Record 7614 View: Standard | Glossary HistCite Guide |
Author(s): Barsh GS; Farooqi IS; O'Rahilly S
Title: Genetics of body-weight regulation
Source: NATURE 404 (6778): 644-651
Date: 2000 APR 6
Document Type: Journal : Review
Language: English
Comment:
Address: Beckman Ctr, Dept Pediat, Stanford, CA 94305 USA.
Beckman Ctr, Dept Genet, Stanford, CA 94305 USA. Beckman Ctr, Howard Hughes Med Inst, Stanford, CA 94305 USA. Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England. Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England. Reprint: Barsh, GS, Beckman Ctr, Dept Pediat, Stanford, CA 94305 USA.
Abstract: The role of genetics in obesity is twofold. Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes. Remarkable progress has been made on both fronts, and the pace of advance is likely to accelerate as functional genomics and the human genome project expand and mature. Approaches based on mendelian and quantitative genetics may well converge, and lead ultimately to more rational and selective therapies.
Cited References: *WHO, 1998, OB PREV MART GLOB EP AHIMA RS, 1996, NATURE, V382, P250 AHIMA RS, 1999, ENDOCRINOLOGY, V140, P4923 ALLISON DB, 1996, INT J OBESITY, V20, P501 ALLISON DB, 1997, BEHAV GENET, V27, P401 ALLISON DB, 1998, INT J OBESITY, V22, P559 ALLISON DB, 1999, AM J HUM GENET, V65, P531 BEALES PL, 1997, J MED GENET, V34, P92 BOGGON TJ, 1999, SCIENCE, V286, P2119 BOSTON BA, 1997, SCIENCE, V278, P1641 BOUCHARD C, 1990, NEW ENGL J MED, V322, P1477 BRAY GA, 1971, PHYSIOL REV, V51, P598 BRENNAN J, 1999, METH MOL B, V97, P123 BROBERGER C, 1998, P NATL ACAD SCI USA, V95, P15043 BROCKMANN GA, 1998, GENETICS, V150, P369 BROWN SDM, 1998, HUM MOL GENET, V7, P1627 BRUFORD EA, 1997, GENOMICS, V41, P93 BULTMAN SJ, 1992, CELL, V71, P1195 CHAGNON YC, 1996, TRENDS GENET, V12, P441 CHEN H, 1996, CELL, V84, P491 CHEUNG CC, 1997, ENDOCRINOLOGY, V138, P4489 CHEVERUD JM, 1995, GENETICS, V139, P1455 CHEVERUD JM, 1996, GENETICS, V142, P1305 CLEMENT K, 1998, NATURE, V392, P398 COLEMAN DL, 1973, DIABETOLOGIA, V9, P294 COLLINS AC, 1993, MAMM GENOME, V4, P454 COMUZZIE AG, 1996, J CLIN ENDOCR METAB, V81, P597 COMUZZIE AG, 1997, NAT GENET, V15, P273 COMUZZIE AG, 1998, SCIENCE, V280, P1374 DEANGELIS MH, 1998, MUTAT RES-FUND MOL M, V400, P25 DRAGANI TA, 1995, MAMM GENOME, V6, P778 ELIAS CF, 1999, NEURON, V23, P75 ELMQUIST JK, 1998, NAT NEUROSCI, V1, P445 ELMQUIST JK, 1999, NEURON, V22, P221 FALCONE DS, 1995, INTRO QUANTITATIVE G FAN W, 1997, NATURE, V385, P165 FAROOQI IS, 1999, NEW ENGL J MED, V341, P879 FISLER JS, 1997, J NUTR, V127, PS1909 FRANKEL WN, 1996, NAT GENET, V14, P371 FRIEDMAN JM, 1998, NATURE, V395, P763 FUJISAWA T, 1998, J CLIN ENDOCR METAB, V83, P2441 GOOD DJ, 1997, NAT GENET, V15, P397 GOODALE HD, 1938, J HERED, V29, P101 GRAHAM M, 1997, NAT GENET, V17, P273 GU W, 1999, DIABETES, V48, P635 GUNAYAYGUN M, 1997, BEHAV GENET, V27, P307 GUNN TM, 1999, NATURE, V398, P152 HAGER J, 1998, NAT GENET, V20, P304 HAHM S, 1999, NEURON, V23, P537 HANSON RL, 1998, AM J HUM GENET, V63, P1130 HILL JO, 1998, SCIENCE, V280, P1371 HINNEY A, 1999, J CLIN ENDOCR METAB, V84, P1483 HIXSON JE, 1999, J CLIN ENDOCR METAB, V84, P3187 HO GY, 1999, J BIOL CHEM, V274, P35816 HUSZAR D, 1997, CELL, V88, P131 JACKSON RS, 1997, NAT GENET, V16, P303 KEIGHTLEY PD, 1996, GENETICS, V142, P227 KISSEBAH AH, 1994, PHYSIOL REV, V74, P761 KOLEHMAINEN J, 1997, EUR J HUM GENET, V5, P206 KRUDE H, 1998, NAT GENET, V19, P155 KRUGLYAK L, 1999, NAT GENET, V22, P139 LANDER E, 1995, NAT GENET, V11, P241 LEE GH, 1996, NATURE, V379, P632 LEE JH, 1999, AM J HUM GENET, V64, P196 LEIBEL RL, 1997, J BIOL CHEM, V272, P31937 LEMBERTAS AV, 1997, J CLIN INVEST, V100, P1240 LI LS, 1996, DIABETOLOGIA, V39, P857 LONG AD, 1999, GENOME RES, V9, P720 LOWELL BB, 1997, ANNU REV MED, V48, P307 MACARTHUR JW, 1944, AM NAT, V78, P142 MAES HHM, 1997, BEHAV GENET, V27, P325 MARSH DJ, 1999, NAT GENET, V21, P119 MARTH GT, 1999, NAT GENET, V23, P452 MATHEWS KD, 1989, AM J MED GENET, V34, P470 MEHRABIAN M, 1998, J CLIN INVEST, V101, P2485 MICHAUD EJ, 1994, P NATL ACAD SCI USA, V91, P2562 MILLER KA, 1997, GENETICS, V146, P1407 MILLER MW, 1993, GENE DEV, V7, P454 MIZUNO TM, 1999, ENDOCRINOLOGY, V140, P814 MONTAGUE CT, 1997, NATURE, V387, P903 MOODY DE, 1999, GENETICS, V152, P699 NAGGERT JK, 1995, NAT GENET, V10, P135 NOBENTRAUTH K, 1996, NATURE, V380, P534 NORMAN RA, 1997, AM J HUM GENET, V60, P166 ODUNSI K, 1999, P NATL ACAD SCI USA, V96, P8315 OHTA T, 1999, AM J HUM GENET, V64, P397 OLLMANN MM, 1997, SCIENCE, V278, P135 PERUSSE L, 1999, OBES RES, V7, P111 PIETRIROUXEL F, 1997, EUR J BIOCHEM, V247, P1174 POMP D, 1999, OBES RES, V7, P106 PRICE RA, 1991, BEHAV GENET, V21, P1 RISCH N, 1996, SCIENCE, V273, P1516 ROSSI M, 1998, ENDOCRINOLOGY, V139, P4428 ROTIMI CN, 1999, DIABETES, V48, P643 RUSSELLEGGITT IM, 1998, OPHTHALMOLOGY, V105, P1274 SEELEY RJ, 1997, NATURE, V390, P349 SHIMADA M, 1998, NATURE, V396, P670 SHUTTER JR, 1997, GENE DEV, V11, P593 SINA M, 1999, AM J HUM GENET, V65, P1501 SIRACUSA LD, 1994, TRENDS GENET, V10, P423 SPIELMAN RS, 1996, AM J HUM GENET, V59, P983 STROBEL A, 1998, NAT GENET, V18, P213 STUNKARD AJ, 1986, NEW ENGL J MED, V314, P193 SUTO J, 1998, MAMM GENOME, V9, P506 TARTAGLIA LA, 1995, CELL, V83, P1263 TAYLOR BA, 1996, GENOMICS, V34, P389 TAYLOR BA, 1997, GENOMICS, V43, P249 TAYLOR BA, 1999, MAMM GENOME, V10, P963 TECOTT LH, 1995, NATURE, V374, P542 THOMSON G, 1995, AM J HUM GENET, V57, P487 URBANEK M, 1999, P NATL ACAD SCI USA, V96, P8573 VAISSE C, 1998, NAT GENET, V20, P113 WARDEN CH, 1995, J CLIN INVEST, V95, P1545 WEST DB, 1994, J CLIN INVEST, V94, P1410 WEST DB, 1994, MAMM GENOME, V5, P546 WEST DB, 1995, AM J PHYSIOL-REG I, V268, PR658 WEST DB, 1996, ENDOCRIN METAB CLIN, V25, P801 WILSON BD, 1999, MOL MED TODAY, V5, P250 WOODS SC, 1998, SCIENCE, V280, P1378 YASWEN L, 1999, NAT MED, V5, P1066 YEO GSH, 1998, NAT GENET, V20, P111 YORK B, 1996, MAMM GENOME, V7, P677 YORK B, 1999, MAMM GENOME, V10, P457 ZAMBROWICZ BP, 1998, NATURE, V392, P608 ZHANG YY, 1994, NATURE, V372, P425 |