Record 6951 View: Standard | Glossary HistCite Guide |
Author(s): Barber BL; Kaufman KD; Kozloff RC; Girman CJ; Guess HA
Title: A hair growth questionnaire for use in the evaluation of therapeutic effects in men
Source: JOURNAL OF DERMATOLOGICAL TREATMENT 9 (3): 181-186
Date: 1998 SEP
Document Type: Journal : Article
Language: English
Comment:
Address: Merck Res Labs, Dept Epidemiol, W Point, PA 19486 USA.
Merck Res Labs, Hlth Econ Stat, W Point, PA 19486 USA. Merck Res Labs, Clin Res, W Point, PA 19486 USA. Merck Res Labs, Clin Res, W Point, PA 19486 USA. Kunitz & Associates Inc, Rockville, MD USA. Reprint: Girman, CJ, Merck Res Labs, Dept Epidemiol, POB 4, W Point, PA 19486
USA. Abstract: BACKGROUND: Male-pattern hair loss (androgenetic alopecia) is a common clinical condition in adult men that is often associated with negative self-perception and has been the target of a number of therapeutic interventions. Despite the importance of self-perceptions of hair growth and appearance with such interventions, no standardized validated questionnaire exists for use in clinical trials. OBJECTIVE: Develop and evaluate a questionnaire to measure patient-perceived changes in hair growth and appearance in clinical trials of medical intervention for androgenetic alopecia in men. METHODS: Literature review and focus groups with men having androgenetic alopecia initially identified 28 potential questions. These questions were assessed in an observational study (n = 204) and a placebo-controlled clinical trial (n = 181). RESULTS: The final questionnaire contained seven global questions addressing change since the start of the study ill satisfaction with hair appearance (three questions), hair growth and appearance, size of the bald spot, and slowing of hair loss. Significant differences favoring active treatment over placebo were evident for all seven questions by 6 months in a clinical trial. CONCLUSIONS: This standardized questionnaire can be used to assess patient perceptions of hair growth in clinical trials of men with androgenetic alopecia.
Cited References: CASH TF, 1992, J AM ACAD DERMATOL, V26, P926 CASH TF, 1993, J AM ACAD DERMATOL, V29, P568 CRONBACH LJ, 1951, PSYCHOMETRIKA, V16, P297 DEYO RA, 1991, CONTROL CLIN TRIALS, V12, PS142 GIRMAN CJ, 1995, J UROLOGY, V153, P1510 GUYATT GH, 1986, CAN MED ASSOC J, V134, P889 KAUFMAN KD, 1996, HAIR RES NEXT MILLEN LIN LI, 1989, BIOMETRICS, V45, P255 NORWOOD OT, 1975, SO MED J, V68, P1359 PASSCHIER J, 1988, INT J DERMATOL S, V27, P441 STEWART AL, 1992, MEASURING FUNCTIONIN, P81 STREINER DL, 1989, HLTH MEASUREMENT SCA STUNKARD AJ, 1967, AM J PSYCHIAT, V123, P1443 STUNKARD AJ, 1967, AM J PSYCHIAT, V123, P1296 TUKEY JW, 1985, BIOMETRICS, V41, P295 VANDERDONK J, 1991, INT J DERMATOL, V30, P22 WARE JE, SF 36 HLTH SURVEY MA, P3 WILSON IB, 1995, JAMA-J AM MED ASSOC, V273, P59 |