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LCS >= 11; Min: 11, Max: 80 (LCS scaled)

1. 17 SUSSMAN JL, HOLBROOK SR, CHURCH GM, KIM SH

STRUCTURE-FACTOR LEAST-SQUARES REFINEMENT PROCEDURE FOR MACROMOLECULAR STRUCTURES USING CONSTRAINED AND RESTRAINED PARAMETERS

ACTA CRYSTALLOGRAPHICA SECTION A. 1977; 33 (SEP1): 800-804
LCR: 2 CR: 26 LCS: 20 GCS: 328 SCS:

2. 60 SUSSMAN JL, HAREL M, FROLOW F, VARON L, TOKER L, et al.

PURIFICATION AND CRYSTALLIZATION OF A DIMERIC FORM OF ACETYLCHOLINESTERASE FROM TORPEDO-CALIFORNICA SUBSEQUENT TO SOLUBILIZATION WITH PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE-C

JOURNAL OF MOLECULAR BIOLOGY. 1988 OCT 5; 203 (3): 821-822
LCR: 0 CR: 20 LCS: 31 GCS: 72 SCS:

3. 66 SUSSMAN JL, HAREL M, FROLOW F, OEFNER C, GOLDMAN A, et al.

ATOMIC-STRUCTURE OF ACETYLCHOLINESTERASE FROM TORPEDO-CALIFORNICA - A PROTOTYPIC ACETYLCHOLINE-BINDING PROTEIN

SCIENCE. 1991 AUG 23; 253 (5022): 872-879
LCR: 2 CR: 99 LCS: 80 GCS: 1675 SCS:

4. 73 OLLIS DL, CHEAH E, CYGLER M, DIJKSTRA B, FROLOW F, et al.

THE ALPHA/BETA-HYDROLASE FOLD

PROTEIN ENGINEERING. 1992 APR; 5 (3): 197-211
LCR: 1 CR: 52 LCS: 17 GCS: 1143 SCS:

5. 77 HAREL M, SUSSMAN JL, KREJCI E, BON S, CHANAL P, et al.

CONVERSION OF ACETYLCHOLINESTERASE TO BUTYRYLCHOLINESTERASE - MODELING AND MUTAGENESIS

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992 NOV 15; 89 (22): 10827-10831
LCR: 1 CR: 37 LCS: 18 GCS: 236 SCS:

6. 85 RIPOLL DR, FAERMAN CH, AXELSEN PH, SILMAN I, SUSSMAN JL

AN ELECTROSTATIC MECHANISM FOR SUBSTRATE GUIDANCE DOWN THE AROMATIC GORGE OF ACETYLCHOLINESTERASE

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1993 JUN 1; 90 (11): 5128-5132
LCR: 3 CR: 26 LCS: 22 GCS: 182 SCS:

7. 89 HAREL M, SCHALK I, EHRETSABATIER L, BOUET F, GOELDNER M, et al.

QUATERNARY LIGAND-BINDING TO AROMATIC RESIDUES IN THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1993 OCT 1; 90 (19): 9031-9035
LCR: 3 CR: 35 LCS: 50 GCS: 501 SCS:

8. 92 AXELSEN PH, HAREL M, SILMAN I, SUSSMAN JL

STRUCTURE AND DYNAMICS OF THE ACTIVE-SITE GORGE OF ACETYLCHOLINESTERASE - SYNERGISTIC USE OF MOLECULAR-DYNAMICS SIMULATION AND X-RAY CRYSTALLOGRAPHY

PROTEIN SCIENCE. 1994 FEB; 3 (2): 188-197
LCR: 7 CR: 32 LCS: 25 GCS: 106 SCS:

9. 93 GILSON MK, STRAATSMA TP, MCCAMMON JA, RIPOLL DR, FAERMAN CH, et al.

OPEN BACK DOOR IN A MOLECULAR-DYNAMICS SIMULATION OF ACETYLCHOLINESTERASE

SCIENCE. 1994 MAR 4; 263 (5151): 1276-1278
LCR: 5 CR: 23 LCS: 17 GCS: 193 SCS:

10. 106 Harel M, Kleywegt GJ, Ravelli RBG, Silman I, Sussman JL

Crystal structure of an acetylcholinesterase-fasciculin complex: Interaction of a three-fingered toxin from snake venom with its target

STRUCTURE. 1995 DEC 15; 3 (12): 1355-1366
LCR: 11 CR: 70 LCS: 27 GCS: 160 SCS:

11. 115 Harel M, Quinn DM, Nair HK, Silman I, Sussman JL

The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1996 MAR 13; 118 (10): 2340-2346
LCR: 6 CR: 79 LCS: 27 GCS: 221 SCS:

12. 130 Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, et al.

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A

NATURE STRUCTURAL BIOLOGY. 1997 JAN; 4 (1): 57-63
LCR: 7 CR: 45 LCS: 35 GCS: 237 SCS:

13. 133 Felder CE, Botti SA, Lifson S, Silman I, Sussman JL

External and internal electrostatic potentials of cholinesterase models

JOURNAL OF MOLECULAR GRAPHICS & MODELLING. 1997 OCT; 15 (5): 318-+
LCR: 5 CR: 36 LCS: 16 GCS: 48 SCS:

14. 161 Kryger G, Silman I, Sussman JL

Structure of acetylcholinesterase complexed with E2020 (Aricept (R)): implications for the design of new anti-Alzheimer drugs

STRUCTURE. 1999 MAR 15; 7 (3): 297-307
LCR: 8 CR: 58 LCS: 26 GCS: 192 SCS:

15. 164 Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, et al.

Crystal structures of aged phosphonylated acetylcholinesterase: Nerve agent reaction products at the atomic level

BIOCHEMISTRY. 1999 JUN 1; 38 (22): 7032-7039
LCR: 5 CR: 63 LCS: 12 GCS: 121 SCS:

16. 166 Millard CB, Koellner G, Ordentlich A, Shafferman A, Silman I, et al.

Reaction products of acetylcholinesterase and VX reveal a mobile histidine in the catalytic triad

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 1999 OCT 27; 121 (42): 9883-9884
LCR: 3 CR: 18 LCS: 12 GCS: 87 SCS:

17. 167 Botti SA, Felder CE, Lifson S, Sussman JL, Silman I

A modular treatment of molecular traffic through the active site of cholinesterase

BIOPHYSICAL JOURNAL. 1999 NOV; 77 (5): 2430-2450
LCR: 9 CR: 105 LCS: 12 GCS: 31 SCS:

18. 169 Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL

Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 angstrom resolution

FEBS LETTERS. 1999 DEC 17; 463 (3): 321-326
LCR: 4 CR: 53 LCS: 16 GCS: 102 SCS:

19. 172 Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, et al.

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica

JOURNAL OF MOLECULAR BIOLOGY. 2000 FEB 18; 296 (2): 713-735
LCR: 17 CR: 66 LCS: 13 GCS: 73 SCS:

20. 179 Kryger G, Harel M, Giles K, Toker L, Velan B, et al.

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY. 2000 NOV; 56: 1385-1394
LCR: 13 CR: 51 LCS: 13 GCS: 130 SCS:

21. 192 Bar-On P, Millard CB, Harel M, Dvir H, Enz A, et al.

Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine

BIOCHEMISTRY. 2002 MAR 19; 41 (11): 3555-3564
LCR: 13 CR: 61 LCS: 11 GCS: 109 SCS:

22. 198 Greenblatt HM, Dvir H, Silman I, Sussman JL

Acetylcholinesterase - A multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease

JOURNAL OF MOLECULAR NEUROSCIENCE. 2003; 20 (3): 369-383
LCR: 23 CR: 77 LCS: 11 GCS: 43 SCS:

23. 203 Dvir H, Harel M, McCarthy AA, Toker L, Silman I, et al.

X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease

EMBO REPORTS. 2003 JUL; 4 (7): 704-709
LCR: 1 CR: 37 LCS: 11 GCS: 73 SCS:

24. 205 Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Auld VJ, et al.

The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded

PROTEINS-STRUCTURE FUNCTION AND GENETICS. 2003 NOV 15; 53 (3): 758-767
LCR: 1 CR: 49 LCS: 12 GCS: 35 SCS:

25. 220 Silman I, Sussman JL

Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology

CURRENT OPINION IN PHARMACOLOGY. 2005 JUN; 5 (3): 293-302
LCR: 14 CR: 73 LCS: 11 GCS: 108 SCS:

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