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#	Date / Author / Journal	LCS	GCS	LCR	CR
1501	5892 LUMPKIN CK, KNEPPER JE, BUTEL JS, SMITH JR, PEREIRASMITH OM MITOGENIC EFFECTS OF THE PROTOONCOGENE AND ONCOGENE FORMS OF C-H-RAS DNA IN HUMAN-DIPLOID FIBROBLASTS MOLECULAR AND CELLULAR BIOLOGY. 1986 AUG; 6 (8): 2990-2993	13	38	14	36
1502	5940 MUKHERJEE AB, WEINSTEIN ME CULTURE MEDIA VARIATION AS RELATED TO INVITRO AGING OF HUMAN- FIBROBLASTS .1. EFFECTS ON POPULATION DOUBLING, NUCLEAR VOLUME AND NUCLEAR MORPHOLOGY MECHANISMS OF AGEING AND DEVELOPMENT. 1986 NOV 28; 37 (1): 55-67	3	4	14	20
1503	5978 ROSEN R CELLULAR SENESCENCE INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY. 1987; : 737-753	0	0	14	44
1504	6195 MADOFF S, HOOPER DC NONGENITOURINARY INFECTIONS CAUSED BY MYCOPLASMA-HOMINIS IN ADULTS REVIEWS OF INFECTIOUS DISEASES. 1988 MAY-JUN; 10 (3): 602-613	5	75	14	48
1505	6197 WASHBURN LR, RAMSAY JR, ANDREWS MB RECOGNITION OF MYCOPLASMA-ARTHRITIDIS MEMBRANE-ANTIGENS BY RATS AND RABBITS - COMPARISON BY IMMUNOBLOTTING AND RADIOIMMUNOPRECIPITATION VETERINARY MICROBIOLOGY. 1988 MAY; 17 (1): 45-57	0	6	14	38
1506	6211 DELLORCO RT, WORTHINGTON MI THE EFFECTS OF INVITRO AGE AND CULTURE STATE ON HISTONE VARIANT SYNTHESIS IN HUMAN-DIPLOID FIBROBLASTS JOURNAL OF CELLULAR PHYSIOLOGY. 1988 JUL; 136 (1): 168-174	5	5	14	31
1507	6292 HIRSCH HR, COOMES JA, WITTEN M THE WASTE-PRODUCT THEORY OF AGING - TRANSFORMATION TO UNLIMITED GROWTH IN CELL-CULTURES EXPERIMENTAL GERONTOLOGY. 1989; 24 (2): 97-112	7	9	14	18
1508	6430 RODEMANN HP DIFFERENTIAL DEGRADATION OF INTRACELLULAR PROTEINS IN HUMAN-SKIN FIBROBLASTS OF MITOTIC AND MITOMYCIN-C (MMC)-INDUCED POSTMITOTIC DIFFERENTIATION STATES INVITRO DIFFERENTIATION. 1989 OCT; 42 (1): 37-43	24	49	14	32
1509	6456 GIORDANO T, FOSTER DN IDENTIFICATION OF A HIGHLY ABUNDANT CDNA ISOLATED FROM SENESCENT WI-38 CELLS EXPERIMENTAL CELL RESEARCH. 1989 DEC; 185 (2): 399-406	23	29	14	27
1510	6580 RUBIN H THE SIGNIFICANCE OF BIOLOGICAL HETEROGENEITY CANCER AND METASTASIS REVIEWS. 1990 JUL; 9 (1): 1-20	0	53	14	92
#	Date / Author / Journal	LCS	GCS	LCR	CR
1511	6605 KENNY GE, KAISER GG, COONEY MK, FOY HM DIAGNOSIS OF MYCOPLASMA-PNEUMONIAE PNEUMONIA - SENSITIVITIES AND SPECIFICITIES OF SEROLOGY WITH LIPID ANTIGEN AND ISOLATION OF THE ORGANISM ON SOY PEPTONE MEDIUM FOR IDENTIFICATION OF INFECTIONS JOURNAL OF CLINICAL MICROBIOLOGY. 1990 SEP; 28 (9): 2087-2093	6	60	14	41
1512	6610 MULLAART E, LOHMAN PHM, BERENDS F, VIJG J DNA DAMAGE METABOLISM AND AGING MUTATION RESEARCH. 1990 SEP-NOV; 237 (5-6): 189-210	8	119	14	202
1513	6709 RINEHART CA, HASKILL JS, MORRIS JS, BUTLER TD, KAUFMAN DG EXTENDED LIFE-SPAN OF HUMAN ENDOMETRIAL STROMAL CELLS TRANSFECTED WITH CLONED ORIGIN-DEFECTIVE, TEMPERATURE-SENSITIVE SIMIAN VIRUS-40 JOURNAL OF VIROLOGY. 1991 MAR; 65 (3): 1458-1465	5	26	14	61
1514	6885 WANG XW, LIN XH, KLEIN CB, BHAMRA RK, LEE YW, et al. A CONSERVED REGION IN HUMAN AND CHINESE-HAMSTER X-CHROMOSOMES CAN INDUCE CELLULAR SENESCENCE OF NICKEL-TRANSFORMED CHINESE-HAMSTER CELL- LINES CARCINOGENESIS. 1992 APR; 13 (4): 555-561	10	33	14	57
1515	6913 KUMAR S, MILLIS AJT, BAGLIONI C EXPRESSION OF INTERLEUKIN-1-INDUCIBLE GENES AND PRODUCTION OF INTERLEUKIN-1 BY AGING HUMAN FIBROBLASTS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992 MAY 15; 89 (10): 4683-4687	35	87	14	47
1516	6926 PIGNOLO RJ, MASORO EJ, NICHOLS WW, BRADT CI, CRISTOFALO VJ SKIN FIBROBLASTS FROM AGED FISCHER-344 RATS UNDERGO SIMILAR CHANGES IN REPLICATIVE LIFE-SPAN BUT NOT IMMORTALIZATION WITH CALORIC RESTRICTION OF DONORS EXPERIMENTAL CELL RESEARCH. 1992 JUL; 201 (1): 16-22	12	21	14	36
1517	6952 DANNER DB THE PROLIFERATION THEORY OF REJUVENATION MECHANISMS OF AGEING AND DEVELOPMENT. 1992 AUG; 65 (1): 85-107	3	4	14	71
1518	6968 MILES RJ CATABOLISM IN MOLLICUTES JOURNAL OF GENERAL MICROBIOLOGY. 1992 SEP; 138: 1773-1783	1	42	14	91
1519	6986 FREDERICH KB, PHILLIPS PD, CRISTOFALO VJ STIMULATION OF DNA-SYNTHESIS IN SENESCENT HUMAN-CELLS FOLLOWING INCUBATION WITH PLASMA-MEMBRANES EXPERIMENTAL CELL RESEARCH. 1992 OCT; 202 (2): 386-390	5	6	14	27
1520	7009 TAKEDA K, GOSIEWSKA A, PETERKOFSKY B SIMILAR, BUT NOT IDENTICAL, MODULATION OF EXPRESSION OF EXTRACELLULAR- MATRIX COMPONENTS DURING INVITRO AND INVIVO AGING OF HUMAN SKIN FIBROBLASTS JOURNAL OF CELLULAR PHYSIOLOGY. 1992 DEC; 153 (3): 450-459	13	65	14	44
#	Date / Author / Journal	LCS	GCS	LCR	CR
1521	7063 PERILLO NL, NAEIM F, WALFORD RL, EFFROS RB THE INVITRO SENESCENCE OF HUMAN T-LYMPHOCYTES - FAILURE TO DIVIDE IS NOT ASSOCIATED WITH A LOSS OF CYTOLYTIC ACTIVITY OR MEMORY T-CELL PHENOTYPE MECHANISMS OF AGEING AND DEVELOPMENT. 1993 FEB; 67 (1-2): 173-185	17	42	14	45
1522	7065 PANG JH, CHEN KY A SPECIFIC CCAAT-BINDING PROTEIN, CBP/TK, MAY BE INVOLVED IN THE REGULATION OF THYMIDINE KINASE GENE-EXPRESSION IN HUMAN IMR-90 DIPLOID FIBROBLASTS DURING SENESCENCE JOURNAL OF BIOLOGICAL CHEMISTRY. 1993 FEB 5; 268 (4): 2909-2916	18	48	14	55
1523	7084 WADHWA R, KAUL SC, IKAWA Y, SUGIMOTO Y IDENTIFICATION OF A NOVEL MEMBER OF MOUSE HSP70 FAMILY - ITS ASSOCIATION WITH CELLULAR MORTAL PHENOTYPE JOURNAL OF BIOLOGICAL CHEMISTRY. 1993 MAR 25; 268 (9): 6615-6621	27	120	14	37
1524	7185 WADHWA R, KAUL SC, SUGIMOTO Y, MITSUI Y INDUCTION OF CELLULAR SENESCENCE BY TRANSFECTION OF CYTOSOLIC MORTALIN CDNA IN NIH-3T3-CELLS JOURNAL OF BIOLOGICAL CHEMISTRY. 1993 OCT 25; 268 (30): 22239-22242	22	75	14	30
1525	7291 BRENNEISEN P, GOGOL J, BAYREUTHER K DNA-SYNTHESIS AND FOS AND JUN PROTEIN EXPRESSION IN MITOTIC AND POSTMITOTIC WI-38 FIBROBLASTS IN-VITRO EXPERIMENTAL CELL RESEARCH. 1994 APR; 211 (2): 219-230	3	19	14	55
1526	7332 ATADJA PW, STRINGER KF, RIABOWOL KT LOSS OF SERUM RESPONSE ELEMENT-BINDING ACTIVITY AND HYPERPHOSPHORYLATION OF SERUM RESPONSE FACTOR DURING CELLULAR AGING MOLECULAR AND CELLULAR BIOLOGY. 1994 JUL; 14 (7): 4991-4999	28	52	14	56
1527	7333 PROFT T, HERRMANN R IDENTIFICATION AND CHARACTERIZATION OF HITHERTO UNKNOWN MYCOPLASMA- PNEUMONIAE PROTEINS MOLECULAR MICROBIOLOGY. 1994 JUL; 13 (2): 337-348	14	47	14	64
1528	7376 MARTIN GM GENETIC MODULATION OF TELOMERIC TERMINAL RESTRICTION FRAGMENT LENGTH - RELEVANCE FOR CLONAL AGING AND LATE-LIFE DISEASE AMERICAN JOURNAL OF HUMAN GENETICS. 1994 NOV; 55 (5): 866-869	1	12	14	42
1529	7396 GOLDSTEIN S, MOERMAN EJ, FUJII S, SOBEL BE OVEREXPRESSION OF PLASMINOGEN-ACTIVATOR INHIBITOR TYPE-1 IN SENESCENT FIBROBLASTS FROM NORMAL SUBJECTS AND THOSE WITH WERNER SYNDROME JOURNAL OF CELLULAR PHYSIOLOGY. 1994 DEC; 161 (3): 571-579	17	32	14	34
1530	7404 SASAKI M, HONDA T, YAMADA H, WAKE N, BARRETT JC, et al. EVIDENCE FOR MULTIPLE PATHWAYS TO CELLULAR SENESCENCE CANCER RESEARCH. 1994 DEC 1; 54 (23): 6090-6093	38	71	14	33
#	Date / Author / Journal	LCS	GCS	LCR	CR
1531	7432 KANEKO S, SATOH Y, IKEMURA K, KONISHI T, OHJI T, et al. ALTERATIONS OF EXPRESSION OF THE CYTOSKELETON AFTER IMMORTALIZATION OF HUMAN FIBROBLASTS CELL STRUCTURE AND FUNCTION. 1995 FEB; 20 (1): 107-115	6	11	14	54
1532	7459 ONEILL FJ, FRISQUE RJ, XU XL, HU YX, CARNEY H IMMORTALIZATION OF HUMAN-CELLS BY MUTANT AND CHIMERIC PRIMATE POLYOMAVIRUS T-ANTIGEN GENES ONCOGENE. 1995 MAR 16; 10 (6): 1131-1139	1	10	14	66
1533	7534 FUJII M, IDE T, WADHWA R, TAHARA H, KAUL SC, et al. INHIBITORS OF CGMP-DEPENDENT PROTEIN-KINASE BLOCK SENESCENCE INDUCED BY INACTIVATION OF T-ANTIGEN IN SV40-TRANSFORMED IMMORTAL HUMAN FIBROBLASTS ONCOGENE. 1995 AUG 17; 11 (4): 627-634	9	26	14	45
1534	7564 DIMRI GP, LEE XH, BASILE G, ACOSTA M, SCOTT C, et al. A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995 SEP 26; 92 (20): 9363-9367	788	2315	14	31
1535	7570 OHMURA H, TAHARA H, SUZUKI M, IDE T, SHIMIZU M, et al. RESTORATION OF THE CELLULAR SENESCENCE PROGRAM AND REPRESSION OF TELOMERASE BY HUMAN-CHROMOSOME-3 JAPANESE JOURNAL OF CANCER RESEARCH. 1995 OCT; 86 (10): 899-904	40	112	14	23
1536	7643 Karlsson C, Stenman G, Vojta PJ, BongcamRudloff E, Barrett JC, et al. Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q CANCER RESEARCH. 1996 JAN 15; 56 (2): 241-245	6	16	14	26
1537	7685 Hu QB, Moerman EJ, Goldstein S Altered expression and regulation of the alpha 5 beta 1 integrin- fibronectin receptor lead to reduced amounts of functional alpha 5 beta 1 heterodimer on the plasma membrane of senescent human diploid fibroblasts EXPERIMENTAL CELL RESEARCH. 1996 MAY 1; 224 (2): 251-263	4	20	14	60
1538	7698 Chin JH, Okazaki M, Frazier JS, Hu ZW, Hoffman BB Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 1996 JUL; 40 (1): C362-C371	0	14	14	30
1539	7716 Yamada O Telomeres and telomerase in human hematologic neoplasia INTERNATIONAL JOURNAL OF HEMATOLOGY. 1996 AUG; 64 (2): 87-99	0	5	14	72
1540	7754 Hiraga S, Arita N, Ohnishi T, Izumoto S, Taki T, et al. Establishment of spontaneously immortalized rat type 1 astroglial cell lines: The role of p53 in astroglial carcinogenesis GLIA. 1996 NOV; 18 (3): 185-199	0	4	14	81
#	Date / Author / Journal	LCS	GCS	LCR	CR
1541	7777 Wang S, Moerman EJ, Jones RA, Thweatt R, Goldstein S Characterization of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblasts MECHANISMS OF AGEING AND DEVELOPMENT. 1996 DEC 20; 92 (2-3): 121-132	3	13	14	45
1542	7824 deHaan G, Nijhof W, VanZant G Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity BLOOD. 1997 MAR 1; 89 (5): 1543-1550	21	124	14	42
1543	7898 Effros RB, Pawelec G Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? IMMUNOLOGY TODAY. 1997 SEP; 18 (9): 450-454	25	204	14	47
1544	7904 Sugrue MM, Shin DY, Lee SW, Aaronson SA Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997 SEP 2; 94 (18): 9648-9653	57	186	14	44
1545	8032 Vogt M, Haggblom C, Yeargin J, Christiansen-Weber T, Haas M Independent induction of senescence by p16(INK4a) and p21(CIP1) in spontaneously immortalized human fibroblasts CELL GROWTH & DIFFERENTIATION. 1998 FEB; 9 (2): 139-146	43	89	14	29
1546	8049 Hahn TW, Willey MJ, Krause DC HMW1 is required for cytadhesin P1 trafficking to the attachment organelle in Mycoplasma pneumoniae JOURNAL OF BACTERIOLOGY. 1998 MAR; 180 (5): 1270-1276	10	36	14	30
1547	8145 Macieira-Coelho A Markers of 'cell senescence' (vol 103, pg 105, 1998) MECHANISMS OF AGEING AND DEVELOPMENT. 1998 AUG 14; 104 (2): 207-211	3	4	14	22
1548	8203 Mendez MV, Stanley A, Phillips T, Menzoian JO, Park HY Fibroblasts cultured from distal lower extremities in patients with venous reflux display cellular characteristics of senescence JOURNAL OF VASCULAR SURGERY. 1998 DEC; 28 (6): 1040-1048	6	29	14	24
1549	8211 Lichtsteiner SP, Lebkowski JS, Vasserot AP Telomerase - A target for anticancer therapy ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN. 1999; 886: 1-11	1	27	14	61
1550	8231 Sourlingas TG, Steger M, Grubeck-Loebenstein B, Tsapali DS, Sekeri-Pataryas KE T-lymphocyte long-term cultures have a constant histone variant pattern during aging EXPERIMENTAL GERONTOLOGY. 1999 JAN; 34 (1): 59-67	0	3	14	35
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1551	8241 Cuthbert AP, Bond J, Trott DA, Gill S, Broni J, et al. Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1999 JAN 6; 91 (1): 37-45	14	92	14	57
1552	8248 Kano Y, Motoda H, Hiragami F, Matsui K, Little JB, et al. SV40LT highly mutates and immortalizes two fibroblast strains from patients with Wilms' tumor CELL STRUCTURE AND FUNCTION. 1999 FEB; 24 (1): 35-41	0	0	14	30
1553	8264 Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, et al. Analysis of genomic integrity and p53-dependent G(1) checkpoint in telomerase-induced extended-life-span human fibroblasts MOLECULAR AND CELLULAR BIOLOGY. 1999 MAR; 19 (3): 2373-2379	29	79	14	36
1554	8281 De Haan G, Van Zant G Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span FASEB JOURNAL. 1999 APR; 13 (6): 707-713	12	49	14	49
1555	8285 Meyyappan M, Wheaton K, Riabowol KT Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 29-39	5	17	14	49
1556	8286 Sayama K, Shirakata Y, Midorikawa K, Hanakawa Y, Hashimoto K Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 40-44	5	24	14	26
1557	8349 Kagawa S, Fujiwara T, Kadowaki Y, Fukazawa T, Sok-Joo R, et al. Overexpression of the p21(sdi1) gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer CELL DEATH AND DIFFERENTIATION. 1999 AUG; 6 (8): 765-772	7	23	14	43
1558	8356 Chang BD, Broude EV, Dokmanovic M, Zhu HM, Ruth A, et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents CANCER RESEARCH. 1999 AUG 1; 59 (15): 3761-3767	56	217	14	55
1559	8363 Chang BD, Xuan YZ, Broude EV, Zhu HM, Schott B, et al. Role of p53 and p21(waf1/cip1) in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs ONCOGENE. 1999 AUG 26; 18 (34): 4808-4818	33	164	14	43
1560	8457 Fossel M Cell senescence in human aging: A review of the theory IN VIVO. 2000 JAN-FEB; 14 (1): 29-34	13	18	14	53
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1561	8464 Effros RB Telomeres and HIV disease MICROBES AND INFECTION. 2000 JAN; 2 (1): 69-76	2	12	14	79
1562	8546 Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, et al. PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000 MAY 10; 271 (2): 305-310	0	4	14	38
1563	8632 Kim JK, Ryll R, Ishizuka Y, Kato S Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts GENE. 2000 OCT 31; 257 (2): 327-334	1	10	14	26
1564	8696 Tan Z Simulated shortening of proliferation-restricting telomeres during clonal proliferation and senescence of human cells EXPERIMENTAL GERONTOLOGY. 2001 JAN; 36 (1): 89-97	3	3	14	26
1565	8700 Suzuki K, Mori I, Nakayama Y, Miyakoda M, Kodama S, et al. Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening RADIATION RESEARCH. 2001 JAN; 155 (1): 248-253	18	59	14	41
1566	8713 Melk A, Halloran PF Cell senescence and its implications for nephrology JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2001 FEB; 12 (2): 385-393	9	48	14	54
1567	8727 Suzuki T, Minagawa S, Michishita E, Ogino H, Fujii M, et al. Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells EXPERIMENTAL GERONTOLOGY. 2001 MAR; 36 (3): 465-474	22	48	14	38
1568	8740 Rocco JW, Sidransky D p16(MTS-1/CDKN2/INK4a) in cancer progression EXPERIMENTAL CELL RESEARCH. 2001 MAR 10; 264 (1): 42-55	5	204	14	260
1569	8756 Allsopp RC, Cheshier S, Weissman IL Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells JOURNAL OF EXPERIMENTAL MEDICINE. 2001 APR 16; 193 (8): 917-924	18	96	14	43
1570	8790 Wagner M, Brosch G, Zwerschke W, Seto E, Loidl P, et al. Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2 FEBS LETTERS. 2001 JUN 15; 499 (1-2): 101-106	5	17	14	45
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1571	8905 Sozou PD, Kirkwood TBL A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA JOURNAL OF THEORETICAL BIOLOGY. 2001 DEC 21; 213 (4): 573-586	18	43	14	26
1572	8919 de Haan G Hematopoietic stem cells: Self-renewing or aging? CELLS TISSUES ORGANS. 2002; 171 (1): 27-37	0	5	14	95
1573	9000 Benvenuti S, Cramer R, Quinn CC, Bruce J, Zvelebil M, et al. Differential proteome analysis of replicative senescence in rat embryo fibroblasts MOLECULAR & CELLULAR PROTEOMICS. 2002 APR; 1 (4): 280-292	6	26	14	68
1574	9026 Park JK, Kim BH, Han YS, Park IK The effect of telomerase expression on the escape from M2 crisis in virus-transformed human retinal pigment epithelial cells EXPERIMENTAL AND MOLECULAR MEDICINE. 2002 MAY 31; 34 (2): 107-113	0	2	14	21
1575	9089 Kim H, Farris J, Christman SA, Kong BW, Foster LK, et al. Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase BIOCHEMICAL JOURNAL. 2002 AUG 1; 365: 765-772	9	24	14	46
1576	9104 Lorenzini A, Tresini M, Mawal-Dewan M, Frisoni L, Zhang H, et al. Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence EXPERIMENTAL GERONTOLOGY. 2002 OCT-NOV; 37 (10-11): 1149-1156	2	18	14	29
1577	9131 Chainiaux F, Magalhaes JP, Eliaers F, Remacle J, Toussaint O UVB-induced premature senescence of human diploid skin fibroblasts INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2002 NOV; 34 (11): 1331-1339	7	19	14	23
1578	9148 Dierick JF, Kalume DE, Wenders F, Salmon M, Dieu M, et al. Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence FEBS LETTERS. 2002 NOV 20; 531 (3): 499-504	16	32	14	39
1579	9161 Huot TJ, Rowe J, Harland M, Drayton S, Brookes S, et al. Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets- induced senescence in human diploid fibroblasts MOLECULAR AND CELLULAR BIOLOGY. 2002 DEC; 22 (23): 8135-8143	19	73	14	54
1580	9207 Roninson IB, Dokmanovic M Induction of senescence-associated growth inhibitors in the tumor- suppressive function of retinoids JOURNAL OF CELLULAR BIOCHEMISTRY. 2003 JAN 1; 88 (1): 83-94	4	24	14	106
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1581	9238 Joosten SA, van Ham V, Nolan CE, Borrias MC, Jardine AG, et al. Telomere shortening and cellular senescence in a model of chronic renal allograft rejection AMERICAN JOURNAL OF PATHOLOGY. 2003 APR; 162 (4): 1305-1312	10	32	14	39
1582	9276 Melk A, Kittikowit W, Sandhu I, Halloran KM, Grimm P, et al. Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening KIDNEY INTERNATIONAL. 2003 JUN; 63 (6): 2134-2143	25	64	14	53
1583	9292 Cui W, Wylie D, Aslam S, Dinnyes A, King T, et al. Telomerase-immortalized sheep fibroblasts can be reprogrammed by nuclear transfer to undergo early development BIOLOGY OF REPRODUCTION. 2003 JUL; 69 (1): 15-21	5	22	14	43
1584	9318 Kim M, Xu LF, Blackburn EH Catalytically active human telomerase mutants with allele-specific biological properties EXPERIMENTAL CELL RESEARCH. 2003 AUG 15; 288 (2): 277-287	3	21	14	58
1585	9329 Ferlicot S, Durrbach A, Ba N, Desvaux D, Bedossa P, et al. The role of replicative senescence in chronic allograft nephropathy HUMAN PATHOLOGY. 2003 SEP; 34 (9): 924-928	4	16	14	22
1586	9348 Unterluggauer H, Hampel B, Zwerschke W, Jansen-Durr P Senescence-associated cell death of human endothelial cells: the role of oxidative stress EXPERIMENTAL GERONTOLOGY. 2003 OCT; 38 (10): 1149-1160	21	55	14	58
1587	9429 Lee KM, Choi KH, Ouellette MM Use of exogenous hTERT to immortalize primary human cells CYTOTECHNOLOGY. 2004 JAN; 45 (1-2): 33-38	1	8	14	41
1588	9514 Huang H, Manton KG The role of oxidative damage in mitochondria during aging: A review FRONTIERS IN BIOSCIENCE. 2004 MAY; 9: 1100-1117	2	52	14	237
1589	9602 de Magalhaes JP, Chainiaux F, de Longueville F, Mainfroid V, Migeot V, et al. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase EXPERIMENTAL GERONTOLOGY. 2004 SEP; 39 (9): 1379-1389	14	30	14	46
1590	9614 Martin JA, Brown TA, Heiner AA, Buckwalter JA Chondrocyte senescence, joint loading and osteoarthritis CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2004 OCT; (427): S96-S103	5	33	14	93
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1591	9629 Yokoo S, Furumoto K, Hiyama E, Miwa N Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress JOURNAL OF CELLULAR BIOCHEMISTRY. 2004 OCT 15; 93 (3): 588-597	0	16	14	48
1592	9643 Chen JH, Stoeber K, Kingsbury S, Ozanne SE, Williams GH, et al. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts JOURNAL OF BIOLOGICAL CHEMISTRY. 2004 NOV 19; 279 (47): 49439-49446	13	49	14	49
1593	9653 Pellegrini G, Dellambra E, Paterna P, Golisano O, Traverso CE, et al. Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes EUROPEAN JOURNAL OF CELL BIOLOGY. 2004 DEC; 83 (11): 691-700	3	11	14	48
1594	9701 Huang H, Patel DD, Manton KG The immune system in aging: Roles of cytokines, T cells and NK cells FRONTIERS IN BIOSCIENCE. 2005 JAN 1; 10: 192-215	2	31	14	362
1595	9708 Katic M, Kahn CR The role of insulin and IGF-1 signaling in longevity CELLULAR AND MOLECULAR LIFE SCIENCES. 2005 FEB; 62 (3): 320-343	3	64	14	332
1596	9753 Colavitti R, Finkel T Reactive oxygen species as mediators of cellular senescence IUBMB LIFE. 2005 APR-MAY; 57 (4-5): 277-281	8	41	14	40
1597	9754 Rattan SIS, Clark BFC Understanding and modulating ageing IUBMB LIFE. 2005 APR-MAY; 57 (4-5): 297-304	5	25	14	103
1598	9775 Baird DM New developments in telomere length analysis EXPERIMENTAL GERONTOLOGY. 2005 MAY; 40 (5): 363-368	8	39	14	52
1599	9782 Gire V Senescence: a telomeric limit to immortality or a cellular response to physiologic stresses? M S-MEDECINE SCIENCES. 2005 MAY; 21 (5): 491-497	1	5	14	42
1600	9845 Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, et al. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation MOLECULAR AND CELLULAR BIOLOGY. 2005 AUG; 25 (15): 6639-6648	6	56	14	54

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5892 LUMPKIN CK, KNEPPER JE, BUTEL JS, SMITH JR, PEREIRASMITH OM

MITOGENIC EFFECTS OF THE PROTOONCOGENE AND ONCOGENE FORMS OF C-H-RAS DNA IN HUMAN-DIPLOID FIBROBLASTS

MOLECULAR AND CELLULAR BIOLOGY. 1986 AUG; 6 (8): 2990-2993

1502

5940 MUKHERJEE AB, WEINSTEIN ME

CULTURE MEDIA VARIATION AS RELATED TO INVITRO AGING OF HUMAN- FIBROBLASTS .1. EFFECTS ON POPULATION DOUBLING, NUCLEAR VOLUME AND NUCLEAR MORPHOLOGY

MECHANISMS OF AGEING AND DEVELOPMENT. 1986 NOV 28; 37 (1): 55-67

1503

5978 ROSEN R

CELLULAR SENESCENCE

INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY. 1987; : 737-753

1504

6195 MADOFF S, HOOPER DC

NONGENITOURINARY INFECTIONS CAUSED BY MYCOPLASMA-HOMINIS IN ADULTS

REVIEWS OF INFECTIOUS DISEASES. 1988 MAY-JUN; 10 (3): 602-613

1505

6197 WASHBURN LR, RAMSAY JR, ANDREWS MB

RECOGNITION OF MYCOPLASMA-ARTHRITIDIS MEMBRANE-ANTIGENS BY RATS AND RABBITS - COMPARISON BY IMMUNOBLOTTING AND RADIOIMMUNOPRECIPITATION

VETERINARY MICROBIOLOGY. 1988 MAY; 17 (1): 45-57

1506

6211 DELLORCO RT, WORTHINGTON MI

THE EFFECTS OF INVITRO AGE AND CULTURE STATE ON HISTONE VARIANT SYNTHESIS IN HUMAN-DIPLOID FIBROBLASTS

JOURNAL OF CELLULAR PHYSIOLOGY. 1988 JUL; 136 (1): 168-174

1507

6292 HIRSCH HR, COOMES JA, WITTEN M

THE WASTE-PRODUCT THEORY OF AGING - TRANSFORMATION TO UNLIMITED GROWTH IN CELL-CULTURES

EXPERIMENTAL GERONTOLOGY. 1989; 24 (2): 97-112

1508

6430 RODEMANN HP

DIFFERENTIAL DEGRADATION OF INTRACELLULAR PROTEINS IN HUMAN-SKIN FIBROBLASTS OF MITOTIC AND MITOMYCIN-C (MMC)-INDUCED POSTMITOTIC DIFFERENTIATION STATES INVITRO

DIFFERENTIATION. 1989 OCT; 42 (1): 37-43

1509

6456 GIORDANO T, FOSTER DN

IDENTIFICATION OF A HIGHLY ABUNDANT CDNA ISOLATED FROM SENESCENT WI-38 CELLS

EXPERIMENTAL CELL RESEARCH. 1989 DEC; 185 (2): 399-406

1510

6580 RUBIN H

THE SIGNIFICANCE OF BIOLOGICAL HETEROGENEITY

CANCER AND METASTASIS REVIEWS. 1990 JUL; 9 (1): 1-20

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1511

6605 KENNY GE, KAISER GG, COONEY MK, FOY HM

DIAGNOSIS OF MYCOPLASMA-PNEUMONIAE PNEUMONIA - SENSITIVITIES AND SPECIFICITIES OF SEROLOGY WITH LIPID ANTIGEN AND ISOLATION OF THE ORGANISM ON SOY PEPTONE MEDIUM FOR IDENTIFICATION OF INFECTIONS

JOURNAL OF CLINICAL MICROBIOLOGY. 1990 SEP; 28 (9): 2087-2093

1512

6610 MULLAART E, LOHMAN PHM, BERENDS F, VIJG J

DNA DAMAGE METABOLISM AND AGING

MUTATION RESEARCH. 1990 SEP-NOV; 237 (5-6): 189-210

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6709 RINEHART CA, HASKILL JS, MORRIS JS, BUTLER TD, KAUFMAN DG

EXTENDED LIFE-SPAN OF HUMAN ENDOMETRIAL STROMAL CELLS TRANSFECTED WITH CLONED ORIGIN-DEFECTIVE, TEMPERATURE-SENSITIVE SIMIAN VIRUS-40

JOURNAL OF VIROLOGY. 1991 MAR; 65 (3): 1458-1465

1514

6885 WANG XW, LIN XH, KLEIN CB, BHAMRA RK, LEE YW, et al.

A CONSERVED REGION IN HUMAN AND CHINESE-HAMSTER X-CHROMOSOMES CAN INDUCE CELLULAR SENESCENCE OF NICKEL-TRANSFORMED CHINESE-HAMSTER CELL- LINES

CARCINOGENESIS. 1992 APR; 13 (4): 555-561

1515

6913 KUMAR S, MILLIS AJT, BAGLIONI C

EXPRESSION OF INTERLEUKIN-1-INDUCIBLE GENES AND PRODUCTION OF INTERLEUKIN-1 BY AGING HUMAN FIBROBLASTS

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992 MAY 15; 89 (10): 4683-4687

1516

6926 PIGNOLO RJ, MASORO EJ, NICHOLS WW, BRADT CI, CRISTOFALO VJ

SKIN FIBROBLASTS FROM AGED FISCHER-344 RATS UNDERGO SIMILAR CHANGES IN REPLICATIVE LIFE-SPAN BUT NOT IMMORTALIZATION WITH CALORIC RESTRICTION OF DONORS

EXPERIMENTAL CELL RESEARCH. 1992 JUL; 201 (1): 16-22

1517

6952 DANNER DB

THE PROLIFERATION THEORY OF REJUVENATION

MECHANISMS OF AGEING AND DEVELOPMENT. 1992 AUG; 65 (1): 85-107

1518

6968 MILES RJ

CATABOLISM IN MOLLICUTES

JOURNAL OF GENERAL MICROBIOLOGY. 1992 SEP; 138: 1773-1783

1519

6986 FREDERICH KB, PHILLIPS PD, CRISTOFALO VJ

STIMULATION OF DNA-SYNTHESIS IN SENESCENT HUMAN-CELLS FOLLOWING INCUBATION WITH PLASMA-MEMBRANES

EXPERIMENTAL CELL RESEARCH. 1992 OCT; 202 (2): 386-390

1520

7009 TAKEDA K, GOSIEWSKA A, PETERKOFSKY B

SIMILAR, BUT NOT IDENTICAL, MODULATION OF EXPRESSION OF EXTRACELLULAR- MATRIX COMPONENTS DURING INVITRO AND INVIVO AGING OF HUMAN SKIN FIBROBLASTS

JOURNAL OF CELLULAR PHYSIOLOGY. 1992 DEC; 153 (3): 450-459

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1521

7063 PERILLO NL, NAEIM F, WALFORD RL, EFFROS RB

THE INVITRO SENESCENCE OF HUMAN T-LYMPHOCYTES - FAILURE TO DIVIDE IS NOT ASSOCIATED WITH A LOSS OF CYTOLYTIC ACTIVITY OR MEMORY T-CELL PHENOTYPE

MECHANISMS OF AGEING AND DEVELOPMENT. 1993 FEB; 67 (1-2): 173-185

1522

7065 PANG JH, CHEN KY

A SPECIFIC CCAAT-BINDING PROTEIN, CBP/TK, MAY BE INVOLVED IN THE REGULATION OF THYMIDINE KINASE GENE-EXPRESSION IN HUMAN IMR-90 DIPLOID FIBROBLASTS DURING SENESCENCE

JOURNAL OF BIOLOGICAL CHEMISTRY. 1993 FEB 5; 268 (4): 2909-2916

1523

7084 WADHWA R, KAUL SC, IKAWA Y, SUGIMOTO Y

IDENTIFICATION OF A NOVEL MEMBER OF MOUSE HSP70 FAMILY - ITS ASSOCIATION WITH CELLULAR MORTAL PHENOTYPE

JOURNAL OF BIOLOGICAL CHEMISTRY. 1993 MAR 25; 268 (9): 6615-6621

120

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7185 WADHWA R, KAUL SC, SUGIMOTO Y, MITSUI Y

INDUCTION OF CELLULAR SENESCENCE BY TRANSFECTION OF CYTOSOLIC MORTALIN CDNA IN NIH-3T3-CELLS

JOURNAL OF BIOLOGICAL CHEMISTRY. 1993 OCT 25; 268 (30): 22239-22242

1525

7291 BRENNEISEN P, GOGOL J, BAYREUTHER K

DNA-SYNTHESIS AND FOS AND JUN PROTEIN EXPRESSION IN MITOTIC AND POSTMITOTIC WI-38 FIBROBLASTS IN-VITRO

EXPERIMENTAL CELL RESEARCH. 1994 APR; 211 (2): 219-230

1526

7332 ATADJA PW, STRINGER KF, RIABOWOL KT

LOSS OF SERUM RESPONSE ELEMENT-BINDING ACTIVITY AND HYPERPHOSPHORYLATION OF SERUM RESPONSE FACTOR DURING CELLULAR AGING

MOLECULAR AND CELLULAR BIOLOGY. 1994 JUL; 14 (7): 4991-4999

1527

7333 PROFT T, HERRMANN R

IDENTIFICATION AND CHARACTERIZATION OF HITHERTO UNKNOWN MYCOPLASMA- PNEUMONIAE PROTEINS

MOLECULAR MICROBIOLOGY. 1994 JUL; 13 (2): 337-348

1528

7376 MARTIN GM

GENETIC MODULATION OF TELOMERIC TERMINAL RESTRICTION FRAGMENT LENGTH - RELEVANCE FOR CLONAL AGING AND LATE-LIFE DISEASE

AMERICAN JOURNAL OF HUMAN GENETICS. 1994 NOV; 55 (5): 866-869

1529

7396 GOLDSTEIN S, MOERMAN EJ, FUJII S, SOBEL BE

OVEREXPRESSION OF PLASMINOGEN-ACTIVATOR INHIBITOR TYPE-1 IN SENESCENT FIBROBLASTS FROM NORMAL SUBJECTS AND THOSE WITH WERNER SYNDROME

JOURNAL OF CELLULAR PHYSIOLOGY. 1994 DEC; 161 (3): 571-579

1530

7404 SASAKI M, HONDA T, YAMADA H, WAKE N, BARRETT JC, et al.

EVIDENCE FOR MULTIPLE PATHWAYS TO CELLULAR SENESCENCE

CANCER RESEARCH. 1994 DEC 1; 54 (23): 6090-6093

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7432 KANEKO S, SATOH Y, IKEMURA K, KONISHI T, OHJI T, et al.

ALTERATIONS OF EXPRESSION OF THE CYTOSKELETON AFTER IMMORTALIZATION OF HUMAN FIBROBLASTS

CELL STRUCTURE AND FUNCTION. 1995 FEB; 20 (1): 107-115

1532

7459 ONEILL FJ, FRISQUE RJ, XU XL, HU YX, CARNEY H

IMMORTALIZATION OF HUMAN-CELLS BY MUTANT AND CHIMERIC PRIMATE POLYOMAVIRUS T-ANTIGEN GENES

ONCOGENE. 1995 MAR 16; 10 (6): 1131-1139

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7534 FUJII M, IDE T, WADHWA R, TAHARA H, KAUL SC, et al.

INHIBITORS OF CGMP-DEPENDENT PROTEIN-KINASE BLOCK SENESCENCE INDUCED BY INACTIVATION OF T-ANTIGEN IN SV40-TRANSFORMED IMMORTAL HUMAN FIBROBLASTS

ONCOGENE. 1995 AUG 17; 11 (4): 627-634

1534

7564 DIMRI GP, LEE XH, BASILE G, ACOSTA M, SCOTT C, et al.

A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995 SEP 26; 92 (20): 9363-9367

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RESTORATION OF THE CELLULAR SENESCENCE PROGRAM AND REPRESSION OF TELOMERASE BY HUMAN-CHROMOSOME-3

JAPANESE JOURNAL OF CANCER RESEARCH. 1995 OCT; 86 (10): 899-904

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7643 Karlsson C, Stenman G, Vojta PJ, BongcamRudloff E, Barrett JC, et al.

Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q

CANCER RESEARCH. 1996 JAN 15; 56 (2): 241-245

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7685 Hu QB, Moerman EJ, Goldstein S

Altered expression and regulation of the alpha 5 beta 1 integrin- fibronectin receptor lead to reduced amounts of functional alpha 5 beta 1 heterodimer on the plasma membrane of senescent human diploid fibroblasts

EXPERIMENTAL CELL RESEARCH. 1996 MAY 1; 224 (2): 251-263

1538

7698 Chin JH, Okazaki M, Frazier JS, Hu ZW, Hoffman BB

Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 1996 JUL; 40 (1): C362-C371

1539

7716 Yamada O

Telomeres and telomerase in human hematologic neoplasia

INTERNATIONAL JOURNAL OF HEMATOLOGY. 1996 AUG; 64 (2): 87-99

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7754 Hiraga S, Arita N, Ohnishi T, Izumoto S, Taki T, et al.

Establishment of spontaneously immortalized rat type 1 astroglial cell lines: The role of p53 in astroglial carcinogenesis

GLIA. 1996 NOV; 18 (3): 185-199

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7777 Wang S, Moerman EJ, Jones RA, Thweatt R, Goldstein S

Characterization of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblasts

MECHANISMS OF AGEING AND DEVELOPMENT. 1996 DEC 20; 92 (2-3): 121-132

1542

7824 deHaan G, Nijhof W, VanZant G

Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity

BLOOD. 1997 MAR 1; 89 (5): 1543-1550

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7898 Effros RB, Pawelec G

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

IMMUNOLOGY TODAY. 1997 SEP; 18 (9): 450-454

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7904 Sugrue MM, Shin DY, Lee SW, Aaronson SA

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997 SEP 2; 94 (18): 9648-9653

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8032 Vogt M, Haggblom C, Yeargin J, Christiansen-Weber T, Haas M

Independent induction of senescence by p16(INK4a) and p21(CIP1) in spontaneously immortalized human fibroblasts

CELL GROWTH & DIFFERENTIATION. 1998 FEB; 9 (2): 139-146

1546

8049 Hahn TW, Willey MJ, Krause DC

HMW1 is required for cytadhesin P1 trafficking to the attachment organelle in Mycoplasma pneumoniae

JOURNAL OF BACTERIOLOGY. 1998 MAR; 180 (5): 1270-1276

1547

8145 Macieira-Coelho A

Markers of 'cell senescence' (vol 103, pg 105, 1998)

MECHANISMS OF AGEING AND DEVELOPMENT. 1998 AUG 14; 104 (2): 207-211

1548

8203 Mendez MV, Stanley A, Phillips T, Menzoian JO, Park HY

Fibroblasts cultured from distal lower extremities in patients with venous reflux display cellular characteristics of senescence

JOURNAL OF VASCULAR SURGERY. 1998 DEC; 28 (6): 1040-1048

1549

8211 Lichtsteiner SP, Lebkowski JS, Vasserot AP

Telomerase - A target for anticancer therapy

ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN. 1999; 886: 1-11

1550

8231 Sourlingas TG, Steger M, Grubeck-Loebenstein B, Tsapali DS, Sekeri-Pataryas KE

T-lymphocyte long-term cultures have a constant histone variant pattern during aging

EXPERIMENTAL GERONTOLOGY. 1999 JAN; 34 (1): 59-67

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8241 Cuthbert AP, Bond J, Trott DA, Gill S, Broni J, et al.

Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells

JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1999 JAN 6; 91 (1): 37-45

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8248 Kano Y, Motoda H, Hiragami F, Matsui K, Little JB, et al.

SV40LT highly mutates and immortalizes two fibroblast strains from patients with Wilms' tumor

CELL STRUCTURE AND FUNCTION. 1999 FEB; 24 (1): 35-41

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8264 Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, et al.

Analysis of genomic integrity and p53-dependent G(1) checkpoint in telomerase-induced extended-life-span human fibroblasts

MOLECULAR AND CELLULAR BIOLOGY. 1999 MAR; 19 (3): 2373-2379

1554

8281 De Haan G, Van Zant G

Genetic analysis of hemopoietic cell cycling in mice suggests its involvement in organismal life span

FASEB JOURNAL. 1999 APR; 13 (6): 707-713

1555

8285 Meyyappan M, Wheaton K, Riabowol KT

Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence

JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 29-39

1556

8286 Sayama K, Shirakata Y, Midorikawa K, Hanakawa Y, Hashimoto K

Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence

JOURNAL OF CELLULAR PHYSIOLOGY. 1999 APR; 179 (1): 40-44

1557

8349 Kagawa S, Fujiwara T, Kadowaki Y, Fukazawa T, Sok-Joo R, et al.

Overexpression of the p21(sdi1) gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer

CELL DEATH AND DIFFERENTIATION. 1999 AUG; 6 (8): 765-772

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8356 Chang BD, Broude EV, Dokmanovic M, Zhu HM, Ruth A, et al.

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

CANCER RESEARCH. 1999 AUG 1; 59 (15): 3761-3767

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8363 Chang BD, Xuan YZ, Broude EV, Zhu HM, Schott B, et al.

Role of p53 and p21(waf1/cip1) in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

ONCOGENE. 1999 AUG 26; 18 (34): 4808-4818

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8457 Fossel M

Cell senescence in human aging: A review of the theory

IN VIVO. 2000 JAN-FEB; 14 (1): 29-34

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Telomeres and HIV disease

MICROBES AND INFECTION. 2000 JAN; 2 (1): 69-76

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8546 Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, et al.

PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000 MAY 10; 271 (2): 305-310

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8632 Kim JK, Ryll R, Ishizuka Y, Kato S

Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts

GENE. 2000 OCT 31; 257 (2): 327-334

1564

8696 Tan Z

Simulated shortening of proliferation-restricting telomeres during clonal proliferation and senescence of human cells

EXPERIMENTAL GERONTOLOGY. 2001 JAN; 36 (1): 89-97

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8700 Suzuki K, Mori I, Nakayama Y, Miyakoda M, Kodama S, et al.

Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening

RADIATION RESEARCH. 2001 JAN; 155 (1): 248-253

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8713 Melk A, Halloran PF

Cell senescence and its implications for nephrology

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2001 FEB; 12 (2): 385-393

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8727 Suzuki T, Minagawa S, Michishita E, Ogino H, Fujii M, et al.

Induction of senescence-associated genes by 5-bromodeoxyuridine in HeLa cells

EXPERIMENTAL GERONTOLOGY. 2001 MAR; 36 (3): 465-474

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8740 Rocco JW, Sidransky D

p16(MTS-1/CDKN2/INK4a) in cancer progression

EXPERIMENTAL CELL RESEARCH. 2001 MAR 10; 264 (1): 42-55

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8756 Allsopp RC, Cheshier S, Weissman IL

Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells

JOURNAL OF EXPERIMENTAL MEDICINE. 2001 APR 16; 193 (8): 917-924

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8790 Wagner M, Brosch G, Zwerschke W, Seto E, Loidl P, et al.

Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2

FEBS LETTERS. 2001 JUN 15; 499 (1-2): 101-106

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8905 Sozou PD, Kirkwood TBL

A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA

JOURNAL OF THEORETICAL BIOLOGY. 2001 DEC 21; 213 (4): 573-586

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8919 de Haan G

Hematopoietic stem cells: Self-renewing or aging?

CELLS TISSUES ORGANS. 2002; 171 (1): 27-37

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9000 Benvenuti S, Cramer R, Quinn CC, Bruce J, Zvelebil M, et al.

Differential proteome analysis of replicative senescence in rat embryo fibroblasts

MOLECULAR & CELLULAR PROTEOMICS. 2002 APR; 1 (4): 280-292

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9026 Park JK, Kim BH, Han YS, Park IK

The effect of telomerase expression on the escape from M2 crisis in virus-transformed human retinal pigment epithelial cells

EXPERIMENTAL AND MOLECULAR MEDICINE. 2002 MAY 31; 34 (2): 107-113

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9089 Kim H, Farris J, Christman SA, Kong BW, Foster LK, et al.

Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase

BIOCHEMICAL JOURNAL. 2002 AUG 1; 365: 765-772

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9104 Lorenzini A, Tresini M, Mawal-Dewan M, Frisoni L, Zhang H, et al.

Role of the Raf/MEK/ERK and the PI3K/Akt(PKB) pathways in fibroblast senescence

EXPERIMENTAL GERONTOLOGY. 2002 OCT-NOV; 37 (10-11): 1149-1156

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9131 Chainiaux F, Magalhaes JP, Eliaers F, Remacle J, Toussaint O

UVB-induced premature senescence of human diploid skin fibroblasts

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2002 NOV; 34 (11): 1331-1339

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9148 Dierick JF, Kalume DE, Wenders F, Salmon M, Dieu M, et al.

Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence

FEBS LETTERS. 2002 NOV 20; 531 (3): 499-504

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9161 Huot TJ, Rowe J, Harland M, Drayton S, Brookes S, et al.

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets- induced senescence in human diploid fibroblasts

MOLECULAR AND CELLULAR BIOLOGY. 2002 DEC; 22 (23): 8135-8143

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9207 Roninson IB, Dokmanovic M

Induction of senescence-associated growth inhibitors in the tumor- suppressive function of retinoids

JOURNAL OF CELLULAR BIOCHEMISTRY. 2003 JAN 1; 88 (1): 83-94

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9238 Joosten SA, van Ham V, Nolan CE, Borrias MC, Jardine AG, et al.

Telomere shortening and cellular senescence in a model of chronic renal allograft rejection

AMERICAN JOURNAL OF PATHOLOGY. 2003 APR; 162 (4): 1305-1312

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9276 Melk A, Kittikowit W, Sandhu I, Halloran KM, Grimm P, et al.

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening

KIDNEY INTERNATIONAL. 2003 JUN; 63 (6): 2134-2143

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9292 Cui W, Wylie D, Aslam S, Dinnyes A, King T, et al.

Telomerase-immortalized sheep fibroblasts can be reprogrammed by nuclear transfer to undergo early development

BIOLOGY OF REPRODUCTION. 2003 JUL; 69 (1): 15-21

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9318 Kim M, Xu LF, Blackburn EH

Catalytically active human telomerase mutants with allele-specific biological properties

EXPERIMENTAL CELL RESEARCH. 2003 AUG 15; 288 (2): 277-287

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9329 Ferlicot S, Durrbach A, Ba N, Desvaux D, Bedossa P, et al.

The role of replicative senescence in chronic allograft nephropathy

HUMAN PATHOLOGY. 2003 SEP; 34 (9): 924-928

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9348 Unterluggauer H, Hampel B, Zwerschke W, Jansen-Durr P

Senescence-associated cell death of human endothelial cells: the role of oxidative stress

EXPERIMENTAL GERONTOLOGY. 2003 OCT; 38 (10): 1149-1160

1587

9429 Lee KM, Choi KH, Ouellette MM

Use of exogenous hTERT to immortalize primary human cells

CYTOTECHNOLOGY. 2004 JAN; 45 (1-2): 33-38

1588

9514 Huang H, Manton KG

The role of oxidative damage in mitochondria during aging: A review

FRONTIERS IN BIOSCIENCE. 2004 MAY; 9: 1100-1117

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Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase

EXPERIMENTAL GERONTOLOGY. 2004 SEP; 39 (9): 1379-1389

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9614 Martin JA, Brown TA, Heiner AA, Buckwalter JA

Chondrocyte senescence, joint loading and osteoarthritis

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2004 OCT; (427): S96-S103

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1591

9629 Yokoo S, Furumoto K, Hiyama E, Miwa N

Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress

JOURNAL OF CELLULAR BIOCHEMISTRY. 2004 OCT 15; 93 (3): 588-597

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9643 Chen JH, Stoeber K, Kingsbury S, Ozanne SE, Williams GH, et al.

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts

JOURNAL OF BIOLOGICAL CHEMISTRY. 2004 NOV 19; 279 (47): 49439-49446

1593

9653 Pellegrini G, Dellambra E, Paterna P, Golisano O, Traverso CE, et al.

Telomerase activity is sufficient to bypass replicative senescence in human limbal and conjunctival but not corneal keratinocytes

EUROPEAN JOURNAL OF CELL BIOLOGY. 2004 DEC; 83 (11): 691-700

1594

9701 Huang H, Patel DD, Manton KG

The immune system in aging: Roles of cytokines, T cells and NK cells

FRONTIERS IN BIOSCIENCE. 2005 JAN 1; 10: 192-215

362

1595

9708 Katic M, Kahn CR

The role of insulin and IGF-1 signaling in longevity

CELLULAR AND MOLECULAR LIFE SCIENCES. 2005 FEB; 62 (3): 320-343

332

1596

9753 Colavitti R, Finkel T

Reactive oxygen species as mediators of cellular senescence

IUBMB LIFE. 2005 APR-MAY; 57 (4-5): 277-281

1597

9754 Rattan SIS, Clark BFC

Understanding and modulating ageing

IUBMB LIFE. 2005 APR-MAY; 57 (4-5): 297-304

103

1598

9775 Baird DM

New developments in telomere length analysis

EXPERIMENTAL GERONTOLOGY. 2005 MAY; 40 (5): 363-368

1599

9782 Gire V

Senescence: a telomeric limit to immortality or a cellular response to physiologic stresses?

M S-MEDECINE SCIENCES. 2005 MAY; 21 (5): 491-497

1600

9845 Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, et al.

ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation

MOLECULAR AND CELLULAR BIOLOGY. 2005 AUG; 25 (15): 6639-6648

Hayflick w/citing papers Len Hayflick publications & the papers citing L Hayflick.	Historiographs	Glossary HistCite Guide About Grand Totals: LCS 84164, GCS 458115, CR 564869 Collection span: 1953 - 2011
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