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#	Date / Author / Journal	LCS	GCS	LCR	CR
2001	6895 ROGER PP, BAPTIST M, DUMONT JE A MECHANISM GENERATING HETEROGENEITY IN THYROID EPITHELIAL-CELLS - SUPPRESSION OF THE THYROTROPIN CAMP-DEPENDENT MITOGENIC PATHWAY AFTER CELL-DIVISION INDUCED BY CAMP-INDEPENDENT FACTORS JOURNAL OF CELL BIOLOGY. 1992 APR; 117 (2): 383-393	0	35	12	56
2002	6919 WRIGHT WE, SHAY JW TELOMERE POSITIONAL EFFECTS AND THE REGULATION OF CELLULAR SENESCENCE TRENDS IN GENETICS. 1992 JUN; 8 (6): 193-197	94	212	12	32
2003	6927 DESMOULIERE A, RUBBIABRANDT L, ABDIU A, WALZ T, MACIEIRACOELHO A, et al. ALPHA-SMOOTH MUSCLE ACTIN IS EXPRESSED IN A SUBPOPULATION OF CULTURED AND CLONED FIBROBLASTS AND IS MODULATED BY GAMMA-INTERFERON EXPERIMENTAL CELL RESEARCH. 1992 JUL; 201 (1): 64-73	2	165	12	78
2004	7002 CAMPISI J GENE-EXPRESSION IN QUIESCENT AND SENESCENT FIBROBLASTS ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1992 NOV 21; 663: 195-201	17	22	12	21
2005	7022 MARTIN GR, DANNER DB, HOLBROOK NJ AGING - CAUSES AND DEFENSES ANNUAL REVIEW OF MEDICINE. 1993; 44: 419-429	3	36	12	45
2006	7069 HIRSCH HR ACCUMULATION OF A SENESCENCE FACTOR IN YEAST-CELLS EXPERIMENTAL GERONTOLOGY. 1993 MAR-APR; 28 (2): 195-204	1	1	12	23
2007	7141 MAZIN AL LOSS OF ALL GENOMIC 5-METHYLCYTOSINE COINCIDES WITH THE HAYFLICK LIMIT OF AGING CELL-LINES MOLECULAR BIOLOGY. 1993 JUL-AUG; 27 (4): 552-559	0	0	12	46
2008	7190 KUMAR S, VINCI JM, MILLIS AJT, BAGLIONI C EXPRESSION OF INTERLEUKIN-1-ALPHA AND INTERLEUKIN-BETA IN EARLY-PASSAGE FIBROBLASTS FROM AGING INDIVIDUALS EXPERIMENTAL GERONTOLOGY. 1993 NOV-DEC; 28 (6): 505-513	9	18	12	21
2009	7219 GOLDSTEIN S, LIU S, LUMPKIN CK, HUANG M, LIPSCHITZ D, et al. DERANGEMENTS IN CALCIUM-DEPENDENT MEMBRANE CURRENTS IN SENESCENT HUMAN FIBROBLASTS ARE ASSOCIATED WITH OVEREXPRESSION OF A NOVEL GENE SEQUENCE CALCIUM HYPOTHESIS OF AGING AND DEMENTIA. 1994; 747: 302-312	0	0	12	38
2010	7261 PATHAK S, RISIN S, BROWN NM, BERRY K TELOMERIC ASSOCIATION OF CHROMOSOMES IS AN EARLY MANIFESTATION OF PROGRAMMED CELL-DEATH INTERNATIONAL JOURNAL OF ONCOLOGY. 1994 FEB; 4 (2): 323-328	1	30	12	64
#	Date / Author / Journal	LCS	GCS	LCR	CR
2011	7263 KILL IR, FARAGHER RGA, LAWRENCE K, SHALL S THE EXPRESSION OF PROLIFERATION-DEPENDENT ANTIGENS DURING THE LIFE-SPAN OF NORMAL AND PROGEROID HUMAN FIBROBLASTS IN CULTURE JOURNAL OF CELL SCIENCE. 1994 FEB; 107: 571-579	24	59	12	36
2012	7274 NODA A, NING Y, VENABLE SF, PEREIRASMITH OM, SMITH JR CLONING OF SENESCENT CELL-DERIVED INHIBITORS OF DNA-SYNTHESIS USING AN EXPRESSION SCREEN EXPERIMENTAL CELL RESEARCH. 1994 MAR; 211 (1): 90-98	270	1262	12	27
2013	7296 HENSLER PJ, ANNAB LA, BARRETT JC, PEREIRASMITH OM A GENE INVOLVED IN CONTROL OF HUMAN CELLULAR SENESCENCE ON HUMAN CHROMOSOME-1Q MOLECULAR AND CELLULAR BIOLOGY. 1994 APR; 14 (4): 2291-2297	63	104	12	33
2014	7311 AFSHARI CA, BARRETT JC DISRUPTION OF G(0)-G(1) ARREST IN QUIESCENT AND SENESCENT CELLS TREATED WITH PHOSPHATASE INHIBITORS CANCER RESEARCH. 1994 MAY 1; 54 (9): 2317-2321	4	34	12	42
2015	7327 GRIGORIEV VG, MOERMAN EJ, GOLDSTEIN S SENESCENCE AND CELL-DENSITY OF HUMAN-DIPLOID FIBROBLASTS INFLUENCE METABOLISM OF INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS JOURNAL OF CELLULAR PHYSIOLOGY. 1994 JUL; 160 (1): 203-211	3	14	12	42
2016	7330 FUKAI N, AOYAGI M, YAMAMOTO M, SAKAMOTO H, OGAMI K, et al. HUMAN ARTERIAL SMOOTH-MUSCLE CELL STRAINS DERIVED FROM PATIENTS WITH MOYAMOYA DISEASE - CHANGES IN BIOLOGICAL CHARACTERISTICS AND PROLIFERATIVE RESPONSE DURING CELLULAR AGING IN-VITRO MECHANISMS OF AGEING AND DEVELOPMENT. 1994 JUL; 75 (1): 21-33	3	6	12	44
2017	7352 SCHMITTGRAFF A, DESMOULIERE A, GABBIANI G HETEROGENEITY OF MYOFIBROBLAST PHENOTYPIC FEATURES - AN EXAMPLE OF FIBROBLASTIC CELL PLASTICITY VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY. 1994 AUG; 425 (1): 3-24	1	308	12	269
2018	7359 CARLIN C, PHILLIPS PD, BROOKSFREDERICH K, KNOWLES BB, CRISTOFALO VJ CLEAVAGE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR BY A MEMBRANE-BOUND LEUPEPTIN-SENSITIVE PROTEASE ACTIVE IN NONIONIC DETERGENT LYSATES OF SENESCENT BUT NOT YOUNG HUMAN-DIPLOID FIBROBLASTS JOURNAL OF CELLULAR PHYSIOLOGY. 1994 SEP; 160 (3): 427-434	7	11	12	44
2019	7360 PANG JH, CHEN KY GLOBAL CHANGE OF GENE-EXPRESSION AT LATE G1/S BOUNDARY MAY OCCUR IN HUMAN IMR-90 DIPLOID FIBROBLASTS DURING SENESCENCE JOURNAL OF CELLULAR PHYSIOLOGY. 1994 SEP; 160 (3): 531-538	29	46	12	41
2020	7374 VANNINI F, MEACCI E, VASTA V, FARNARARO M, BRUNI P INVOLVEMENT OF PROTEIN-KINASE-C AND ARACHIDONATE SIGNALING PATHWAYS IN THE ALTERATION OF PROLIFERATIVE RESPONSE OF SENESCENT IMR-90 HUMAN FIBROBLASTS MECHANISMS OF AGEING AND DEVELOPMENT. 1994 OCT 20; 76 (2-3): 101-111	4	8	12	34
#	Date / Author / Journal	LCS	GCS	LCR	CR
2021	7375 VENABLE ME, BLOBE GC, OBEID LM IDENTIFICATION OF A DEFECT IN THE PHOSPHOLIPASE-D DIACYLGLYCEROL PATHWAY IN CELLULAR SENESCENCE JOURNAL OF BIOLOGICAL CHEMISTRY. 1994 OCT 21; 269 (42): 26040-26044	19	88	12	32
2022	7406 Morrison SJ, Uchida N, Weissman IL The biology of hematopoietic stem cells ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 1995; 11: 35-71	11	414	12	241
2023	7409 Pommier JP, Lebeau J, Ducray C, Sabatier L Chromosomal instability and alteration of telomere repeat sequences BIOCHIMIE. 1995; 77 (10): 817-825	1	11	12	75
2024	7430 JAHAN I, BAI LY, IJIMA M, KONDO T, NAMBA M KARYOTYPIC ANALYSIS IN THE PROCESS OF IMMORTALIZATION OF HUMAN-CELLS TREATED WITH 4-NITROQUINOLINE I-OXIDE ACTA MEDICA OKAYAMA. 1995 FEB; 49 (1): 25-28	1	2	12	22
2025	7464 ATADJA P, WONG H, VEILLETE C, RIABOWOL K OVEREXPRESSION OF CYCLIN D1 BLOCKS PROLIFERATION OF NORMAL DIPLOID FIBROBLASTS EXPERIMENTAL CELL RESEARCH. 1995 APR; 217 (2): 205-216	15	62	12	71
2026	7472 LI JH, ZHANG ZY, TONG TJ THE PROLIFERATIVE RESPONSE AND ANTIONCOGENE EXPRESSION IN OLD 2BS CELLS AFTER GROWTH-FACTOR STIMULATION MECHANISMS OF AGEING AND DEVELOPMENT. 1995 APR 21; 80 (1): 25-34	9	18	12	32
2027	7499 WANG E SENESCENT HUMAN FIBROBLASTS RESIST PROGRAMMED CELL-DEATH, AND FAILURE TO SUPPRESS BCL2 IS INVOLVED CANCER RESEARCH. 1995 JUN 1; 55 (11): 2284-2292	88	200	12	37
2028	7551 BACCHETTI S, COUNTER CM TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW) INTERNATIONAL JOURNAL OF ONCOLOGY. 1995 SEP; 7 (3): 423-432	22	114	12	93
2029	7559 WHITAKER NJ, BRYAN TM, BONNEFIN P, CHANG ACM, MUSGROVE EA, et al. INVOLVEMENT OF RB-1, P53, P16(INK4) AND TELOMERASE IN IMMORTALIZATION OF HUMAN-CELLS ONCOGENE. 1995 SEP 7; 11 (5): 971-976	33	76	12	41
2030	7607 Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW Telomerase activity in human germline and embryonic tissues and cells DEVELOPMENTAL GENETICS. 1996; 18 (2): 173-179	110	608	12	44
#	Date / Author / Journal	LCS	GCS	LCR	CR
2031	7638 Smith JR, Nakanishi M, Robetorye RS, Venable SF, PereiraSmith OM Studies demonstrating the complexity of regulation and action of the growth inhibitory gene SDI1 EXPERIMENTAL GERONTOLOGY. 1996 JAN-APR; 31 (1-2): 327-335	4	6	12	36
2032	7729 Morrison SJ, Prowse KR, Ho P, Weissman IL Telomerase activity in hematopoietic cells is associated with self- renewal potential IMMUNITY. 1996 SEP; 5 (3): 207-216	33	202	12	69
2033	7737 Chow M, Rubin H Irreversibility of cellular aging and neoplastic transformation: A clonal analysis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996 SEP 3; 93 (18): 9793-9798	5	18	12	41
2034	7748 Medcalf ASC, KleinSzanto AJP, Cristofalo VJ Expression of p21 is not required for senescence of human fibroblasts CANCER RESEARCH. 1996 OCT 15; 56 (20): 4582-4585	23	34	12	20
2035	7851 Bladier C, Wolvetang EJ, Hutchinson P, deHaan JB, Kola I Response of a primary human fibroblast cell line to H2O2: Senescence- like growth arrest or apoptosis CELL GROWTH & DIFFERENTIATION. 1997 MAY; 8 (5): 589-598	19	107	12	54
2036	7888 Cheng RZ, Shammas MA, Li J, Reis RJS Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells EXPERIMENTAL CELL RESEARCH. 1997 AUG 1; 234 (2): 300-312	2	6	12	53
2037	7891 Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, et al. hEST2, the putative human telomerase catalytic subunit gene, is up- regulated in tumor cells and during immortalization CELL. 1997 AUG 22; 90 (4): 785-795	166	1250	12	65
2038	7899 Kino K, Fushimi K, Gao C, Shima T, Mihara K, et al. Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 1997 SEP; 33 (8): 628-632	0	5	12	27
2039	7924 Ershler WB, Longo DL The biology of aging - The current research agenda CANCER. 1997 OCT 1; 80 (7): 1284-1293	1	21	12	103
2040	7929 Thomas E, AlBaker E, Dropcova S, Denyer S, Ostad N, et al. Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells EXPERIMENTAL CELL RESEARCH. 1997 OCT 10; 236 (1): 355-358	20	36	12	20
#	Date / Author / Journal	LCS	GCS	LCR	CR
2041	8116 Wu JG, He J, Mountz JD Effect of age and apoptosis on the mouse homologue of the huWRN gene MECHANISMS OF AGEING AND DEVELOPMENT. 1998 JUN 1; 103 (1): 27-44	0	12	12	69
2042	8193 Sell DR, Primc M, Schafer IA, Kovach M, Weiss MA, et al. Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo MECHANISMS OF AGEING AND DEVELOPMENT. 1998 NOV 16; 105 (3): 221-240	0	12	12	66
2043	8244 Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW Telomerase activity does not always imply telomere maintenance BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999 JAN 27; 254 (3): 795-803	22	73	12	49
2044	8337 Mochizuki K, Yamaguchi M, Abiko Y Enhancement of LPS-stimulated plasminogen activator production in aged gingival fibroblasts JOURNAL OF PERIODONTAL RESEARCH. 1999 JUL; 34 (5): 251-260	0	7	12	47
2045	8348 Newbold RF Telomerase as an anti-cancer drug target: will it fulfil its early promise? ANTI-CANCER DRUG DESIGN. 1999 AUG; 14 (4): 349-354	1	11	12	35
2046	8440 Ishino K, Kaneyama JRK, Shibanuma M, Nose K Specific decrease in the level of Hic-5, a focal adhesion protein, during immortalization of mouse embryonic fibroblasts, and its association with focal adhesion kinase JOURNAL OF CELLULAR BIOCHEMISTRY. 2000; 76 (3): 411-419	0	25	12	37
2047	8444 Bandyopadhyay D, Medrano EE Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16(INK4a)/CDK4/pRB and E2F1 MOLECULAR AND CELLULAR GERONTOLOGY. 2000; 908: 71-84	5	21	12	69
2048	8499 Layh-Schmitt G, Podtelejnikov A, Mann M Proteins complexed to the P1 adhesin of Mycoplasma pneumoniae MICROBIOLOGY-SGM. 2000 MAR; 146: 741-747	3	40	12	34
2049	8507 Openo KP, Kadrofske MM, Patterson RJ, Wang JL Galectin-3 expression and subcellular localization in senescent human fibroblasts EXPERIMENTAL CELL RESEARCH. 2000 MAR 15; 255 (2): 278-290	1	21	12	42
2050	8511 Chen JC, Astle CM, Harrison DE Genetic regulation of primitive hematopoietic stem cell senescence EXPERIMENTAL HEMATOLOGY. 2000 APR; 28 (4): 442-450	17	81	12	42
#	Date / Author / Journal	LCS	GCS	LCR	CR
2051	8545 Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, et al. Telomere reduction in human liver tissues with age and chronic inflammation EXPERIMENTAL CELL RESEARCH. 2000 MAY 1; 256 (2): 578-582	24	60	12	28
2052	8565 Fuxe J, Akusjarvi G, Goike HM, Roos G, Collins VP, et al. Adenovirus-mediated overexpression of p15(INK4B) inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16(INK4A) CELL GROWTH & DIFFERENTIATION. 2000 JUL; 11 (7): 373-384	9	47	12	80
2053	8579 Park JI, Jeong JS, Han JY, Kim DI, Gao YH, et al. Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2000 AUG; 126 (8): 455-460	13	20	12	29
2054	8596 Herskind C, Rodemann HP Spontaneous and radiation-induced differentiation of fibroblasts EXPERIMENTAL GERONTOLOGY. 2000 SEP; 35 (6-7): 747-755	11	28	12	30
2055	8665 James SE, Faragher RGA, Burke JF, Shall S, Mayne LV Werner's syndrome T lymphocytes display a normal in vitro life-span MECHANISMS OF AGEING AND DEVELOPMENT. 2000 DEC 20; 121 (1-3): 139-149	7	22	12	28
2056	8692 Uehara N, Katakura Y, Miura T, Shirahata S Subtractive screening of genes involved in cellular senescence CYTOTECHNOLOGY. 2001 JAN; 35 (1): 35-42	2	2	12	29
2057	8725 Diez C, Nestler M, Friedrich U, Vieth M, Stolte M, et al. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation CARDIOVASCULAR RESEARCH. 2001 MAR; 49 (4): 731-740	1	13	12	50
2058	8750 Aviv A Hypothesis - Pulse pressure and human longevity HYPERTENSION. 2001 APR; 37 (4): 1060-1066	2	35	12	113
2059	8754 Park WY, Hwang CI, Kang MJ, Seo JY, Chung JH, et al. Gene profile of replicative senescence is different from progeria or elderly donor BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001 APR 13; 282 (4): 934-939	7	28	12	24
2060	8763 Okumoto H Establishment of three cell lines derived from frog melanophores ZOOLOGICAL SCIENCE. 2001 MAY; 18 (4): 483-496	0	0	12	41
#	Date / Author / Journal	LCS	GCS	LCR	CR
2061	8777 Backsch C, Wagenbach N, Nonn M, Leistritz S, Stanbridge E, et al. Microcell-mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity GENES CHROMOSOMES & CANCER. 2001 JUN; 31 (2): 196-198	6	30	12	27
2062	8821 Hyland P, Barnett C, Pawelec G, Barnett Y Age-related accumulation of oxidative DNA damage and alterations in levels of p16(INK4a/CDKN2a), p21(WAF1/CIP1/SDI1) and p27(KIP1) in human CD4+T cell clones in vitro MECHANISMS OF AGEING AND DEVELOPMENT. 2001 AUG; 122 (11): 1151-1167	2	21	12	59
2063	8835 Reddel RR An alternative lifestyle for immortalized oral keratinocytes JOURNAL OF CLINICAL INVESTIGATION. 2001 SEP; 108 (5): 665-667	1	5	12	20
2064	8853 Schlessinger D, Van Zant G Does functional depletion of stem cells drive aging? MECHANISMS OF AGEING AND DEVELOPMENT. 2001 SEP 30; 122 (14): 1537-1553	5	34	12	73
2065	8867 Kool J, van Zaane W, van der Eb AJ, Terleth C Down-regulation of T-STAR, a growth inhibitory protein, after SV40- mediated immortalization CELL GROWTH & DIFFERENTIATION. 2001 NOV; 12 (11): 535-541	0	9	12	31
2066	8869 Paulus JM, Levin J, Debili N, Albert A, Vainchenker W Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies: The stochastic model revisited EXPERIMENTAL HEMATOLOGY. 2001 NOV; 29 (11): 1256-1269	0	2	12	192
2067	8901 Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation EMBO JOURNAL. 2001 DEC 17; 20 (24): 6958-6968	33	192	12	44
2068	8907 Grubeck-Loebenstein B, Wick G The aging of the immune system ADVANCES IN IMMUNOLOGY, VOL 80. 2002; 80: 243-284	6	100	12	203
2069	8918 Helder MN, Wisman GBA, van der Zee AGJ Telomerase and telomeres: From basic biology to cancer treatment CANCER INVESTIGATION. 2002; 20 (1): 82-101	4	33	12	135
2070	8937 Effros RB, Globerson A Hematopoietic cells and replicative senescence EXPERIMENTAL GERONTOLOGY. 2002 JAN-MAR; 37 (2-3): 191-196	5	16	12	43
#	Date / Author / Journal	LCS	GCS	LCR	CR
2071	8951 Steinert S, White DM, Zou Y, Shay JW, Wright WE Telomere biology and cellular aging in nonhuman primate cells EXPERIMENTAL CELL RESEARCH. 2002 JAN 15; 272 (2): 146-152	20	48	12	31
2072	9007 Schaniel C, Gottar M, Roosnek E, Melchers F, Rolink AG Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones BLOOD. 2002 APR 15; 99 (8): 2760-2766	1	29	12	35
2073	9021 Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, et al. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence EMBO JOURNAL. 2002 MAY 1; 21 (9): 2180-2188	26	93	12	57
2074	9034 Forsythe HL, Elmore LW, Jensen KO, Landon MR, Holt SE Retroviral-mediated expression of telomerase in normal human cells provides a selective growth advantage INTERNATIONAL JOURNAL OF ONCOLOGY. 2002 JUN; 20 (6): 1137-1143	4	9	12	31
2075	9075 Ohtsuka T, Yamakage A, Yamazaki S The polymorphism of telomerase RNA component gene in patients with systemic sclerosis BRITISH JOURNAL OF DERMATOLOGY. 2002 AUG; 147 (2): 250-254	0	5	12	43
2076	9084 Olshansky SJ, Hayflick L, Carnes BA Position statement on human aging JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2002 AUG; 57 (8): B292-B297	56	56	12	100
2077	9107 Brummendorf TH, Mak J, Sabo KM, Baerlocher GM, Dietz K, et al. Longitudinal studies of telomere length in feline blood cells: Implications for hematopoietic stem cell turnover in vivo EXPERIMENTAL HEMATOLOGY. 2002 OCT; 30 (10): 1147-1152	19	28	12	45
2078	9158 Lodygin D, Menssen A, Hermeking H Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner JOURNAL OF CLINICAL INVESTIGATION. 2002 DEC; 110 (11): 1717-1727	2	28	12	49
2079	9247 Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, et al. Erosion of the telomeric single-strand overhang at replicative senescence NATURE GENETICS. 2003 APR; 33 (4): 492-496	59	185	12	28
2080	9257 Tsutsui T, Kumakura S, Tamura Y, Tsutsui TW, Sekiguchi M, et al. Immortal, telomerase-negative cell lines derived from a Li-Fraumeni syndrome patient exhibit telomere length variability and chromosomal and minisatellite instabilities CARCINOGENESIS. 2003 MAY; 24 (5): 953-965	1	12	12	49
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2081	9271 Chkhotua AB, Gabusi E, Altimari A, D'Errico A, Yakubovich M, et al. Increased expression of p16((INK4a)) and p27((Kip1)) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy AMERICAN JOURNAL OF KIDNEY DISEASES. 2003 JUN; 41 (6): 1303-1313	8	30	12	30
2082	9281 Delany ME, Daniels LM, Swanberg SE, Taylor HA Telomeres in the chicken: Genome stability and chromosome ends POULTRY SCIENCE. 2003 JUN; 82 (6): 917-926	2	26	12	94
2083	9304 Kang MK, Kameta A, Shin KH, Baluda MA, Kim HR, et al. Senescence-associated genes in normal human oral keratinocytes EXPERIMENTAL CELL RESEARCH. 2003 JUL 15; 287 (2): 272-281	12	38	12	40
2084	9339 Yamamoto A, Kumakura S, Uchida M, Barrett JC, Tsutsui T Immortalization of normal human embryonic fibroblasts by introduction of either the human papillomavirus type 16 E6 or E7 gene alone INTERNATIONAL JOURNAL OF CANCER. 2003 SEP 1; 106 (3): 301-309	1	18	12	36
2085	9390 Rangarajan A, Weinberg RA Opinion - Comparative biology of mouse versus human cells: modelling human cancer in mice NATURE REVIEWS CANCER. 2003 DEC; 3 (12): 952-959	12	165	12	66
2086	9412 Ginaldi L, De Martinis M, Monti D, Franceschi C The immune system in the elderly - Activation-induced and damage- induced apoptosis IMMUNOLOGIC RESEARCH. 2004; 30 (1): 81-94	1	28	12	100
2087	9487 Wadhwa R, Takano S, Taira K, Kaul SC Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells JOURNAL OF GENE MEDICINE. 2004 APR; 6 (4): 439-444	2	28	12	30
2088	9503 Jung MS, Jin DH, Chae HD, Kang S, Kim SC, et al. Bcl-x(L) and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation JOURNAL OF BIOLOGICAL CHEMISTRY. 2004 APR 23; 279 (17): 17765-17771	4	21	12	46
2089	9513 Gerland LM, Genestier L, Peyrol S, Michallet MC, Hayette S, et al. Autolysosomes accumulate during in vitro CD8(+) T-lymphocyte aging and may participate in induced death sensitization of senescent cells EXPERIMENTAL GERONTOLOGY. 2004 MAY; 39 (5): 789-800	3	12	12	46
2090	9532 Zhu H, Tamot B, Quinton M, Walton J, Hacker RR, et al. Influence of tissue origins and external microenvironment on porcine foetal fibroblast growth, proliferative life span and genome stability CELL PROLIFERATION. 2004 JUN; 37 (3): 255-266	3	12	12	26
#	Date / Author / Journal	LCS	GCS	LCR	CR
2091	9536 Kang MK, Kameta A, Shin KH, Baluda MA, Park NH Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells JOURNAL OF CELLULAR PHYSIOLOGY. 2004 JUN; 199 (3): 364-370	4	17	12	23
2092	9550 Woo RA, Poon RYC Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation GENES & DEVELOPMENT. 2004 JUN 1; 18 (11): 1317-1330	4	39	12	65
2093	9553 Kim KH, Park GT, Lim YB, Rue SW, Jung JC, et al. Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004 JUN 11; 318 (4): 819-825	5	19	12	50
2094	9579 Mondello C, Scovassi AI Telomeres, telomerase, and apoptosis BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE. 2004 AUG; 82 (4): 498-507	2	25	12	107
2095	9596 Bocchetta M, Carbone M Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation ONCOGENE. 2004 AUG 23; 23 (38): 6484-6491	0	13	12	74
2096	9630 Caballero M, Liton PB, Challa P, Epstein DL, Gonzalez P Effects of donor age on proteasome activity and senescence in trabecular meshwork cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004 OCT 22; 323 (3): 1048-1054	0	14	12	55
2097	9635 Hampel B, Malisan F, Niederegger H, Testi R, Jansen-Durr P Differential regulation of apoptotic cell death in senescent human cells EXPERIMENTAL GERONTOLOGY. 2004 NOV-DEC; 39 (11-12): 1713-1721	18	33	12	46
2098	9674 Wennmalm K, Wahlestedt C, Larsson O The expression signature of in vitro senescence resembles mouse but not human aging GENOME BIOLOGY. 2005; 6 (13): Art. No. R109	1	13	12	30
2099	9685 Smelick C, Ahmed S Achieving immortality in the C-elegans germline AGEING RESEARCH REVIEWS. 2005 JAN; 4 (1): 67-82	1	6	12	89
2100	9705 Delgado JP, Parouchev A, Allain JE, Pennarun L, Gauthier LR, et al. Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer ONCOGENE. 2005 JAN 20; 24 (4): 541-551	0	14	12	54

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6895 ROGER PP, BAPTIST M, DUMONT JE

A MECHANISM GENERATING HETEROGENEITY IN THYROID EPITHELIAL-CELLS - SUPPRESSION OF THE THYROTROPIN CAMP-DEPENDENT MITOGENIC PATHWAY AFTER CELL-DIVISION INDUCED BY CAMP-INDEPENDENT FACTORS

JOURNAL OF CELL BIOLOGY. 1992 APR; 117 (2): 383-393

2002

6919 WRIGHT WE, SHAY JW

TELOMERE POSITIONAL EFFECTS AND THE REGULATION OF CELLULAR SENESCENCE

TRENDS IN GENETICS. 1992 JUN; 8 (6): 193-197

212

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6927 DESMOULIERE A, RUBBIABRANDT L, ABDIU A, WALZ T, MACIEIRACOELHO A, et al.

ALPHA-SMOOTH MUSCLE ACTIN IS EXPRESSED IN A SUBPOPULATION OF CULTURED AND CLONED FIBROBLASTS AND IS MODULATED BY GAMMA-INTERFERON

EXPERIMENTAL CELL RESEARCH. 1992 JUL; 201 (1): 64-73

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7002 CAMPISI J

GENE-EXPRESSION IN QUIESCENT AND SENESCENT FIBROBLASTS

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1992 NOV 21; 663: 195-201

2005

7022 MARTIN GR, DANNER DB, HOLBROOK NJ

AGING - CAUSES AND DEFENSES

ANNUAL REVIEW OF MEDICINE. 1993; 44: 419-429

2006

7069 HIRSCH HR

ACCUMULATION OF A SENESCENCE FACTOR IN YEAST-CELLS

EXPERIMENTAL GERONTOLOGY. 1993 MAR-APR; 28 (2): 195-204

2007

7141 MAZIN AL

LOSS OF ALL GENOMIC 5-METHYLCYTOSINE COINCIDES WITH THE HAYFLICK LIMIT OF AGING CELL-LINES

MOLECULAR BIOLOGY. 1993 JUL-AUG; 27 (4): 552-559

2008

7190 KUMAR S, VINCI JM, MILLIS AJT, BAGLIONI C

EXPRESSION OF INTERLEUKIN-1-ALPHA AND INTERLEUKIN-BETA IN EARLY-PASSAGE FIBROBLASTS FROM AGING INDIVIDUALS

EXPERIMENTAL GERONTOLOGY. 1993 NOV-DEC; 28 (6): 505-513

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7219 GOLDSTEIN S, LIU S, LUMPKIN CK, HUANG M, LIPSCHITZ D, et al.

DERANGEMENTS IN CALCIUM-DEPENDENT MEMBRANE CURRENTS IN SENESCENT HUMAN FIBROBLASTS ARE ASSOCIATED WITH OVEREXPRESSION OF A NOVEL GENE SEQUENCE

CALCIUM HYPOTHESIS OF AGING AND DEMENTIA. 1994; 747: 302-312

2010

7261 PATHAK S, RISIN S, BROWN NM, BERRY K

TELOMERIC ASSOCIATION OF CHROMOSOMES IS AN EARLY MANIFESTATION OF PROGRAMMED CELL-DEATH

INTERNATIONAL JOURNAL OF ONCOLOGY. 1994 FEB; 4 (2): 323-328

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7263 KILL IR, FARAGHER RGA, LAWRENCE K, SHALL S

THE EXPRESSION OF PROLIFERATION-DEPENDENT ANTIGENS DURING THE LIFE-SPAN OF NORMAL AND PROGEROID HUMAN FIBROBLASTS IN CULTURE

JOURNAL OF CELL SCIENCE. 1994 FEB; 107: 571-579

2012

7274 NODA A, NING Y, VENABLE SF, PEREIRASMITH OM, SMITH JR

CLONING OF SENESCENT CELL-DERIVED INHIBITORS OF DNA-SYNTHESIS USING AN EXPRESSION SCREEN

EXPERIMENTAL CELL RESEARCH. 1994 MAR; 211 (1): 90-98

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7296 HENSLER PJ, ANNAB LA, BARRETT JC, PEREIRASMITH OM

A GENE INVOLVED IN CONTROL OF HUMAN CELLULAR SENESCENCE ON HUMAN CHROMOSOME-1Q

MOLECULAR AND CELLULAR BIOLOGY. 1994 APR; 14 (4): 2291-2297

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7311 AFSHARI CA, BARRETT JC

DISRUPTION OF G(0)-G(1) ARREST IN QUIESCENT AND SENESCENT CELLS TREATED WITH PHOSPHATASE INHIBITORS

CANCER RESEARCH. 1994 MAY 1; 54 (9): 2317-2321

2015

7327 GRIGORIEV VG, MOERMAN EJ, GOLDSTEIN S

SENESCENCE AND CELL-DENSITY OF HUMAN-DIPLOID FIBROBLASTS INFLUENCE METABOLISM OF INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS

JOURNAL OF CELLULAR PHYSIOLOGY. 1994 JUL; 160 (1): 203-211

2016

7330 FUKAI N, AOYAGI M, YAMAMOTO M, SAKAMOTO H, OGAMI K, et al.

HUMAN ARTERIAL SMOOTH-MUSCLE CELL STRAINS DERIVED FROM PATIENTS WITH MOYAMOYA DISEASE - CHANGES IN BIOLOGICAL CHARACTERISTICS AND PROLIFERATIVE RESPONSE DURING CELLULAR AGING IN-VITRO

MECHANISMS OF AGEING AND DEVELOPMENT. 1994 JUL; 75 (1): 21-33

2017

7352 SCHMITTGRAFF A, DESMOULIERE A, GABBIANI G

HETEROGENEITY OF MYOFIBROBLAST PHENOTYPIC FEATURES - AN EXAMPLE OF FIBROBLASTIC CELL PLASTICITY

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY. 1994 AUG; 425 (1): 3-24

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2018

7359 CARLIN C, PHILLIPS PD, BROOKSFREDERICH K, KNOWLES BB, CRISTOFALO VJ

CLEAVAGE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR BY A MEMBRANE-BOUND LEUPEPTIN-SENSITIVE PROTEASE ACTIVE IN NONIONIC DETERGENT LYSATES OF SENESCENT BUT NOT YOUNG HUMAN-DIPLOID FIBROBLASTS

JOURNAL OF CELLULAR PHYSIOLOGY. 1994 SEP; 160 (3): 427-434

2019

7360 PANG JH, CHEN KY

GLOBAL CHANGE OF GENE-EXPRESSION AT LATE G1/S BOUNDARY MAY OCCUR IN HUMAN IMR-90 DIPLOID FIBROBLASTS DURING SENESCENCE

JOURNAL OF CELLULAR PHYSIOLOGY. 1994 SEP; 160 (3): 531-538

2020

7374 VANNINI F, MEACCI E, VASTA V, FARNARARO M, BRUNI P

INVOLVEMENT OF PROTEIN-KINASE-C AND ARACHIDONATE SIGNALING PATHWAYS IN THE ALTERATION OF PROLIFERATIVE RESPONSE OF SENESCENT IMR-90 HUMAN FIBROBLASTS

MECHANISMS OF AGEING AND DEVELOPMENT. 1994 OCT 20; 76 (2-3): 101-111

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2021

7375 VENABLE ME, BLOBE GC, OBEID LM

IDENTIFICATION OF A DEFECT IN THE PHOSPHOLIPASE-D DIACYLGLYCEROL PATHWAY IN CELLULAR SENESCENCE

JOURNAL OF BIOLOGICAL CHEMISTRY. 1994 OCT 21; 269 (42): 26040-26044

2022

7406 Morrison SJ, Uchida N, Weissman IL

The biology of hematopoietic stem cells

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 1995; 11: 35-71

414

241

2023

7409 Pommier JP, Lebeau J, Ducray C, Sabatier L

Chromosomal instability and alteration of telomere repeat sequences

BIOCHIMIE. 1995; 77 (10): 817-825

2024

7430 JAHAN I, BAI LY, IJIMA M, KONDO T, NAMBA M

KARYOTYPIC ANALYSIS IN THE PROCESS OF IMMORTALIZATION OF HUMAN-CELLS TREATED WITH 4-NITROQUINOLINE I-OXIDE

ACTA MEDICA OKAYAMA. 1995 FEB; 49 (1): 25-28

2025

7464 ATADJA P, WONG H, VEILLETE C, RIABOWOL K

OVEREXPRESSION OF CYCLIN D1 BLOCKS PROLIFERATION OF NORMAL DIPLOID FIBROBLASTS

EXPERIMENTAL CELL RESEARCH. 1995 APR; 217 (2): 205-216

2026

7472 LI JH, ZHANG ZY, TONG TJ

THE PROLIFERATIVE RESPONSE AND ANTIONCOGENE EXPRESSION IN OLD 2BS CELLS AFTER GROWTH-FACTOR STIMULATION

MECHANISMS OF AGEING AND DEVELOPMENT. 1995 APR 21; 80 (1): 25-34

2027

7499 WANG E

SENESCENT HUMAN FIBROBLASTS RESIST PROGRAMMED CELL-DEATH, AND FAILURE TO SUPPRESS BCL2 IS INVOLVED

CANCER RESEARCH. 1995 JUN 1; 55 (11): 2284-2292

200

2028

7551 BACCHETTI S, COUNTER CM

TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW)

INTERNATIONAL JOURNAL OF ONCOLOGY. 1995 SEP; 7 (3): 423-432

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2029

7559 WHITAKER NJ, BRYAN TM, BONNEFIN P, CHANG ACM, MUSGROVE EA, et al.

INVOLVEMENT OF RB-1, P53, P16(INK4) AND TELOMERASE IN IMMORTALIZATION OF HUMAN-CELLS

ONCOGENE. 1995 SEP 7; 11 (5): 971-976

2030

7607 Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW

Telomerase activity in human germline and embryonic tissues and cells

DEVELOPMENTAL GENETICS. 1996; 18 (2): 173-179

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2031

7638 Smith JR, Nakanishi M, Robetorye RS, Venable SF, PereiraSmith OM

Studies demonstrating the complexity of regulation and action of the growth inhibitory gene SDI1

EXPERIMENTAL GERONTOLOGY. 1996 JAN-APR; 31 (1-2): 327-335

2032

7729 Morrison SJ, Prowse KR, Ho P, Weissman IL

Telomerase activity in hematopoietic cells is associated with self- renewal potential

IMMUNITY. 1996 SEP; 5 (3): 207-216

202

2033

7737 Chow M, Rubin H

Irreversibility of cellular aging and neoplastic transformation: A clonal analysis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996 SEP 3; 93 (18): 9793-9798

2034

7748 Medcalf ASC, KleinSzanto AJP, Cristofalo VJ

Expression of p21 is not required for senescence of human fibroblasts

CANCER RESEARCH. 1996 OCT 15; 56 (20): 4582-4585

2035

7851 Bladier C, Wolvetang EJ, Hutchinson P, deHaan JB, Kola I

Response of a primary human fibroblast cell line to H2O2: Senescence- like growth arrest or apoptosis

CELL GROWTH & DIFFERENTIATION. 1997 MAY; 8 (5): 589-598

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2036

7888 Cheng RZ, Shammas MA, Li J, Reis RJS

Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells

EXPERIMENTAL CELL RESEARCH. 1997 AUG 1; 234 (2): 300-312

2037

7891 Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, et al.

hEST2, the putative human telomerase catalytic subunit gene, is up- regulated in tumor cells and during immortalization

CELL. 1997 AUG 22; 90 (4): 785-795

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7899 Kino K, Fushimi K, Gao C, Shima T, Mihara K, et al.

Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 1997 SEP; 33 (8): 628-632

2039

7924 Ershler WB, Longo DL

The biology of aging - The current research agenda

CANCER. 1997 OCT 1; 80 (7): 1284-1293

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7929 Thomas E, AlBaker E, Dropcova S, Denyer S, Ostad N, et al.

Different kinetics of senescence in human fibroblasts and peritoneal mesothelial cells

EXPERIMENTAL CELL RESEARCH. 1997 OCT 10; 236 (1): 355-358

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2041

8116 Wu JG, He J, Mountz JD

Effect of age and apoptosis on the mouse homologue of the huWRN gene

MECHANISMS OF AGEING AND DEVELOPMENT. 1998 JUN 1; 103 (1): 27-44

2042

8193 Sell DR, Primc M, Schafer IA, Kovach M, Weiss MA, et al.

Cell-associated pentosidine as a marker of aging in human diploid cells in vitro and in vivo

MECHANISMS OF AGEING AND DEVELOPMENT. 1998 NOV 16; 105 (3): 221-240

2043

8244 Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW

Telomerase activity does not always imply telomere maintenance

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999 JAN 27; 254 (3): 795-803

2044

8337 Mochizuki K, Yamaguchi M, Abiko Y

Enhancement of LPS-stimulated plasminogen activator production in aged gingival fibroblasts

JOURNAL OF PERIODONTAL RESEARCH. 1999 JUL; 34 (5): 251-260

2045

8348 Newbold RF

Telomerase as an anti-cancer drug target: will it fulfil its early promise?

ANTI-CANCER DRUG DESIGN. 1999 AUG; 14 (4): 349-354

2046

8440 Ishino K, Kaneyama JRK, Shibanuma M, Nose K

Specific decrease in the level of Hic-5, a focal adhesion protein, during immortalization of mouse embryonic fibroblasts, and its association with focal adhesion kinase

JOURNAL OF CELLULAR BIOCHEMISTRY. 2000; 76 (3): 411-419

2047

8444 Bandyopadhyay D, Medrano EE

Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16(INK4a)/CDK4/pRB and E2F1

MOLECULAR AND CELLULAR GERONTOLOGY. 2000; 908: 71-84

2048

8499 Layh-Schmitt G, Podtelejnikov A, Mann M

Proteins complexed to the P1 adhesin of Mycoplasma pneumoniae

MICROBIOLOGY-SGM. 2000 MAR; 146: 741-747

2049

8507 Openo KP, Kadrofske MM, Patterson RJ, Wang JL

Galectin-3 expression and subcellular localization in senescent human fibroblasts

EXPERIMENTAL CELL RESEARCH. 2000 MAR 15; 255 (2): 278-290

2050

8511 Chen JC, Astle CM, Harrison DE

Genetic regulation of primitive hematopoietic stem cell senescence

EXPERIMENTAL HEMATOLOGY. 2000 APR; 28 (4): 442-450

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2051

8545 Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, et al.

Telomere reduction in human liver tissues with age and chronic inflammation

EXPERIMENTAL CELL RESEARCH. 2000 MAY 1; 256 (2): 578-582

2052

8565 Fuxe J, Akusjarvi G, Goike HM, Roos G, Collins VP, et al.

Adenovirus-mediated overexpression of p15(INK4B) inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16(INK4A)

CELL GROWTH & DIFFERENTIATION. 2000 JUL; 11 (7): 373-384

2053

8579 Park JI, Jeong JS, Han JY, Kim DI, Gao YH, et al.

Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2000 AUG; 126 (8): 455-460

2054

8596 Herskind C, Rodemann HP

Spontaneous and radiation-induced differentiation of fibroblasts

EXPERIMENTAL GERONTOLOGY. 2000 SEP; 35 (6-7): 747-755

2055

8665 James SE, Faragher RGA, Burke JF, Shall S, Mayne LV

Werner's syndrome T lymphocytes display a normal in vitro life-span

MECHANISMS OF AGEING AND DEVELOPMENT. 2000 DEC 20; 121 (1-3): 139-149

2056

8692 Uehara N, Katakura Y, Miura T, Shirahata S

Subtractive screening of genes involved in cellular senescence

CYTOTECHNOLOGY. 2001 JAN; 35 (1): 35-42

2057

8725 Diez C, Nestler M, Friedrich U, Vieth M, Stolte M, et al.

Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation

CARDIOVASCULAR RESEARCH. 2001 MAR; 49 (4): 731-740

2058

8750 Aviv A

Hypothesis - Pulse pressure and human longevity

HYPERTENSION. 2001 APR; 37 (4): 1060-1066

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8754 Park WY, Hwang CI, Kang MJ, Seo JY, Chung JH, et al.

Gene profile of replicative senescence is different from progeria or elderly donor

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001 APR 13; 282 (4): 934-939

2060

8763 Okumoto H

Establishment of three cell lines derived from frog melanophores

ZOOLOGICAL SCIENCE. 2001 MAY; 18 (4): 483-496

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2061

8777 Backsch C, Wagenbach N, Nonn M, Leistritz S, Stanbridge E, et al.

Microcell-mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity

GENES CHROMOSOMES & CANCER. 2001 JUN; 31 (2): 196-198

2062

8821 Hyland P, Barnett C, Pawelec G, Barnett Y

Age-related accumulation of oxidative DNA damage and alterations in levels of p16(INK4a/CDKN2a), p21(WAF1/CIP1/SDI1) and p27(KIP1) in human CD4+T cell clones in vitro

MECHANISMS OF AGEING AND DEVELOPMENT. 2001 AUG; 122 (11): 1151-1167

2063

8835 Reddel RR

An alternative lifestyle for immortalized oral keratinocytes

JOURNAL OF CLINICAL INVESTIGATION. 2001 SEP; 108 (5): 665-667

2064

8853 Schlessinger D, Van Zant G

Does functional depletion of stem cells drive aging?

MECHANISMS OF AGEING AND DEVELOPMENT. 2001 SEP 30; 122 (14): 1537-1553

2065

8867 Kool J, van Zaane W, van der Eb AJ, Terleth C

Down-regulation of T-STAR, a growth inhibitory protein, after SV40- mediated immortalization

CELL GROWTH & DIFFERENTIATION. 2001 NOV; 12 (11): 535-541

2066

8869 Paulus JM, Levin J, Debili N, Albert A, Vainchenker W

Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies: The stochastic model revisited

EXPERIMENTAL HEMATOLOGY. 2001 NOV; 29 (11): 1256-1269

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2067

8901 Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, et al.

A highly selective telomerase inhibitor limiting human cancer cell proliferation

EMBO JOURNAL. 2001 DEC 17; 20 (24): 6958-6968

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8907 Grubeck-Loebenstein B, Wick G

The aging of the immune system

ADVANCES IN IMMUNOLOGY, VOL 80. 2002; 80: 243-284

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203

2069

8918 Helder MN, Wisman GBA, van der Zee AGJ

Telomerase and telomeres: From basic biology to cancer treatment

CANCER INVESTIGATION. 2002; 20 (1): 82-101

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8937 Effros RB, Globerson A

Hematopoietic cells and replicative senescence

EXPERIMENTAL GERONTOLOGY. 2002 JAN-MAR; 37 (2-3): 191-196

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2071

8951 Steinert S, White DM, Zou Y, Shay JW, Wright WE

Telomere biology and cellular aging in nonhuman primate cells

EXPERIMENTAL CELL RESEARCH. 2002 JAN 15; 272 (2): 146-152

2072

9007 Schaniel C, Gottar M, Roosnek E, Melchers F, Rolink AG

Extensive in vivo self-renewal, long-term reconstitution capacity, and hematopoietic multipotency of Pax5-deficient precursor B-cell clones

BLOOD. 2002 APR 15; 99 (8): 2760-2766

2073

9021 Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, et al.

Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

EMBO JOURNAL. 2002 MAY 1; 21 (9): 2180-2188

2074

9034 Forsythe HL, Elmore LW, Jensen KO, Landon MR, Holt SE

Retroviral-mediated expression of telomerase in normal human cells provides a selective growth advantage

INTERNATIONAL JOURNAL OF ONCOLOGY. 2002 JUN; 20 (6): 1137-1143

2075

9075 Ohtsuka T, Yamakage A, Yamazaki S

The polymorphism of telomerase RNA component gene in patients with systemic sclerosis

BRITISH JOURNAL OF DERMATOLOGY. 2002 AUG; 147 (2): 250-254

2076

9084 Olshansky SJ, Hayflick L, Carnes BA

Position statement on human aging

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2002 AUG; 57 (8): B292-B297

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9107 Brummendorf TH, Mak J, Sabo KM, Baerlocher GM, Dietz K, et al.

Longitudinal studies of telomere length in feline blood cells: Implications for hematopoietic stem cell turnover in vivo

EXPERIMENTAL HEMATOLOGY. 2002 OCT; 30 (10): 1147-1152

2078

9158 Lodygin D, Menssen A, Hermeking H

Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

JOURNAL OF CLINICAL INVESTIGATION. 2002 DEC; 110 (11): 1717-1727

2079

9247 Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, et al.

Erosion of the telomeric single-strand overhang at replicative senescence

NATURE GENETICS. 2003 APR; 33 (4): 492-496

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9257 Tsutsui T, Kumakura S, Tamura Y, Tsutsui TW, Sekiguchi M, et al.

Immortal, telomerase-negative cell lines derived from a Li-Fraumeni syndrome patient exhibit telomere length variability and chromosomal and minisatellite instabilities

CARCINOGENESIS. 2003 MAY; 24 (5): 953-965

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2081

9271 Chkhotua AB, Gabusi E, Altimari A, D'Errico A, Yakubovich M, et al.

Increased expression of p16((INK4a)) and p27((Kip1)) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy

AMERICAN JOURNAL OF KIDNEY DISEASES. 2003 JUN; 41 (6): 1303-1313

2082

9281 Delany ME, Daniels LM, Swanberg SE, Taylor HA

Telomeres in the chicken: Genome stability and chromosome ends

POULTRY SCIENCE. 2003 JUN; 82 (6): 917-926

2083

9304 Kang MK, Kameta A, Shin KH, Baluda MA, Kim HR, et al.

Senescence-associated genes in normal human oral keratinocytes

EXPERIMENTAL CELL RESEARCH. 2003 JUL 15; 287 (2): 272-281

2084

9339 Yamamoto A, Kumakura S, Uchida M, Barrett JC, Tsutsui T

Immortalization of normal human embryonic fibroblasts by introduction of either the human papillomavirus type 16 E6 or E7 gene alone

INTERNATIONAL JOURNAL OF CANCER. 2003 SEP 1; 106 (3): 301-309

2085

9390 Rangarajan A, Weinberg RA

Opinion - Comparative biology of mouse versus human cells: modelling human cancer in mice

NATURE REVIEWS CANCER. 2003 DEC; 3 (12): 952-959

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9412 Ginaldi L, De Martinis M, Monti D, Franceschi C

The immune system in the elderly - Activation-induced and damage- induced apoptosis

IMMUNOLOGIC RESEARCH. 2004; 30 (1): 81-94

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9487 Wadhwa R, Takano S, Taira K, Kaul SC

Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells

JOURNAL OF GENE MEDICINE. 2004 APR; 6 (4): 439-444

2088

9503 Jung MS, Jin DH, Chae HD, Kang S, Kim SC, et al.

Bcl-x(L) and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation

JOURNAL OF BIOLOGICAL CHEMISTRY. 2004 APR 23; 279 (17): 17765-17771

2089

9513 Gerland LM, Genestier L, Peyrol S, Michallet MC, Hayette S, et al.

Autolysosomes accumulate during in vitro CD8(+) T-lymphocyte aging and may participate in induced death sensitization of senescent cells

EXPERIMENTAL GERONTOLOGY. 2004 MAY; 39 (5): 789-800

2090

9532 Zhu H, Tamot B, Quinton M, Walton J, Hacker RR, et al.

Influence of tissue origins and external microenvironment on porcine foetal fibroblast growth, proliferative life span and genome stability

CELL PROLIFERATION. 2004 JUN; 37 (3): 255-266

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2091

9536 Kang MK, Kameta A, Shin KH, Baluda MA, Park NH

Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells

JOURNAL OF CELLULAR PHYSIOLOGY. 2004 JUN; 199 (3): 364-370

2092

9550 Woo RA, Poon RYC

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

GENES & DEVELOPMENT. 2004 JUN 1; 18 (11): 1317-1330

2093

9553 Kim KH, Park GT, Lim YB, Rue SW, Jung JC, et al.

Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004 JUN 11; 318 (4): 819-825

2094

9579 Mondello C, Scovassi AI

Telomeres, telomerase, and apoptosis

BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE. 2004 AUG; 82 (4): 498-507

107

2095

9596 Bocchetta M, Carbone M

Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation

ONCOGENE. 2004 AUG 23; 23 (38): 6484-6491

2096

9630 Caballero M, Liton PB, Challa P, Epstein DL, Gonzalez P

Effects of donor age on proteasome activity and senescence in trabecular meshwork cells

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004 OCT 22; 323 (3): 1048-1054

2097

9635 Hampel B, Malisan F, Niederegger H, Testi R, Jansen-Durr P

Differential regulation of apoptotic cell death in senescent human cells

EXPERIMENTAL GERONTOLOGY. 2004 NOV-DEC; 39 (11-12): 1713-1721

2098

9674 Wennmalm K, Wahlestedt C, Larsson O

The expression signature of in vitro senescence resembles mouse but not human aging

GENOME BIOLOGY. 2005; 6 (13): Art. No. R109

2099

9685 Smelick C, Ahmed S

Achieving immortality in the C-elegans germline

AGEING RESEARCH REVIEWS. 2005 JAN; 4 (1): 67-82

2100

9705 Delgado JP, Parouchev A, Allain JE, Pennarun L, Gauthier LR, et al.

Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer

ONCOGENE. 2005 JAN 20; 24 (4): 541-551

Hayflick w/citing papers Len Hayflick publications & the papers citing L Hayflick.	Historiographs	Glossary HistCite Guide About Grand Totals: LCS 84164, GCS 458115, CR 564869 Collection span: 1953 - 2011
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