Record 7614   View: Standard Glossary  HistCite Guide
Author(s): Barsh GS; Farooqi IS; O'Rahilly S
Title: Genetics of body-weight regulation
Source: NATURE 404 (6778): 644-651
Date: 2000 APR 6
Document Type: Journal : Review
Language: English
Comment:  
Address: Beckman Ctr, Dept Pediat, Stanford, CA 94305 USA.
Beckman Ctr, Dept Genet, Stanford, CA 94305 USA.
Beckman Ctr, Howard Hughes Med Inst, Stanford, CA 94305 USA.
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England.
Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England.
Reprint: Barsh, GS, Beckman Ctr, Dept Pediat, Stanford, CA 94305 USA.
Abstract: The role of genetics in obesity is twofold. Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes. Remarkable progress has been made on both fronts, and the pace of advance is likely to accelerate as functional genomics and the human genome project expand and mature. Approaches based on mendelian and quantitative genetics may well converge, and lead ultimately to more rational and selective therapies.
Cited References:
*WHO, 1998, OB PREV MART GLOB EP
AHIMA RS, 1996, NATURE, V382, P250
AHIMA RS, 1999, ENDOCRINOLOGY, V140, P4923
ALLISON DB, 1996, INT J OBESITY, V20, P501
ALLISON DB, 1997, BEHAV GENET, V27, P401
ALLISON DB, 1998, INT J OBESITY, V22, P559
ALLISON DB, 1999, AM J HUM GENET, V65, P531
BEALES PL, 1997, J MED GENET, V34, P92
BOGGON TJ, 1999, SCIENCE, V286, P2119
BOSTON BA, 1997, SCIENCE, V278, P1641
BOUCHARD C, 1990, NEW ENGL J MED, V322, P1477
BRAY GA, 1971, PHYSIOL REV, V51, P598
BRENNAN J, 1999, METH MOL B, V97, P123
BROBERGER C, 1998, P NATL ACAD SCI USA, V95, P15043
BROCKMANN GA, 1998, GENETICS, V150, P369
BROWN SDM, 1998, HUM MOL GENET, V7, P1627
BRUFORD EA, 1997, GENOMICS, V41, P93
BULTMAN SJ, 1992, CELL, V71, P1195
CHAGNON YC, 1996, TRENDS GENET, V12, P441
CHEN H, 1996, CELL, V84, P491
CHEUNG CC, 1997, ENDOCRINOLOGY, V138, P4489
CHEVERUD JM, 1995, GENETICS, V139, P1455
CHEVERUD JM, 1996, GENETICS, V142, P1305
CLEMENT K, 1998, NATURE, V392, P398
COLEMAN DL, 1973, DIABETOLOGIA, V9, P294
COLLINS AC, 1993, MAMM GENOME, V4, P454
COMUZZIE AG, 1996, J CLIN ENDOCR METAB, V81, P597
COMUZZIE AG, 1997, NAT GENET, V15, P273
COMUZZIE AG, 1998, SCIENCE, V280, P1374
DEANGELIS MH, 1998, MUTAT RES-FUND MOL M, V400, P25
DRAGANI TA, 1995, MAMM GENOME, V6, P778
ELIAS CF, 1999, NEURON, V23, P75
ELMQUIST JK, 1998, NAT NEUROSCI, V1, P445
ELMQUIST JK, 1999, NEURON, V22, P221
FALCONE DS, 1995, INTRO QUANTITATIVE G
FAN W, 1997, NATURE, V385, P165
FAROOQI IS, 1999, NEW ENGL J MED, V341, P879
FISLER JS, 1997, J NUTR, V127, PS1909
FRANKEL WN, 1996, NAT GENET, V14, P371
FRIEDMAN JM, 1998, NATURE, V395, P763
FUJISAWA T, 1998, J CLIN ENDOCR METAB, V83, P2441
GOOD DJ, 1997, NAT GENET, V15, P397
GOODALE HD, 1938, J HERED, V29, P101
GRAHAM M, 1997, NAT GENET, V17, P273
GU W, 1999, DIABETES, V48, P635
GUNAYAYGUN M, 1997, BEHAV GENET, V27, P307
GUNN TM, 1999, NATURE, V398, P152
HAGER J, 1998, NAT GENET, V20, P304
HAHM S, 1999, NEURON, V23, P537
HANSON RL, 1998, AM J HUM GENET, V63, P1130
HILL JO, 1998, SCIENCE, V280, P1371
HINNEY A, 1999, J CLIN ENDOCR METAB, V84, P1483
HIXSON JE, 1999, J CLIN ENDOCR METAB, V84, P3187
HO GY, 1999, J BIOL CHEM, V274, P35816
HUSZAR D, 1997, CELL, V88, P131
JACKSON RS, 1997, NAT GENET, V16, P303
KEIGHTLEY PD, 1996, GENETICS, V142, P227
KISSEBAH AH, 1994, PHYSIOL REV, V74, P761
KOLEHMAINEN J, 1997, EUR J HUM GENET, V5, P206
KRUDE H, 1998, NAT GENET, V19, P155
KRUGLYAK L, 1999, NAT GENET, V22, P139
LANDER E, 1995, NAT GENET, V11, P241
LEE GH, 1996, NATURE, V379, P632
LEE JH, 1999, AM J HUM GENET, V64, P196
LEIBEL RL, 1997, J BIOL CHEM, V272, P31937
LEMBERTAS AV, 1997, J CLIN INVEST, V100, P1240
LI LS, 1996, DIABETOLOGIA, V39, P857
LONG AD, 1999, GENOME RES, V9, P720
LOWELL BB, 1997, ANNU REV MED, V48, P307
MACARTHUR JW, 1944, AM NAT, V78, P142
MAES HHM, 1997, BEHAV GENET, V27, P325
MARSH DJ, 1999, NAT GENET, V21, P119
MARTH GT, 1999, NAT GENET, V23, P452
MATHEWS KD, 1989, AM J MED GENET, V34, P470
MEHRABIAN M, 1998, J CLIN INVEST, V101, P2485
MICHAUD EJ, 1994, P NATL ACAD SCI USA, V91, P2562
MILLER KA, 1997, GENETICS, V146, P1407
MILLER MW, 1993, GENE DEV, V7, P454
MIZUNO TM, 1999, ENDOCRINOLOGY, V140, P814
MONTAGUE CT, 1997, NATURE, V387, P903
MOODY DE, 1999, GENETICS, V152, P699
NAGGERT JK, 1995, NAT GENET, V10, P135
NOBENTRAUTH K, 1996, NATURE, V380, P534
NORMAN RA, 1997, AM J HUM GENET, V60, P166
ODUNSI K, 1999, P NATL ACAD SCI USA, V96, P8315
OHTA T, 1999, AM J HUM GENET, V64, P397
OLLMANN MM, 1997, SCIENCE, V278, P135
PERUSSE L, 1999, OBES RES, V7, P111
PIETRIROUXEL F, 1997, EUR J BIOCHEM, V247, P1174
POMP D, 1999, OBES RES, V7, P106
PRICE RA, 1991, BEHAV GENET, V21, P1
RISCH N, 1996, SCIENCE, V273, P1516
ROSSI M, 1998, ENDOCRINOLOGY, V139, P4428
ROTIMI CN, 1999, DIABETES, V48, P643
RUSSELLEGGITT IM, 1998, OPHTHALMOLOGY, V105, P1274
SEELEY RJ, 1997, NATURE, V390, P349
SHIMADA M, 1998, NATURE, V396, P670
SHUTTER JR, 1997, GENE DEV, V11, P593
SINA M, 1999, AM J HUM GENET, V65, P1501
SIRACUSA LD, 1994, TRENDS GENET, V10, P423
SPIELMAN RS, 1996, AM J HUM GENET, V59, P983
STROBEL A, 1998, NAT GENET, V18, P213
STUNKARD AJ, 1986, NEW ENGL J MED, V314, P193
SUTO J, 1998, MAMM GENOME, V9, P506
TARTAGLIA LA, 1995, CELL, V83, P1263
TAYLOR BA, 1996, GENOMICS, V34, P389
TAYLOR BA, 1997, GENOMICS, V43, P249
TAYLOR BA, 1999, MAMM GENOME, V10, P963
TECOTT LH, 1995, NATURE, V374, P542
THOMSON G, 1995, AM J HUM GENET, V57, P487
URBANEK M, 1999, P NATL ACAD SCI USA, V96, P8573
VAISSE C, 1998, NAT GENET, V20, P113
WARDEN CH, 1995, J CLIN INVEST, V95, P1545
WEST DB, 1994, J CLIN INVEST, V94, P1410
WEST DB, 1994, MAMM GENOME, V5, P546
WEST DB, 1995, AM J PHYSIOL-REG I, V268, PR658
WEST DB, 1996, ENDOCRIN METAB CLIN, V25, P801
WILSON BD, 1999, MOL MED TODAY, V5, P250
WOODS SC, 1998, SCIENCE, V280, P1378
YASWEN L, 1999, NAT MED, V5, P1066
YEO GSH, 1998, NAT GENET, V20, P111
YORK B, 1996, MAMM GENOME, V7, P677
YORK B, 1999, MAMM GENOME, V10, P457
ZAMBROWICZ BP, 1998, NATURE, V392, P608
ZHANG YY, 1994, NATURE, V372, P425