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#	Date / Author / Journal	LCS	GCS	LCR	CR
2901	6741 AOYAGI M, FUKAI N, SAKAMOTO H, SHINKAI T, MATSUSHIMA Y, et al. ALTERED CELLULAR-RESPONSES TO SERUM MITOGENS, INCLUDING PLATELET- DERIVED GROWTH-FACTOR, IN CULTURED SMOOTH-MUSCLE CELLS DERIVED FROM ARTERIES OF PATIENTS WITH MOYAMOYA DISEASE JOURNAL OF CELLULAR PHYSIOLOGY. 1991 MAY; 147 (2): 191-198	5	44	4	55
2902	6773 ROSENGARTEN R, WISE KS THE VLP SYSTEM OF MYCOPLASMA-HYORHINIS - COMBINATORIAL EXPRESSION OF DISTINCT SIZE VARIANT LIPOPROTEINS GENERATING HIGH-FREQUENCY SURFACE ANTIGENIC VARIATION JOURNAL OF BACTERIOLOGY. 1991 AUG; 173 (15): 4782-4793	5	81	3	48
2903	6805 LIMOUSE M, MANIE S, KONSTANTINOVA I, FERRUA B, SCHAFFAR L INHIBITION OF PHORBOL ESTER-INDUCED CELL ACTIVATION IN MICROGRAVITY EXPERIMENTAL CELL RESEARCH. 1991 NOV; 197 (1): 82-86	5	53	3	20
2904	6822 TAYLORROBINSON D, DAVIES HA, SARATHCHANDRA P, FURR PM INTRACELLULAR LOCATION OF MYCOPLASMAS IN CULTURED-CELLS DEMONSTRATED BY IMMUNOCYTOCHEMISTRY AND ELECTRON-MICROSCOPY INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. 1991 DEC; 72 (6): 705-714	5	62	7	30
2905	6866 PIENTA KJ, GETZENBERG RH, COFFEY DS CHARACTERIZATION OF NUCLEAR MORPHOLOGY AND NUCLEAR MATRICES IN AGING HUMAN FIBROBLASTS MECHANISMS OF AGEING AND DEVELOPMENT. 1992 JAN; 62 (1): 13-24	5	10	6	21
2906	6941 LAYHSCHMITT G, HERRMANN R LOCALIZATION AND BIOCHEMICAL-CHARACTERIZATION OF THE ORF6 GENE-PRODUCT OF THE MYCOPLASMA-PNEUMONIAE P1 OPERON INFECTION AND IMMUNITY. 1992 JUL; 60 (7): 2906-2913	5	28	7	37
2907	6965 PEREIRASMITH OM, NING Y MOLECULAR GENETIC-STUDIES OF CELLULAR SENESCENCE EXPERIMENTAL GERONTOLOGY. 1992 SEP-DEC; 27 (5-6): 519-522	5	8	6	11
2908	6973 LINNANE AW, ZHANG CF, BAUMER A, NAGLEY P MITOCHONDRIAL-DNA MUTATION AND THE AGING PROCESS - BIOENERGY AND PHARMACOLOGICAL INTERVENTION MUTATION RESEARCH. 1992 SEP; 275 (3-6): 195-208	5	107	3	51
2909	6986 FREDERICH KB, PHILLIPS PD, CRISTOFALO VJ STIMULATION OF DNA-SYNTHESIS IN SENESCENT HUMAN-CELLS FOLLOWING INCUBATION WITH PLASMA-MEMBRANES EXPERIMENTAL CELL RESEARCH. 1992 OCT; 202 (2): 386-390	5	6	14	27
2910	7018 HARMAN D ROLE OF FREE-RADICALS IN AGING AND DISEASE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1992 DEC 26; 673: 126-141	5	110	5	117
#	Date / Author / Journal	LCS	GCS	LCR	CR
2911	7140 TOLLEFSBOL TO, ANDREWS LG MECHANISMS FOR METHYLATION-MEDIATED GENE SILENCING AND AGING MEDICAL HYPOTHESES. 1993 JUL; 41 (1): 83-92	5	13	2	55
2912	7193 AUGUSTINVOSS HG, VOSS AK, PAULI BU SENESCENCE OF AORTIC ENDOTHELIAL-CELLS IN CULTURE - EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR EXPRESSION ON CELL PHENOTYPE, MIGRATION, AND PROLIFERATION JOURNAL OF CELLULAR PHYSIOLOGY. 1993 NOV; 157 (2): 279-288	5	40	9	66
2913	7205 TSUJI Y, NINOMIYATSUJI J, TORTI SV, TORTI FM SELECTIVE LOSS OF CDC2 AND CDK2 INDUCTION BY TUMOR-NECROSIS-FACTOR- ALPHA IN SENESCENT HUMAN-DIPLOID FIBROBLASTS EXPERIMENTAL CELL RESEARCH. 1993 DEC; 209 (2): 175-182	5	13	21	58
2914	7313 SOLMI R, PALLOTTI F, RUGOLO M, GENOVA ML, ESTORNELL E, et al. LACK OF MAJOR MITOCHONDRIAL BIOENERGETIC CHANGES IN CULTURED SKIN FIBROBLASTS FROM AGED INDIVIDUALS BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL. 1994 JUN; 33 (3): 477-484	5	19	3	17
2915	7364 HARMAN D AGING - PROSPECTS FOR FURTHER INCREASES IN THE FUNCTIONAL LIFE-SPAN AGE. 1994 OCT; 17 (4): 119-146	5	54	9	279
2916	7380 GOLETZ TJ, ROBETORYE S, PEREIRASMITH OM GENETIC-ANALYSIS OF INDEFINITE DIVISION IN HUMAN-CELLS - EVIDENCE FOR A COMMON IMMORTALIZING MECHANISM IN T-LYMPHOID AND B-LYMPHOID CELL LINES EXPERIMENTAL CELL RESEARCH. 1994 NOV; 215 (1): 82-89	5	8	23	42
2917	7477 KALTOFT K, PEDERSEN CB, HANSEN BH, THESTRUPPEDERSEN K APPEARANCE OF ISOCHROMOSOME 18Q CAN BE ASSOCIATED WITH IN-VITRO IMMORTALIZATION OF HUMAN T-LYMPHOCYTES CANCER GENETICS AND CYTOGENETICS. 1995 MAY; 81 (1): 13-16	5	14	7	18
2918	7540 WIERENGA DE, COGAN J, PETRICCIANI JC ADMINISTRATION OF TUMOR-CELL CHROMATIN TO IMMUNOSUPPRESSED AND NONIMMUNOSUPPRESSED NONHUMAN-PRIMATES BIOLOGICALS. 1995 SEP; 23 (3): 221-224	5	16	0	9
2919	7542 PETRICCIANI JC, HORAUD FN DNA, DRAGONS AND SANITY BIOLOGICALS. 1995 SEP; 23 (3): 233-238	5	17	1	26
2920	7614 WynfordThomas D Telomeres, p53 and cellular senescence ONCOLOGY RESEARCH. 1996; 8 (10-11): 387-398	5	18	38	94
#	Date / Author / Journal	LCS	GCS	LCR	CR
2921	7703 Yuan HT, Kaneko T, Matsuo M Increased susceptibility of late passage human diploid fibroblasts to oxidative stress EXPERIMENTAL GERONTOLOGY. 1996 JUL-AUG; 31 (4): 465-474	5	15	11	30
2922	7737 Chow M, Rubin H Irreversibility of cellular aging and neoplastic transformation: A clonal analysis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996 SEP 3; 93 (18): 9793-9798	5	18	12	41
2923	7780 Warner HR Aging and regulation of apoptosis CURRENT TOPICS IN CELLULAR REGULATION, VOL 35. 1997; 35: 107-121	5	43	6	89
2924	7788 Johnson TE Genetic influences on aging EXPERIMENTAL GERONTOLOGY. 1997 JAN-APR; 32 (1-2): 11-22	5	22	10	91
2925	7870 McClearn GE, Johansson B, Berg S, Pedersen NL, Ahern F, et al. Substantial genetic influence on cognitive abilities in twins 80 or more years old SCIENCE. 1997 JUN 6; 276 (5318): 1560-1563	5	290	2	37
2926	7877 Lind K, Benzon MW, Jensen JS, Clyde WA A seroepidemiological study of Mycoplasma pneumoniae infections in Denmark over the 50-year period 1946-1995 EUROPEAN JOURNAL OF EPIDEMIOLOGY. 1997 JUL; 13 (5): 581-586	5	39	11	33
2927	7880 Shimizu N, Goseki T, Yamaguchi M, Iwasawa T, Takiguchi H, et al. In vitro cellular aging stimulates interleukin-1 beta production in stretched human periodontal-ligament-derived cells JOURNAL OF DENTAL RESEARCH. 1997 JUL; 76 (7): 1367-1375	5	12	4	43
2928	7886 Anisimov VN, Mylnikov SV, Oparina TI, Khavinson VK Effect of melatonin and pineal peptide preparation epithalamin on life spall and free radical oxidation in Drosophila melanogaster MECHANISMS OF AGEING AND DEVELOPMENT. 1997 AUG; 97 (2): 81-91	5	33	4	34
2929	7915 Shay JW Molecular pathogenesis of aging and cancer: are telomeres and telomerase the connection? JOURNAL OF CLINICAL PATHOLOGY. 1997 OCT; 50 (10): 799-800	5	8	7	24
2930	7922 Perkins DJ, Kniss DA Tumor necrosis factor-alpha promotes sustained cyclooxygenase-2 expression: Attenuation by dexamethasone and NSAIDs PROSTAGLANDINS & OTHER LIPID MEDIATORS. 1997 OCT; 54 (4): 727-743	5	72	3	51
#	Date / Author / Journal	LCS	GCS	LCR	CR
2931	7932 Banks DA, Fossel M Telomeres, cancer, and aging - Altering the human life span JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 1997 OCT 22; 278 (16): 1345-1348	5	23	9	59
2932	7933 Sharma S, Raymond E, Soda H, Sun D, Hilsenbeck SG, et al. Preclinical and clinical strategies for development of telomerase and telomere inhibitors ANNALS OF ONCOLOGY. 1997 NOV; 8 (11): 1063-1074	5	62	15	116
2933	7950 Marusic L, Anton M, Tidy A, Wang P, Villeponteau B, et al. Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability MOLECULAR AND CELLULAR BIOLOGY. 1997 NOV; 17 (11): 6394-6401	5	51	11	63
2934	7976 Sanchez-Martin MM, Cabezas JA Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages MECHANISMS OF AGEING AND DEVELOPMENT. 1997 DEC 15; 99 (2): 95-107	5	8	0	40
2935	8012 Garkavtsev I, Hull C, Riabowol K Molecular aspects of the relationship between cancer and aging: Tumor suppressor activity during cellular senescence EXPERIMENTAL GERONTOLOGY. 1998 JAN-MAR; 33 (1-2): 81-94	5	20	37	103
2936	8034 Ling ZD, Potter ED, Lipton JW, Carvey PM Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines EXPERIMENTAL NEUROLOGY. 1998 FEB; 149 (2): 411-423	5	176	1	80
2937	8052 Yang Z, Kodama S, Suzuki K, Watanabe M Telomerase activity, telomere length, and chromosome aberrations in the extension of life span of human embryo cells induced by low-dose X-rays JOURNAL OF RADIATION RESEARCH. 1998 MAR; 39 (1): 35-51	5	12	17	35
2938	8062 Kumazaki T, Sakano T, Yoshida T, Hamada K, Sumida H, et al. Enhanced expression of mitochondrial genes in senescent endothelial cells and fibroblasts MECHANISMS OF AGEING AND DEVELOPMENT. 1998 MAR 16; 101 (1-2): 91-99	5	12	19	37
2939	8066 Bartke A Growth hormone and aging ENDOCRINE. 1998 APR; 8 (2): 103-108	5	27	2	87
2940	8069 Hansen WR, Sato T, Mitchell MD Tumour necrosis factor-alpha stimulates increased expression of prostaglandin endoperoxide H synthase type 2 mRNA in amnion-derived WISH cells JOURNAL OF MOLECULAR ENDOCRINOLOGY. 1998 APR; 20 (2): 221-231	5	24	1	48
#	Date / Author / Journal	LCS	GCS	LCR	CR
2941	8117 Macieira-Coelho A Markers of 'cell senescence' MECHANISMS OF AGEING AND DEVELOPMENT. 1998 JUN 1; 103 (1): 105-109	5	5	13	21
2942	8161 Terman A, Brunk UT Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis MECHANISMS OF AGEING AND DEVELOPMENT. 1998 SEP 1; 104 (3): 277-291	5	63	7	42
2943	8230 McFarland GA, Holliday R Further evidence for the rejuvenating effects of the dipeptide L- carnosine on cultured human diploid fibroblasts EXPERIMENTAL GERONTOLOGY. 1999 JAN; 34 (1): 35-45	5	36	7	15
2944	8265 McKenzie KE, Umbricht CB, Sukumar S Applications of telomerase research in the fight against cancer MOLECULAR MEDICINE TODAY. 1999 MAR; 5 (3): 114-122	5	25	6	65
2945	8269 Hayflick L Aging and the genome SCIENCE. 1999 MAR 26; 283 (5410): 2019-2019	5	5	0	0
2946	8285 Meyyappan M, Wheaton K, Riabowol KT Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 29-39	5	17	14	49
2947	8286 Sayama K, Shirakata Y, Midorikawa K, Hanakawa Y, Hashimoto K Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 40-44	5	24	14	26
2948	8366 Rogakou EP, Sekeri-Pataryas KE Histone variants of H2A and H3 families are regulated during in vitro aging in the same manner as during differentiation EXPERIMENTAL GERONTOLOGY. 1999 SEP; 34 (6): 741-754	5	18	19	40
2949	8369 Martin GM, Oshima J, Gray MD, Poot M What geriatricians should know about the Werner syndrome JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 1999 SEP; 47 (9): 1136-1144	5	45	10	69
2950	8388 Barker MG, Walmsley RM Replicative ageing in the fission yeast Schizosaccharomyces pombe YEAST. 1999 OCT; 15 (14): 1511-1518	5	39	2	19
#	Date / Author / Journal	LCS	GCS	LCR	CR
2951	8405 Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, et al. A proinflammatory cytokine inhibits p53 tumor suppressor activity JOURNAL OF EXPERIMENTAL MEDICINE. 1999 NOV 15; 190 (10): 1375-1382	5	308	1	45
2952	8444 Bandyopadhyay D, Medrano EE Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16(INK4a)/CDK4/pRB and E2F1 MOLECULAR AND CELLULAR GERONTOLOGY. 2000; 908: 71-84	5	21	12	69
2953	8495 Macieira-Coelho A Ups and downs of aging studies in vitro: The crooked path of science GERONTOLOGY. 2000 MAR-APR; 46 (2): 55-63	5	5	48	87
2954	8577 Yeo EJ, Hwang YC, Kang CM, Kim IH, Kim DI, et al. Senescence-like changes induced by hydroxyurea in human diploid fibroblasts EXPERIMENTAL GERONTOLOGY. 2000 AUG; 35 (5): 553-571	5	23	28	80
2955	8612 Duesberg P, Rasnick D Aneuploidy, the somatic mutation that makes cancer a species of its own CELL MOTILITY AND THE CYTOSKELETON. 2000 OCT; 47 (2): 81-107	5	106	10	228
2956	8618 Chakravarthy MV, Davis BS, Booth FW IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle JOURNAL OF APPLIED PHYSIOLOGY. 2000 OCT; 89 (4): 1365-1379	5	122	6	55
2957	8623 Holliday R Somatic mutations and ageing MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. 2000 OCT; 463 (3): 173-178	5	19	15	42
2958	8636 Brod SA Unregulated inflammation shortens human functional longevity INFLAMMATION RESEARCH. 2000 NOV; 49 (11): 561-570	5	33	9	160
2959	8637 Dumont P, Balbeur L, Remacle J, Toussaint O Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1 alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition JOURNAL OF ANATOMY. 2000 NOV; 197: 529-537	5	14	8	22
2960	8687 Terman A Garbage catastrophe theory of aging: imperfect removal of oxidative damage? REDOX REPORT. 2001; 6 (1): 15-26	5	62	23	181
#	Date / Author / Journal	LCS	GCS	LCR	CR
2961	8740 Rocco JW, Sidransky D p16(MTS-1/CDKN2/INK4a) in cancer progression EXPERIMENTAL CELL RESEARCH. 2001 MAR 10; 264 (1): 42-55	5	204	14	260
2962	8747 Majumdar AS, Hughes DE, Lichtsteiner SP, Wang Z, Lebkowski JS, et al. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters GENE THERAPY. 2001 APR; 8 (7): 568-578	5	83	6	52
2963	8768 Park JS, Park WY, Cho KA, Kim DI, Jhun BH, et al. Down-regulation of amphiphysin-1 is responsible for reduced receptor- mediated endocytosis in the senescent cells FASEB JOURNAL. 2001 MAY 29; 15 (7): 1625-+	5	20	8	24
2964	8790 Wagner M, Brosch G, Zwerschke W, Seto E, Loidl P, et al. Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2 FEBS LETTERS. 2001 JUN 15; 499 (1-2): 101-106	5	17	14	45
2965	8802 Anisimov VN, Zavarzina NY, Zabezhinski MA, Popovich IG, Zimina OA, et al. Melatonin increases both life span and tumor incidence in female CBA mice JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2001 JUL; 56 (7): B311-B323	5	34	3	73
2966	8813 Bandyopadhyay D, Timchenko N, Suwa T, Hornsby PJ, Campisi J, et al. The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells EXPERIMENTAL GERONTOLOGY. 2001 AUG; 36 (8): 1265-1275	5	26	13	38
2967	8836 Opitz OG, Suliman Y, Hahn WC, Harada H, Blum HE, et al. Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism JOURNAL OF CLINICAL INVESTIGATION. 2001 SEP; 108 (5): 725-732	5	37	19	50
2968	8853 Schlessinger D, Van Zant G Does functional depletion of stem cells drive aging? MECHANISMS OF AGEING AND DEVELOPMENT. 2001 SEP 30; 122 (14): 1537-1553	5	34	12	73
2969	8864 Bernard D, Slomianny C, Vandenbunder B, Abbadie C cRel induces mitochondrial alterations in correlation with proliferation arrest FREE RADICAL BIOLOGY AND MEDICINE. 2001 OCT 15; 31 (8): 943-953	5	13	4	45
2970	8937 Effros RB, Globerson A Hematopoietic cells and replicative senescence EXPERIMENTAL GERONTOLOGY. 2002 JAN-MAR; 37 (2-3): 191-196	5	16	12	43
#	Date / Author / Journal	LCS	GCS	LCR	CR
2971	8967 Haussmann MF, Vleck CM Telomere length provides a new technique for aging animals OECOLOGIA. 2002 FEB; 130 (3): 325-328	5	29	5	33
2972	9001 Geiger H, Van Zant G The aging of lympho-hematopoietic stem cells NATURE IMMUNOLOGY. 2002 APR; 3 (4): 329-333	5	107	21	65
2973	9031 de Magalhaes JP, Toussaint O The evolution of mammalian aging EXPERIMENTAL GERONTOLOGY. 2002 JUN; 37 (6): 769-775	5	11	7	45
2974	9033 Hayflick L Handbook of the biology of aging, 5th edition. GERONTOLOGIST. 2002 JUN; 42 (3): 416-421	5	5	5	9
2975	9037 Nakamura H, Fukami H, Hayashi Y, Kiyono T, Nakatsugawa S, et al. Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene JOURNAL OF RADIATION RESEARCH. 2002 JUN; 43 (2): 167-174	5	21	4	25
2976	9112 Zhu DG, Xu G, Ghandhi S, Hubbard K Modulation of the expression of p16(INK4a) and p14(ARF) by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence JOURNAL OF CELLULAR PHYSIOLOGY. 2002 OCT; 193 (1): 19-25	5	17	6	32
2977	9123 Rincheval V, Renaud F, Lemaire C, Godefroy N, Trotot P, et al. Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002 OCT 25; 298 (2): 282-288	5	21	7	30
2978	9136 Neumeister P, Albanese C, Balent B, Greally J, Pestell RG Senescence and epigenetic dysregulation in cancer INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2002 NOV; 34 (11): 1475-1490	5	27	31	132
2979	9137 Nakamura KI, Izumiyama-Shimomura N, Sawabe M, Arai T, Aoyagi Y, et al. Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2002 NOV; 119 (5): 1014-1019	5	27	18	46
2980	9166 Leszczyniecka M, Kang DC, Sarkar D, Su ZZ, Holmes M, et al. Identification and cloning of human polynucleotide phosphorylase, hPNPase(')(old-35) in the context of terminal differentiation and cellular senescence PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002 DEC 24; 99 (26): 16636-16641	5	57	8	51
#	Date / Author / Journal	LCS	GCS	LCR	CR
2981	9182 Flanary BE, Streit WJ Telomeres shorten with age in rat cerebellum and cortex in vivo JOURNAL OF ANTI-AGING MEDICINE. 2003; 6 (4): 299-308	5	27	25	52
2982	9183 Richel T Will human life expectancy quadruple in the next hundred years? Sixty gerontologists say public debate on life extension is necessary JOURNAL OF ANTI-AGING MEDICINE. 2003; 6 (4): 309-314	5	10	3	35
2983	9217 Morley JE Anorexia and weight loss in older persons JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2003 FEB; 58 (2): 131-137	5	71	2	123
2984	9219 Shimizu Y, Suzuki J, Terao K, Ishida T In vitro aging of macaque adherent cells: similar pattern of cellular aging between human and macaque MECHANISMS OF AGEING AND DEVELOPMENT. 2003 FEB; 124 (2): 237-244	5	6	15	29
2985	9249 Saldanha SN, Andrews LG, Tollefsbol TO Analysis of telomerase activity and detection of its catalytic subunit, hTERT ANALYTICAL BIOCHEMISTRY. 2003 APR 1; 315 (1): 1-21	5	36	9	109
2986	9255 Yegorov YE, Zelenin AV Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts FEBS LETTERS. 2003 APR 24; 541 (1-3): 6-10	5	10	38	65
2987	9264 Wyllie F, Haughton M, Bartek J, Rowson J, Wynford-Thomasa D Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression EXPERIMENTAL CELL RESEARCH. 2003 MAY 1; 285 (2): 236-242	5	6	16	35
2988	9269 Young JI, Sedivy JM, Smith JR Telomerase expression in normal human fibroblasts stabilizes DNA 5- methylcytosine transferase I JOURNAL OF BIOLOGICAL CHEMISTRY. 2003 MAY 30; 278 (22): 19904-19908	5	25	11	29
2989	9292 Cui W, Wylie D, Aslam S, Dinnyes A, King T, et al. Telomerase-immortalized sheep fibroblasts can be reprogrammed by nuclear transfer to undergo early development BIOLOGY OF REPRODUCTION. 2003 JUL; 69 (1): 15-21	5	22	14	43
2990	9301 Sarkar D, Leszczyniecka M, Kang DC, Lebedeva IV, Valerie K, et al. Down-regulation of myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPase(old-35)) in human melanoma cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2003 JUL 4; 278 (27): 24542-24551	5	32	5	72
#	Date / Author / Journal	LCS	GCS	LCR	CR
2991	9307 Austad SN, Kristan DM Are mice calorically restricted in nature? AGING CELL. 2003 AUG; 2 (4): 201-207	5	26	1	43
2992	9317 Evans RJ, Wyllie FS, Wynford-Thomas D, Kipling D, Jones CJ A p53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development CANCER RESEARCH. 2003 AUG 15; 63 (16): 4854-4861	5	21	16	36
2993	9416 Kosmadaki MG, Gilchrest BA The role of telomeres in skin aging/photoaging MICRON. 2004; 35 (3): 155-159	5	34	16	45
2994	9422 Busuttil RA, Dolle M, Campisi J, Vijg J Genomic instability, aging, and cellular senescence STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE. 2004; 1019: 245-255	5	20	7	37
2995	9453 Kwak IH, Kim HS, Choi OR, Ryu MS, Lim IK Nuclear accumulation of globular actin as a cellular senescence marker CANCER RESEARCH. 2004 JAN 15; 64 (2): 572-580	5	22	16	61
2996	9454 Shammas MA, Reis RJS, Li C, Koley H, Hurley LH, et al. Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma CLINICAL CANCER RESEARCH. 2004 JAN 15; 10 (2): 770-776	5	53	6	32
2997	9457 Kondo T, Setoguchi T, Taga T Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004 JAN 20; 101 (3): 781-786	5	417	1	37
2998	9499 Shammas MA, Liu XH, Gavory G, Raney KD, Balasubramanian S, et al. Targeting the single-strand G-rich overhang of telomeres with PNA inhibits cell growth and induces apoptosis of human immortal cells EXPERIMENTAL CELL RESEARCH. 2004 APR 15; 295 (1): 204-214	5	22	11	47
2999	9524 Nickoloff BJ, Lingen MW, Chang BD, Shen M, Swift M, et al. Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity CANCER RESEARCH. 2004 MAY 1; 64 (9): 2956-2961	5	22	5	39
3000	9541 Holliday R The close relationship between biological aging and age-associated pathologies in humans JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2004 JUN; 59 (6): 543-546	5	8	2	17

Date / Author / Journal

LCS

GCS

LCR

2901

6741 AOYAGI M, FUKAI N, SAKAMOTO H, SHINKAI T, MATSUSHIMA Y, et al.

ALTERED CELLULAR-RESPONSES TO SERUM MITOGENS, INCLUDING PLATELET- DERIVED GROWTH-FACTOR, IN CULTURED SMOOTH-MUSCLE CELLS DERIVED FROM ARTERIES OF PATIENTS WITH MOYAMOYA DISEASE

JOURNAL OF CELLULAR PHYSIOLOGY. 1991 MAY; 147 (2): 191-198

2902

6773 ROSENGARTEN R, WISE KS

THE VLP SYSTEM OF MYCOPLASMA-HYORHINIS - COMBINATORIAL EXPRESSION OF DISTINCT SIZE VARIANT LIPOPROTEINS GENERATING HIGH-FREQUENCY SURFACE ANTIGENIC VARIATION

JOURNAL OF BACTERIOLOGY. 1991 AUG; 173 (15): 4782-4793

2903

6805 LIMOUSE M, MANIE S, KONSTANTINOVA I, FERRUA B, SCHAFFAR L

INHIBITION OF PHORBOL ESTER-INDUCED CELL ACTIVATION IN MICROGRAVITY

EXPERIMENTAL CELL RESEARCH. 1991 NOV; 197 (1): 82-86

2904

6822 TAYLORROBINSON D, DAVIES HA, SARATHCHANDRA P, FURR PM

INTRACELLULAR LOCATION OF MYCOPLASMAS IN CULTURED-CELLS DEMONSTRATED BY IMMUNOCYTOCHEMISTRY AND ELECTRON-MICROSCOPY

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. 1991 DEC; 72 (6): 705-714

2905

6866 PIENTA KJ, GETZENBERG RH, COFFEY DS

CHARACTERIZATION OF NUCLEAR MORPHOLOGY AND NUCLEAR MATRICES IN AGING HUMAN FIBROBLASTS

MECHANISMS OF AGEING AND DEVELOPMENT. 1992 JAN; 62 (1): 13-24

2906

6941 LAYHSCHMITT G, HERRMANN R

LOCALIZATION AND BIOCHEMICAL-CHARACTERIZATION OF THE ORF6 GENE-PRODUCT OF THE MYCOPLASMA-PNEUMONIAE P1 OPERON

INFECTION AND IMMUNITY. 1992 JUL; 60 (7): 2906-2913

2907

6965 PEREIRASMITH OM, NING Y

MOLECULAR GENETIC-STUDIES OF CELLULAR SENESCENCE

EXPERIMENTAL GERONTOLOGY. 1992 SEP-DEC; 27 (5-6): 519-522

2908

6973 LINNANE AW, ZHANG CF, BAUMER A, NAGLEY P

MITOCHONDRIAL-DNA MUTATION AND THE AGING PROCESS - BIOENERGY AND PHARMACOLOGICAL INTERVENTION

MUTATION RESEARCH. 1992 SEP; 275 (3-6): 195-208

107

2909

6986 FREDERICH KB, PHILLIPS PD, CRISTOFALO VJ

STIMULATION OF DNA-SYNTHESIS IN SENESCENT HUMAN-CELLS FOLLOWING INCUBATION WITH PLASMA-MEMBRANES

EXPERIMENTAL CELL RESEARCH. 1992 OCT; 202 (2): 386-390

2910

7018 HARMAN D

ROLE OF FREE-RADICALS IN AGING AND DISEASE

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1992 DEC 26; 673: 126-141

110

117

Date / Author / Journal

LCS

GCS

LCR

2911

7140 TOLLEFSBOL TO, ANDREWS LG

MECHANISMS FOR METHYLATION-MEDIATED GENE SILENCING AND AGING

MEDICAL HYPOTHESES. 1993 JUL; 41 (1): 83-92

2912

7193 AUGUSTINVOSS HG, VOSS AK, PAULI BU

SENESCENCE OF AORTIC ENDOTHELIAL-CELLS IN CULTURE - EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR EXPRESSION ON CELL PHENOTYPE, MIGRATION, AND PROLIFERATION

JOURNAL OF CELLULAR PHYSIOLOGY. 1993 NOV; 157 (2): 279-288

2913

7205 TSUJI Y, NINOMIYATSUJI J, TORTI SV, TORTI FM

SELECTIVE LOSS OF CDC2 AND CDK2 INDUCTION BY TUMOR-NECROSIS-FACTOR- ALPHA IN SENESCENT HUMAN-DIPLOID FIBROBLASTS

EXPERIMENTAL CELL RESEARCH. 1993 DEC; 209 (2): 175-182

2914

7313 SOLMI R, PALLOTTI F, RUGOLO M, GENOVA ML, ESTORNELL E, et al.

LACK OF MAJOR MITOCHONDRIAL BIOENERGETIC CHANGES IN CULTURED SKIN FIBROBLASTS FROM AGED INDIVIDUALS

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL. 1994 JUN; 33 (3): 477-484

2915

7364 HARMAN D

AGING - PROSPECTS FOR FURTHER INCREASES IN THE FUNCTIONAL LIFE-SPAN

AGE. 1994 OCT; 17 (4): 119-146

279

2916

7380 GOLETZ TJ, ROBETORYE S, PEREIRASMITH OM

GENETIC-ANALYSIS OF INDEFINITE DIVISION IN HUMAN-CELLS - EVIDENCE FOR A COMMON IMMORTALIZING MECHANISM IN T-LYMPHOID AND B-LYMPHOID CELL LINES

EXPERIMENTAL CELL RESEARCH. 1994 NOV; 215 (1): 82-89

2917

7477 KALTOFT K, PEDERSEN CB, HANSEN BH, THESTRUPPEDERSEN K

APPEARANCE OF ISOCHROMOSOME 18Q CAN BE ASSOCIATED WITH IN-VITRO IMMORTALIZATION OF HUMAN T-LYMPHOCYTES

CANCER GENETICS AND CYTOGENETICS. 1995 MAY; 81 (1): 13-16

2918

7540 WIERENGA DE, COGAN J, PETRICCIANI JC

ADMINISTRATION OF TUMOR-CELL CHROMATIN TO IMMUNOSUPPRESSED AND NONIMMUNOSUPPRESSED NONHUMAN-PRIMATES

BIOLOGICALS. 1995 SEP; 23 (3): 221-224

2919

7542 PETRICCIANI JC, HORAUD FN

DNA, DRAGONS AND SANITY

BIOLOGICALS. 1995 SEP; 23 (3): 233-238

2920

7614 WynfordThomas D

Telomeres, p53 and cellular senescence

ONCOLOGY RESEARCH. 1996; 8 (10-11): 387-398

Date / Author / Journal

LCS

GCS

LCR

2921

7703 Yuan HT, Kaneko T, Matsuo M

Increased susceptibility of late passage human diploid fibroblasts to oxidative stress

EXPERIMENTAL GERONTOLOGY. 1996 JUL-AUG; 31 (4): 465-474

2922

7737 Chow M, Rubin H

Irreversibility of cellular aging and neoplastic transformation: A clonal analysis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996 SEP 3; 93 (18): 9793-9798

2923

7780 Warner HR

Aging and regulation of apoptosis

CURRENT TOPICS IN CELLULAR REGULATION, VOL 35. 1997; 35: 107-121

2924

7788 Johnson TE

Genetic influences on aging

EXPERIMENTAL GERONTOLOGY. 1997 JAN-APR; 32 (1-2): 11-22

2925

7870 McClearn GE, Johansson B, Berg S, Pedersen NL, Ahern F, et al.

Substantial genetic influence on cognitive abilities in twins 80 or more years old

SCIENCE. 1997 JUN 6; 276 (5318): 1560-1563

290

2926

7877 Lind K, Benzon MW, Jensen JS, Clyde WA

A seroepidemiological study of Mycoplasma pneumoniae infections in Denmark over the 50-year period 1946-1995

EUROPEAN JOURNAL OF EPIDEMIOLOGY. 1997 JUL; 13 (5): 581-586

2927

7880 Shimizu N, Goseki T, Yamaguchi M, Iwasawa T, Takiguchi H, et al.

In vitro cellular aging stimulates interleukin-1 beta production in stretched human periodontal-ligament-derived cells

JOURNAL OF DENTAL RESEARCH. 1997 JUL; 76 (7): 1367-1375

2928

7886 Anisimov VN, Mylnikov SV, Oparina TI, Khavinson VK

Effect of melatonin and pineal peptide preparation epithalamin on life spall and free radical oxidation in Drosophila melanogaster

MECHANISMS OF AGEING AND DEVELOPMENT. 1997 AUG; 97 (2): 81-91

2929

7915 Shay JW

Molecular pathogenesis of aging and cancer: are telomeres and telomerase the connection?

JOURNAL OF CLINICAL PATHOLOGY. 1997 OCT; 50 (10): 799-800

2930

7922 Perkins DJ, Kniss DA

Tumor necrosis factor-alpha promotes sustained cyclooxygenase-2 expression: Attenuation by dexamethasone and NSAIDs

PROSTAGLANDINS & OTHER LIPID MEDIATORS. 1997 OCT; 54 (4): 727-743

Date / Author / Journal

LCS

GCS

LCR

2931

7932 Banks DA, Fossel M

Telomeres, cancer, and aging - Altering the human life span

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 1997 OCT 22; 278 (16): 1345-1348

2932

7933 Sharma S, Raymond E, Soda H, Sun D, Hilsenbeck SG, et al.

Preclinical and clinical strategies for development of telomerase and telomere inhibitors

ANNALS OF ONCOLOGY. 1997 NOV; 8 (11): 1063-1074

116

2933

7950 Marusic L, Anton M, Tidy A, Wang P, Villeponteau B, et al.

Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability

MOLECULAR AND CELLULAR BIOLOGY. 1997 NOV; 17 (11): 6394-6401

2934

7976 Sanchez-Martin MM, Cabezas JA

Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages

MECHANISMS OF AGEING AND DEVELOPMENT. 1997 DEC 15; 99 (2): 95-107

2935

8012 Garkavtsev I, Hull C, Riabowol K

Molecular aspects of the relationship between cancer and aging: Tumor suppressor activity during cellular senescence

EXPERIMENTAL GERONTOLOGY. 1998 JAN-MAR; 33 (1-2): 81-94

103

2936

8034 Ling ZD, Potter ED, Lipton JW, Carvey PM

Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines

EXPERIMENTAL NEUROLOGY. 1998 FEB; 149 (2): 411-423

176

2937

8052 Yang Z, Kodama S, Suzuki K, Watanabe M

Telomerase activity, telomere length, and chromosome aberrations in the extension of life span of human embryo cells induced by low-dose X-rays

JOURNAL OF RADIATION RESEARCH. 1998 MAR; 39 (1): 35-51

2938

8062 Kumazaki T, Sakano T, Yoshida T, Hamada K, Sumida H, et al.

Enhanced expression of mitochondrial genes in senescent endothelial cells and fibroblasts

MECHANISMS OF AGEING AND DEVELOPMENT. 1998 MAR 16; 101 (1-2): 91-99

2939

8066 Bartke A

Growth hormone and aging

ENDOCRINE. 1998 APR; 8 (2): 103-108

2940

8069 Hansen WR, Sato T, Mitchell MD

Tumour necrosis factor-alpha stimulates increased expression of prostaglandin endoperoxide H synthase type 2 mRNA in amnion-derived WISH cells

JOURNAL OF MOLECULAR ENDOCRINOLOGY. 1998 APR; 20 (2): 221-231

Date / Author / Journal

LCS

GCS

LCR

2941

8117 Macieira-Coelho A

Markers of 'cell senescence'

MECHANISMS OF AGEING AND DEVELOPMENT. 1998 JUN 1; 103 (1): 105-109

2942

8161 Terman A, Brunk UT

Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis

MECHANISMS OF AGEING AND DEVELOPMENT. 1998 SEP 1; 104 (3): 277-291

2943

8230 McFarland GA, Holliday R

Further evidence for the rejuvenating effects of the dipeptide L- carnosine on cultured human diploid fibroblasts

EXPERIMENTAL GERONTOLOGY. 1999 JAN; 34 (1): 35-45

2944

8265 McKenzie KE, Umbricht CB, Sukumar S

Applications of telomerase research in the fight against cancer

MOLECULAR MEDICINE TODAY. 1999 MAR; 5 (3): 114-122

2945

8269 Hayflick L

Aging and the genome

SCIENCE. 1999 MAR 26; 283 (5410): 2019-2019

2946

8285 Meyyappan M, Wheaton K, Riabowol KT

Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence

JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 29-39

2947

8286 Sayama K, Shirakata Y, Midorikawa K, Hanakawa Y, Hashimoto K

Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence

JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 40-44

2948

8366 Rogakou EP, Sekeri-Pataryas KE

Histone variants of H2A and H3 families are regulated during in vitro aging in the same manner as during differentiation

EXPERIMENTAL GERONTOLOGY. 1999 SEP; 34 (6): 741-754

2949

8369 Martin GM, Oshima J, Gray MD, Poot M

What geriatricians should know about the Werner syndrome

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 1999 SEP; 47 (9): 1136-1144

2950

8388 Barker MG, Walmsley RM

Replicative ageing in the fission yeast Schizosaccharomyces pombe

YEAST. 1999 OCT; 15 (14): 1511-1518

Date / Author / Journal

LCS

GCS

LCR

2951

8405 Hudson JD, Shoaibi MA, Maestro R, Carnero A, Hannon GJ, et al.

A proinflammatory cytokine inhibits p53 tumor suppressor activity

JOURNAL OF EXPERIMENTAL MEDICINE. 1999 NOV 15; 190 (10): 1375-1382

308

2952

8444 Bandyopadhyay D, Medrano EE

Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16(INK4a)/CDK4/pRB and E2F1

MOLECULAR AND CELLULAR GERONTOLOGY. 2000; 908: 71-84

2953

8495 Macieira-Coelho A

Ups and downs of aging studies in vitro: The crooked path of science

GERONTOLOGY. 2000 MAR-APR; 46 (2): 55-63

2954

8577 Yeo EJ, Hwang YC, Kang CM, Kim IH, Kim DI, et al.

Senescence-like changes induced by hydroxyurea in human diploid fibroblasts

EXPERIMENTAL GERONTOLOGY. 2000 AUG; 35 (5): 553-571

2955

8612 Duesberg P, Rasnick D

Aneuploidy, the somatic mutation that makes cancer a species of its own

CELL MOTILITY AND THE CYTOSKELETON. 2000 OCT; 47 (2): 81-107

106

228

2956

8618 Chakravarthy MV, Davis BS, Booth FW

IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle

JOURNAL OF APPLIED PHYSIOLOGY. 2000 OCT; 89 (4): 1365-1379

122

2957

8623 Holliday R

Somatic mutations and ageing

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH. 2000 OCT; 463 (3): 173-178

2958

8636 Brod SA

Unregulated inflammation shortens human functional longevity

INFLAMMATION RESEARCH. 2000 NOV; 49 (11): 561-570

160

2959

8637 Dumont P, Balbeur L, Remacle J, Toussaint O

Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1 alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition

JOURNAL OF ANATOMY. 2000 NOV; 197: 529-537

2960

8687 Terman A

Garbage catastrophe theory of aging: imperfect removal of oxidative damage?

REDOX REPORT. 2001; 6 (1): 15-26

181

Date / Author / Journal

LCS

GCS

LCR

2961

8740 Rocco JW, Sidransky D

p16(MTS-1/CDKN2/INK4a) in cancer progression

EXPERIMENTAL CELL RESEARCH. 2001 MAR 10; 264 (1): 42-55

204

260

2962

8747 Majumdar AS, Hughes DE, Lichtsteiner SP, Wang Z, Lebkowski JS, et al.

The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

GENE THERAPY. 2001 APR; 8 (7): 568-578

2963

8768 Park JS, Park WY, Cho KA, Kim DI, Jhun BH, et al.

Down-regulation of amphiphysin-1 is responsible for reduced receptor- mediated endocytosis in the senescent cells

FASEB JOURNAL. 2001 MAY 29; 15 (7): 1625-+

2964

8790 Wagner M, Brosch G, Zwerschke W, Seto E, Loidl P, et al.

Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2

FEBS LETTERS. 2001 JUN 15; 499 (1-2): 101-106

2965

8802 Anisimov VN, Zavarzina NY, Zabezhinski MA, Popovich IG, Zimina OA, et al.

Melatonin increases both life span and tumor incidence in female CBA mice

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2001 JUL; 56 (7): B311-B323

2966

8813 Bandyopadhyay D, Timchenko N, Suwa T, Hornsby PJ, Campisi J, et al.

The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells

EXPERIMENTAL GERONTOLOGY. 2001 AUG; 36 (8): 1265-1275

2967

8836 Opitz OG, Suliman Y, Hahn WC, Harada H, Blum HE, et al.

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

JOURNAL OF CLINICAL INVESTIGATION. 2001 SEP; 108 (5): 725-732

2968

8853 Schlessinger D, Van Zant G

Does functional depletion of stem cells drive aging?

MECHANISMS OF AGEING AND DEVELOPMENT. 2001 SEP 30; 122 (14): 1537-1553

2969

8864 Bernard D, Slomianny C, Vandenbunder B, Abbadie C

cRel induces mitochondrial alterations in correlation with proliferation arrest

FREE RADICAL BIOLOGY AND MEDICINE. 2001 OCT 15; 31 (8): 943-953

2970

8937 Effros RB, Globerson A

Hematopoietic cells and replicative senescence

EXPERIMENTAL GERONTOLOGY. 2002 JAN-MAR; 37 (2-3): 191-196

Date / Author / Journal

LCS

GCS

LCR

2971

8967 Haussmann MF, Vleck CM

Telomere length provides a new technique for aging animals

OECOLOGIA. 2002 FEB; 130 (3): 325-328

2972

9001 Geiger H, Van Zant G

The aging of lympho-hematopoietic stem cells

NATURE IMMUNOLOGY. 2002 APR; 3 (4): 329-333

107

2973

9031 de Magalhaes JP, Toussaint O

The evolution of mammalian aging

EXPERIMENTAL GERONTOLOGY. 2002 JUN; 37 (6): 769-775

2974

9033 Hayflick L

Handbook of the biology of aging, 5th edition.

GERONTOLOGIST. 2002 JUN; 42 (3): 416-421

2975

9037 Nakamura H, Fukami H, Hayashi Y, Kiyono T, Nakatsugawa S, et al.

Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT gene

JOURNAL OF RADIATION RESEARCH. 2002 JUN; 43 (2): 167-174

2976

9112 Zhu DG, Xu G, Ghandhi S, Hubbard K

Modulation of the expression of p16(INK4a) and p14(ARF) by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence

JOURNAL OF CELLULAR PHYSIOLOGY. 2002 OCT; 193 (1): 19-25

2977

9123 Rincheval V, Renaud F, Lemaire C, Godefroy N, Trotot P, et al.

Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002 OCT 25; 298 (2): 282-288

2978

9136 Neumeister P, Albanese C, Balent B, Greally J, Pestell RG

Senescence and epigenetic dysregulation in cancer

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2002 NOV; 34 (11): 1475-1490

132

2979

9137 Nakamura KI, Izumiyama-Shimomura N, Sawabe M, Arai T, Aoyagi Y, et al.

Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium

JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2002 NOV; 119 (5): 1014-1019

2980

9166 Leszczyniecka M, Kang DC, Sarkar D, Su ZZ, Holmes M, et al.

Identification and cloning of human polynucleotide phosphorylase, hPNPase(')(old-35) in the context of terminal differentiation and cellular senescence

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002 DEC 24; 99 (26): 16636-16641

Date / Author / Journal

LCS

GCS

LCR

2981

9182 Flanary BE, Streit WJ

Telomeres shorten with age in rat cerebellum and cortex in vivo

JOURNAL OF ANTI-AGING MEDICINE. 2003; 6 (4): 299-308

2982

9183 Richel T

Will human life expectancy quadruple in the next hundred years? Sixty gerontologists say public debate on life extension is necessary

JOURNAL OF ANTI-AGING MEDICINE. 2003; 6 (4): 309-314

2983

9217 Morley JE

Anorexia and weight loss in older persons

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2003 FEB; 58 (2): 131-137

123

2984

9219 Shimizu Y, Suzuki J, Terao K, Ishida T

In vitro aging of macaque adherent cells: similar pattern of cellular aging between human and macaque

MECHANISMS OF AGEING AND DEVELOPMENT. 2003 FEB; 124 (2): 237-244

2985

9249 Saldanha SN, Andrews LG, Tollefsbol TO

Analysis of telomerase activity and detection of its catalytic subunit, hTERT

ANALYTICAL BIOCHEMISTRY. 2003 APR 1; 315 (1): 1-21

109

2986

9255 Yegorov YE, Zelenin AV

Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts

FEBS LETTERS. 2003 APR 24; 541 (1-3): 6-10

2987

9264 Wyllie F, Haughton M, Bartek J, Rowson J, Wynford-Thomasa D

Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression

EXPERIMENTAL CELL RESEARCH. 2003 MAY 1; 285 (2): 236-242

2988

9269 Young JI, Sedivy JM, Smith JR

Telomerase expression in normal human fibroblasts stabilizes DNA 5- methylcytosine transferase I

JOURNAL OF BIOLOGICAL CHEMISTRY. 2003 MAY 30; 278 (22): 19904-19908

2989

9292 Cui W, Wylie D, Aslam S, Dinnyes A, King T, et al.

Telomerase-immortalized sheep fibroblasts can be reprogrammed by nuclear transfer to undergo early development

BIOLOGY OF REPRODUCTION. 2003 JUL; 69 (1): 15-21

2990

9301 Sarkar D, Leszczyniecka M, Kang DC, Lebedeva IV, Valerie K, et al.

Down-regulation of myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPase(old-35)) in human melanoma cells

JOURNAL OF BIOLOGICAL CHEMISTRY. 2003 JUL 4; 278 (27): 24542-24551

Date / Author / Journal

LCS

GCS

LCR

2991

9307 Austad SN, Kristan DM

Are mice calorically restricted in nature?

AGING CELL. 2003 AUG; 2 (4): 201-207

2992

9317 Evans RJ, Wyllie FS, Wynford-Thomas D, Kipling D, Jones CJ

A p53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development

CANCER RESEARCH. 2003 AUG 15; 63 (16): 4854-4861

2993

9416 Kosmadaki MG, Gilchrest BA

The role of telomeres in skin aging/photoaging

MICRON. 2004; 35 (3): 155-159

2994

9422 Busuttil RA, Dolle M, Campisi J, Vijg J

Genomic instability, aging, and cellular senescence

STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE. 2004; 1019: 245-255

2995

9453 Kwak IH, Kim HS, Choi OR, Ryu MS, Lim IK

Nuclear accumulation of globular actin as a cellular senescence marker

CANCER RESEARCH. 2004 JAN 15; 64 (2): 572-580

2996

9454 Shammas MA, Reis RJS, Li C, Koley H, Hurley LH, et al.

Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma

CLINICAL CANCER RESEARCH. 2004 JAN 15; 10 (2): 770-776

2997

9457 Kondo T, Setoguchi T, Taga T

Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004 JAN 20; 101 (3): 781-786

417

2998

9499 Shammas MA, Liu XH, Gavory G, Raney KD, Balasubramanian S, et al.

Targeting the single-strand G-rich overhang of telomeres with PNA inhibits cell growth and induces apoptosis of human immortal cells

EXPERIMENTAL CELL RESEARCH. 2004 APR 15; 295 (1): 204-214

2999

9524 Nickoloff BJ, Lingen MW, Chang BD, Shen M, Swift M, et al.

Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity

CANCER RESEARCH. 2004 MAY 1; 64 (9): 2956-2961

3000

9541 Holliday R

The close relationship between biological aging and age-associated pathologies in humans

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2004 JUN; 59 (6): 543-546

Hayflick w/citing papers Len Hayflick publications & the papers citing L Hayflick.	Historiographs	Glossary HistCite Guide About Grand Totals: LCS 84164, GCS 458115, CR 564869 Collection span: 1953 - 2011
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