Record 37389 View: Standard | Glossary HistCite Guide |
Author(s): Saper CB; Scammell TE; Lu J
Title: Hypothalamic regulation of sleep and circadian rhythms
Source: NATURE 437 (7063): 1257-1263
Date: 2005 OCT 27
Document Type: Journal : Review
DOI: 10.1038/nature04284
Language: English
Comment:
Address: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA.
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Program Neurosci, Boston, MA 02215 USA. Reprint: Saper, CB, Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA.
E-mail: csaper@bidmc.harvard.edu
Author Keywords:
KeyWords Plus: VENTROLATERAL PREOPTIC NUCLEUS; BEHAVIORAL STATE; SUPRACHIASMATIC NUCLEUS; BASAL FOREBRAIN;
TUBEROMAMMILLARY NEURONS; GALANINERGIC NEURONS; PARADOXICAL SLEEP;
WAKING DISCHARGE; LOCUS-COERULEUS; HUMAN-BRAIN
Abstract: A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake - sleep cycles into the optimal pattern for survival.
Cited References: ACHERMANN P, 2003, FRONT BIOSCI, V8, PS683 ALLEN LS, 1989, J NEUROSCI, V9, P497 ANCOLIISRAEL S, 1991, BIOFEEDBACK SELF-REG, V16, P349 ASTONJONES G, 1981, J NEUROSCI, V1, P876 ASTONJONES G, 2001, NAT NEUROSCI, V4, P732 BENINGTON JH, 1995, PROG NEUROBIOL, V45, P347 BORBELY AA, 1985, BRAIN MECH SLEEP, P35 BYNE W, 2000, BRAIN RES, V856, P254 CASSONE VM, 1986, PHYSIOL BEHAV, V36, P1111 CHAMBERLIN NL, 2003, NEUROSCIENCE, V119, P913, DOI 10.1016/S0306-4522(03)00246-X CHEMELLI RM, 1999, CELL, V98, P437 CHOU TC, 2002, J NEUROSCI, V22, P977 CHOU TC, 2003, THESIS HARVARD U, P82 CHOU WB, 2002, ACTA PHARMACOL SIN, V23, P691 DELECEA L, 1998, P NATL ACAD SCI USA, V95, P322 DEURVEILHER S, 2005, NEUROSCIENCE, V130, P165, DOI 10.1016/j.neuroscience.2004.08.030 DIJK DJ, 1995, J NEUROSCI, V15, P3526 DORAN SM, 2001, ARCH ITAL BIOL, V139, P253 ELMQUIST JK, 1998, P NATL ACAD SCI USA, V95, P741 ELMQUIST JK, 1999, NEURON, V22, P221 ESTABROOKE IV, 2001, J NEUROSCI, V21, P1656 FORNAL C, 1985, EXP NEUROL, V88, P590 GALLOPIN T, 2000, NATURE, V404, P992 GAUS SE, 2002, NEUROSCIENCE, V115, P285 GERASHCHENKO D, 2003, NEUROSCIENCE, V116, P223 GOOLEY JJ, 2003, J NEUROSCI, V23, P7093 HALLANGER AH, 1987, J COMP NEUROL, V262, P104 HOFMAN MA, 1989, J ANAT, V164, P55 JIN X, 1999, CELL, V96, P1 JOHN J, 2004, NEURON, V42, P619 JOHNSON RF, 1988, BRAIN RES, V460, P297 JONES BE, 2003, FRONT BIOSCI, V8, P438 KO EM, 2003, BRAIN RES, V992, P220, DOI 10.1016/j.brainres.2003.08.044 KOHLER C, 1986, J COMP NEUROL, V250, P58 KONG JM, 2002, J NEUROSCI, V22, P5581 KROUT KE, 2002, J COMP NEUROL, V448, P53 KROUT KE, 2002, NEUROSCIENCE, V110, P73 LANCEL M, 2001, AM J PHYSIOL-ENDOC M, V281, PE130 LANDRIGAN CP, 2004, NEW ENGL J MED, V351, P1838 LEE MG, 2005, J NEUROSCI, V25, P4365, DOI 10.1523/JNEUROSCI.0178-05.2005 LEE MG, 2005, J NEUROSCI, V25, P6716, DOI 10.1523/JNEUROSCI.1887-05.2005 LIN L, 1999, CELL, V98, P365 LU J, 2000, J NEUROSCI, V20, P3830 LU J, 2001, J NEUROSCI, V21, P4864 LU J, 2002, J NEUROSCI, V22, P4568 MARCUS JN, 2001, J COMP NEUROL, V435, P6 MARTINSCHILD S, 1999, J COMP NEUROL, V405, P450 MCCORMICK DA, 1989, TRENDS NEUROSCI, V12, P215 MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093 MCGINTY DJ, 1968, SCIENCE, V160, P1253 MEIEREWERT HK, 2004, J AM COLL CARDIOL, V43, P678, DOI 10.1016/j.jacc.2003.07.050 MILEYKOVSKIY BY, 2005, NEURON, V46, P787, DOI 10.1016/j.neuron.2005.04.035 MOCHIZUKI T, 2004, J NEUROSCI, V24, P6291, DOI 10.1523/JNEUROSCI.0586-04.2004 MOORE RY, 1972, BRAIN RES, V42, P201 MORUZZI G, 1949, ELECTROEN CLIN NEURO, V1, P455 NAUTA WJH, 1946, J NEUROPHYSIOL, V9, P285 NELSON LE, 2003, ANESTHESIOLOGY, V98, P428 NOFZINGER EA, 2004, AM J PSYCHIAT, V161, P2126 NYHOLM H, 1955, ANN ZOOL FENN, V2, P77 PEYRON C, 1998, J NEUROSCI, V18, P9996 PEYRON C, 2000, NAT MED, V6, P991 PORKKAHEISKANEN T, 2000, NEUROSCIENCE, V99, P507 PRINZ PN, 2004, EXP GERONTOL, V39, P1739, DOI 10.1016/j.exger.2004.06.023 RADULOVACKI M, 1984, J PHARMACOL EXP THER, V228, P268 RANSON SW, 1939, ARCH NEURO PSYCHIATR, V41, P1 REPPERT SM, 2002, NATURE, V418, P935, DOI 10.1038/nature00965 RIPLEY B, 2001, NEUROLOGY, V57, P2253 ROTH T, 2003, SLEEP MED, V4, P275, DOI 10.1016/S1389-9457(03)00058-3 RUDOLPH U, 2004, ANNU REV PHARMACOL, V44, P475 SAKURAI T, 1998, CELL, V92, P573 SAKURAI T, 2005, NEURON, V46, P297, DOI 10.1016/j.neuron.2005.03.010 SAPER CB, 1985, J COMP NEUROL, V237, P21 SAPER CB, 2001, TRENDS NEUROSCI, V24, P726 SAPER CB, 2004, RAT NERVOUS SYSTEM, P761 SAPER CB, 2004, SLEEP, V27, P11 SAPER CB, 2005, TRENDS NEUROSCI, V28, P152, DOI 10.1016/j.tins.2004.12.009 SCAMMELL TE, 2001, NEUROSCIENCE, V107, P653 SCAMMELL TE, 2003, ANN NEUROL, V53, P154, DOI 10.1002/ana.10444 SCHACHTER SC, 1998, EPILEPSIA, V39, P677 SHEPEL PN, 2005, NEUROL RES, V27, P139, DOI 10.1179/016164105x21832 SHERIN JE, 1996, SCIENCE, V271, P216 SHERIN JE, 1998, J NEUROSCI, V18, P4705 STARZL TE, 1951, J NEUROPHYSIOL, V14, P461 STEININGER TL, 1999, BRAIN RES, V840, P138 STEPHAN FK, 2002, J BIOL RHYTHM, V17, P284 STRECKER RE, 2000, BEHAV BRAIN RES, V115, P183 SZYMUSIAK R, 1998, BRAIN RES, V803, P178 THANNICKAL TC, 2000, NEURON, V27, P469 THOMPSON R, 1997, J COMP NEUROL, V376, P143 VANDONGEN HPA, 2003, SLEEP, V26, P117 VERRET L, 2003, BMC NEUROSCI, V4, AR19 VERRET L, IN PRESS J COMP NEUR VINCENT SR, 1982, NEUROENDOCRINOLOGY, V34, P117 VONECONOMO C, 1930, J NERV MENT DIS, V71, P249 WATTS AG, 1987, J COMP NEUROL, V258, P204 WILSON SAK, 1928, MODERN PROBLEMS NEUR WISDEN W, 1992, J NEUROSCI, V12, P1040 WISOR JP, 2001, J NEUROSCI, V21, P1787 YAMANAKA A, 2003, NEURON, V38, P701 YOSHIDA K, IN PRESS J COMP NEUR |