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Author(s): Cuervo AM
Title: Autophagy: Many paths to the same end
Source: MOLECULAR AND CELLULAR BIOCHEMISTRY 263 (1): 55-72
Date: 2004 AUG
Document Type: Journal : Proceedings Paper
DOI:
Language: English
Comment:
Address: Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept Anat & Struct Biol, Bronx, NY 10461 USA.
Reprint: Cuervo, AM, Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Dept
Anat & Struct Biol, Ullmann Bldg Room 614,1300 Morris Pk Ave, Bronx, NY 10461 USA. E-mail: amcuervo@aecom.yu.edu
Author Keywords: lysosomes; cathepsins; protein targeting; aging; cellular death;
cardiomyopathies
KeyWords Plus: PROGRAMMED CELL-DEATH; RAT-LIVER LYSOSOMES; CHAPERONE-MEDIATED
AUTOPHAGY; AGE-RELATED DECLINE; HEAT-SHOCK-PROTEIN; SACCHAROMYCES-
CEREVISIAE; VESICLE FORMATION; SELECTIVE UPTAKE; YEAST VACUOLE;
PEROXISOME DEGRADATION
Abstract: Different mechanisms lead to the degradation of intracellular proteins in the lysosomal compartment. Activation of one autophagic pathway or another, under specific cellular conditions, plays an important role in the ability of the cell to adapt to environmental changes. Each form of autophagy has its own individual characteristics, but it also shares common steps and components with the others. This interdependence of the autophagic pathways confers to the lysosomal system, both specificity and flexibility on substrate degradation. We describe in this review some of the recent findings on the molecular basis and regulation for each of the different autophagic pathways. We also discuss the cellular consequences of their interdependent function. Malfunctioning of the autophagic systems has dramatic consequences, especially in non-dividing differentiated cells. Using the heart as an example of such cells, we analyze the relevance of autophagy in aging and cell death, as well as in different pathological conditions.
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