#	Cited nodes	Nodes / Authors	GCS	LCS
101	1	38 1999 CARCINOGENESIS 20(4):635-640 McEntee MF; Chiu CH; Whelan J Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice	29	9
102	2	40 1999 CELL 98(6):779-790 Johnston LA; Prober DA; Edgar BA; Eisenman RN; Gallant P Drosophila myc regulates cellular growth during development	109	9
103	1	45 1999 CELL GROWTH & DIFFERENTIATION 10(10):713-720 Bordonaro M; Mariadason JM; Aslam F; Heerdt BG; Augenlicht LH Butyrate-induced apoptotic cascade in colonic carcinoma cells: Modulation of the beta-catenin-Tcf pathway and concordance with effects of sulindac and trichostatin a but not curcumin	28	9
104	2	121 1999 ONCOGENE 18(19):3004-3016 Nesbit CE; Tersak JM; Prochownik EV MYC oncogenes and human neoplastic disease	140	9
105	2	193 2000 CARCINOGENESIS 21(11):1935-1940 Iwamoto M; Ahnen DJ; Franklin WA; Maltzman TH Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues	15	9
106	5	288 2000 JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 59(4):333-337 Eberhart CG; Tihan T; Burger PC Nuclear localization and mutation of beta-catenin in medulloblastomas	23	9
107	6	310 2000 ONCOGENE 19(8):1002-1009 Li Y; Hively WP; Varmus HE Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer	26	9
108	3	323 2000 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 97(22):12103-12108 Playford MP; Bicknell D; Bodmer WF; Macaulay VM Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin	39	9
109	15	327 2000 SEMINARS IN CANCER BIOLOGY 10(3):185-200 Buendia MA Genetics of hepatocellular carcinoma	50	9
110	8	381 2001 CANCER RESEARCH 61(21):7722-7726 Fujita M; Furukawa Y; Tsunoda T; Tanaka T; Ogawa M; Nakamura Y Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas	14	9
111	9	394 2001 CLINICAL CANCER RESEARCH 7(4):901-908 Takayasu H; Horie H; Hiyama E; Matsunaga T; Hayashi Y; Watanabe Y; Suita S; Kaneko M; Sasaki F; Hashizume K; Ozaki T; Furuuchi K; Tada M; Ohnuma N; Nakagawara A Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma	19	9
112	13	451 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(23):20436-20443 Piedra J; Martinez D; Castano J; Miravet S; Dunach M; de Herreros AG Regulation of beta-catenin structure and activity by tyrosine phosphorylation	27	9
113	5	459 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(48):45113-45119 Rockman SP; Currie SA; Ciavarella M; Vincan E; Dow C; Thomas RJS; Phillips WA Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma	18	9
114	17	470 2001 JOURNAL OF CELL BIOLOGY 154(2):369-387 Palmer HG; Gonzalez-Sancho JM; Espada J; Berciano MT; Puig I; Baulida J; Quintanilla M; Cano A; de Herreros AG; Lafarga M; Munoz A Vitamin D-3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling	20	9
115	13	514 2001 NATURE CELL BIOLOGY 3(9):793-801 Ryo A; Nakamura M; Wulf G; Liou YC; Lu KP Pin 1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC	31	9
116	13	546 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(18):10356-10361 Brabletz T; Jung A; Reu S; Porzner M; Hlubek F; Kunz-Schughart LA; Knuechel R; Kirchner T Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment	30	9
117	2	18 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 263(2):384-388 Wright M; Aikawa M; Szeto W; Papkoff J Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells	19	8
118	1	53 1999 COLON CANCER PREVENTION 470():23-32 Polakis P; Hart M; Rubinfeld B Defects in the regulation of beta-catenin in colorectal cancer	22	8
119	1	68 1999 EUROPEAN JOURNAL OF CANCER 35(3):335-351 Ilyas M; Straub J; Tomlinson IPM; Bodmer WF Genetic pathways in colorectal and other cancers	52	8
120	2	95 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(49):35247-35254 Zhang Y; Neo SY; Wang XH; Han JH; Lin SC Axin forms a complex with MEKK1 and activates c-Jun NH2-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling	28	8
121	1	106 1999 MECHANISMS OF DEVELOPMENT 81(1-2):65-74 Vleminckx K; Kemler R; Hecht A The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis	22	8
122	2	120 1999 ONCOGENE 18(19):2967-2987 Prendergast GC Mechanisms of apoptosis by c-Myc	152	8
123	2	128 1999 ONCOGENE 18(48):6806-6809 Duval A; Iacopetta B; Ranzani GN; Lothe RA; Thomas G; Hamelin R Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability	23	8
124	2	155 2000 AMERICAN JOURNAL OF PATHOLOGY 156(6):1997-2005 Furuuchi K; Tada M; Yamada H; Kataoka A; Furuuchi N; Hamada J; Takahashi M; Todo S; Moriuchi T Somatic mutations of the APC gene in primary breast cancers	19	8
125	4	162 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 269(1):103-109 Koike J; Sagara N; Kirikoshi H; Takagi A; Miwa T; Hirai M; Katoh M Molecular cloning and genomic structure of the beta TRCP2 gene on chromosome 5q35.1	49	8
126	4	179 2000 CANCER RESEARCH 60(13):3323-3327 Yamada Y; Yoshimi N; Hirose Y; Kawabata K; Matsunaga K; Shimizu M; Hara A; Mori H Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis	35	8
127	5	259 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(15):10905-10911 Hakimelahi S; Parker HR; Gilchrist AJ; Barry M; Li Z; Bleackley RC; Pasdar M Plakoglobin regulates the expression of the anti-apoptotic protein BCL-2	25	8
128	4	267 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(31):23790-23797 Song DH; Sussman DJ; Seldin DC Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells	51	8
129	14	272 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(44):34399-34406 Hinoi T; Yamamoto H; Kishida M; Takada S; Kishida S; Kikuchi A Complex formation of adenomatous polyposis coli gene product and Axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin	21	8
130	1	308 2000 ONCOGENE 19(3):365-372 Ishidate T; Matsumine A; Toyoshima K; Akiyama T The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase	28	8
131	11	324 2000 PROSTATE 45(4):323-334 Chesire DR; Ewing CM; Sauvageot J; Bova GS; Isaacs WB Detection and analysis of beta-catenin mutations in prostate cancer	20	8
132	6	377 2001 CANCER RESEARCH 61(17):6345-6349 Lin YM; Ono K; Satoh S; Ishiguro H; Fujita M; Miwa N; Tanaka T; Tsunoda T; Yang KC; Nakamura Y; Furukawa Y Identification of AF17 as a downstream gene of the beta-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis	14	8
133	11	378 2001 CANCER RESEARCH 61(17):6563-6568 Roh H; Green DW; Boswell CB; Pippin JA; Drebin JA Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells	15	8
134	23	506 2001 MOLECULAR AND CELLULAR BIOLOGY 21(20):6768-6781 Sadot E; Geiger B; Oren M; Ben-Ze'ev A Down-regulation of beta-catenin by activated p53	26	8
135	18	584 2002 CANCER CELL 1(2):145-155 Kolligs FT; Nieman MT; Winer I; Hu G; Van Mater D; Feng Y; Smith IM; Wu R; Zhai YL; Cho KR; Fearon ER ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation	11	8
136	1	33 1999 CANCER RESEARCH 59(8):1830-1833 Ogawa K; Yamada Y; Kishibe K; Ishizaki K; Tokusashi Y beta-Catenin mutations are frequent in hepatocellular carcinomas but absent in adenomas induced by diethylnitrosamine in B6C3F1 mice	28	7
137	1	34 1999 CANCER RESEARCH 59(12):2759-2765 Bieche I; Laurendeau I; Tozlu S; Olivi M; Vidaud D; Lidereau R; Vidaud M Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay	88	7
138	6	47 1999 CELLULAR AND MOLECULAR LIFE SCIENCES 56(5-6):523-537 Novak A; Dedhar S Signaling through beta-catenin and Lef/Tcf	41	7
139	1	67 1999 ENDOCRINE REVIEWS 20(2):207-239 Potter E; Bergwitz C; Brabant G The cadherin-catenin system: Implications for growth and differentiation of endocrine tissues	42	7
140	1	117 1999 ONCOGENE 18(10):1903-1910 Ugolini F; Adelaide J; Charafe-Jauffret E; Nguyen C; Jacquemier J; Jordan B; Birnbaum D; Pebusque MJ Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes	33	7
141	5	163 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 272(1):144-150 Neo SY; Zhang Y; Yaw LP; Li P; Lin SC Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels	16	7
142	5	185 2000 CANCER RESEARCH 60(22):6288-6292 Maiti S; Alam R; Amos CI; Huff V Frequent association of beta-catenin and WT1 mutations in Wilms tumors	14	7
143	3	256 2000 JAPANESE JOURNAL OF CANCER RESEARCH 91(6):597-603 Ishiguro H; Furukawa Y; Daigo Y; Miyoshi Y; Nagasawa Y; Nishiwaki T; Kawasoe T; Fujita M; Satoh S; Miwa N; Fujii Y; Nakamura Y Isolation and characterization of human NBL4, a gene involved in the beta-catenin/Tcf signaling pathway	7	7
144	5	257 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(6):4374-4382 Uren A; Reichsman F; Anest V; Taylor WG; Muraiso K; Bottaro DP; Cumberledge S; Rubin JS Secreted frizzled-related protein-1 binds directly to wingless and is a biphasic modulator of Wnt signaling	37	7
145	4	365 2001 CANCER RESEARCH 61(5):1874-1878 Yamada Y; Yoshimi N; Hirose Y; Matsunaga K; Katayama M; Sakata K; Shimizu M; Kuno T; Mori H Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts, provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis	25	7
146	4	386 2001 CANCER RESEARCH 61(24):8664-8667 Zhang T; Otevrel T; Gao ZQ; Gao ZP; Ehrlich SM; Fields JZ; Boman BM Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer	15	7
147	7	438 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(5):991-996 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2	67	7
148	16	472 2001 JOURNAL OF CELL BIOLOGY 155(6):1055-1064 Hsu W; Shakya R; Costantini F Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice	16	7
149	5	486 2001 JOURNAL OF PATHOLOGY 194(1):59-67 Saegusa M; Okayasu I Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation	12	7
150	5	522 2001 ONCOGENE 20(1):133-140 Tan C; Costello P; Sanghera J; Dominguez D; Baulida J; de Herreros AG; Dedhar S Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells	35	7
151	8	547 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(19):10863-10868 Xia XF; Qian S; Soriano S; Wu Y; Fletcher AM; Wang XJ; Koo EH; Wu XW; Zheng H Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis	26	7
152	4	548 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(26):14973-14978 Yan D; Wiesmann M; Rohan M; Chan V; Jefferson AB; Guo LD; Sakamoto D; Caothien RH; Fuller JH; Reinhard C; Garcia PD; Randazzo FM; Escobedo J; Fantl WJ; Williams LT Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta-catenin signaling is activated in human colon tumors	13	7
153	11	625 2002 GASTROENTEROLOGY 122(1):60-71 Ougolkov AV; Yamashita K; Mai M; Minamoto T Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer	9	7
154	1	42 1999 CELL 99(4):399-408 Kim L; Liu JC; Kimmel AR The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification	48	6
155	7	60 1999 CYTOKINE & GROWTH FACTOR REVIEWS 10(3-4):255-265 Kikuchi A Modulation of Wnt signaling by Axin and Axil	17	6
156	1	102 1999 JOURNAL OF THE NATIONAL CANCER INSTITUTE 91(11):916-932 Potter JD Colorectal cancer: Molecules and populations	193	6
157	3	125 1999 ONCOGENE 18(38):5325-5333 Heyer J; Yang K; Lipkin M; Edelmann W; Kucherlapati R Mouse models for colorectal cancer	25	6
158	1	134 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(5):2322-2326 Laken SJ; Papadopoulos N; Petersen GM; Gruber SB; Hamilton SR; Giardiello FM; Brensinger JD; Vogelstein B; Kinzler KW Analysis of masked mutations in familial adenomatous polyposis	37	6
159	6	181 2000 CANCER RESEARCH 60(13):3354-3358 Kawasoe T; Furukawa Y; Daigo Y; Nishiwaki T; Ishiguro H; Fujita M; Satoh S; Miwa N; Nagasawa Y; Miyoshi Y; Ogawa M; Nakamura Y Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin	6	6
160	12	212 2000 CYTOKINE & GROWTH FACTOR REVIEWS 11(4):273-282 Akiyama T Wnt/beta-catenin signaling	24	6
161	10	214 2000 DEVELOPMENT 127(17):3805-3813 Lickert H; Domon C; Huls G; Wehrle C; Duluc I; Clevers H; Meyer BI; Freund JN; Kemler R Wnt/beta-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine	43	6
162	2	223 2000 EUROPEAN JOURNAL OF CANCER 36(2):242-248 Jonsson M; Borg A; Nilbert M; Andersson T Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer	19	6
163	3	226 2000 EUROPEAN JOURNAL OF CANCER 36(13):1607-1620 Beavon IRG The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation	33	6
164	5	261 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(21):16345-16353 Steinhusen U; Badock V; Bauer A; Behrens J; Wittman-Liebold B; Dorken B; Bommert K Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential	22	6
165	3	291 2000 MODERN PATHOLOGY 13(10):1066-1071 Schlosshauer PW; Pirog EC; Levine RL; Ellenson LH Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma	17	6
166	18	314 2000 ONCOGENE 19(50):5720-5728 Williams BO; Barish GD; Klymkowsky MW; Varmus HE A comparative evaluation of beta-catenin and plakoglobin signaling activity	13	6
167	5	375 2001 CANCER RESEARCH 61(16):6050-6054 Zhang XB; Gaspard JP; Chung DC Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia	13	6
168	6	384 2001 CANCER RESEARCH 61(22):8089-8093 Hlubek F; Jung A; Kotzor N; Kirchner T; Brabletz T Expression of the invasion factor laminin gamma 2 in colorectal carcinomas is regulated by beta-catenin	17	6
169	5	391 2001 CELL 105(6):721-732 Dajani R; Fraser E; Roe SM; Young N; Good V; Dale TC; Pearl LH Crystal structure of glycogen synthase kinase 3 beta: Structural basis for phosphate-primed substrate specificity and autoinhibition	75	6
170	5	437 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(5):959-964 Saitoh T; Katoh M Expression profiles of beta TRCP1 and beta TRCP2, and mutation analysis of beta TRCP2 in gastric cancer	46	6
171	10	503 2001 MOLECULAR AND CELLULAR BIOLOGY 21(4):1370-1383 Crawford HC; Fingleton B; Gustavson MD; Kurpios N; Wagenaar RA; Hassell JA; Matrisian LM The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors	35	6
172	6	517 2001 NATURE IMMUNOLOGY 2(8):691-697 Ioannidis V; Beermann F; Clevers H; Held W The beta-catenin-TCF-I pathway ensures CD4(+)CD8(+) thymocyte survival	22	6
173	10	594 2002 CANCER RESEARCH 62(7):1971-1977 Harada N; Miyoshi H; Murai N; Oshima H; Tamai Y; Oshima M; Taketo MM Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin	7	6
174	13	607 2002 DEVELOPMENT 129(1):95-109 Niemann C; Owens DM; Hulsken J; Birchmeier W; Watt FM Expression of Delta NLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours	26	6
175	1	17 1999 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 256(3):584-590 Omer CA; Miller PJ; Diehl RE; Kral AM Identification of Tcf4 residues involved in high-affinity beta-catenin binding	16	5
176	3	19 1999 BIOCHEMICAL JOURNAL 344():565-570 Baulida J; Batlle E; de Herreros AG Adenomatous polyposis coil protein (APC)-independent regulation of beta-catenin/Tcf-4 mediated transcription in intestinal cells	7	5
177	2	75 1999 GENES TO CELLS 4(8):465-474 Hamada F; Murata Y; Nishida A; Fujita F; Tomoyasu Y; Nakamura M; Toyoshima K; Tabata T; Ueno N; Akiyama T Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC	14	5
178	12	172 2000 BRITISH JOURNAL OF SURGERY 87(8):992-1005 Wijnhoven BPL; Dinjens WNM; Pignatelli M E-cadherin-catenin cell-cell adhesion complex and human cancer	48	5
179	2	188 2000 CANCER RESEARCH 60(23):6611-6616 Tsujiuchi T; Tsutsumi M; Sasaki Y; Murata N; Konishi Y Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats	14	5
180	4	195 2000 CELL 100(1):143-155 Fuchs E; Segre JA Stem cells: A new lease on life	182	5
181	8	217 2000 EMBO JOURNAL 19(10):2270-2279 Spink KE; Polakis P; Weis WI Structural basis of the Axin-adenomatous polyposis coli interaction	27	5
182	1	241 2000 GUT 47(6):812-819 Kishimoto Y; Takata N; Jinnai T; Morisawa T; Shiota G; Kawasaki H; Hasegawa J Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane	9	5
183	5	313 2000 ONCOGENE 19(34):3894-3901 Erdmann KS; Kuhlmann J; Lessmann V; Herrmann L; Eulenburg V; Muller O; Heumann R The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain	19	5
184	4	379 2001 CANCER RESEARCH 61(18):6656-6659 Fujimori M; Ikeda S; Shimizu Y; Okajima M; Asahara T Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor	11	5
185	8	450 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(23):20108-20115 Howe LR; Crawford HC; Subbaramaiah K; Hassell JA; Dannenberg AJ; Brown AMC PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2	26	5
186	6	457 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(45):42276-42286 Lamberti C; Lin KM; Yamamoto Y; Verma U; Verma IM; Byers S; Gaynor RB Regulation of beta-catenin function by the I kappa B kinases	10	5
187	21	471 2001 JOURNAL OF CELL BIOLOGY 154(6):1185-1196 Stockinger A; Eger A; Wolf J; Beug H; Foisner R E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity	31	5
188	7	484 2001 JOURNAL OF PATHOLOGY 193(4):483-490 Park WS; Oh RR; Park JY; Kim PJ; Shin MS; Lee JH; Kim HS; Lee SH; Kim SY; Park YG; An WG; Kim HS; Jang JJ; Yoo NJ; Lee JY Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma	15	5
189	6	497 2001 MODERN PATHOLOGY 14(9):900-905 Sugimachi K; Taguchi K; Aishima S; Tanaka S; Shimada M; Kajiyama K; Sugimachi K; Tsuneyoshi M Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma	7	5
190	10	500 2001 MOLECULAR AND CELLULAR BIOLOGY 21(2):562-574 Ziemer LT; Pennica D; Levine AJ Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene	13	5
191	7	507 2001 MOLECULAR AND CELLULAR BIOLOGY 21(23):8143-8156 Zhang F; White RL; Neufeld KL Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein	13	5
192	1	516 2001 NATURE GENETICS 28(2):165-168 Waikel RL; Kawachi Y; Waikel PA; Wang XJ; Roop DR Deregulated expression of c-Myc depletes epidermal stem cells	24	5
193	16	518 2001 NATURE REVIEWS CANCER 1(1):55-67 Fodde R; Smits R; Clevers H APC, signal transduction and genetic instability in colorectal cancer	46	5
194	2	543 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(3):992-999 Chen CR; Kang YB; Massague J Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program	64	5
195	26	555 2002 AMERICAN JOURNAL OF PATHOLOGY 160(2):389-401 Wong NACS; Pignatelli M beta-catenin - A linchpin in colorectal carcinogenesis?	33	5
196	11	595 2002 CANCER RESEARCH 62(12):3503-3506 Clements WM; Wang J; Sarnaik A; Kim OJ; MacDonald J; Fenoglio-Preiser C; Groden J; Lowy AM beta-catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer	8	5
197	9	674 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(25):22692-22698 Schroeder JA; Adriance MC; McConnell EJ; Thompson MC; Pockaj B; Gendler SJ ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu Transgenic carcinomas	7	5
198	14	751 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(12):8265-8270 Chan TA; Wang ZH; Dang LH; Vogelstein B; Kinzler KW Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation	11	5
199	12	27 1999 CANCER AND METASTASIS REVIEWS 18(2):231-246 Waltzer L; Bienz M The control of beta-catenin and TCF during embryonic development and cancer	15	4
200	1	39 1999 CARCINOGENESIS 20(9):1709-1713 Erdman SH; Ignatenko NA; Powell MB; Blohm-Mangone KA; Holubec H; Guillen-Rodriguez JM; Gerner EW APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse	14	4

#	Cited nodes	Nodes / Authors	GCS	LCS
201	1	50 1999 CLINICAL CANCER RESEARCH 5(5):945-951 Meyskens FL; Gerner EW Development of difluoromethylornithine (DFMO) as a chemoprevention agent	71	4
202	2	126 1999 ONCOGENE 18(44):5959-5966 Gazit A; Yaniv A; Bafico A; Pramila T; Igarashi M; Kitajewski J; Aaronson SA Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response	8	4
203	3	175 2000 CANCER LETTERS 159(1):73-78 Murata M; Iwao K; Miyoshi Y; Nagasawa Y; Yabu M; Himeno S; Imanishi K; Ohsawa M; Wada H; Tominaga S; Shimano T; Kobayashi T; Nakamura Y Activation of the beta-catenin gene by interstitial deletions involving exon 3 as an early event in colorectal tumorigenesis	6	4
204	10	189 2000 CANCER RESEARCH 60(23):6683-6687 Fujita M; Furukawa Y; Nagasawa Y; Ogawa M; Nakamura Y Down-regulation of monocyte chemotactic protein-3 by activated beta-catenin	4	4
205	3	224 2000 EUROPEAN JOURNAL OF CANCER 36(5):664-674 Smith ML; Hawcroft G; Hull MA The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action	60	4
206	5	236 2000 GENES & DEVELOPMENT 14(13):1553-1577 Goodman RH; Smolik S CBP/p300 in cell growth, transformation, and development	286	4
207	2	240 2000 GLIA 32(2):146-154 Gunnersen JM; Spirkoska V; Smith PE; Danks RA; Tan SS Growth and migration markers of rat C6 glioma cells identified by serial analysis of gene expression	21	4
208	4	290 2000 MECHANISMS OF DEVELOPMENT 91(1-2):249-258 Arnold SJ; Stappert J; Bauer A; Kispert A; Herrmann BG; Kemler R Brachyury is a target gene of the Wnt/beta-catenin signaling pathway	31	4
209	2	300 2000 NATURE 406(6798):897-902 Sasaki T; Irie-Sasaki J; Horie Y; Bachmaier K; Fata JE; Li M; Suzuki A; Bouchard D; Ho A; Redston M; Gallinger S; Khokha R; Mak TW; Hawkins PT; Stephens L; Scherer SW; Tsao M; Penninger JM Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma	46	4
210	10	338 2001 AMERICAN JOURNAL OF PATHOLOGY 159(5):1613-1617 Jung A; Schrauder M; Oswald U; Knoll C; Sellberg P; Palmqvist R; Niedobitek G; Brabletz T; Kirchner T The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D-1, and p16(INK4A) and is a region of low proliferation	16	4
211	4	345 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 281(3):815-820 Saitoh T; Moriwaki J; Koike J; Takagi A; Miwa T; Shiokawa K; Katoh M Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway	54	4
212	2	361 2001 CANCER RESEARCH 61(2):565-569 Yang WC; Mathew J; Velcich A; Edelmann W; Kucherlapati R; Lipkin M; Yang K; Augenlicht LH Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a western-style high-risk diet by altering cell maturation in the intestinal mucosa	15	4
213	4	364 2001 CANCER RESEARCH 61(4):1671-1677 Bonvini P; An WG; Rosolen A; Nguyen P; Trepel J; de Herreros AG; Dunach M; Neckers LM Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription	18	4
214	4	368 2001 CANCER RESEARCH 61(7):2899-2906 Sellin JH; Umar S; Xiao JG; Morris AP Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo	13	4
215	7	373 2001 CANCER RESEARCH 61(11):4445-4449 Chen RH; McCormick F Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells	13	4
216	4	387 2001 CARCINOGENESIS 22(2):315-320 Blum CA; Xu MR; Orner GA; Fong AT; Bailey GS; Stoner GD; Horio DT; Dashwood RH beta-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol	16	4
217	6	431 2001 INTERNATIONAL JOURNAL OF CANCER 93(3):445-449 Koch A; Waha A; Tonn JC; Sorensen N; Berthold F; Wolter M; Reifenberger J; Hartmann W; Friedl W; Reifenberger G; Wiestler OD; Pietsch T Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors	18	4
218	3	433 2001 INTERNATIONAL JOURNAL OF CANCER 95(2):108-113 Woo DK; Kim HS; Lee HS; Kang YH; Yang HK; Kim WH Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines	18	4
219	9	452 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(28):25883-25888 Eleftheriou A; Yoshida M; Henderson BR Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor	15	4
220	7	466 2001 JOURNAL OF CELL BIOLOGY 152(4):785-794 Soriano S; Kang DE; Fu MF; Pestell R; Chevallier N; Zheng H; Koo EH Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and Notch processing	39	4
221	11	469 2001 JOURNAL OF CELL BIOLOGY 153(6):1161-1173 Persad S; Troussard AA; McPhee TR; Mulholland DJ; Dedhar S Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation	37	4
222	6	532 2001 ONCOGENE 20(41):5810-5817 Ugolini F; Charafe-Jauffret E; Bardou VJ; Geneix J; Adelaide J; Labat-Moleur F; Penault-Llorca F; Longy M; Jacquemier J; Birnbaum D; Pebusque MJ WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type	14	4
223	21	632 2002 GENES CHROMOSOMES & CANCER 34(3):255-268 Hajra KM; Fearon ER Cadherin and catenin alterations in human cancer	19	4
224	14	645 2002 INTERNATIONAL JOURNAL OF CANCER 100(5):549-556 Reifenberger J; Knobbe CB; Wolter M; Blaschke B; Schulte KW; Pietsch T; Ruzicka T; Reifenberger G Molecular genetic analysis of malignant melanomas for aberrations of the Wnt signaling pathway genes CTNNB1, APC, ICAT and BTRC	8	4
225	7	683 2002 JOURNAL OF CELL BIOLOGY 158(6):1079-1087 Widlund HR; Horstmann MA; Price ER; Cui JI; Lessnick SL; Wu M; He X; Fisher DE beta-Catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor	8	4
226	6	702 2002 JOURNAL OF PATHOLOGY 196(2):145-153 Wong SCC; Lo SFE; Lee KC; Yam JWP; Chan JKC; Hsiao WLW Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours	9	4
227	8	729 2002 ONCOGENE 21(26):4099-4107 Gounari F; Signoretti S; Bronson R; Klein L; Sellers WR; Kum J; Siermann A; Taketo MM; von Boehmer H; Khazaie K Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia	6	4
228	8	761 2002 VIRCHOWS ARCHIV 440(4):381-386 Sekine S; Shibata T; Yamauchi Y; Nakanishi Y; Shimoda T; Sakamoto M; Hirohashi S beta-catenin mutations in sporadic fundic gland polyps	10	4
229	36	762 2002 VIRCHOWS ARCHIV 441(1):1-11 Brabletz T; Jung A; Kirchner T beta-Catenin and the morphogenesis of colorectal cancer	8	4
230	1	1 1998 AMERICAN JOURNAL OF HUMAN GENETICS 63(6):1588-1593 Semb H; Christofori G The tumor-suppressor function of E-cadherin	20	3
231	1	5 1998 CURRENT OPINION IN CELL BIOLOGY 10(6):702-709 Stappenbeck TS; Wong MH; Saam JR; Mysorekar IU; Gordon JI Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium	28	3
232	5	97 1999 JOURNAL OF CELL BIOLOGY 147(2):367-374 Nelson RW; Gumbiner BM A cell-free assay system for beta-catenin signaling that recapitulates direct inductive events in the early Xenopus laevis embryo	13	3
233	1	131 1999 ONCOLOGY REPORTS 6(6):1253-1256 Jaiswal AS; Kennedy CH; Narayan S A correlation of APC and c-myc mRNA levels in lung cancer cell lines	3	3
234	4	164 2000 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(3):1162-1169 Julius MA; Schelbert B; Hsu W; Fitzpatrick E; Jho E; Fagotto F; Costantini F; Kitajewski J Domains of Axin and disheveled required for interaction and function in Wnt signaling	7	3
235	7	180 2000 CANCER RESEARCH 60(13):3338-3342 Thompson WJ; Piazza GA; Li H; Liu L; Fetter J; Zhu B; Sperl G; Ahnen D; Pamukcu R Exisulind induction of apoptosis involves guanosine 3 ',5 '-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin	49	3
236	4	213 2000 DEVELOPMENT 127(3):469-482 Galceran J; Miyashita-Lin EM; Devaney E; Rubenstein JLR; Grosschedl R Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1	44	3
237	3	231 2000 GENES & DEVELOPMENT 14(2):158-162 Dorsky RI; Raible DW; Moon RT Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway	34	3
238	6	243 2000 GYNECOLOGIC ONCOLOGY 77(1):97-104 Furlong MT; Morin PJ Rare activation of the TCF/beta-catenin pathway in ovarian cancer	10	3
239	4	251 2000 INTERNATIONAL JOURNAL OF CANCER 86(4):533-537 Wijnhoven BPL; Nollet F; De Both NJ; Tilanus HW; Dinjens WNM Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus	8	3
240	4	260 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(19):14736-14742 Rimerman RA; Gellert-Randleman A; Diehl JA Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation	25	3
241	2	266 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(29):21797-21800 Osthus RC; Shim H; Kim S; Li Q; Reddy R; Mukherjee M; Xu Y; Wonsey D; Lee LA; Dang CV Accelerated publication - Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc	29	3
242	3	268 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(32):25008-25014 Zhang Y; Neo SY; Han JH; Lin SC Dimerization choices control the ability of axin and dishevelled to activate c-jun N-terminal kinase/stress-activated protein kinase	11	3
243	6	278 2000 JOURNAL OF CELL BIOLOGY 149(4):761-766 Tirnauer JS; Bierer BE EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability	44	3
244	11	279 2000 JOURNAL OF CELL SCIENCE 113(6):911-919 Behrens J Cross-regulation of the Wnt signalling pathway: a role of MAP kinases	14	3
245	7	297 2000 MOLECULAR MEDICINE TODAY 6(12):462-469 Sieber OM; Tomlinson IP; Lamlum H The adenomatous polyposis coli (APC) tumour suppressor - genetics, function and disease	13	3
246	3	306 2000 NUCLEIC ACIDS RESEARCH 28(2):446-453 Greasley PJ; Bonnard C; Amati B Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis	31	3
247	1	307 2000 NUCLEIC ACIDS RESEARCH 28(15):2969-2976 Shie JL; Chen ZY; Fu MF; Pestell RG; Tseng CC Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif	33	3
248	3	332 2000 TRENDS IN GENETICS 16(10):423-425 Velculescu VE; Vogelstein B; Kinzler KW Analysing uncharted transcriptomes with SAGE	53	3
249	15	404 2001 EMBO JOURNAL 20(16):4500-4511 Sampson EM; Haque ZK; Ku MC; Tevosian SG; Albanese C; Pestell RG; Paulson KE; Yee AS Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1	11	3
250	1	408 2001 EMBO REPORTS 2(4):306-312 Vietor I; Bader T; Paiha K; Huber LA Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription	10	3
251	8	441 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):111-115 Kirikoshi H; Sekihara H; Katoh M Up-regulation of Frizzled-7 (FZD7) in human gastric cancer	66	3
252	10	499 2001 MOLECULAR AND CELLULAR BIOLOGY 21(1):330-342 Hino SI; Kishida S; Michiue T; Fukui A; Sakamoto I; Takada S; Asashima M; Kikuchi A Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein	14	3
253	8	502 2001 MOLECULAR AND CELLULAR BIOLOGY 21(3):902-915 Goruppi S; Chiaruttini C; Ruaro ME; Varnum B; Schneider C Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells	14	3
254	10	508 2001 MOLECULAR CARCINOGENESIS 31(1):56-62 Uthoff SMS; Eichenberger MR; McAuliffe TL; Hamilton CJ; Galandiuk S Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer	6	3
255	11	529 2001 ONCOGENE 20(36):5062-5066 Ishiguro H; Tsunoda T; Tanaka T; Fujii Y; Nakamura Y; Furukawa Y Identification of AXUD1, a novel human gene induced by AXIN1 and its reduced expression in human carcinomas of the lung, liver, colon and kidney	4	3
256	10	537 2001 ONCOLOGY 61(3):226-233 Utsunomiya T; Doki Y; Takemoto H; Shiozaki H; Yano M; Sekimoto M; Tamura S; Yasuda T; Fujiwara Y; Monden M Correlation of beta-catenin and cyclin D1 expression in colon cancers	4	3
257	11	538 2001 ONCOLOGY RESEARCH 12(11-12):469-476 Miwa N; Furuse M; Tsukita S; Niikawa N; Nakamura Y; Furukawa Y Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers	6	3
258	3	544 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(5):2598-2603 Park BH; Vogelstein B; Kinzler KW Genetic disruption of PPAR delta decreases the tumorigenicity of human colon cancer cells	45	3
259	5	557 2002 AMERICAN JOURNAL OF PATHOLOGY 160(4):1361-1369 Abraham SC; Klimstra DS; Wilentz RE; Yeo CJ; Conlon K; Brennan M; Cameron JL; Wu TT; Hruban RH Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations	9	3
260	3	566 2002 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 292(1):195-199 Dietrich C; Scherwat J; Faust D; Oesch F Subcellular localization of beta-catenin is regulated by cell density	4	3
261	20	611 2002 EMBO JOURNAL 21(10):2303-2311 Hurlstone A; Clevers H T-cell factors: turn-ons and turn-offs	14	3
262	12	614 2002 EUROPEAN JOURNAL OF CANCER 38(7):867-871 Fodde R The APC gene in colorectal cancer	5	3
263	13	623 2002 EXPERIMENTAL CELL RESEARCH 280(1):119-133 Muller T; Bain G; Wang X; Papkoff J Regulation of epithelial cell migration and tumor formation by beta-catenin signaling	8	3
264	2	661 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(1):854-861 Yagi K; Furuhashi M; Aoki H; Goto D; Kuwano H; Sugamura K; Miyazono K; Kato M c-myc is a downstream target of the Smad pathway	26	3
265	12	662 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(3):1884-1891 Miravet S; Piedra J; Miro F; Itarte E; de Herreros AG; Dunach M The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin	10	3
266	7	672 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(23):20702-20710 Pawlowski JE; Ertel JR; Allen MP; Xu M; Butler C; Wilson EM; Wierman ME Liganded androgen receptor interaction with beta-catenin - Nuclear co-localization and modulation of transcriptional activity in neuronal cells	14	3
267	23	673 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(24):21657-21665 Leung JY; Kolligs FT; Wu R; Zhai YL; Kuick R; Hanash S; Cho KR; Fearon ER Activation of AXIN2 expression by beta-catenin-T cell factor - A feedback repressor pathway regulating Wnt signaling	5	3
268	6	676 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(28):25562-25567 Wolf D; Rodova M; Miska EA; Calvet JP; Kouzarides T Acetylation of beta-catenin by CREB-binding protein (CBP)	6	3
269	12	713 2002 LUNG CANCER 36(2):115-124 Bremnes RM; Veve R; Hirsch FR; Franklin WA The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis	14	3
270	5	720 2002 MOLECULAR CARCINOGENESIS 34(1):10-18 Fultz KE; Gerner EW APC-dependent regulation of ornithine decarboxylase in human colon tumor cells	5	3
271	17	728 2002 ONCOGENE 21(17):2679-2694 Chesire DR; Ewing CM; Gage WR; Isaacs WB In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis	10	3
272	13	737 2002 ONCOGENE 21(42):6446-6457 Gallagher RCJ; Hay T; Meniel V; Naughton C; Anderson TJ; Shibata H; Ito M; Clevers H; Noda T; Sansom OJ; Mason JO; Clarke AR Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency	4	3
273	13	750 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(9):6064-6069 Li BA; Mackay DR; Dai Q; Li TWH; Nair M; Fallahi M; Schonbaum CP; Fantes J; Mahowald AP; Waterma ML; Fuchs E; Dai X The LEF1/beta-catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation	6	3
274	2	756 2002 SCIENCE 295(5560):1726-1729 Velcich A; Yang WC; Heyer J; Fragale A; Nicholas C; Viani S; Kucherlapati R; Lipkin M; Yang K; Augenlicht L Colorectal cancer in mice genetically deficient in the mucin Muc2	30	3
275	1	3 1998 BULLETIN DU CANCER 85(11):925-928 Jeanteur P The role of APC in colon cancer: zeroing in on MYC	6	2
276	1	12 1999 AMERICAN JOURNAL OF PATHOLOGY 155(4):1027-1032 Sarbia M; Loberg C; Wolter M; Arjumand J; Heep H; Reifenberger G; Gabbert HE Expression of Bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus	10	2
277	1	28 1999 CANCER PREVENTION: NOVEL NUTRIENT AND PHARMACEUTICAL DEVELOPMENTS 889():20-31 Augenlicht LH; Bordonaro M; Heerdt BG; Mariadason J; Velcich A Cellular mechanisms of risk and transformation	9	2
278	1	31 1999 CANCER RESEARCH 59(4):826-830 Horikawa I; Cable PL; Afshari C; Barrett JJ Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene	107	2
279	1	44 1999 CELL GROWTH & DIFFERENTIATION 10(6):423-434 Foster KW; Ren SR; Louro ID; Lobo-Ruppert SM; McKie-Bell P; Grizzle W; Hayes MR; Broker TR; Chow LT; Ruppert JM Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: Transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF	15	2
280	3	59 1999 CURRENT OPINION IN MOLECULAR THERAPEUTICS 1(6):720-726 Lal A; Siu IM; Riggins GJ Serial analysis of gene expression: Probing transcriptomes for molecular targets	4	2
281	2	69 1999 EUROPEAN JOURNAL OF CANCER 35(14):1986-2002 Ilyas M; Straub J; Tomlinson IPM; Bodmer WF Genetic pathways in colorectal and other cancers (Reprinted from Eur J Cancer, vol 35, pg 335-351, 1999)	22	2
282	5	71 1999 EXPERIMENTAL CELL RESEARCH 253(1):63-77 Dang CV; Resar LMS; Emison E; Kim S; Li Q; Prescott JE; Wonsey D; Zeller K Function of the c-Myc oncogenic transcription factor	66	2
283	1	77 1999 GENOMICS 57(2):235-248 Wang YK; Sporle R; Paperna T; Schughart K; Francke U Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome	20	2
284	1	78 1999 GUT 45(5):730-732 Dimberg J; Samuelsson A; Hugander A; Soderkvist P Differential expression of cyclooxygenase 2 in human colorectal cancer	36	2
285	2	82 1999 IMMUNITY 11(4):433-442 Held W; Kunz B; Lowin-Kropf B; van de Wetering M; Clevers H Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1	31	2
286	1	103 1999 LABORATORY INVESTIGATION 79(12):1489-1499 Perry I; Tselepis C; Hoyland J; Iqbal TH; Sanders DSA; Cooper BT; Jankowski JAZ Reduced cadherin/catenin complex expression in celiac disease can be reproduced in vitro by cytokine stimulation	17	2
287	1	111 1999 MOLECULAR MEDICINE TODAY 5(4):172-177 Guilford P E-cadherin downregulation in cancer: fuel on the fire?	33	2
288	1	118 1999 ONCOGENE 18(15):2507-2517 Rosenwald IB; Chen JJ; Wang ST; Savas L; London IM; Pullman J Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis	36	2
289	1	136 1999 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96(20):11566-11571 Jayachandra S; Low KG; Thlick AE; Yu J; Ling PD; Chang Y; Moore PS Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors (Retracted article. See vol 98, pg 12313, 2001)	55	2
290	3	170 2000 BLOOD 96(6):2206-2214 Hashimoto S; Suzuki T; Nagai S; Yamashita T; Toyoda N; Matsushima K Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression	57	2
291	1	176 2000 CANCER RESEARCH 60(4):1070-1076 Hassan AB; Howell JA Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice	17	2
292	4	178 2000 CANCER RESEARCH 60(11):2864-2868 Anna CH; Sills RC; Foley JF; Stockton PS; Ton TV; Devereux TR beta-Catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam	14	2
293	2	191 2000 CARCINOGENESIS 21(3):469-476 Bach SP; Renehan AG; Potten CS Stem cells: the intestinal stem cell as a paradigm	47	2
294	2	192 2000 CARCINOGENESIS 21(6):1167-1173 Mutanen M; Pajari AM; Oikarinen SI Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes	26	2
295	4	197 2000 CELL ADHESION AND COMMUNICATION 7(5):391-408 Luber B; Candidus S; Handschuh G; Mentele E; Hutzler P; Feller S; Voss J; Hofler H; Becker KF Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate	8	2
296	4	207 2000 CRITICAL REVIEWS IN ONCOGENESIS 11(1):19-62 Feo F; Pascale RM; Simile MM; De Miglio MR; Muroni MR; Calvisi D Genetic alterations in liver carcinogenesis: Implications for new preventive and therapeutic strategies	15	2
297	4	209 2000 CURRENT OPINION IN GENETICS & DEVELOPMENT 10(1):81-93 Macleod K Tumor suppressor genes	35	2
298	3	211 2000 CYTOGENETICS AND CELL GENETICS 88(3-4):264-265 Duval A; Busson-Leconiat M; Berger R; Hamelin R Assignment of the TCF-4 gene (TCF7L2) to human chromosome band 10q25.3	3	2
299	6	215 2000 DEVELOPMENTAL BIOLOGY 219(1):98-114 Widelitz RB; Jiang TX; Lu JF; Chuong CM beta-catenin in epithelial morphogenesis: Conversion of part of avian foot scales into feather buds with a mutated beta-catenin	33	2
300	3	216 2000 DRUG DISCOVERY TODAY 5(9):415-425 Madden SL; Wang CJ; Landes G Serial analysis of gene expression: from gene discovery to target identification	21	2

#	Cited nodes	Nodes / Authors	GCS	LCS
301	5	218 2000 EMBO JOURNAL 19(21):5813-5823 Beier R; Burgin A; Kiermaier A; Fero M; Karsunky H; Saffrich R; Moroy T; Ansorge W; Roberts J; Eilers M Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events	32	2
302	4	220 2000 ENDOCRINE 12(3):295-302 Peluso JJ; Pappalardo A; Hess SA Effect of disrupting cell contact on the nuclear accumulation of beta-catenin and subsequent apoptosis of rat ovarian surface epithelial cells in vitro	5	2
303	1	232 2000 GENES & DEVELOPMENT 14(3):272-277 Kung AL; Rebel VI; Bronson RT; Ch'ng LE; Sieff CA; Livingston DM; Yao TP Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP	97	2
304	1	234 2000 GENES & DEVELOPMENT 14(8):889-894 Robinson GW; Hennighausen L; Johnson PF Side-branching in the mammary gland: the progesterone-Wnt connection	17	2
305	1	245 2000 HISTOLOGY AND HISTOPATHOLOGY 15(1):251-260 Tucker EL; Pignatelli M Catenins and their associated proteins in colorectal cancer	11	2
306	6	280 2000 JOURNAL OF CELL SCIENCE 113(12):2129-2138 Naylor S; Smalley MJ; Robertson D; Gusterson BA; Edwards PAW; Dale TC Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium	6	2
307	6	346 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 283(4):798-805 Kirikoshi H; Sekihara H; Katoh M WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells	60	2
308	9	347 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 284(5):1168-1175 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region	61	2
309	2	354 2001 CANCER 91(1):42-48 Semba S; Han SY; Ikeda H; Horii A Frequent nuclear accumulation of beta-catenin in pituitary adenoma	0	2
310	13	366 2001 CANCER RESEARCH 61(5):2097-2104 Wagenaar RA; Crawford HC; Matrisian LM Stabilized beta-catenin immortalizes colonic epithelial cells	7	2
311	11	372 2001 CANCER RESEARCH 61(10):4197-4205 Szeto W; Jiang W; Tice DA; Rubinfeld B; Hollingshead PG; Fong SE; Dugger DL; Pham T; Yansura DG; Wong TA; Grimaldi JC; Corpuz RT; Singh JS; Frantz GD; Devaux B; Crowley CW; Schwall RH; Eberhard DA; Rastelli L; Polakis P; Pennica D Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid	7	2
312	2	374 2001 CANCER RESEARCH 61(12):4910-4915 Arango D; Corner GA; Wadler S; Catalano PJ; Augenlicht LH c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo	18	2
313	5	376 2001 CANCER RESEARCH 61(16):6297-6302 Yang WC; Velcich A; Mariadason J; Nicholas C; Corner G; Houston M; Edelmann W; Kucherlapati R; Holt PR; Augenlicht LH p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo	6	2
314	7	382 2001 CANCER RESEARCH 61(21):7978-7984 Jarrett CR; Blancato J; Cao T; Bressette DS; Cepeda M; Young PE; King CR; Byers SW Human APC2 localization and allelic imbalance	3	2
315	7	383 2001 CANCER RESEARCH 61(22):8085-8088 Hao XP; Pretlow TG; Rao JS; Pretlow TP beta-catenin expression is altered in human colonic aberrant crypt foci	6	2
316	3	413 2001 EUROPEAN JOURNAL OF IMMUNOLOGY 31(1):285-293 Staal FJT; Meeldijk J; Moerer P; Jay P; van de Weerdt BCM; Vainio S; Nolan GP; Clevers H Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription	20	2
317	12	422 2001 GENES & DEVELOPMENT 15(14):1796-1807 Tao WK; Pennica D; Xu LF; Kalejta RF; Levine AJ Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1	27	2
318	10	424 2001 HEPATOLOGY 33(5):1098-1109 Monga SPS; Pediaditakis P; Mule K; Stolz DB; Michalopoulos GK Changes in wnt/beta-catenin pathway during regulated growth in rat liver regeneration	10	2
319	2	427 2001 HISTOPATHOLOGY 39(2):141-149 Grabsch H; Takeno S; Noguchi T; Hommel G; Gabbert HE; Mueller W Different patterns of beta-catenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome	7	2
320	3	428 2001 HUMAN MOLECULAR GENETICS 10(7):699-703 Nevins JR The Rb/E2F pathway and cancer	77	2
321	6	440 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):105-110 Saitoh T; Hirai M; Katoh M Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region	62	2
322	9	442 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(1):123-127 Saitoh T; Katoh M Molecular cloning and characterization of human WNT8A	59	2
323	8	443 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 19(2):311-315 Saitoh T; Katoh M FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer	41	2
324	10	453 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(28):26180-26188 Mao CD; Hoang P; DiCorleto PE Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells	9	2
325	16	454 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(29):26875-26882 Yamamoto H; Hinoi T; Michiue T; Fukui A; Usui H; Janssens V; Van Hoof C; Goris J; Asashima M; Kikuchi A Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A	10	2
326	12	455 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(34):32152-32159 Zhang Y; Qiu WJ; Liu DX; Neo SY; He X; Lin SC Differential molecular assemblies underlie the dual function of axin in modulating the Wnt and JNK pathways	8	2
327	14	456 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(35):33147-33155 Kishida M; Hino S; Michiue T; Yamamoto H; Kishida S; Fukui A; Asashima M; Kikuchi A Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase I epsilon	15	2
328	4	458 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(46):43328-43333 Perreault N; Katz JP; Sackett SD; Kaestner KH Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut	5	2
329	8	461 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(49):45833-45839 Galea MA; Eleftheriou A; Henderson BR ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A	6	2
330	7	476 2001 JOURNAL OF CLINICAL ONCOLOGY 19(11):2948-2958 Polyak K; Riggins GJ Gene discovery using the serial analysis of gene expression technique: Implications for cancer research	24	2
331	8	479 2001 JOURNAL OF IMMUNOLOGY 166(7):4713-4720 Monick MM; Carter AB; Robeff PK; Flaherty DM; Peterson MW; Hunninghake GW Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin	28	2
332	22	482 2001 JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA 6(1):37-52 Smalley MJ; Dale TC Wnt signaling and mammary tumorigenesis	11	2
333	7	487 2001 JOURNAL OF PATHOLOGY 195(2):222-228 Saito T; Oda Y; Tanaka K; Matsuda S; Tamiya S; Iwamoto Y; Tsuneyoshi M beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours	7	2
334	6	492 2001 MEDICAL HYPOTHESES 56(5):573-581 Pearson CA; Prozialeck WC E-cadherin, beta-catenin and cadmium carcinogenesis	3	2
335	1	495 2001 MODERN PATHOLOGY 14(1):29-39 Aust DE; Terdiman TP; Willenbucher RF; Chew K; Ferrell L; Florendo C; Molinaro-Clark A; Baretton GB; Lohrs U; Waldman FM Altered distribution of beta-catenin, and its binding proteins E-cadherin and APC, in ulcerative colitis-related colorectal cancers	6	2
336	1	501 2001 MOLECULAR AND CELLULAR BIOLOGY 21(2):575-594 Reeves R; Edberg DD; Li Y Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells	23	2
337	1	511 2001 MOLECULAR CELL 7(3):673-682 Yu J; Zhang L; Hwang PM; Kinzler KW; Vogelstein B PUMA induces the rapid apoptosis of colorectal cancer cells	137	2
338	5	519 2001 NATURE STRUCTURAL BIOLOGY 8(12):1048-1052 Graham TA; Ferkey DM; Mao F; Kimelman D; Xu WQ Tcf4 can specifically recognize beta-catenin using alternative conformations	9	2
339	12	531 2001 ONCOGENE 20(40):5595-5610 Boxer LM; Dang CV Translocations involving c-myc and c-myc function	28	2
340	9	534 2001 ONCOGENE 20(43):6250-6257 Marotta A; Tan C; Gray V; Malik S; Gallinger S; Sanghera J; Dupuis B; Owen D; Dedhar S; Salh B Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis	10	2
341	4	541 2001 PEDIATRIC SURGERY INTERNATIONAL 17(7):508-512 Udatsu Y; Kusafuka T; Kuroda S; Miao J; Okada A High frequency of beta-catenin mutations in hepatoblastoma	5	2
342	2	549 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(26):15203-15208 Nacht M; Dracheva T; Gao YH; Fujii T; Chen YD; Player A; Akmaev V; Cook B; Dufault M; Zhang M; Zhang W; Guo MZ; Curran J; Han S; Sidransky D; Buetow K; Madden SL; Jen J Molecular characteristics of non-small cell lung cancer	22	2
343	16	573 2002 BIOLOGICAL CHEMISTRY 383(2):255-261 Brantjes H; Barker N; van Es J; Clevers H TCF: Lady justice casting the final verdict on the outcome of Wnt signalling	20	2
344	15	593 2002 CANCER RESEARCH 62(1):277-282 Mizushima T; Nakagawa H; Kamberov YG; Wilder EL; Klein PS; Rustgi AK Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells	3	2
345	4	612 2002 EMBO REPORTS 3(6):521-526 Shaw PE Peptidyl-prolyl isomerases: a new twist to transcription	8	2
346	14	646 2002 INTERNATIONAL JOURNAL OF CANCER 101(4):301-310 Wang HLL; Wang J; Xiao SY; Haydon R; Stoiber D; He TC; Bissonnette M; Hart J Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin	6	2
347	3	668 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(19):16464-16469 Hanai J; Dhanabal M; Karumanchi SA; Albanese C; Waterman M; Chan B; Ramchandran R; Pestell R; Sukhatme VP Endostatin causes G(1) arrest of endothelial cells through inhibition of cyclin D1	20	2
348	10	687 2002 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 87(7):3433-3440 Ishigaki K; Namba H; Nakashima M; Nakayama T; Mitsutake N; Hayashi T; Maeda S; Ichinose M; Kanematsu T Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer	4	2
349	1	711 2002 LABORATORY INVESTIGATION 82(3):257-264 Hoshida Y; Hongyo T; Nakatsuka S; Nishiu M; Takakuwa T; Tomita Y; Nomura T; Aozasa K Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients	5	2
350	1	721 2002 MOLECULAR CELL 10(3):509-521 Herold S; Wanzel M; Beuger V; Frohme C; Beul D; Hillukkala T; Syvaoja J; Saluz HP; Haenel F; Eilers M Negative regulation of the mammalian UV response by Myc through association with Miz-1	9	2
351	12	732 2002 ONCOGENE 21(36):5548-5556 Miyoshi K; Rosner A; Nozawa M; Byrd C; Morgan F; Landesman-Bollag E; Xu X; Seldin DC; Schmidt EV; Taketo MM; Robinson GW; Cardiff RD; Hennighausen L Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors	5	2
352	21	745 2002 ONCOGENE 21(55):8453-8469 Chesire DR; Isaacs WB Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor	3	2
353	5	805 2003 CARCINOGENESIS 24(1):91-97 Yamada Y; Oyama T; Hirose Y; Hara A; Sugie S; Yoshida K; Yoshimi N; Mori H beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis	2	2
354	1	10 1999 AMERICAN JOURNAL OF PATHOLOGY 154(4):965-973 Jankowski JA; Wright NA; Meltzer SJ; Triadafilopoulos G; Geboes K; Casson AG; Kerr D; Young LS Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus	91	1
355	1	14 1999 ANNUAL REVIEW OF BIOCHEMISTRY 68():965-1014 Chan TO; Rittenhouse SE; Tsichlis PN AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation	242	1
356	1	66 1999 ENDOCRINE 10(1):67-76 Heinrich CA; Lail-Trecker MR; Peluso JJ; White BA Negative regulation of N-cadherin-mediated cell-cell adhesion by the estrogen receptor signaling pathway in rat pituitary GH(3) cells	7	1
357	1	73 1999 GENE 238(2):301-313 Krupnik VE; Sharp JD; Jiang C; Robison K; Chickering TW; Amaravadi L; Brown DE; Guyot D; Mays G; Leiby K; Chang B; Duong T; Goodearl ADJ; Gearing DP; Sokol SY; McCarthy SA Functional and structural diversity of the human Dickkopf gene family	35	1
358	1	79 1999 HEPATOLOGY 29(4):1208-1214 Zimonjic DB; Keck CL; Thorgeirsson SS; Popescu NC Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization	47	1
359	1	81 1999 HUMAN MOLECULAR GENETICS 8(10):1821-1832 Claverie JM Computational methods for the identification of differential and coordinated gene expression	98	1
360	1	86 1999 JAPANESE JOURNAL OF CANCER RESEARCH 90(8):824-828 Yamada Y; Yoshimi N; Sugie S; Suzui M; Matsunaga K; Kawabata K; Hara A; Mori H beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats	8	1
361	1	93 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(42):29583-29586 Fry CJ; Farnham PJ Context-dependent transcriptional regulation	66	1
362	1	98 1999 JOURNAL OF CHILD NEUROLOGY 14(7):411-417 Adesina AM Molecular heterogeneity in medulloblastoma with implications for differing tumor biology	3	1
363	1	107 1999 MELANOMA RESEARCH 9(5):421-432 Castellano M; Parmiani G Genes involved in melanoma: overview of INK4a and other loci	30	1
364	1	123 1999 ONCOGENE 18(34):4777-4787 Yamashita A; Hakura A; Inoue H Suppression of anchorage-independent growth of human cancer cell lines by the drs gene	8	1
365	1	140 1999 SCIENCE 286(5444):1491-1492 Velculescu VE Essay: Amersham Pharmacia Biotech & Science Prize - Tantalizing transcriptomes - SAGE and its use in global gene expression analysis	18	1
366	2	157 2000 AMERICAN JOURNAL OF PATHOLOGY 157(5):1563-1573 Wielenga VJM; van der Voort R; Taher TEI; Smit L; Beuling EA; van Krimpen C; Spaargaren M; Pals ST Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer	12	1
367	5	169 2000 BIOLOGICAL SIGNALS AND RECEPTORS 9(2):115-121 Peluso JJ N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival	13	1
368	4	171 2000 BRITISH JOURNAL OF CANCER 83(1):1-5 Compagni A; Christofori G Recent advances in research on multistage tumorigenesis	27	1
369	4	183 2000 CANCER RESEARCH 60(16):4602-4609 Bissonnette M; Khare S; von Lintig FC; Wali RK; Nguyen L; Zhang YC; Hart J; Skarosi S; Varki N; Boss GR; Brasitus TA Mutational and nonmutational activation of p21(ras) in rat colonic azoxymethane-induced tumors: Effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1	19	1
370	3	186 2000 CANCER RESEARCH 60(22):6318-6325 Mitchell KO; Ricci MS; Miyashita T; Dicker DT; Jin ZY; Reed JC; El-Deiry WS Bax is a transcriptional target and mediator of c-Myc-induced apoptosis	26	1
371	1	198 2000 CELL GROWTH & DIFFERENTIATION 11(4):201-210 Ngo CV; Gee M; Akhtar N; Yu D; Volpert O; Auerbach R; Thomas-Tikhonenko A An in vivo function for the transforming Myc protein: Elicitation of the angiogenic phenotype	21	1
372	2	199 2000 CELL PROLIFERATION 33(1):1-18 Roncucci L; Pedroni M; Vaccina F; Benatti P; Marzona L; De Pol A Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics	22	1
373	2	221 2000 ENDOCRINE PATHOLOGY 11(3):243-250 Semba S; Kusumi R; Moriya T; Sasano H Nuclear accumulation of beta-catenin in human endocrine tumors: Association with Ki-67 (MIB-1) proliferative activity	4	1
374	4	228 2000 FEBS LETTERS 476(3):203-207 Dang DT; Bachman KE; Mahatan CS; Dang LH; Giardiello FM; Yang VW Decreased expression of the gut-enriched Kruppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients	17	1
375	1	242 2000 GUT 47(6):820-824 Smith AM; Watson SA Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence	26	1
376	1	255 2000 INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 81(2):117-143 Wright NA Epithelial stem cell repertoire in the gut: clues to the origin of cell lineages, proliferative units and cancer	19	1
377	6	264 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(27):20707-20716 Stewart DB; Barth AIM; Nelson WJ Differential regulation of endogenous cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and activation of beta-catenin signaling	12	1
378	5	265 2000 JOURNAL OF BIOLOGICAL CHEMISTRY 275(28):21435-21443 Ilan N; Cheung L; Pinter E; Madri JA Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation	30	1
379	2	285 2000 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 19(3):349-355 Ougolkov A; Mai M; Takahashi Y; Omote K; Bilim V; Shimizu A; Minamoto T Altered expression of beta-catenin and c-erbB-2 in early gastric cancer	6	1
380	1	287 2000 JOURNAL OF MOLECULAR BIOLOGY 301(1):147-156 Day CL; Alber T Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor	12	1
381	6	305 2000 NEUROSURGERY 47(4):888-901 Taylor MD; Mainprize TG; Rutka JT Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: A review	10	1
382	3	316 2000 ONCOLOGY 59(4):302-309 Maruyama K; Ochiai A; Akimoto S; Nakamura S; Baba S; Moriya Y; Hirohashi S Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer	7	1
383	2	328 2000 SEMINARS IN CANCER BIOLOGY 10(4):289-298 Aaltonen LA Hereditary intestinal cancer	5	1
384	5	336 2001 AMERICAN JOURNAL OF CLINICAL PATHOLOGY 115(6):835-840 Sarbia M; Arjumand J; Wolter M; Reifenberger G; Heep H; Gabbert HE Frequent c-myc amplification in high-grade dysplasia and adenocarcinoma in Barrett esophagus	9	1
385	5	348 2001 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 286(1):94-100 Yam JWP; Chan KW; Wong VKW; Hsiao WLW Transcriptional activity of the promoter region of rat frizzled-related protein gene	4	1
386	2	349 2001 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1519(1-2):13-29 Reeves R; Beckerbauer L HMGI/Y proteins: flexible regulators of transcription and chromatin structure	32	1
387	5	371 2001 CANCER RESEARCH 61(8):3480-3485 Moser AR; Hegge LF; Cardiff RD Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(Min)/+ mice	5	1
388	6	392 2001 CELL BIOLOGY INTERNATIONAL 25(5):421-427 Kim K; Lee KY Tyrosine phosphorylation translocates beta-catenin from cell-cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function	5	1
389	5	395 2001 CLINICAL CANCER RESEARCH 7(8):2425-2433 Grotzer MA; Hogarty MD; Janss AJ; Liu XY; Zhao HQ; Eggert A; Sutton LN; Rorke LB; Brodeur GM; Phillips PC MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma	17	1
390	8	398 2001 CURRENT OPINION IN GENETICS & DEVELOPMENT 11(1):19-26 Prober DA; Edgar BA Growth regulation by oncogenes - new insights from model organisms	23	1
391	6	402 2001 DIGESTIVE DISEASES AND SCIENCES 46(11):2314-2321 Brown WA; Skinner SA; Vogiagis D; O'Brien PE Inhibition of beta-catenin translocation in rodent colorectal tumors - A novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer	3	1
392	8	403 2001 DISEASE MARKERS 17(2):41-48 Riggins GJ Using Serial Analysis of Gene Expression to identify tumor markers and antigens	3	1
393	9	410 2001 ENDOCRINOLOGY 142(12):5261-5266 Helmbrecht K; Kispert A; von Wasielewski R; Brabant G Identification of a Wnt/beta-catenin signaling pathway in human thyroid cells	4	1
394	6	415 2001 EXPERIMENTAL CELL RESEARCH 264(1):169-184 Elenbaas B; Weinberg RA Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation	38	1
395	1	423 2001 GUT 48(5):660-666 Brown WA; Skinner SA; Malcontenti-Wilson C; Vogiagis D; O'Brien PE Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation	6	1
396	5	425 2001 HEPATOLOGY RESEARCH 20(1):39-51 Fujie H; Moriya K; Shintani Y; Tsutsumi T; Takayama T; Makuuchi M; Kimura S; Koike K Frequent beta-catenin aberration in human hepatocellular carcinoma	3	1
397	5	426 2001 HEPATOLOGY RESEARCH 21(2):126-135 Murata M; Miyoshi Y; Ohsawa M; Shibata K; Ohta T; Imai Y; Nishikawa M; Iwao K; Tateishi H; Shimano T; Kobayashi T; Nakamura Y Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis	1	1
398	4	435 2001 INTERNATIONAL JOURNAL OF ONCOLOGY 18(3):541-548 Yang SZ; Kohno N; Yokoyama A; Kondo K; Hamada H; Hiwada K Decreased E-cadherin augments beta-catenin nuclear localization: Studies in breast cancer cell lines	8	1
399	4	447 2001 JAPANESE JOURNAL OF CANCER RESEARCH 92(6):617-623 Yamada Y; Yoshimi N; Hirose Y; Hara A; Shimizu M; Kuno T; Katayama M; Qiao Z; Mori H Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib	8	1
400	7	448 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(12):8968-8978 Pukrop T; Gradl D; Henningfeld KA; Knochel W; Wedlich D; Kuhl M Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4	8	1

#	Cited nodes	Nodes / Authors	GCS	LCS
401	11	449 2001 JOURNAL OF BIOLOGICAL CHEMISTRY 276(21):18193-18199 Jaiswal AS; Narayan S p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents	10	1
402	2	474 2001 JOURNAL OF CELLULAR BIOCHEMISTRY 81(2):262-277 Jaiswal AS; Narayan S Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the Adenomatous polyposis coli (APC) tumor suppressor gene	7	1
403	9	475 2001 JOURNAL OF CELLULAR PHYSIOLOGY 189(2):121-132 Pla P; Moore R; Morali OG; Grille S; Martinozzi S; Delmas V; Larue L Cadherins in neural crest cell development and transformation	7	1
404	5	477 2001 JOURNAL OF DERMATOLOGICAL SCIENCE 27(3):170-177 Tsuji H; Ishida-Yamamoto A; Takahashi H; Iizuka H Nuclear localization of beta-catenin in the hair matrix cells and differentiated keratinocytes	2	1
405	3	481 2001 JOURNAL OF INVESTIGATIVE DERMATOLOGY 116(5):739-742 Bonifas JM; Pennypacker S; Chuang PT; McMahon AP; Williams M; Rosenthal A; de Sauvage FJ; Epstein EH Activation of expression of hedgehog target genes in basal cell carcinomas	11	1
406	8	485 2001 JOURNAL OF PATHOLOGY 194(1):20-26 Clavel CE; Nollet F; Berx G; Tejpar S; Naworcki-Raby B; Kaplan HH; van Roy FM; Birembaut PL Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours	10	1
407	5	509 2001 MOLECULAR CARCINOGENESIS 31(2):68-73 Devereux TR; Stern MC; Flake GP; Yu MC; Zhang ZQ; London SJ; Taylor JA CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1	6	1
408	6	536 2001 ONCOLOGY 61(2):156-161 Saeki H; Tanaka S; Tokunaga E; Kawaguchi H; Ikeda Y; Maehara Y; Sugimachi K Genetic alterations in the human Tcf-4 gene in Japanese patients with sporadic gastrointestinal cancers with microsatellite instability	2	1
409	8	539 2001 PATHOLOGY INTERNATIONAL 51(9):680-685 Miyake N; Maeta H; Horie S; Kitamura Y; Nanba E; Kobayashi K; Terada T Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas	1	1
410	7	540 2001 PEDIATRIC AND DEVELOPMENTAL PATHOLOGY 4(4):351-357 Eberhart CG; Argani P Wnt signaling in human development: Beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage	5	1
411	4	545 2001 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98(8):4646-4651 Kolli S; Buchmann AM; Williams J; Weitzman S; Thimmapaya B Antisense-mediated depletion of p300 in human cells leads to premature G(1) exit and up-regulation of c-MYC	8	1
412	5	551 2001 SEMINARS IN CANCER BIOLOGY 11(3):219-225 Kucherlapati R; Lin DP; Edelmann W Mouse models for human familial adenomatous polyposis	2	1
413	27	556 2002 AMERICAN JOURNAL OF PATHOLOGY 160(4):1229-1238 Zhai Y; Wu R; Schwartz DR; Darrah D; Reed H; Kolligs FT; Nieman MT; Fearon ER; Cho KR Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas	7	1
414	6	564 2002 ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 126(9):1071-1078 Sakamoto A; Oda Y; Adachi T; Saito T; Tamiya S; Iwamoto Y; Tsuneyoshi M beta-Catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma	1	1
415	15	570 2002 BIOCHEMICAL PHARMACOLOGY 64(9):1325-1336 Li H; Liu L; David ML; Whitehead CM; Chen M; Fetter JR; Sperl GJ; Pamukcu R; Thompson WJ Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation	5	1
416	11	575 2002 BIOTECHNIQUES 33(5):1126-+ Zhou L; An N; Jiang W; Haydon R; Cheng H; Zhou Q; Breyer B; Feng T; He TC Fluorescence-based functional assay for Wnt/beta-catenin signaling activity	1	1
417	17	576 2002 BLOOD 100(3):982-990 Chung EJ; Hwang SG; Nguyen P; Lee S; Kim JS; Kim JW; Henkart PA; Bottaro DP; Soon L; Bonvini P; Lee SJ; Karp JE; Oh HJ; Rubin JS; Trepel JB Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin	1	1
418	1	579 2002 BRITISH JOURNAL OF SURGERY 89(7):845-860 Leslie A; Carey FA; Pratt NR; Steele RJC The colorectal adenoma-carcinoma sequence	6	1
419	13	586 2002 CANCER CELL 1(4):369-379 Patturajan M; Nomoto S; Sommer M; Fomenkov A; Hibi K; Zangen R; Poliak N; Califano J; Trink B; Ratovitski E; Sidransky D Delta Np63 induces beta-catenin nuclear accumulation and signaling	10	1
420	11	587 2002 CANCER CELL 2(4):323-334 Deng JO; Miller SA; Wang HY; Xia WY; Wen Y; Zhou BHP; Li Y; Lin SY; Hung MC beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer	3	1
421	4	596 2002 CANCER RESEARCH 62(16):4562-4565 Wilding J; Straub J; Bee J; Churchman M; Bodmer W; Dickson C; Tomlinson I; Ilyas M Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice	3	1
422	25	617 2002 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 32(6):448-457 Oving IM; Clevers HC Molecular causes of colon cancer	1	1
423	7	621 2002 EXPERIMENTAL CELL RESEARCH 280(1):12-23 Cui HY; Dong M; Sadhu DN; Rosenberg DW Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells	2	1
424	5	626 2002 GASTROENTEROLOGY 123(2):492-504 Janssen KP; El Marjou F; Pinto D; Sastre X; Rouillard D; Fouquet C; Soussi T; Louvard D; Robine S Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice	4	1
425	4	627 2002 GASTROENTEROLOGY 123(3):751-763 Heinen CD; Goss KH; Cornelius JR; Babcock GF; Knudsen ES; Kowalik T; Groden J The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway	3	1
426	7	629 2002 GENE THERAPY 9(4):270-281 Fuerer C; Iggo R Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway	10	1
427	3	633 2002 GUT 50(4):513-519 Hardy RG; Tselepis C; Hoyland J; Wallis Y; Pretlow TP; Talbot I; Sanders DSA; Matthews G; Morton D; Jankowski JAZ Aberrant P-cadherin expression is an early event in hyperplastic and dlysplastic transformation in the colon	2	1
428	1	636 2002 GUT 51(1):56-59 Salovaara R; Roth S; Loukola A; Launonen V; Sistonen P; Avizienyte E; Kristo P; Jarvinen H; Souchelnytskyi S; Sarlomo-Rikala M; Aaltonen LA Frequent loss of SMAD4/DPC4 protein in colorectal cancers	4	1
429	15	644 2002 INTERNATIONAL JOURNAL OF CANCER 99(5):681-688 Ueda Y; Hijikata M; Takagi S; Takada R; Takada S; Chiba T; Shimotohno K Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts	3	1
430	12	648 2002 INTERNATIONAL JOURNAL OF CANCER 102(4):338-342 Haydon RC; Deyrup A; Ishikawa A; Heck R; Jiang W; Zhou L; Feng T; King D; Chew HW; Breyer B; Peabody T; Simon MA; Montag AG; He TC Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma	2	1
431	9	651 2002 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10(4):395-399 Kusafuka T; Miao J; Kuroda S; Udatsu Y; Yoneda A Codon 45 of the beta-catenin gene, a specific mutational target site of Wilms' tumor	2	1
432	9	653 2002 INTERNATIONAL JOURNAL OF ONCOLOGY 20(5):905-911 Stoehr R; Krieg RC; Knuechel R; Hofstaedter F; Pilarsky C; Zaak D; Schmitt R; Hartmann A No evidence for involvement of beta-catenin and APC in urothelial carcinomas	4	1
433	9	666 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(16):14329-14335 Tice DA; Szeto W; Soloviev I; Rubinfeld B; Fong SE; Dugger DL; Winer J; Williams PM; Wieand D; Smith V; Schwall RH; Pennica D; Polakis P Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling	9	1
434	11	667 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(18):15843-15850 Wong MH; Huelsken J; Birchmeier W; Gordon JI Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling	8	1
435	14	671 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(21):18677-18686 Weng ZG; Xin M; Pablo L; Grueneberg D; Hagel M; Bain G; Muller T; Papkoff J Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein	2	1
436	12	675 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(27):24258-24264 Henderson BR; Galea M; Schuechner S; Leung L Lymphoid enhancer factor-1 blocks adenomatous polyposis coli-mediated nuclear export and degradation of beta-catenin - Regulation by histone deacetylase 1	5	1
437	6	677 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(29):26031-26035 Koh SS; Li HW; Lee YH; Widelitz RB; Chuong CM; Stallcup MR Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators	5	1
438	20	679 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(44):42386-42393 Levy L; Neuveut C; Renard CA; Charneau P; Branchereau S; Gauthier F; Van Nhieu JT; Cherqui D; Petit-Bertron AF; Mathieu D; Buendia MA Transcriptional activation of interleukin-8 by beta-catenin-Tcf4	3	1
439	21	681 2002 JOURNAL OF CELL BIOLOGY 157(3):429-440 You ZB; Saims D; Chen SQ; Zhang ZC; Guttridge DC; Guan KL; MacDougald OA; Brown AMC; Evan G; Kitajewski J; Wang CY Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis	10	1
440	10	682 2002 JOURNAL OF CELL BIOLOGY 158(3):529-539 Hanai J; Gloy J; Karumanchi SA; Kale S; Tang JA; Hu GA; Chan B; Ramchandran R; Jha V; Sukhatme VP; Sokol S Endostatin is a potential inhibitor of Wnt signaling	12	1
441	8	690 2002 JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY 55(4):220-226 Holcombe RF; Marsh JL; Waterman ML; Lin F; Milovanovic T; Truong T Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma	2	1
442	5	692 2002 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 21(1):23-27 Kawakami M; Kimura Y; Furuhata T; Zenbutsu H; Yanai Y; Mukaiya M; Satoh Y; Murata S; Hirata K beta-catenin alteration in cancer of the ampulla of Vater	1	1
443	9	697 2002 JOURNAL OF IMMUNOLOGY 169(2):758-769 Christian SL; Sims PV; Gold MR The B cell antigen receptor regulates the transcriptional activator beta-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3	4	1
444	3	707 2002 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 13(5):1152-1161 Price VR; Reed CA; Lieberthal W; Schwartz JH ATP depletion of tubular cells causes dissociation of the zonula adherens and nuclear translocation of beta-catenin and LEF-1	3	1
445	2	708 2002 JOURNAL OF THE NATIONAL CANCER INSTITUTE 94(4):252-266 Thun MJ; Henley SJ; Patrono C Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues	83	1
446	8	710 2002 LABORATORY INVESTIGATION 82(1):97-103 Saito T; Oda Y; Kawaguchi K; Tanaka K; Matsuda S; Tamiya S; Iwamoto Y; Tsuneyoshi M Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: Real-time semiquantitative assay by TaqMan polymerase chain reaction	2	1
447	8	714 2002 MECHANISMS OF AGEING AND DEVELOPMENT 123(12):1665-1680 Lim IK Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats	1	1
448	12	718 2002 MOLECULAR CANCER THERAPEUTICS 1(14):1355-1359 Kim JS; Crooks H; Foxworth A; Waldman T Proof-of-principle: Oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitors	2	1
449	14	722 2002 MOLECULAR CELL 10(3):563-571 Graham TA; Clements WK; Kimelman D; Xu WQ The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT	4	1
450	4	723 2002 MOLECULAR CELL 10(6):1260-1261 Clevers H Inflating cell numbers by Wnt	1	1
451	13	734 2002 ONCOGENE 21(38):5861-5867 Takahashi M; Tsunoda T; Seiki M; Nakamura Y; Furukawa Y Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers	10	1
452	12	735 2002 ONCOGENE 21(38):5906-5911 Sekine S; Shibata T; Sakamoto M; Hirohashi S Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype	3	1
453	15	738 2002 ONCOGENE 21(46):6983-6991 Aoki M; Sobek V; Maslyar DJ; Hecht A; Vogt PK Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes	1	1
454	11	744 2002 ONCOGENE 21(55):8414-8427 Jaiswal AS; Marlow BP; Gupta N; Narayan S beta-Catenin-mediated transactivation and cell - cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells	2	1
455	5	755 2002 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 37(10):1184-1193 Lovig T; Meling GI; Diep CB; Thorstensen L; Andersen SN; Lothe RA; Rognum TO APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status	2	1
456	14	786 2003 CANCER RESEARCH 63(8):1906-1913 Howe LR; Watanabe O; Leonard J; Brown AMC Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation	2	1
457	1	822 2003 DEVELOPMENT 130(7):1367-1379 Chen W; Liang YQ; Deng WJ; Shimizu K; Ashique AM; Li E; Li YP The zinc-finger protein CNBP is required for forebrain formation in the mouse	1	1
458	2	826 2003 DEVELOPMENTAL CELL 4(6):827-839 Bellmeyer A; Krase J; Lindgren J; LaBonne C The protooncogene c-Myc is an essential regulator of neural crest formation in Xenopus	1	1
459	13	844 2003 INTERNATIONAL JOURNAL OF CANCER 103(5):652-656 Kielhorn E; Provost E; Olsen D; D'Aquila TG; Smith BL; Camp RL; Rimm DL Tissue microarray-based analysis shows phospho-beta-catenin expression in malignant melanoma is associated with poor outcome	3	1
460	14	851 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(7):5188-5194 Wei Y; Renard CA; Labalette C; Wu YF; Levy L; Neuveut C; Prieur X; Flajolet M; Prigent S; Buendia MA Identification of the LIM protein FHL2 as a coactivator of beta-catenin	3	1
461	5	890 2003 MOLECULAR PSYCHIATRY 8(2):135-144 Lenox RH; Wang L Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks	3	1
462	1	6 1998 GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE 22(12):1071-1080 Jais P; Laurent-Puig P; Olschwang S APC protein: protein interactions and cellular functions	0	0
463	4	11 1999 AMERICAN JOURNAL OF PATHOLOGY 155(3):703-710 Van Nhieu JT; Renard CA; Wei Y; Cherqui D; Zafrani ES; Buendia MA Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation	20	0
464	1	15 1999 ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN 886():37-47 Ben-Ze'Ev A The dual role of cytoskeletal anchor proteins in cell adhesion and signal transduction	9	0
465	1	16 1999 ANTICANCER RESEARCH 19(6A):4715-4728 Teh BT; Larsson C; Nordenskjold M Tumor suppressor genes (TSG)	7	0
466	2	20 1999 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1450(3):331-340 Wang B; Kishihara K; Zhang DL; Sakamoto T; Nomoto K Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells	1	0
467	5	21 1999 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER 1424(2-3):M23-M37 Roose J; Clevers H TCF transcription factors: molecular switches in carcinogenesis	53	0
468	1	23 1999 BRITISH JOURNAL OF CANCER 81(7):1116-1121 Park KS; Kim NG; Kim JJ; Kim H; Ahn YH; Choi KY Differential regulation of MAP kinase cascade in human colorectal tumorigenesis	7	0
469	3	24 1999 BULLETIN DU CANCER 86(4):336-336 Jeanteur P beta-catenin, APC, C-MYC and the others...	0	0
470	4	25 1999 BULLETIN DU CANCER 86(9):725-726 Durand M; Moles JP beta-catenin mutations in a common skin cancer: pilomatricoma	2	0
471	1	29 1999 CANCER PREVENTION: NOVEL NUTRIENT AND PHARMACEUTICAL DEVELOPMENTS 889():32-44 Bertagnolli MM APC and intestinal carcinogenesis - Insights from animal models	4	0
472	1	32 1999 CANCER RESEARCH 59(8):1811-1815 Garcia-Rostan G; Tallini G; Herrero A; D'Aquila TG; Carcangiu ML; Rimm DL Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma	90	0
473	1	46 1999 CELL PROLIFERATION 32(2-3):79-84 Del Buono R; Pignatelli M The role of the E-cadherin complex in gastrointestinal cell differentiation	1	0
474	2	49 1999 CHIRURGISCHE GASTROENTEROLOGIE 15(2):163-172 Gebert J; Doeberitz CV Hereditary tumors of the gastrointestinal tract (FAP/HNPCC)	3	0
475	3	51 1999 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 64():141-147 Korswagen HC; Clevers HC Activation and repression of Wingless/Wnt target genes by the TCF/LEF-1 family of transcription factors	8	0
476	1	52 1999 COLON CANCER PREVENTION 470():15-22 Augenlicht L; Velcich A; Mariadason J; Bordonaro M; Heerdt B Colonic cell proliferation, differentiation, and apoptosis	4	0
477	1	54 1999 CURRENT BIOLOGY 9(2):R62-R65 Fearon ER; Dang CV Cancer genetics: Tumor suppressor meets oncogene	11	0
478	1	55 1999 CURRENT BIOLOGY 9(2):105-108 van Es JH; Kirkpatrick C; van de Wetering M; Molenaar M; Miles A; Kuipers J; Destree O; Peifer M; Clevers H Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor	37	0
479	1	57 1999 CURRENT OPINION IN GASTROENTEROLOGY 15(1):3-8 Shattuck-Brandt RL; DuBois RN The molecular basis of colorectal carcinogenesis	0	0
480	1	63 1999 DEVELOPMENTAL BIOLOGY 207(2):350-363 Paulson AF; Fang X; Ji H; Reynolds AB; McCrea PD Misexpression of the catenin p120(ctn)1A perturbs Xenopus gastrulation but does not elicit Wnt-directed axis specification	11	0
481	1	70 1999 EUROPEAN JOURNAL OF CANCER PREVENTION 8():S39-S47 Laurent-Puig P; Blons H; Cugnenc PH Sequence of molecular genetic events in colorectal tumorigenesis	16	0
482	1	72 1999 EXPERIMENTAL CELL RESEARCH 253(2):336-348 Uusitalo M; Heikkila M; Vainio S Molecular genetic studies of Wnt signaling in the mouse	23	0
483	1	76 1999 GENOME RESEARCH 9(10):950-959 Ewing RM; Ben Kahla A; Poirot O; Lopez F; Audic S; Claverie JM Large-scale statistical analyses of rice ESTs reveal correlated patterns of gene expression	47	0
484	1	80 1999 HUMAN MOLECULAR GENETICS 8(8):1479-1485 Smith DP; Spicer J; Smith A; Swift S; Ashworth A The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase	23	0
485	3	83 1999 IMMUNOLOGY AND CELL BIOLOGY 77(5):460-467 Leenen PJM; Egeler RM Langerhans' cell histiocytosis is caused by dysregulation of the E-cadherin-beta-catenin cascade: A hypothesis	3	0
486	2	85 1999 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 4(5):541-544 Kucerova D; Sloncova E; Tuhackova Z; Uhlirova M; Kos M; Sovova V Changes of E-cadherin and beta-catenin levels during induced differentiation of colorectal carcinoma cells	6	0
487	1	91 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(32):22705-22712 Spychala J; Zimmermann AG; Mitchell BS Tissue-specific regulation of the ecto-5 '-nucleotidase promoter - Role of the cAMP response element site in mediating repression by the upstream regulatory region	11	0
488	1	94 1999 JOURNAL OF BIOLOGICAL CHEMISTRY 274(43):31062-31067 Alberta JA; Auger KR; Batt D; Iannarelli P; Hwang G; Elliott HL; Duke R; Roberts TM; Stiles CD Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway	10	0
489	1	99 1999 JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 84(4):1491-1492 Stratakis CA Carney complex and related syndromes and their genetic loci - Response	0	0
490	1	100 1999 JOURNAL OF CLINICAL PATHOLOGY 52(8):555-568 Michalides RJAM Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer	42	0
491	1	101 1999 JOURNAL OF INVESTIGATIVE DERMATOLOGY 113(2):258-262 Takata M; Fujimoto A; Aoki H; Hatta N; Ooi A; Takehara K erbB-2 overexpression but no activation of beta-catenin gene in extramammary Paget's disease	7	0
492	2	104 1999 M S-MEDECINE SCIENCES 15(3):427-428 L'Allemain G The WISP genes, a family of novel connective tissue growth factors, are dysregulated in Wnt-1-transformed cells and in human colon cancer.	0	0
493	1	105 1999 M S-MEDECINE SCIENCES 15(10):1105-1117 Perrin L; Arquier N; Semeriva M Links between growth rate and proliferation revisited in Drosophila	1	0
494	1	124 1999 ONCOGENE 18(35):5010-5014 da Costa LT; He TC; Yu J; Sparks AB; Morin PJ; Polyak K; Laken S; Vogelstein B; Kinzler KW CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling	31	0
495	3	129 1999 ONCOGENE 18(50):7080-7090 Ito K; Okamoto I; Araki N; Kawano Y; Nakao M; Fujiyama S; Tomita K; Mimori T; Saya H Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts	19	0
496	5	137 1999 PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY 72(3):299-328 Craig KL; Tyers M The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction	43	0
497	2	141 1999 SCIENTIST 13(14):15-15 Kinzler KW Hot papers - Cancer - Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC by P.J. Morin, A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, K.W. Kinzler - Comments	0	0
498	1	142 1999 SCIENTIST 13(8):15-15 Birchmeier W Hot papers - Cell biology - Functional interaction of beta-catenin with the transcription factor LEF-I by J. Behrens, J.P. von Kries, M. Kuhl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier - Comments	0	0
499	1	143 1999 SCIENTIST 13(2):24-24 [Anon] Serial analysis of gene expression: An alternative to chip arrays	0	0
500	1	144 1999 SEMINARS IN LIVER DISEASE 19(3):253-262 Chen PJ; Chen DS Hepatitis B virus infection and hepatocellular carcinoma: Molecular genetics and clinical perspectives	27	0

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