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Author(s): Ballatore C; Lee VMY; Trojanowski JQ
Title: Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Source: NATURE REVIEWS NEUROSCIENCE 8 (9): 663-672
Date: 2007 SEP
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: Univ Penn, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA.
Univ Penn, Inst Aging, Philadelphia, PA 19104 USA. Univ Penn, Dept Chem, Philadelphia, PA 19104 USA. Reprint: Trojanowski, JQ, Univ Penn, Dept Pathol & Lab Med, Ctr Neurodegenerat
Dis Res, 3600 Spurce St, Philadelphia, PA 19104 USA. E-mail: trojanow@mail.med.upenn.edu
Author Keywords:
KeyWords Plus: PAIRED HELICAL FILAMENTS; TRANSGENIC ANIMAL-MODELS; AXONAL-TRANSPORT;
MOUSE MODEL; IN-VIVO; PROTEIN AGGREGATION; P301L TAU; NEUROFIBRILLARY
TANGLES; PROMINENT AXONOPATHY; O-GLCNACYLATION
Abstract: Advances in our understanding of the mechanisms of tau-mediated neurodegeneration in Alzheimer's disease ( AD) and related tauopathies, which are characterized by prominent CNS accumulations of fibrillar tau inclusions, are rapidly moving this previously underexplored disease pathway to centre stage for disease-modifying drug discovery efforts. However, controversies abound concerning whether or not the deleterious effects of tau pathologies result from toxic gains-of-function by pathological tau or from critical losses of normal tau function in the disease state. This Review summarizes the most recent advances in our knowledge of the mechanisms of tau-mediated neurodegeneration to forge an integrated concept of those tau-linked disease processes that drive the onset and progression of AD and related tauopathies.
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