL CANCER INSTITUTE 91(11):916-932 Potter JD Colorectal cancer: Molecules and populations	193	6
103	1	103 1999 LABORATORY INVESTIGATION 79(12):1489-1499 Perry I; Tselepis C; Hoyland J; Iqbal TH; Sanders DSA; Cooper BT; Jankowski JAZ Reduced cadherin/catenin complex expression in celiac disease can be reproduced in vitro by cytokine stimulation	17	2
104	2	104 1999 M S-MEDECINE SCIENCES 15(3):427-428 L'Allemain G The WISP genes, a family of novel connective tissue growth factors, are dysregulated in Wnt-1-transformed cells and in human colon cancer.	0	0
105	1	105 1999 M S-MEDECINE SCIENCES 15(10):1105-1117 Perrin L; Arquier N; Semeriva M Links between growth rate and proliferation revisited in Drosophila	1	0
106	1	106 1999 MECHANISMS OF DEVELOPMENT 81(1-2):65-74 Vleminckx K; Kemler R; Hecht A The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis	22	8
107	1	107 1999 MELANOMA RESEARCH 9(5):421-432 Castellano M; Parmiani G Genes involved in melanoma: overview of INK4a and other loci	30	1
108	1	108 1999 MOLECULAR AND CELLULAR BIOLOGY 19(1):1-11 Dang CV c-myc target genes involved in cell growth, apoptosis, and metabolism	309	31
109	1	109 1999 MOLECULAR AND CELLULAR BIOLOGY 19(8):5576-5587 Gradl D; Kuhl M; Wedlich D The Wnt/Wg signal transducer beta-catenin controls fibronectin expression	83	49
110	5	110 1999 MOLECULAR AND CELLULAR BIOLOGY 19(8):5696-5706 Kolligs FT; Hu G; Dang CV; Fearon ER Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression	62	38
111	1	111 1999 MOLECULAR MEDICINE TODAY 5(4):172-177 Guilford P E-cadherin downregulation in cancer: fuel on the fire?	33	2
112	1	112 1999 NATURE 398(6726):422-426 Tetsu O; McCormick F beta-catenin regulates expression of cyclin D1 in colon carcinoma cells	698	498
113	2	113 1999 NATURE CELL BIOLOGY 1(3):144-151 Yu X; Waltzer L; Bienz M A new Drosophila APC homologue associated with adhesive zones of epithelial cells	46	13
114	2	114 1999 NATURE GENETICS 21(4):410-413 Chan EF; Gat U; McNiff JM; Fuchs E A common human skin tumour is caused by activating mutations in beta-catenin	155	69
115	1	115 1999 NATURE GENETICS 23(4):387-388 Velculescu VE; Madden SL; Zhang L; Lash AE; Yu J; Rago C; Lal A; Wang CJ; Beaudry GA; Ciriello KM; Cook BP; Dufault MR; Ferguson AT; Gao YH; He TC; Hermeking H; Hiraldo SK; Hwang PM; Lopez MA; Luderer HF; Mathews B; Petroziello JM; Polyak K; Zawel L; Zhang W; Zhang XM; Zhou W; Haluska FG; Jen J; Sukumar S; Landes GM; Riggins GJ; Vogelstein B; Kinzler KW Analysis of human transcriptomes	159	11
116	1	116 1999 ONCOGENE 18(4):849-854 Latres E; Chiaur DS; Pagano M The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin	81	22
117	1	117 1999 ONCOGENE 18(10):1903-1910 Ugolini F; Adelaide J; Charafe-Jauffret E; Nguyen C; Jacquemier J; Jordan B; Birnbaum D; Pebusque MJ Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes	33	7
118	1	118 1999 ONCOGENE 18(15):2507-2517 Rosenwald IB; Chen JJ; Wang ST; Savas L; London IM; Pullman J Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis	36	2
119	1	119 1999 ONCOGENE 18(18):2883-2891 Crawford HC; Fingleton BM; Rudolph-Owen LA; Goss KJH; Rubinfeld B; Polakis P; Matrisian LM The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors	206	146
120	2	120 1999 ONCOGENE 18(19):2967-2987 Prendergast GC Mechanisms of apoptosis by c-Myc	152	8
121	2	121 1999 ONCOGENE 18(19):3004-3016 Nesbit CE; Tersak JM; Prochownik EV MYC oncogenes and human neoplastic disease	140	9
122	1	122 1999 ONCOGENE 18(33):4726-4733 Devereux TR; Anna CH; Foley JF; White CM; Sills RC; Barrett JC Mutation of beta-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis	36	10
123	1	123 1999 ONCOGENE 18(34):4777-4787 Yamashita A; Hakura A; Inoue H Suppression of anchorage-independent growth of human cancer cell lines by the drs gene	8	1
124	1	124 1999 ONCOGENE 18(35):5010-5014 da Costa LT; He TC; Yu J; Sparks AB; Morin PJ; Polyak K; Laken S; Vogelstein B; Kinzler KW CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling	31	0
125	3	125 1999 ONCOGENE 18(38):5325-5333 Heyer J; Yang K; Lipkin M; Edelmann W; Kucherlapati R Mouse models for colorectal cancer	25	6
126	2	126 1999 ONCOGENE 18(44):5959-5966 Gazit A; Yaniv A; Bafico A; Pramila T; Igarashi M; Kitajewski J; Aaronson SA Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response	8	4
127	2	127 1999 ONCOGENE 18(47):6583-6588 Terris B; Pineau P; Bregeaud L; Valla D; Belghiti J; Tiollais P; Degott C; Dejean A Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas	32	13
128	2	128 1999 ONCOGENE 18(48):6806-6809 Duval A; Iacopetta B; Ranzani GN; Lothe RA; Thomas G; Hamelin R Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability	23	8
129	3	129 1999 ONCOGENE 18(50):7080-7090 Ito K; Okamoto I; Araki N; Kawano Y; Nakao M; Fujiyama S; Tomita K; Mimori T; Saya H Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts	19	0
130	11	130 1999 ONCOGENE 18(55):7860-7872 Miller JR; Hocking AM; Brown JD; Moon RT Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways	189	35
131	1	131 1999 ONCOLOGY REPORTS 6(6):1253-1256 Jaiswal AS; Kennedy CH; Narayan S A correlation of APC and c-myc mRNA levels in lung cancer cell lines	3	3
132	1	132 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(1):139-144 Aoki M; Hecht A; Kruse U; Kemler R; Vogt PK Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1	59	27
133	1	133 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(4):1603-1608 Mann B; Gelos M; Siedow A; Hanski ML; Gratchev A; Ilyas M; Bodmer WF; Moyer MP; Riecken EO; Buhr HJ; Hanski C Target genes of beta-catenin-T cell-factor lymphoid-enhancer-factor signaling in human colorectal carcinomas	204	147
134	1	134 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(5):2322-2326 Laken SJ; Papadopoulos N; Petersen GM; Gruber SB; Hamilton SR; Giardiello FM; Brensinger JD; Vogelstein B; Kinzler KW Analysis of masked mutations in familial adenomatous polyposis	37	6
135	1	135 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(10):5522-5527 Shtutman M; Zhurinsky J; Simcha I; Albanese C; D'Amico M; Pestell R; Ben-Ze'ev A The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway	351	229
136	1	136 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(20):11566-11571 Jayachandra S; Low KG; Thlick AE; Yu J; Ling PD; Chang Y; Moore PS Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors (Retracted article. See vol 98, pg 12313, 2001)	55	2
137	5	137 1999 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 72(3):299-328 Craig KL; Tyers M The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction	43	0
138	1	138 1999 SCIENCE 283(5410):2089-2091 Seeling JM; Miller JR; Gil R; Moon RT; White R; Virshup DM Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A	117	44
139	3	139 1999 SCIENCE 285(5435):1923-1926 Roose J; Huls G; van Beest M; Moerer P; van der Horn K; Goldschmeding R; Logtenberg T; Cleavers H Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1	124	82
140	1	140 1999 SCIENCE 286(5444):1491-1492 Velculescu VE Essay: Amersham Pharmacia Biotech & Science Prize - Tantalizing transcriptomes - SAGE and its use in global gene expression analysis	18	1
141	2	141 1999 SCIENTIST 13(14):15-15 Kinzler KW Hot papers - Cancer - Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC by P.J. Morin, A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, K.W. Kinzler - Comments	0	0
142	1	142 1999 SCIENTIST 13(8):15-15 Birchmeier W Hot papers - Cell biology - Functional interaction of beta-catenin with the transcription factor LEF-I by J. Behrens, J.P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier - Comments	0	0
143	1	143 1999 SCIENTIST 13(2):24-24 [Anon] Serial analysis of gene expression: An alternative to chip arrays	0	0
144	1	144 1999 SEMINARS IN LIVER DISEASE 19(3):253-262 Chen PJ; Chen DS Hepatitis B virus infection and hepatocellular carcinoma: Molecular genetics and clinical perspectives	27	0
145	6	145 1999 TRENDS IN BIOCHEMICAL SCIENCES 24(12):M53-M56 McCormick F Signalling networks that cause cancer	6	0
146	6	146 1999 TRENDS IN CELL BIOLOGY 9(12):M53-M56 McCormick F Signalling networks that cause cancer (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999)	26	0
147	6	147 1999 TRENDS IN GENETICS 15(12):M53-M56 McCormick F Signalling networks that cause cancer (Reprinted from Trends in Biochemical Sciences, vol 12, Dec., 1999)	1	0
148	1	148 1999 TRENDS IN GENETICS 15(3):109-112 Greider CW Telomerase activation - one step on the road to cancer?	39	0
149	1	149 1999 UROLOGY 53(4):707-713 De Marzo AM; Knudsen B; Chan-Tack K; Epstein JI E-cadherin expression as a marker of tumor aggressiveness in routinely processed radical prostatectomy specimens	27	0
150	1	150 1999 WORLD JOURNAL OF GASTROENTEROLOGY 5(5):451-454 Zhang J; Lai MD; Chen J Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa	7	0
151	1	151 2000 ADVANCES IN CANCER RESEARCH, VOL 77 77():1-24 Barker N; Morin PJ; Clevers H The yin-yang of TCF/beta-catenin signaling	93	44
152	1	152 2000 ALIMENTARY PHARMACOLOGY & THERAPEUTICS 14(10):1231-1247 Smith AM; Watson SA Review article: gastrin and colorectal cancer	16	0
153	1	153 2000 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 113(2):266-274 Kawanishi K; Doki Y; Shiozaki H; Yano M; Inoue M; Fukuchi N; Utsunomiya T; Watanabe H; Monden M Correlation between loss of E-cadherin expression and overexpression of autocrine motility factor receptor in association with progression of human gastric cancers	3	0
154	7	154 2000 AMERICAN JOURNAL OF PATHOLOGY 156(3):865-870 Brabletz T; Herrmann K; Jung A; Faller G; Kirchner T Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas	43	24
155	2	155 2000 AMERICAN JOURNAL OF PATHOLOGY 156(6):1997-2005 Furuuchi K; Tada M; Yamada H; Kataoka A; Furuuchi N; Hamada J; Takahashi M; Todo S; Moriuchi T Somatic mutations of the APC gene in primary breast cancers	19	8
156	7	156 2000 AMERICAN JOURNAL OF PATHOLOGY 157(4):1113-1121 Kirchner T; Brabletz T Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence - Analogies with embryonic gastrulation	22	11
157	2	157 2000 AMERICAN JOURNAL OF PATHOLOGY 157(5):1563-1573 Wielenga VJM; van der Voort R; Taher TEI; Smit L; Beuling EA; van Krimpen C; Spaargaren M; Pals ST Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer	12	1
158	2	158 2000 ANTICANCER RESEARCH 20(1A):407-416 Page C; Lin HJ; Jin Y; Castle VP; Nunez G; Huang M; Lin JY Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis	37	0
159	3	159 2000 ANTICANCER RESEARCH 20(5A):2835-2847 Papadopoulos V; Kapsis A; Li H; Amri H; Hardwick M; Culty M; Kasprzyk PG; Carlson M; Moreau JP; Drieu K Drug-induced inhibition of the peripheral-type benzodiazepine receptor expression and cell proliferation in human breast cancer cells	10	0
160	3	160 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(1):20-24 Tsuji T; Miyazaki M; Sakaguchi M; Inoue Y; Namba M A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines	9	0
161	7	161 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 268(2):243-248 Kikuchi A Regulation of beta-catenin signaling in the Wnt pathway	42	15
162	4	162 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(1):103-109 Koike J; Sagara N; Kirikoshi H; Takagi A; Miwa T; Hirai M; Katoh M Molecular cloning and genomic structure of the beta TRCP2 gene on chromosome 5q35.1	49	8
163	5	163 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 272(1):144-150 Neo SY; Zhang Y; Yaw LP; Li P; Lin SC Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels	16	7
164	4	164 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(3):1162-1169 Julius MA; Schelbert B; Hsu W; Fitzpatrick E; Jho E; Fagotto F; Costantini F; Kitajewski J Domains of Axin and disheveled required for interaction and function in Wnt signaling	7	3
165	3	165 2000 BIOCHEMISTRY-MOSCOW 65(1):2-27 Kopnin BP Targets of oncogenes and tumor suppressors: Key for understanding basic mechanisms of carcinogenesis	10	0
166	16	166 2000 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1495(2):168-182 Seidensticker MJ; Behrens J Biochemical interactions in the wnt pathway	67	11
167	4	167 2000 BIOESSAYS 22(10):902-910 Kitajewski J; Sassoon D The emergence of molecular gynecology: homeobox and Wnt genes in the female reproductive tract	9	0
168	16	168 2000 BIOESSAYS 22(11):961-965 Barker N; Clevers H Catenins, Wnt signaling and cancer	45	20
169	5	169 2000 BIOLOGICAL SIGNALS AND RECEPTORS 9(2):115-121 Peluso JJ N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival	13	1
170	3	170 2000 BLOOD 96(6):2206-2214 Hashimoto S; Suzuki T; Nagai S; Yamashita T; Toyoda N; Matsushima K Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression	57	2
171	4	171 2000 BRITISH JOURNAL OF CANCER 83(1):1-5 Compagni A; Christofori G Recent advances in research on multistage tumorigenesis	27	1
172	12	172 2000 BRITISH JOURNAL OF SURGERY 87(8):992-1005 Wijnhoven BPL; Dinjens WNM; Pignatelli M E-cadherin-catenin cell-cell adhesion complex and human cancer	48	5
173	1	173 2000 CANCER GENETICS AND CYTOGENETICS 121(1):17-21 Masramon L; Ribas M; Cifuentes P; Arribas R; Garcia F; Egozcue J; Peinado MA; Miro R Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting	12	0
174	3	174 2000 CANCER LETTERS 157(2):185-191 Akiyama Y; Nagasaki H; Yagi KO; Nomizu T; Yuasa Y beta-Catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients	3	0
175	3	175 2000 CANCER LETTERS 159(1):73-78 Murata M; Iwao K; Miyoshi Y; Nagasawa Y; Yabu M; Himeno S; Imanishi K; Ohsawa M; Wada H; Tominaga S; Shimano T; Kobayashi T; Nakamura Y Activation of the beta-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis	6	4
176	1	176 2000 CANCER RESEARCH 60(4):1070-1076 Hassan AB; Howell JA Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice	17	2
177	4	177 2000 CANCER RESEARCH 60(6):1671-1676 Shih IM; Tu J; He TC; Vogelstein B; Kinzler KW The beta-catenin binding domain of adenomatous polyposis coil is sufficient for tumor suppression	42	23
178	4	178 2000 CANCER RESEARCH 60(11):2864-2868 Anna CH; Sills RC; Foley JF; Stockton PS; Ton TV; Devereux TR beta-Catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam	14	2
179	4	179 2000 CANCER RESEARCH 60(13):3323-3327 Yamada Y; Yoshimi N; Hirose Y; Kawabata K; Matsunaga K; Shimizu M; Hara A; Mori H Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis	35	8
180	7	180 2000 CANCER RESEARCH 60(13):3338-3342 Thompson WJ; Piazza GA; Li H; Liu L; Fetter J; Zhu B; Sperl G; Ahnen D; Pamukcu R Exisulind induction of apoptosis involves guanosine 3 ',5 '-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin	49	3
181	6	181 2000 CANCER RESEARCH 60(13):3354-3358 Kawasoe T; Furukawa Y; Daigo Y; Nishiwaki T; Ishiguro H; Fujita M; Satoh S; Miwa N; Nagasawa Y; Miyoshi Y; Ogawa M; Nakamura Y Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin	6	6
182	5	182 2000 CANCER RESEARCH 60(14):3872-3879 Duval A; Rolland S; Tubacher E; Bui H; Thomas G; Hamelin R The human T-cell transcription factor-4 gene: Structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines	32	15
183	4	183 2000 CANCER RESEARCH 60(16):4602-4609 Bissonnette M; Khare S; von Lintig FC; Wali RK; Nguyen L; Zhang YC; Hart J; Skarosi S; Varki N; Boss GR; Brasitus TA Mutational and nonmutational activation of p21(ras) in rat colonic azoxymethane-induced tumors: Effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1	19	1
184	2	184 2000 CANCER RESEARCH 60(21):6178-6183 Lewis BC; Prescott JE; Campbell SE; Shim H; Orlowski RZ; Dang CV Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A	3	0
185	5	185 2000 CANCER RESEARCH 60(22):6288-6292 Maiti S; Alam R; Amos CI; Huff V Frequent association of beta-catenin and WT1 mutations in Wilms tumors	14	7
186	3	186 2000 CANCER RESEARCH 60(22):6318-6325 Mitchell KO; Ricci MS; Miyashita T; Dicker DT; Jin ZY; Reed JC; El-Deiry WS Bax is a transcriptional target and mediator of c-Myc-induced apoptosis	26	1
187	8	187 2000 CANCER RESEARCH 60(22):6488-6495 Foster KW; Frost AR; McKie-Bell P; Lin CY; Engler JA; Grizzle WE; Ruppert JM Increase of GKLF messenger RNA and protein expression during progression of breast cancer	17	0
188	2	188 2000 CANCER RESEARCH 60(23):6611-6616 Tsujiuchi T; Tsutsumi M; Sasaki Y; Murata N; Konishi Y Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats	14	5
189	10	189 2000 CANCER RESEARCH 60(23):6683-6687 Fujita M; Furukawa Y; Nagasawa Y; Ogawa M; Nakamura Y Down-regulation of monocyte chemotactic protein-3 by activated beta-catenin	4	4
190	5	190 2000 CANCER RESEARCH 60(24):7057-7065 Sasaki CY; Lin HC; Morin PJ; Longo DL Truncation of the extracellular region abrogrates cell contact but retains the growth-suppressive activity of E-cadherin	9	0
191	2	191 2000 CARCINOGENESIS 21(3):469-476 Bach SP; Renehan AG; Potten CS Stem cells: the intestinal stem cell as a paradigm	47	2
192	2	192 2000 CARCINOGENESIS 21(6):1167-1173 Mutanen M; Pajari AM; Oikarinen SI Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes	26	2
193	2	193 2000 CARCINOGENESIS 21(11):1935-1940 Iwamoto M; Ahnen DJ; Franklin WA; Maltzman TH Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues	15	9
194	1	194 2000 CARDIOVASCULAR RESEARCH 45(3):621-629 Rezvani M; Barrans JD; Dai KS; Liew CC Apoptosis-related genes expressed in cardiovascular development and disease: an EST approach	7	0
195	4	195 2000 CELL 100(1):143-155 Fuchs E; Segre JA Stem cells: A new lease on life	182	5
196	15	196 2000 CELL 103(2):311-320 Bienz M; Clevers H Linking colorectal cancer to Wnt signaling	190	60
197	4	197 2000 CELL ADHESION AND COMMUNICATION 7(5):391-408 Luber B; Candidus S; Handschuh G; Mentele E; Hutzler P; Feller S; Voss J; Hofler H; Becker KF Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate	8	2
198	1	198 2000 CELL GROWTH & DIFFERENTIATION 11(4):201-210 Ngo CV; Gee M; Akhtar N; Yu D; Volpert O; Auerbach R; Thomas-Tikhonenko A An in vivo function for the transforming Myc protein: Elicitation of the angiogenic phenotype	21	1
199	2	199 2000 CELL PROLIFERATION 33(1):1-18 Roncucci L; Pedroni M; Vaccina F; Benatti P; Marzona L; De Pol A Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics	22	1
200	1	200 2000 CELLULAR & MOLECULAR BIOLOGY LETTERS 5(1):3-18 Miturski R; Burnouf D; Nothisen M; Bogusiewicz M; Jakowicki JA Molecular biology and clinical implications of the adenomatous polyposis coli (APC) gene	1	0

#	Cited nodes	Nodes / Authors	GCS	LCS
201	4	201 2000 CELLULAR AND MOLECULAR LIFE SCIENCES 57(8-9):1207-1219 Desterro JMP; Rodriguez MS; Hay RT Regulation of transcription factors by protein degradation	16	0
202	1	202 2000 CHINESE SCIENCE BULLETIN 45(21):1973-1977 Lin GT; Zhang ZW; Zang T; Xin DQ; Chang ZJ; Guo YL Interaction of hTCF4 by yeast two-hybrid system	1	0
203	2	203 2000 CHIRURGISCHE GASTROENTEROLOGIE 16(3):206-212 Muller H; Dobbie Z; Heinimann K Familial colorectal cancer and genetic screening	1	0
204	2	204 2000 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 65():511-520 Wahl G; Vafa O Genetic instability, oncogenes, and the p53 pathway	0	0
205	3	205 2000 COLORECTAL CANCER: NEW ASPECTS OF MOLECULAR BIOLOGY AND IMMUNOLOGY AND THEIR CLINICAL APPLICATIONS 910():1-9 Hanski C; Itzkowitz SH Translating the knowledge of molecular alterations that occur during colon carcinogenesis into clinically relevant solutions	2	0
206	13	206 2000 COLORECTAL CANCER: NEW ASPECTS OF MOLECULAR BIOLOGY AND IMMUNOLOGY AND THEIR CLINICAL APPLICATIONS 910():21-35 Behrens J Control of beta-catenin signaling in tumor development	45	12
207	4	207 2000 CRITICAL REVIEWS IN ONCOGENESIS 11(1):19-62 Feo F; Pascale RM; Simile MM; De Miglio MR; Muroni MR; Calvisi D Genetic alterations in liver carcinogenesis: Implications for new preventive and therapeutic strategies	15	2
208	5	208 2000 CURRENT OPINION IN GASTROENTEROLOGY 16(5):419-425 Su GH; Kern SE Molecular genetics of ductal pancreatic neoplasia	2	0
209	4	209 2000 CURRENT OPINION IN GENETICS & DEVELOPMENT 10(1):81-93 Macleod K Tumor suppressor genes	35	2
210	4	210 2000 CURRENT OPINION IN MOLECULAR THERAPEUTICS 2(6):682-690 Ricci MS; El-Deiry WS Novel strategies for therapeutic design in molecular oncology using gene expression profiles	5	0
211	3	211 2000 CYTOGENETICS AND CELL GENETICS 88(3-4):264-265 Duval A; Busson-Leconiat M; Berger R; Hamelin R Assignment of the TCF-4 gene (TCF7L2) to human chromosome band 10q25.3	3	2
212	12	212 2000 CYTOKINE & GROWTH FACTOR REVIEWS 11(4):273-282 Akiyama T Wnt/beta-catenin signaling	24	6
213	4	213 2000 DEVELOPMENT 127(3):469-482 Galceran J; Miyashita-Lin EM; Devaney E; Rubenstein JLR; Grosschedl R Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1	44	3
214	10	214 2000 DEVELOPMENT 127(17):3805-3813 Lickert H; Domon C; Huls G; Wehrle C; Duluc I; Clevers H; Meyer BI; Freund JN; Kemler R Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine	43	6
215	6	215 2000 DEVELOPMENTAL BIOLOGY 219(1):98-114 Widelitz RB; Jiang TX; Lu JF; Chuong CM beta-catenin in epithelial morphogenesis: Conversion of part of avian foot scales into feather buds with a mutated beta-catenin	33	2
216	3	216 2000 DRUG DISCOVERY TODAY 5(9):415-425 Madden SL; Wang CJ; Landes G Serial analysis of gene expression: from gene discovery to target identification	21	2
217	8	217 2000 EMBO JOURNAL 19(10):2270-2279 Spink KE; Polakis P; Weis WI Structural basis of the Axin-adenomatous polyposis coli interaction	27	5
218	5	218 2000 EMBO JOURNAL 19(21):5813-5823 Beier R; Burgin A; Kiermaier A; Fero M; Karsunky H; Saffrich R; Moroy T; Ansorge W; Roberts J; Eilers M Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events	32	2
219	4	219 2000 EMBO REPORTS 1(6):519-523 Neufeld KL; Zhang F; Cullen BR; White RL APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export	29	10
220	4	220 2000 ENDOCRINE 12(3):295-302 Peluso JJ; Pappalardo A; Hess SA Effect of disrupting cell contact on the nuclear accumulation of beta-catenin and subsequent apoptosis of rat ovarian surface epithelial cells in vitro	5	2
221	2	221 2000 ENDOCRINE PATHOLOGY 11(3):243-250 Semba S; Kusumi R; Moriya T; Sasano H Nuclear accumulation of beta-catenin in human endocrine tumors: Association with Ki-67 (MIB-1) proliferative activity	4	1
222	2	222 2000 EPITHELIAL TRANSPORT AND BARRIER FUNCTION 915():136-143 Gessner R; Tauber R Intestinal cell adhesion molecules - Liver-intestine cadherin	5	0
223	2	223 2000 EUROPEAN JOURNAL OF CANCER 36(2):242-248 Jonsson M; Borg A; Nilbert M; Andersson T Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer	19	6
224	3	224 2000 EUROPEAN JOURNAL OF CANCER 36(5):664-674 Smith ML; Hawcroft G; Hull MA The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action	60	4
225	1	225 2000 EUROPEAN JOURNAL OF CANCER 36(8):1043-1049 Bourgarel-Rey V; El Khyari S; Rimet O; Bordas B; Guigal N; Braguer D; Seree E; Barra Y; Briand C Opposite effects of antimicrotubule agents on c-myc oncogene expression depending on the cell lines used	3	0
226	3	226 2000 EUROPEAN JOURNAL OF CANCER 36(13):1607-1620 Beavon IRG The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation	33	6
227	23	227 2000 EXPERIMENTAL CELL RESEARCH 261(1):75-82 Ben-Ze'ev A; Shtutman M; Zhurinsky J The integration of cell adhesion with gene expression: The role of beta-catenin	24	0
228	4	228 2000 FEBS LETTERS 476(3):203-207 Dang DT; Bachman KE; Mahatan CS; Dang LH; Giardiello FM; Yang VW Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients	17	1
229	3	229 2000 FRONTIERS IN BIOSCIENCE 5():D372-D390 Amanatullah DF; Reutens AT; Zafonte BT; Fu MF; Mani S; Pestell RG Cell-cycle dysregulation and the molecular mechanisms of prostate cancer	13	0
230	8	230 2000 GASTROENTEROLOGY 119(3):854-865 Chung DC The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis	78	10
231	3	231 2000 GENES & DEVELOPMENT 14(2):158-162 Dorsky RI; Raible DW; Moon RT Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway	34	3
232	1	232 2000 GENES & DEVELOPMENT 14(3):272-277 Kung AL; Rebel VI; Bronson RT; Ch'ng LE; Sieff CA; Livingston DM; Yao TP Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP	97	2
233	5	233 2000 GENES & DEVELOPMENT 14(5):585-595 Xu LF; Corcoran RB; Welsh JW; Pennica D; Levine AJ WISP-1 is a Wnt-1-and beta-catenin-responsive oncogene	67	38
234	1	234 2000 GENES & DEVELOPMENT 14(8):889-894 Robinson GW; Hennighausen L; Johnson PF Side-branching in the mammary gland: the progesterone-Wnt connection	17	2
235	15	235 2000 GENES & DEVELOPMENT 14(11):1319-1331 Kolligs FT; Kolligs B; Hajra KM; Hu G; Tani M; Cho KR; Fearon ER gamma-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin	74	41
236	5	236 2000 GENES & DEVELOPMENT 14(13):1553-1577 Goodman RH; Smolik S CBP/p300 in cell growth, transformation, and development	286	4
237	24	237 2000 GENES & DEVELOPMENT 14(15):1837-1851 Polakis P Wnt signaling and cancer	448	140
238	4	238 2000 GENES CHROMOSOMES & CANCER 28(4):443-453 Webster MT; Rozycka M; Sara E; Davis E; Smalley M; Young N; Dale TC; Wooster R Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding	43	20
239	3	239 2000 GENOME RESEARCH 10(12):2006-2021 Chrast R; Scott HS; Papasavvas MP; Rossier C; Antonarakis ES; Barras C; Davisson MT; Schmidt C; Estivill X; Dierssen M; Pritchard M; Antonarakis SE The mouse brain transcriptome by SAGE: Differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals	18	0
240	2	240 2000 GLIA 32(2):146-154 Gunnersen JM; Spirkoska V; Smith PE; Danks RA; Tan SS Growth and migration markers of rat C6 glioma cells identified by serial analysis of gene expression	21	4
241	1	241 2000 GUT 47(6):812-819 Kishimoto Y; Takata N; Jinnai T; Morisawa T; Shiota G; Kawasaki H; Hasegawa J Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane	9	5
242	1	242 2000 GUT 47(6):820-824 Smith AM; Watson SA Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence	26	1
243	6	243 2000 GYNECOLOGIC ONCOLOGY 77(1):97-104 Furlong MT; Morin PJ Rare activation of the TCF/beta-catenin pathway in ovarian cancer	10	3
244	2	244 2000 HARVEY LECTURES, SERIES 94, 1998-1999 94():47-+ Fuchs E Beauty is skin deep: The fascinating biology of the epidermis and its appendages	0	0
245	1	245 2000 HISTOLOGY AND HISTOPATHOLOGY 15(1):251-260 Tucker EL; Pignatelli M Catenins and their associated proteins in colorectal cancer	11	2
246	3	246 2000 HUMAN GENE THERAPY 11(16):2261-2266 Watt FM Epidermal stem cells as targets for gene transfer	6	0
247	5	247 2000 IMMUNITY 13(1):15-24 Reya T; O'Riordan M; Okamura R; Devaney E; Willert K; Nusse R; Grosschedl R Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism	49	11
248	3	248 2000 IMMUNOLOGICAL REVIEWS 175():94-103 O'Riordan M; Grosschedl R Transcriptional regulation of early B-lymphocyte differentiation	14	0
249	3	249 2000 IMMUNOLOGICAL REVIEWS 176():47-68 Gold MR; Ingham RJ; McLeod SJ; Christian SL; Scheid MP; Duronio V; Santos L; Matsuuchi L Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap 1 GTPase	12	0
250	3	250 2000 INTERNATIONAL JOURNAL OF CANCER 86(4):480-488 Hanada N; Makino K; Koga H; Morisaki T; Kuwahara H; Masuko N; Tabira Y; Hiraoka T; Kitamura N; Kikuchi A; Saya H NE-dlg, a mammalian homolog of Drosophila DLG tumor suppressor, induces growth suppression and impairment of cell adhesion: Possible involvement of down-regulation of beta-catenin by NE-dlg expression	2	0
251	4	251 2000 INTERNATIONAL JOURNAL OF CANCER 86(4):533-537 Wijnhoven BPL; Nollet F; De Both NJ; Tilanus HW; Dinjens WNM Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus	8	3
252	2	252 2000 INTERNATIONAL JOURNAL OF CANCER 87(1):5-11 Shimakage M; Kawahara K; Kikkawa N; Sasagawa T; Yutsudo M; Inoue H Down-regulation of drs mRNA in human colon adenocarcinomas	6	0
253	2	253 2000 INTERNATIONAL JOURNAL OF CANCER 89(2):172-176 Latil A; Vidaud D; Valeri A; Fournier G; Vidaud M; Lidereau R; Cussenot O; Bieche I htert expression correlates with myc over-expression in human prostate cancer	29	0
254	1	254 2000 INTERNATIONAL JOURNAL OF CANCER 90(4):175-185 Kennedy AS; Harrison GH; Mansfield CM; Zhou XJ; Xu JF; Balcer-Kubiczek EK Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: Effect of TP53 or hMLH1 deficiency	7	0
255	1	255 2000 INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 81(2):117-143 Wright NA Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer	19	1
256	3	256 2000 JAPANESE JOURNAL OF CANCER RESEARCH 91(6):597-603 Ishiguro H; Furukawa Y; Daigo Y; Miyoshi Y; Nagasawa Y; Nishiwaki T; Kawasoe T; Fujita M; Satoh S; Miwa N; Fujii Y; Nakamura Y Isolation and characterization of human NBL4, a gene involved in the beta-catenin/Tcf signaling pathway	7	7
257	5	257 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(6):4374-4382 Uren A; Reichsman F; Anest V; Taylor WG; Muraiso K; Bottaro DP; Cumberledge S; Rubin JS Secreted frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of Wnt signaling	37	7
258	1	258 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(12):8369-8374 Kawahara K; Morishita T; Nakamura T; Hamada F; Toyoshima K; Akiyama T Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with axin and beta-catenin	23	10
259	5	259 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(15):10905-10911 Hakimelahi S; Parker HR; Gilchrist AJ; Barry M; Li Z; Bleackley RC; Pasdar M Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2	25	8
260	4	260 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(19):14736-14742 Rimerman RA; Gellert-Randleman A; Diehl JA Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation	25	3
261	5	261 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(21):16345-16353 Steinhusen U; Badock V; Bauer A; Behrens J; Wittman-Liebold B; Dorken B; Bommert K Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential	22	6
262	7	262 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(23):17894-17899 Chen RH; Ding WV; McCormick F Wnt signaling to beta-catenin involves two interactive components - Glycogen synthase kinase-3 beta inhibition and activation of protein kinase C	45	12
263	1	263 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(24):18470-18475 Rezvani M; Liew CC Role of the adenomatous polyposis coli gene product in human cardiac development and disease	7	0
264	6	264 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(27):20707-20716 Stewart DB; Barth AIM; Nelson WJ Differential regulation of endogenous cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and activation of beta-catenin signaling	12	1
265	5	265 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(28):21435-21443 Ilan N; Cheung L; Pinter E; Madri JA Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation	30	1
266	2	266 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(29):21797-21800 Osthus RC; Shim H; Kim S; Li Q; Reddy R; Mukherjee M; Xu Y; Wonsey D; Lee LA; Dang CV Accelerated publication - Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc	29	3
267	4	267 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(31):23790-23797 Song DH; Sussman DJ; Seldin DC Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells	51	8
268	3	268 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(32):25008-25014 Zhang Y; Neo SY; Han JH; Lin SC Dimerization choices control the ability of axin and dishevelled to activate c-jun N-terminal kinase/stress-activated protein kinase	11	3
269	2	269 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(33):25805-25813 van de Water B; Tijdens IB; Verbrugge A; Huigsloot M; Dihal AA; Stevens JL; Jaken S; Mulder GJ Cleavage of the actin-capping protein alpha-adducin at Asp-Asp-Ser-Asp(633)-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells	18	0
270	3	270 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(35):27266-27273 van Beest M; Dooijes D; van de Wetering M; Kjaerulff S; Bonvin A; Nielsen O; Clevers H Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs	6	0
271	4	271 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(41):32046-32051 Haertel-Wiesmann M; Liang YX; Fantl WJ; Williams LT Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells	21	0
272	14	272 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(44):34399-34406 Hinoi T; Yamamoto H; Kishida M; Takada S; Kishida S; Kikuchi A Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin	21	8
273	2	273 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(45):35170-35175 Miyagishi M; Fujii R; Hatta M; Yoshida E; Araya N; Nagafuchi A; Ishihara S; Nakajima T; Fukamizu A Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300	40	13
274	2	274 2000 JOURNAL OF CELL BIOLOGY 148(1):173-187 Eger A; Stockinger A; Schaffhauser B; Beug H; Foisner R Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity	34	10
275	5	275 2000 JOURNAL OF CELL BIOLOGY 148(3):567-578 Huelsken J; Vogel R; Brinkmann V; Erdmann B; Birchmeier C; Birchmeier W Requirement for beta-catenin in anterior-posterior axis formation in mice	58	14
276	5	276 2000 JOURNAL OF CELL BIOLOGY 149(2):249-254 Takemaru KI; Moon RT The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression	85	43
277	4	277 2000 JOURNAL OF CELL BIOLOGY 149(2):503-519 Charpentier E; Lavker RM; Acquista E; Cowin P Plakoglobin suppresses epithelial proliferation and hair growth in vivo.	34	11
278	6	278 2000 JOURNAL OF CELL BIOLOGY 149(4):761-766 Tirnauer JS; Bierer BE EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability	44	3
279	11	279 2000 JOURNAL OF CELL SCIENCE 113(6):911-919 Behrens J Cross-regulation of the Wnt signalling pathway: a role of MAP kinases	14	3
280	6	280 2000 JOURNAL OF CELL SCIENCE 113(12):2129-2138 Naylor S; Smalley MJ; Robertson D; Gusterson BA; Edwards PAW; Dale TC Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium	6	2
281	29	281 2000 JOURNAL OF CELL SCIENCE 113(18):3127-3139 Zhurinsky J; Shtutman M; Ben-Ze'ev A Plakoglobin and beta-catenin: protein interactions, regulation and biological roles	57	18
282	1	282 2000 JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 28(3):113-127 Napierala D; Plawski A; Kalak R; Jura J; Wronka J; Sowinska J; Banasiewicz T; Slomski R Molecular diagnostics of genetic diseases: Experience from studies of DMD, APC, TSC1, and OPG genes. Part 1	0	0
283	4	283 2000 JOURNAL OF CLINICAL INVESTIGATION 106(4):533-539 Koh TJ; Bulitta CJ; Fleming JV; Dockray GJ; Varro A; Wang TC Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis	41	23
284	10	284 2000 JOURNAL OF CLINICAL ONCOLOGY 18(9):1967-1979 Goss KH; Groden J Biology of the adenomatous polyposis coli tumor suppressor	50	15
285	2	285 2000 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 19(3):349-355 Ougolkov A; Mai M; Takahashi Y; Omote K; Bilim V; Shimizu A; Minamoto T Altered expression of beta-catenin and c-erbB-2 in early gastric cancer	6	1
286	9	286 2000 JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS 5(1):10-13 Petzelbauer P; Halama T; Groger M Endothelial adherens junctions	6	0
287	1	287 2000 JOURNAL OF MOLECULAR BIOLOGY 301(1):147-156 Day CL; Alber T Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor	12	1
288	5	288 2000 JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 59(4):333-337 Eberhart CG; Tihan T; Burger PC Nuclear localization and mutation of beta-catenin in medulloblastomas	23	9
289	2	289 2000 JOURNAL OF PATHOLOGY 190(4):412-416 Arends JW Molecular interactions in the Vogelstein model of colorectal carcinoma	17	0
290	4	290 2000 MECHANISMS OF DEVELOPMENT 91(1-2):249-258 Arnold SJ; Stappert J; Bauer A; Kispert A; Herrmann BG; Kemler R Brachyury is a target gene of the Wnt/beta-catenin signaling pathway	31	4
291	3	291 2000 MODERN PATHOLOGY 13(10):1066-1071 Schlosshauer PW; Pirog EC; Levine RL; Ellenson LH Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma	17	6
292	1	292 2000 MOLECULAR AND CELLULAR BIOLOGY 20(5):1733-1746 Kobayashi A; Yamagiwa H; Hoshino H; Muto A; Sato K; Morita M; Hayashi N; Yamamoto M; Igarashi K A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain	18	0
293	3	293 2000 MOLECULAR AND CELLULAR BIOLOGY 20(10):3497-3509 Santoni-Rugiu E; Falck J; Mailand N; Bartek J; Lukas J Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway	53	0
294	14	294 2000 MOLECULAR AND CELLULAR BIOLOGY 20(12):4238-4252 Zhurinsky J; Shtutman M; Ben-Ze'ev A Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin	35	18
295	11	295 2000 MOLECULAR BIOLOGY OF THE CELL 11(10):3509-3523 Kim K; Pang KM; Evans M; Hay ED Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators	34	17
296	2	296 2000 MOLECULAR BRAIN RESEARCH 77(2):232-245 Chou AH; Zheng S; Itsukaichi T; Howard BD Wnt-1 inhibits nerve growth factor-induced differentiation of PC12 cells by preventing the induction of some but not all late-response genes	5	0
297	7	297 2000 MOLECULAR MEDICINE TODAY 6(12):462-469 Sieber OM; Tomlinson IP; Lamlum H The adenomatous polyposis coli (APC) tumour suppressor - genetics, function and disease	13	3
298	1	298 2000 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 453(2):129-181 Sankaranarayanan K; Chakraborty R Ionizing radiation and genetic risks XII. The concept of "potential recoverability correction factor" (PRCF) and its use for predicting the risk of radiation-inducible genetic disease in human live births	2	0
299	2	299 2000 NATURE 403(6771):781-785 Nishita M; Hashimoto MK; Ogata S; Laurent MN; Ueno N; Shibuya H; Cho KWY Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer	108	18
300	2	300 2000 NATURE 406(6798):897-902 Sasaki T; Irie-Sasaki J; Horie Y; Bachmaier K; Fata JE; Li M; Suzuki A; Bouchard D; Ho A; Redston M; Gallinger S; Khokha R; Mak TW; Hawkins PT; Stephens L; Scherer SW; Tsao M; Penninger JM Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma	46	4

#	Cited nodes	Nodes / Authors	GCS	LCS
301	5	301 2000 NATURE CELL BIOLOGY 2(9):653-660 Henderson BR Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover	109	39
302	4	302 2000 NATURE GENETICS 24(3):245-250 Satoh S; Daigo Y; Furukawa Y; Kato T; Miwa N; Nishiwaki T; Kawasoe T; Ishiguro H; Fujita M; Tokino T; Sasaki Y; Imaoka S; Murata M; Shimano T; Yamaoka Y; Nakamura Y AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1	257	122
303	3	303 2000 NATURE GENETICS 26(3):291-299 Jacobs JJL; Keblusek P; Robanus-Maandag E; Kristel P; Lingbeek M; Nederlof PM; van Welsem T; van de Vijver MJ; Koh EY; Daley GQ; van Lohuizen M Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers	61	0
304	3	304 2000 NEPHROLOGY DIALYSIS TRANSPLANTATION 15(1):1-2 van Adelsberg J Polycystin-1 interacts with E-cadherin and the catenins - clues to the pathogenesis of cyst formation in ADPKD?	2	0
305	6	305 2000 NEUROSURGERY 47(4):888-901 Taylor MD; Mainprize TG; Rutka JT Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: A review	10	1
306	3	306 2000 NUCLEIC ACIDS RESEARCH 28(2):446-453 Greasley PJ; Bonnard C; Amati B Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis	31	3
307	1	307 2000 NUCLEIC ACIDS RESEARCH 28(15):2969-2976 Shie JL; Chen ZY; Fu MF; Pestell RG; Tseng CC Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif	33	3
308	1	308 2000 ONCOGENE 19(3):365-372 Ishidate T; Matsumine A; Toyoshima K; Akiyama T The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase	28	8
309	5	309 2000 ONCOGENE 19(4):537-545 Ikeda S; Kishida M; Matsuura Y; Usui H; Kikuchi A GSK-3 beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin	46	21
310	6	310 2000 ONCOGENE 19(8):1002-1009 Li Y; Hively WP; Varmus HE Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer	26	9
311	2	311 2000 ONCOGENE 19(8):1102-1113 Sternlicht MD; Bissell MJ; Werb Z The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter	49	0
312	11	312 2000 ONCOGENE 19(16):1992-2001 Sadot E; Simcha I; Iwai K; Ciechanover A; Geiger B; Ben-Ze'ev A Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system	17	10
313	5	313 2000 ONCOGENE 19(34):3894-3901 Erdmann KS; Kuhlmann J; Lessmann V; Herrmann L; Eulenburg V; Muller O; Heumann R The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain	19	5
314	18	314 2000 ONCOGENE 19(50):5720-5728 Williams BO; Barish GD; Klymkowsky MW; Varmus HE A comparative evaluation of beta-catenin and plakoglobin signaling activity	13	6
315	4	315 2000 ONCOGENE 19(50):5755-5763 Kuraguchi M; Edelmann W; Yang K; Lipkin M; Kucherlapati R; Brown AMC Tumor-associated Apc mutations in Mlh1(-/-) Apc(1638N) mice reveal a mutational signature of Mlh1 deficiency	10	0
316	3	316 2000 ONCOLOGY 59(4):302-309 Maruyama K; Ochiai A; Akimoto S; Nakamura S; Baba S; Moriya Y; Hirohashi S Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer	7	1
317	1	317 2000 ONCOLOGY REPORTS 7(2):427-431 Uhrhammer N; Bay JO; Gosse-Brun S; Kwiatkowski F; Rio P; Daver A; Bignon YJ Allelic imbalance at NBS1 is frequent in both proximal and distal colorectal carcinoma	3	0
318	1	318 2000 ONCOLOGY REPORTS 7(4):707-712 Kim HJ; Guo WT; Park NH HPV-16 E6 oncoprotein induces mutations via p53-dependent and -independent pathways	0	0
319	5	319 2000 ONCOLOGY RESEARCH 12(4):193-201 Vincan E; Leet CSF; Reyes NI; Dilley RJ; Thomas RJS; Phillips WA Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3 beta activity and increases levels of both membrane-bound and APC/Axin/GSK-3 beta complex-associated pools of beta-catenin	2	0
320	4	320 2000 PATHOLOGY INTERNATIONAL 50(12):945-952 Zhu XD; Kanai Y; Saito A; Kondo Y; Hirohashi S Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas	2	0
321	2	321 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(5):2229-2234 Hermeking H; Rago C; Schuhmacher M; Li Q; Barrett JF; Obaya AJ; O'Connell BC; Mateyak MK; Tam W; Kohlhuber F; Dang CV; Sedivy JM; Eick D; Vogelstein B; Kinzler KW Identification of CDK4 as a target of c-MYC	89	15
322	4	322 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(8):4262-4266 Lin SY; Xia WY; Wang JC; Kwong KY; Spohn B; Wen Y; Pestell RG; Hung MC beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression	85	39
323	3	323 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(22):12103-12108 Playford MP; Bicknell D; Bodmer WF; Macaulay VM Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin	39	9
324	11	324 2000 PROSTATE 45(4):323-334 Chesire DR; Ewing CM; Sauvageot J; Bova GS; Isaacs WB Detection and analysis of beta-catenin mutations in prostate cancer	20	8
325	4	325 2000 REVIEWS OF REPRODUCTION 5(1):53-61 Rowlands TM; Symonds JM; Farookhi R; Blaschuk OW Cadherins: crucial regulators of structure and function in reproductive tissues	10	0
326	3	326 2000 SCIENTIST 14(11):20-21 Halim NS Hot papers - Converging pathways - Comment	0	0
327	15	327 2000 SEMINARS IN CANCER BIOLOGY 10(3):185-200 Buendia MA Genetics of hepatocellular carcinoma	50	9
328	2	328 2000 SEMINARS IN CANCER BIOLOGY 10(4):289-298 Aaltonen LA Hereditary intestinal cancer	5	1
329	1	329 2000 SURGERY 127(5):552-561 Shiozaki H; Doki Y; Kawanishi K; Shamma A; Yano M; Inoue M; Monden M Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers	11	0
330	5	330 2000 SURGICAL ONCOLOGY-OXFORD 9(3):95-101 Sohn TA; Yeo CJ The molecular genetics of pancreatic ductal carcinoma: a review	3	0
331	6	331 2000 TOXICOLOGY LETTERS 112():403-409 Paulsen JE Modulation by dietary factors in murine FAP models	7	0
332	3	332 2000 TRENDS IN GENETICS 16(10):423-425 Velculescu VE; Vogelstein B; Kinzler KW Analysing uncharted transcriptomes with SAGE	53	3
333	4	333 2001 ACTA GASTRO-ENTEROLOGICA BELGICA 64(3):249-254 Tejpar S; Cassiman JJ; Van Cutsem E The molecular basis of colorectal cancer	0	0
334	1	334 2001 ADVANCES IN CANCER RESEARCH, VOL 80 80():83-114 Shibata D; Aaltonen LA Genetic predisposition and somatic diversification in tumor development and progression	8	0
335	6	335 2001 ADVANCES IN CANCER RESEARCH, VOL 83 83():55-65 Dunbier A; Guilford P Hereditary diffuse gastric cancer	5	0
336	5	336 2001 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 115(6):835-840 Sarbia M; Arjumand J; Wolter M; Reifenberger G; Heep H; Gabbert HE Frequent c-myc amplification in high-grade dysplasia and adenocarcinoma in Barrett esophagus	9	1
337	3	337 2001 AMERICAN JOURNAL OF DERMATOPATHOLOGY 23(6):521-524 Nishie W; Iitoyo M; Miyazawa H Follicular cyst in a patient with myotonic dystrophy - A case of cyst with differentiation toward follicular infundibulum, isthmus, inner root sheath, and hair	0	0
338	10	338 2001 AMERICAN JOURNAL OF PATHOLOGY 159(5):1613-1617 Jung A; Schrauder M; Oswald U; Knoll C; Sellberg P; Palmqvist R; Niedobitek G; Brabletz T; Kirchner T The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D-1, and p16(INK4A) and is a region of low proliferation	16	4
339	1	339 2001 AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 281(5):G1279-G1289 Bradham CA; Hatano E; Brenner DA Dominant-negative TAK1 induces c-Myc and G(0) exit in liver	7	0
340	1	340 2001 ANALYTICAL BIOCHEMISTRY 288(2):141-148 Kim S; Zeller K; Dang CV; Sandgren EP; Lee LA A strategy to identify differentially expressed genes using representational difference analysis and cDNA arrays	8	0
341	1	341 2001 ANTICANCER RESEARCH 21(1A):65-70 Sundfeldt K; Ivarsson K; Rask K; Haeger M; Hedin L; Brannstrom M Higher levels of soluble E-cadherin in cyst fluid from malignant ovarian tumours than in benign cysts	1	0
342	11	342 2001 ANTICANCER RESEARCH 21(2A):911-915 Dimberg J; Hugander A; Sirsjo A; Soderkvist P Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer	8	0
343	1	343 2001 APOPTOSIS 6(1-2):133-137 Henriksson M; Selivanova G; Lindstrom M; Wiman KG Inactivation of Myc-induced p53-dependent apoptosis in human tumors	11	0
344	2	344 2001 BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY 15(5):821-833 Giercksky KE COX-2 inhibition and prevention of cancer	6	0
345	4	345 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 281(3):815-820 Saitoh T; Moriwaki J; Koike J; Takagi A; Miwa T; Shiokawa K; Katoh M Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway	54	4
346	6	346 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 283(4):798-805 Kirikoshi H; Sekihara H; Katoh M WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells	60	2
347	9	347 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284(5):1168-1175 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region	61	2
348	5	348 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 286(1):94-100 Yam JWP; Chan KW; Wong VKW; Hsiao WLW Transcriptional activity of the promoter region of rat frizzled-related protein gene	4	1
349	2	349 2001 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1519(1-2):13-29 Reeves R; Beckerbauer L HMGI/Y proteins: flexible regulators of transcription and chromatin structure	32	1
350	3	350 2001 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1538(2-3):129-140 Bergwitz C; Wendlandt T; Kispert A; Brabant G Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells	5	0
351	5	351 2001 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1471(3):M135-M145 Amati B; Frank SR; Donjerkovic D; Taubert S Function of the c-Myc oncoprotein in chromatin remodeling and transcription	39	0
352	5	352 2001 BRITISH JOURNAL OF DERMATOLOGY 145(4):576-581 Moreno-Bueno G; Gamallo C; Perez-Gallego L; Contreras F; Palacios J beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles	4	0
353	2	353 2001 BULLETIN DU CANCER 88(3):269-276 Claverie JM Bioinformatics of transcriptome analysis in cancer biology	2	0
354	2	354 2001 CANCER 91(1):42-48 Semba S; Han SY; Ikeda H; Horii A Frequent nuclear accumulation of beta-catenin in pituitary adenoma	0	2
355	3	355 2001 CANCER 92(11):2786-2795 Kallakury BVS; Sheehan CE; Winn-Deen E; Oliver J; Fisher HAG; Kaufman RP; Ross JS Decreased expression of catenins (alpha and beta), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas	5	0
356	4	356 2001 CANCER LETTERS 165(1):71-79 Nimmrich I; Erdmann S; Melchers U; Chtarbova S; Finke U; Hentsch S; Hoffmann I; Oertel M; Hoffmann W; Muller O The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells	4	0
357	12	357 2001 CANCER LETTERS 166(2):185-191 Dimitriadis A; Vincan E; Mohammed IM; Roczo N; Phillips WA; Baindur-Hudson S Expression of Wnt genes in human colon cancers	1	0
358	5	358 2001 CANCER LETTERS 168(1):1-6 Kubozoe TO; Tsujiuchi T; Murata N; Sasaki Y; Tsunoda T; Konishi Y; Tsutsumi R Absence of beta-catenin gene mutations in pancreatic duct lesions induced by N-nitrosobis(2-oxopropyl)amine in hamsters	0	0
359	3	359 2001 CANCER LETTERS 173(2):175-182 Nishizuka I; Ichikawa Y; Ishikawa T; Kamiyama M; Hasegawa S; Momiyama N; Miyazaki K; Shimada H Matrilysin stimulates DNA synthesis of cultured vascular endothelial cells and induces angiogenesis in vivo	5	0
360	9	360 2001 CANCER RESEARCH 61(1):278-284 van de Wetering M; Barker N; Harkes IC; van der Heyden M; Dijk NJ; Hollestelle A; Klijn JGM; Clevers H; Schutte M Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling	19	0
361	2	361 2001 CANCER RESEARCH 61(2):565-569 Yang WC; Mathew J; Velcich A; Edelmann W; Kucherlapati R; Lipkin M; Yang K; Augenlicht LH Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a western-style high-risk diet by altering cell maturation in the intestinal mucosa	15	4
362	3	362 2001 CANCER RESEARCH 61(3):854-858 Wakita K; Tetsu O; McCormick F A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics	1	0
363	1	363 2001 CANCER RESEARCH 61(4):1386-1391 Boudreau MD; Sohn KH; Rhee SH; Lee SW; Hunt JD; Hwang DH Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: Mediation through cyclooxygenase-independent pathways	7	0
364	4	364 2001 CANCER RESEARCH 61(4):1671-1677 Bonvini P; An WG; Rosolen A; Nguyen P; Trepel J; de Herreros AG; Dunach M; Neckers LM Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription	18	4
365	4	365 2001 CANCER RESEARCH 61(5):1874-1878 Yamada Y; Yoshimi N; Hirose Y; Matsunaga K; Katayama M; Sakata K; Shimizu M; Kuno T; Mori H Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis	25	7
366	13	366 2001 CANCER RESEARCH 61(5):2097-2104 Wagenaar RA; Crawford HC; Matrisian LM Stabilized beta-catenin immortalizes colonic epithelial cells	7	2
367	9	367 2001 CANCER RESEARCH 61(6):2751-2758 Naishiro Y; Yamada T; Takaoka AS; Hayashi R; Hasegawa F; Imai K; Hirohashi S Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation	18	10
368	4	368 2001 CANCER RESEARCH 61(7):2899-2906 Sellin JH; Umar S; Xiao JG; Morris AP Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo	13	4
369	10	369 2001 CANCER RESEARCH 61(8):3245-3249 Cadoret A; Ovejero C; Saadi-Kheddouci S; Souil E; Fabre M; Romagnolo B; Kahn A; Perret C Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin	17	10
370	4	370 2001 CANCER RESEARCH 61(8):3465-3471 Mariadason JM; Bordonaro M; Aslam F; Shi L; Kuraguchi M; Velcich A; Augenlicht LH Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation	28	15
371	5	371 2001 CANCER RESEARCH 61(8):3480-3485 Moser AR; Hegge LF; Cardiff RD Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(Min)/+ mice	5	1
372	11	372 2001 CANCER RESEARCH 61(10):4197-4205 Szeto W; Jiang W; Tice DA; Rubinfeld B; Hollingshead PG; Fong SE; Dugger DL; Pham T; Yansura DG; Wong TA; Grimaldi JC; Corpuz RT; Singh JS; Frantz GD; Devaux B; Crowley CW; Schwall RH; Eberhard DA; Rastelli L; Polakis P; Pennica D Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid	7	2
373	7	373 2001 CANCER RESEARCH 61(11):4445-4449 Chen RH; McCormick F Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells	13	4
374	2	374 2001 CANCER RESEARCH 61(12):4910-4915 Arango D; Corner GA; Wadler S; Catalano PJ; Augenlicht LH c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo	18	2
375	5	375 2001 CANCER RESEARCH 61(16):6050-6054 Zhang XB; Gaspard JP; Chung DC Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia	13	6
376	5	376 2001 CANCER RESEARCH 61(16):6297-6302 Yang WC; Velcich A; Mariadason J; Nicholas C; Corner G; Houston M; Edelmann W; Kucherlapati R; Holt PR; Augenlicht LH p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo	6	2
377	6	377 2001 CANCER RESEARCH 61(17):6345-6349 Lin YM; Ono K; Satoh S; Ishiguro H; Fujita M; Miwa N; Tanaka T; Tsunoda T; Yang KC; Nakamura Y; Furukawa Y Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis	14	8
378	11	378 2001 CANCER RESEARCH 61(17):6563-6568 Roh H; Green DW; Boswell CB; Pippin JA; Drebin JA Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells	15	8
379	4	379 2001 CANCER RESEARCH 61(18):6656-6659 Fujimori M; Ikeda S; Shimizu Y; Okajima M; Asahara T Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor	11	5
380	6	380 2001 CANCER RESEARCH 61(19):7101-7109 Shiina H; Igawa M; Urakami S; Shigeno K; Yoneda T; Terashima M; Deguchi M; Ribeiro L; Dahiya R Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer	2	0
381	8	381 2001 CANCER RESEARCH 61(21):7722-7726 Fujita M; Furukawa Y; Tsunoda T; Tanaka T; Ogawa M; Nakamura Y Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas	14	9
382	7	382 2001 CANCER RESEARCH 61(21):7978-7984 Jarrett CR; Blancato J; Cao T; Bressette DS; Cepeda M; Young PE; King CR; Byers SW Human APC2 localization and allelic imbalance	3	2
383	7	383 2001 CANCER RESEARCH 61(22):8085-8088 Hao XP; Pretlow TG; Rao JS; Pretlow TP beta-catenin expression is altered in human colonic aberrant crypt foci	6	2
384	6	384 2001 CANCER RESEARCH 61(22):8089-8093 Hlubek F; Jung A; Kotzor N; Kirchner T; Brabletz T Expression of the invasion factor laminin gamma 2 in colorectal carcinomas is regulated by beta-catenin	17	6
385	21	385 2001 CANCER RESEARCH 61(22):8247-8255 Wu R; Zhai Y; Fearon ER; Cho KR Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas	21	14
386	4	386 2001 CANCER RESEARCH 61(24):8664-8667 Zhang T; Otevrel T; Gao ZQ; Gao ZP; Ehrlich SM; Fields JZ; Boman BM Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer	15	7
387	4	387 2001 CARCINOGENESIS 22(2):315-320 Blum CA; Xu MR; Orner GA; Fong AT; Bailey GS; Stoner GD; Horio DT; Dashwood RH beta-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol	16	4
388	3	388 2001 CARCINOGENESIS 22(11):1885-1890 Koesters R; Hans MA; Benner A; Prosst R; Boehm J; Gahlen J; Doeberitz MVK Predominant mutation of codon 41 of the beta-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol	6	0
389	2	389 2001 CARCINOGENESIS 22(12):1965-1970 Hashimoto K; Nakagawa Y; Morikawa H; Niki M; Egashira Y; Hirata I; Katsu K; Akao Y Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines	3	0
390	10	390 2001 CELL 105(4):533-545 Huelsken J; Vogel R; Erdmann B; Cotsarelis G; Birchmeier W beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin	110	20
391	5	391 2001 CELL 105(6):721-732 Dajani R; Fraser E; Roe SM; Young N; Good V; Dale TC; Pearl LH Crystal structure of glycogen synthase kinase 3 beta: Structural basis for phosphate-primed substrate specificity and autoinhibition	75	6
392	6	392 2001 CELL BIOLOGY INTERNATIONAL 25(5):421-427 Kim K; Lee KY Tyrosine phosphorylation translocates beta-catenin from cell-cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function	5	1
393	14	393 2001 CHEMICAL REVIEWS 101(8):2527-2540 Ali A; Hoeflich KP; Woodgett JR Glycogen synthase kinase-3: Properties, functions, and regulation	13	0
394	9	394 2001 CLINICAL CANCER RESEARCH 7(4):901-908 Takayasu H; Horie H; Hiyama E; Matsunaga T; Hayashi Y; Watanabe Y; Suita S; Kaneko M; Sasaki F; Hashizume K; Ozaki T; Furuuchi K; Tada M; Ohnuma N; Nakagawara A Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma	19	9
395	5	395 2001 CLINICAL CANCER RESEARCH 7(8):2425-2433 Grotzer MA; Hogarty MD; Janss AJ; Liu XY; Zhao HQ; Eggert A; Sutton LN; Rorke LB; Brodeur GM; Phillips PC MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma	17	1
396	13	396 2001 CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE 12(2):152-165 Lo Muzio L A possible role for the WNT-1 pathway in oral carcinogenesis	1	0
397	6	397 2001 CURRENT OPINION IN GASTROENTEROLOGY 17(1):65-71 DuBois RN Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention	1	0
398	8	398 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(1):19-26 Prober DA; Edgar BA Growth regulation by oncogenes - new insights from model organisms	23	1
399	10	399 2001 CURRENT OPINION IN MOLECULAR THERAPEUTICS 3(1):85-96 Bartlett J Technology evaluation: SAGE, Genzyme Molecular Oncology	3	0
400	5	400 2001 CURRENT OPINION IN ONCOLOGY 13(1):78-83 Park BH; Breyer B; He TC Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer	11	0

#	Cited nodes	Nodes / Authors	GCS	LCS
401	2	401 2001 CYTOGENETICS AND CELL GENETICS 93(1-2):26-28 Dong X; Seelan RS; Qian C; Mai M; Liu W Genomic structure, chromosome mapping and expression analysis of the human AXIN2 gene	1	0
402	6	402 2001 DIGESTIVE DISEASES AND SCIENCES 46(11):2314-2321 Brown WA; Skinner SA; Vogiagis D; O'Brien PE Inhibition of beta-catenin translocation in rodent colorectal tumors - A novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer	3	1
403	8	403 2001 DISEASE MARKERS 17(2):41-48 Riggins GJ Using Serial Analysis of Gene Expression to identify tumor markers and antigens	3	1
404	15	404 2001 EMBO JOURNAL 20(16):4500-4511 Sampson EM; Haque ZK; Ku MC; Tevosian SG; Albanese C; Pestell RG; Paulson KE; Yee AS Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1	11	3
405	13	405 2001 EMBO JOURNAL 20(17):4912-4922 Damalas A; Kahan S; Shtutman M; Ben-Ze'ev A; Oren M Deregulated beta-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation	33	12
406	5	406 2001 EMBO JOURNAL 20(17):4935-4943 Barker N; Hurlstone A; Musisi H; Miles A; Bienz M; Clevers H The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation	50	22
407	6	407 2001 EMBO JOURNAL 20(22):6203-6212 Spink KE; Fridman SG; Weis WI Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex	8	0
408	1	408 2001 EMBO REPORTS 2(4):306-312 Vietor I; Bader T; Paiha K; Huber LA Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription	10	3
409	4	409 2001 ENDOCRINE PATHOLOGY 12(1):1-13 Semba S; Yamakawa M; Sasano H The cadherin-catenin superfamily in endocrine tumors	0	0
410	9	410 2001 ENDOCRINOLOGY 142(12):5261-5266 Helmbrecht K; Kispert A; von Wasielewski R; Brabant G Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells	4	1
411	3	411 2001 EUROPEAN JOURNAL OF CANCER 37(1):12-22 Sharma RA; Manson MM; Gescher A; Steward WP Colorectal cancer chemoprevention: biochemical targets and clinical development of promising agents	18	0
412	4	412 2001 EUROPEAN JOURNAL OF CANCER PREVENTION 10(2):139-145 Dashwood RH; Xu M; Orner GA; Horio DT Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidazo[4,5-f]quinoline and treated postinitiation with chlorophyllin	5	0
413	3	413 2001 EUROPEAN JOURNAL OF IMMUNOLOGY 31(1):285-293 Staal FJT; Meeldijk J; Moerer P; Jay P; van de Weerdt BCM; Vainio S; Nolan GP; Clevers H Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription	20	2
414	10	414 2001 EXPERIMENTAL CELL RESEARCH 264(1):126-134 van Es JH; Giles RH; Clevers HC The many faces of the tumor suppressor gene APC	27	0
415	6	415 2001 EXPERIMENTAL CELL RESEARCH 264(1):169-184 Elenbaas B; Weinberg RA Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation	38	1
416	6	416 2001 FASEB JOURNAL 15(12):2057-2072 Tegeder I; Pfeilschifter J; Geisslinger G Cyclooxygenase-independent actions of cyclooxygenase inhibitors	70	0
417	7	417 2001 FEBS LETTERS 490(3):153-162 Nasi S; Ciarapica R; Jucker R; Rosati J; Soucek L Making decisions through Myc	32	0
418	7	418 2001 FEBS LETTERS 490(3):179-189 DeSalle LM; Pagano M Regulation of the G1 to S transition by the ubiquitin pathway	25	0
419	3	419 2001 GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE 25(11):967-978 Buecher B; Heymann MF; Blottiere HM Rationale and prospects for the use of cyclooxygenase-2 (COX-2) inhibitors in colorectal cancer	1	0
420	3	420 2001 GASTROENTEROLOGY 120(7):1680-1688 Bartkova J; Thullberg M; Slezak P; Jaramillo E; Rubio C; Thomassen LH; Bartek J Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon	9	0
421	3	421 2001 GENE 277(1-2):63-81 Reeves R Molecular biology of HMGA proteins: hubs of nuclear function	21	0
422	12	422 2001 GENES & DEVELOPMENT 15(14):1796-1807 Tao WK; Pennica D; Xu LF; Kalejta RF; Levine AJ Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1	27	2
423	1	423 2001 GUT 48(5):660-666 Brown WA; Skinner SA; Malcontenti-Wilson C; Vogiagis D; O'Brien PE Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation	6	1
424	10	424 2001 HEPATOLOGY 33(5):1098-1109 Monga SPS; Pediaditakis P; Mule K; Stolz DB; Michalopoulos GK Changes in wnt/beta-catenin pathway during regulated growth in rat liver regeneration	10	2
425	5	425 2001 HEPATOLOGY RESEARCH 20(1):39-51 Fujie H; Moriya K; Shintani Y; Tsutsumi T; Takayama T; Makuuchi M; Kimura S; Koike K Frequent beta-catenin aberration in human hepatocellular carcinoma	3	1
426	5	426 2001 HEPATOLOGY RESEARCH 21(2):126-135 Murata M; Miyoshi Y; Ohsawa M; Shibata K; Ohta T; Imai Y; Nishikawa M; Iwao K; Tateishi H; Shimano T; Kobayashi T; Nakamura Y Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis	1	1
427	2	427 2001 HISTOPATHOLOGY 39(2):141-149 Grabsch H; Takeno S; Noguchi T; Hommel G; Gabbert HE; Mueller W Different patterns of beta-catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome	7	2
428	3	428 2001 HUMAN MOLECULAR GENETICS 10(7):699-703 Nevins JR The Rb/E2F pathway and cancer	77	2
429	23	429 2001 HUMAN MOLECULAR GENETICS 10(7):721-733 Fearnhead NS; Britton MP; Bodmer WF The ABC of APC	61	12
430	5	430 2001 INTERNATIONAL JOURNAL OF CANCER 92(6):839-842 Omholt K; Platz A; Ringborg U; Hansson J Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma	16	12
431	6	431 2001 INTERNATIONAL JOURNAL OF CANCER 93(3):445-449 Koch A; Waha A; Tonn JC; Sorensen N; Berthold F; Wolter M; Reifenberger J; Hartmann W; Friedl W; Reifenberger G; Wiestler OD; Pietsch T Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors	18	4
432	3	432 2001 INTERNATIONAL JOURNAL OF CANCER 94(1):148-149 Bukholm IRK; Bukholm G; Nesland JM Coexpression of cyclin A and beta-catenin and survival in breast cancer patients	3	0
433	3	433 2001 INTERNATIONAL JOURNAL OF CANCER 95(2):108-113 Woo DK; Kim HS; Lee HS; Kang YH; Yang HK; Kim WH Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines	18	4
434	1	434 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(2):233-239 Obara K; Yokoyama M; Asano G; Tanaka S Evaluation of myc and chromosome 8 copy number in colorectal cancer using interphase cytogenetics	3	0
435	4	435 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(3):541-548 Yang SZ; Kohno N; Yokoyama A; Kondo K; Hamada H; Hiwada K Decreased E-cadherin augments beta-catenin nuclear localization: Studies in breast cancer cell lines	8	1
436	4	436 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(4):843-847 Davies G; Jiang WG; Mason MD The interaction between beta-catenin, GSM3 beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer	3	0
437	5	437 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(5):959-964 Saitoh T; Katoh M Expression profiles of beta TRCP1 and beta TRCP2, and mutation analysis of beta TRCP2 in gastric cancer	46	6
438	7	438 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(5):991-996 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2	67	7
439	3	439 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(6):1271-1278 Kondoh N; Wakatsuki T; Hada A; Shuda M; Tanaka K; Arai M; Yamamoto M Genetic and epigenetic events in human hepatocarcinogenesis (Review)	14	0
440	6	440 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):105-110 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region	62	2
441	8	441 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):111-115 Kirikoshi H; Sekihara H; Katoh M Up-regulation of Frizzled-7 (FZD7) in human gastric cancer	66	3
442	9	442 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):123-127 Saitoh T; Katoh M Molecular cloning and characterization of human WNT8A	59	2
443	8	443 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(2):311-315 Saitoh T; Katoh M FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer	41	2
444	7	444 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(4):803-810 Uthoff SMS; Eichenberger MR; Lewis RK; Fox MP; Hamilton CJ; McAuliffe TL; Grimes HL; Galandiuk S Identification of candidate genes in ulcerative colitis and Crohn's disease using cDNA array technology	2	0
445	14	445 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(6):1227-1233 Williams CL; Noti JD Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha	1	0
446	4	446 2001 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 9(4):273-279 Lifschitz-Mercer B; Amitai R; Maymon BBS; Shechtman L; Czernobilsky B; Leider-Trejo L; Ben-Ze'ev A; Geiger B Nuclear localization of beta-catenin and plakoglobin in primary and metastatic human colonic carcinomas, colonic adenomas, and normal colon	0	0
447	4	447 2001 JAPANESE JOURNAL OF CANCER RESEARCH 92(6):617-623 Yamada Y; Yoshimi N; Hirose Y; Hara A; Shimizu M; Kuno T; Katayama M; Qiao Z; Mori H Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib	8	1
448	7	448 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(12):8968-8978 Pukrop T; Gradl D; Henningfeld KA; Knochel W; Wedlich D; Kuhl M Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4	8	1
449	11	449 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(21):18193-18199 Jaiswal AS; Narayan S p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents	10	1
450	8	450 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(23):20108-20115 Howe LR; Crawford HC; Subbaramaiah K; Hassell JA; Dannenberg AJ; Brown AMC PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2	26	5
451	13	451 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(23):20436-20443 Piedra J; Martinez D; Castano J; Miravet S; Dunach M; de Herreros AG Regulation of beta-catenin structure and activity by tyrosine phosphorylation	27	9
452	9	452 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(28):25883-25888 Eleftheriou A; Yoshida M; Henderson BR Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor	15	4
453	10	453 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(28):26180-26188 Mao CD; Hoang P; DiCorleto PE Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells	9	2
454	16	454 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(29):26875-26882 Yamamoto H; Hinoi T; Michiue T; Fukui A; Usui H; Janssens V; Van Hoof C; Goris J; Asashima M; Kikuchi A Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A	10	2
455	12	455 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(34):32152-32159 Zhang Y; Qiu WJ; Liu DX; Neo SY; He X; Lin SC Differential molecular assemblies underlie the dual function of axin in modulating the Wnt and JNK pathways	8	2
456	14	456 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(35):33147-33155 Kishida M; Hino S; Michiue T; Yamamoto H; Kishida S; Fukui A; Asashima M; Kikuchi A Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase I epsilon	15	2
457	6	457 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(45):42276-42286 Lamberti C; Lin KM; Yamamoto Y; Verma U; Verma IM; Byers S; Gaynor RB Regulation of beta-catenin function by the I kappa B kinases	10	5
458	4	458 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(46):43328-43333 Perreault N; Katz JP; Sackett SD; Kaestner KH Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut	5	2
459	5	459 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):45113-45119 Rockman SP; Currie SA; Ciavarella M; Vincan E; Dow C; Thomas RJS; Phillips WA Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma	18	9
460	1	460 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):45168-45174 Jiang W; Zhou L; Breyer B; Feng T; Cheng HW; Haydon R; Ishikawa A; He TC Tetracycline-regulated gene expression mediated by a novel chimeric repressor that recruits histone deacetylases in mammalian cells	1	0
461	8	461 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(49):45833-45839 Galea MA; Eleftheriou A; Henderson BR ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A	6	2
462	6	462 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(51):48276-48284 Prescott JE; Osthus RC; Lee LA; Lewis BC; Shim H; Barrett JF; Guo QB; Hawkins AL; Griffin CA; Dang CV A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation	5	0
463	1	463 2001 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 127(9):577-581 Cui J; Zhou XD; Liu YK; Tang ZY Mutation and overexpression of the beta-catenin gene may play an important role in primary hepatocellular carcinoma among Chinese people	3	0
464	18	464 2001 JOURNAL OF CELL BIOLOGY 152(1):87-96 Chen SQ; Guttridge DC; You ZB; Zhang ZC; Fribley A; Mayo MW; Kitajewski J; Wang CY Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription	35	13
465	6	465 2001 JOURNAL OF CELL BIOLOGY 152(3):491-502 Reinacher-Schick A; Gumbiner BM Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells	22	0
466	7	466 2001 JOURNAL OF CELL BIOLOGY 152(4):785-794 Soriano S; Kang DE; Fu MF; Pestell R; Chevallier N; Zheng H; Koo EH Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and Notch processing	39	4
467	11	467 2001 JOURNAL OF CELL BIOLOGY 153(3):555-568 Imbert A; Eelkema R; Jordan S; Feiner H; Cowin P Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland	28	12
468	10	468 2001 JOURNAL OF CELL BIOLOGY 153(5):1049-1059 Gottardi CJ; Wong E; Gumbiner BM E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner	47	13
469	11	469 2001 JOURNAL OF CELL BIOLOGY 153(6):1161-1173 Persad S; Troussard AA; McPhee TR; Mulholland DJ; Dedhar S Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation	37	4
470	17	470 2001 JOURNAL OF CELL BIOLOGY 154(2):369-387 Palmer HG; Gonzalez-Sancho JM; Espada J; Berciano MT; Puig I; Baulida J; Quintanilla M; Cano A; de Herreros AG; Lafarga M; Munoz A Vitamin D-3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling	20	9
471	21	471 2001 JOURNAL OF CELL BIOLOGY 154(6):1185-1196 Stockinger A; Eger A; Wolf J; Beug H; Foisner R E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity	31	5
472	16	472 2001 JOURNAL OF CELL BIOLOGY 155(6):1055-1064 Hsu W; Shakya R; Costantini F Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice	16	7
473	7	473 2001 JOURNAL OF CELL SCIENCE 114(7):1309-1319 Goichberg P; Shtutman M; Ben-Ze'ev A; Geiger B Recruitment of beta-catenin to cadherin-mediated intercellular adhesions is involved in myogenic induction	7	0
474	2	474 2001 JOURNAL OF CELLULAR BIOCHEMISTRY 81(2):262-277 Jaiswal AS; Narayan S Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the Adenomatous polyposis coli (APC) tumor suppressor gene	7	1
475	9	475 2001 JOURNAL OF CELLULAR PHYSIOLOGY 189(2):121-132 Pla P; Moore R; Morali OG; Grille S; Martinozzi S; Delmas V; Larue L Cadherins in neural crest cell development and transformation	7	1
476	7	476 2001 JOURNAL OF CLINICAL ONCOLOGY 19(11):2948-2958 Polyak K; Riggins GJ Gene discovery using the serial analysis of gene expression technique: Implications for cancer research	24	2
477	5	477 2001 JOURNAL OF DERMATOLOGICAL SCIENCE 27(3):170-177 Tsuji H; Ishida-Yamamoto A; Takahashi H; Iizuka H Nuclear localization of beta-catenin in the hair matrix cells and differentiated keratinocytes	2	1
478	4	478 2001 JOURNAL OF GASTROENTEROLOGY 36(9):587-594 Fujimori T; Kawamata H; Kashida H Precancerous lesions of the colorectum	0	0
479	8	479 2001 JOURNAL OF IMMUNOLOGY 166(7):4713-4720 Monick MM; Carter AB; Robeff PK; Flaherty DM; Peterson MW; Hunninghake GW Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin	28	2
480	17	480 2001 JOURNAL OF IMMUNOLOGY 167(12):6786-6793 Thiele A; Wasner M; Muller C; Engeland K; Hauschildt S Regulation and possible function of beta-catenin in human monocytes	0	0
481	3	481 2001 JOURNAL OF INVESTIGATIVE DERMATOLOGY 116(5):739-742 Bonifas JM; Pennypacker S; Chuang PT; McMahon AP; Williams M; Rosenthal A; de Sauvage FJ; Epstein EH Activation of expression of hedgehog target genes in basal cell carcinomas	11	1
482	22	482 2001 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 6(1):37-52 Smalley MJ; Dale TC Wnt signaling and mammary tumorigenesis	11	2
483	5	483 2001 JOURNAL OF PATHOLOGY 193(4):427-432 Saldanha G The Hedgehog signalling pathway and cancer	7	0
484	7	484 2001 JOURNAL OF PATHOLOGY 193(4):483-490 Park WS; Oh RR; Park JY; Kim PJ; Shin MS; Lee JH; Kim HS; Lee SH; Kim SY; Park YG; An WG; Kim HS; Jang JJ; Yoo NJ; Lee JY Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma	15	5
485	8	485 2001 JOURNAL OF PATHOLOGY 194(1):20-26 Clavel CE; Nollet F; Berx G; Tejpar S; Naworcki-Raby B; Kaplan HH; van Roy FM; Birembaut PL Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours	10	1
486	5	486 2001 JOURNAL OF PATHOLOGY 194(1):59-67 Saegusa M; Okayasu I Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation	12	7
487	7	487 2001 JOURNAL OF PATHOLOGY 195(2):222-228 Saito T; Oda Y; Tanaka K; Matsuda S; Tamiya S; Iwamoto Y; Tsuneyoshi M beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours	7	2
488	7	488 2001 JOURNAL OF PEPTIDE RESEARCH 58(6):493-503 Catimel B; Faux MC; Nerrie M; Rothacker J; Otvos L; Wade JD; Nice EC; Burgess AW The use of coiled-coil interactions for the analysis and micropreparative isolation of adenomatous polyposis coli protein complexes	1	0
489	5	489 2001 JOURNAL OF SURGICAL RESEARCH 101(1):16-20 Green DW; Roh H; Pippin JA; Drebin JA beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts	2	0
490	6	490 2001 LANCET 357(9256):572-573 Watson SA Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis	3	0
491	10	491 2001 MECHANISMS OF DEVELOPMENT 109(2):173-181 Ridanpaa M; Fodde R; Kielman M Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures	2	0
492	6	492 2001 MEDICAL HYPOTHESES 56(5):573-581 Pearson CA; Prozialeck WC E-cadherin, beta-catenin and cadmium carcinogenesis	3	2
493	4	493 2001 MEDICINAL RESEARCH REVIEWS 21(4):245-273 Myung J; Kim KB; Crews CM The ubiquitin-proteasome pathway and proteasome inhibitors	34	0
494	1	494 2001 MICROSCOPY RESEARCH AND TECHNIQUE 52(2):171-181 Strange R; Metcalfe T; Thackray L; Dang M Apoptosis in normal and neoplastic mammary gland development	9	0
495	1	495 2001 MODERN PATHOLOGY 14(1):29-39 Aust DE; Terdiman TP; Willenbucher RF; Chew K; Ferrell L; Florendo C; Molinaro-Clark A; Baretton GB; Lohrs U; Waldman FM Altered distribution of beta-catenin, and its binding proteins E-cadherin and APC, in ulcerative colitis-related colorectal cancers	6	2
496	3	496 2001 MODERN PATHOLOGY 14(3):236-245 Redston M Carcinogenesis in the GI tract: From morphology to genetics and back again	5	0
497	6	497 2001 MODERN PATHOLOGY 14(9):900-905 Sugimachi K; Taguchi K; Aishima S; Tanaka S; Shimada M; Kajiyama K; Sugimachi K; Tsuneyoshi M Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma	7	5
498	1	498 2001 MOLECULAR AND CELLULAR BIOCHEMISTRY 227(1-2):153-165 Landesman-Bollag E; Song DH; Romieu-Mourez R; Sussman DJ; Cardiff RD; Sonenshein GE; Seldin DC Protein kinase CK2: Signaling and tumorigenesis in the mammary gland	8	0
499	10	499 2001 MOLECULAR AND CELLULAR BIOLOGY 21(1):330-342 Hino SI; Kishida S; Michiue T; Fukui A; Sakamoto I; Takada S; Asashima M; Kikuchi A Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein	14	3
500	10	500 2001 MOLECULAR AND CELLULAR BIOLOGY 21(2):562-574 Ziemer LT; Pennica D; Levine AJ Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene	13	5

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