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Author(s): Gagnon E; Duclos S; Rondeau C; Chevet E; Cameron PH; Steele-Mortimer O; Paiement J; Bergeron JJM; Desjardins M
Title: Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
Source: CELL 110 (1): 119-131
Date: 2002 JUL 12
Document Type: Journal : Article
DOI:
Language: English
Comment:
Address: Univ Montreal, Dept Pathol & Biol Cellulaire, Montreal, PQ H3C 3J7, Canada.
McGill Univ, Dept Surg, Montreal, PQ H3A 2T5, Canada. McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2T5, Canada. NIAID, Rocky Mt Labs, Intracellular Parasites Lab, Hamilton, MT 59840 USA. Caprion Pharmaceut Inc, Montreal, PQ, Canada. Reprint: Desjardins, M, Univ Montreal, Dept Pathol & Biol Cellulaire, Montreal,
PQ H3C 3J7, Canada. E-mail:
Author Keywords:
KeyWords Plus: ISOLATED RAT HEPATOCYTES; LEGIONELLA-PNEUMOPHILA; PHOSPHATIDYLINOSITOL
3-KINASE; MATURING PHAGOSOMES; CONTAINING VACUOLES; IN-VITRO;
MATURATION; FUSION; CALRETICULIN; CELLS
Abstract: Phagocytosis is a key aspect of our innate ability to fight infectious diseases. In this study, we have found that fusion of the endoplasmic reticulum (ER) with the macrophage plasmalemma, underneath phagocytic cups, is a source of membrane for phagosome formation in macrophages. Successive waves of ER become associated with maturing phagosomes during phagolysosome biogenesis. Thus, the ER appears to possess unexpectedly pluripotent fusion properties. ER-mediated phagocytosis is regulated in part by phosphatidylinositol 3-kinase and used for the internalization of inert particles and intracellular pathogens, regardless of their final trafficking in the host. In neutrophils, where pathogens are rapidly killed, the ER is not used as a major source of membrane for phagocytosis. We propose that intracellular pathogens have evolved to adapt and exploit ER-mediated phagocytosis to avoid destruction in host cells.
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