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Author(s): Manthey JA; Guthrie N; Grohmann K
Title: Biological properties of citrus flavonoids pertaining to cancer and inflammation
Source: CURRENT MEDICINAL CHEMISTRY 8 (2): 135-153
Date: 2001 FEB
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: ARS, US Citrus & Subtrop Prod Lab, USDA, SAA, Winter Haven, FL 33881 USA.
Univ Western Ontario, KGK Synergize Inc, London, ON N6G 4X8, Canada. Reprint: Manthey, JA, ARS, US Citrus & Subtrop Prod Lab, USDA, SAA, 600 Ave S
NW, Winter Haven, FL 33881 USA. E-mail: jmanthey@citrus.usda.gov
Author Keywords:
KeyWords Plus: PROTEIN-KINASE-C; PHYSIOLOGICALLY ACTIVE SUBSTANCES; CYCLIC-AMP
PHOSPHODIESTERASE; BASOPHIL HISTAMINE-RELEASE; RAT-LIVER MICROSOMES;
METABOLIZING ENZYME-ACTIVITIES; PHOSPHOLIPASE A(2) INHIBITORS; HL-60
CELL-DIFFERENTIATION; NECROSIS-FACTOR-ALPHA; DAFLON(R) 500 MG
Abstract: Citrus flavonoids encompass a diverse set of structures, including numerous flavanone and flavone O-and C-glycosides and methoxylated flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions. These biological properties are consistent with their effects on the microvascular endothelial tissue. Evidence suggests that the biological actions of the citrus flavonoids are possibly linked to their interactions with key regulatory enzymes involved in cell activation and receptor binding. The citrus flavonoids show little effect on normal, healthy cells, and thus typically exhibit remarkably low toxicity in animals. The citrus flavonoids extend their influence in vivo through their induction of hepatic phase I and II enzymes, and through the biological actions of their metabolites. Evidence clearly indicates to the potential health promoting properties of these dietary compounds.
Cited References: AGULLO G, 1997, BIOCHEM PHARMACOL, V53, P1649 ALLEN DO, 1973, J PHARMACOL EXP THER, V185, P379 AMATO C, 1994, ANGIOLOGY, V45, P531 ANNE S, 1994, J ALLERGY CLIN IMM 2, V93, P276 ARMENTANO L, 1936, DEUT MED WOCHENSCHR, V62, P1326 AUSTIN CA, 1992, BIOCHEM J 3, V282, P883 BAUMANN J, 1980, PROSTAG OTH LIPID M, V20, P627 BENTSATH A, 1937, NATURE, V139, P326 BERHOW MA, 1998, USDA ARS TECHNICAL B, V1856 BOEGE F, 1996, J BIOL CHEM, V271, P2262 BOOTH AN, 1958, J BIOL CHEM, V230, P661 BOOTH AN, 1958, J BIOL CHEM, V233, P280 BOUSKELA E, 1995, INT J MICROCIRC, V15, P293 BOUSKELA E, 1997, INT J MICROCIRC S1, V17, P18 BOUTIN JA, 1993, DRUG METAB DISPOS, V21, P1157 BRACKE M, 1991, CLIN EXP METASTAS, V9, P13 BRACKE ME, 1989, CLIN EXP METASTAS, V7, P283 BRACKE ME, 1994, FOOD TECHNOL-CHICAGO, V48, P121 BRACKE ME, 1999, J NATL CANCER I, V91, P354 BROUARD C, 1988, FOOD CHEM TOXICOL, V26, P99 CANIVENCLAVIER MC, 1993, XENOBIOTICA, V23, P259 CANIVENCLAVIER MC, 1996, TOXICOL APPL PHARM, V136, P348 CANIVENCLAVIER MC, 1996, TOXICOLOGY, V114, P19 CHAUMONTET C, 1994, CARCINOGENESIS, V15, P2325 CHAUMONTET C, 1997, CANCER LETT, V114, P207 CHEN J, 1997, J AGR FOOD CHEM, V45, P364 COCHET C, 1982, BIOCHEM PHARMACOL, V31, P1357 CONSEIL G, 1998, P NATL ACAD SCI USA, V95, P9831 CONSTANTINOU A, 1990, CANCER RES, V50, P2618 CONSTANTINOU A, 1995, J NAT PRODUCTS, V58, P217 COVA D, 1992, INT J CLIN PHARM TH, V30, P29 CRESPY V, 1999, AM J PHYSIOL-GASTR L, V277, PG120 CYBULSKY MI, 1991, SCIENCE, V251, P788 CYPRIANI B, 1993, BIOCHEM PHARMACOL, V45, P1531 DAI RK, 1997, LIFE SCI, V61, PPL75 DAMON M, 1987, ARZNEIM FORSCH DRUG, V37, P1149 DANA R, 1994, BIOCHEM J 1, V297, P217 DEVRIES JHM, 1998, AM J CLIN NUTR, V68, P60 DUBOIS RN, 1998, FASEB J, V12, P1063 DUCHENEMARULLAZ P, 1988, INT ANGIOL S2, V7, P25 EMIN JAD, 1994, J PHARM PHARMACOL, V46, P118 FERRELL JE, 1979, MOL PHARMACOL, V16, P556 FERRIOLA PC, 1989, BIOCHEM PHARMACOL, V38, P1617 FREEDMAN L, 1963, SCIENCE, V139, P344 FRIESENECKER B, 1994, INT J MICROCIRC, V14, P50 FRIESENECKER B, 1995, INT J MICROCIRC S1, V15, P17 FROLICH JC, 1997, ARZNEIMITTEL-FORSCH, V47, P1289 GABOR M, 1979, HDB EXP PHARM, V50, P698 GENTILI B, 1964, TETRAHEDRON, V20, P2313 GERRITSEN ME, 1993, FASEB J, V7, P523 GERRITSEN ME, 1995, AM J PATHOL, V147, P278 GERRITSEN ME, 1998, ADV EXP MED BIOL, V439, P183 GIL B, 1994, LIFE SCI, V54, P333 GORDON PB, 1995, J BIOL CHEM, V270, P5830 GRAY AI, 1978, PHYTOCHEMISTRY, V17, P845 GRAZIANI Y, 1983, EUR J BIOCHEM, V135, P583 GUTHRIE N, 1998, ADV EXP MED BIOL, V439, P227 GUTHRIE N, 1998, BIOL OXIDANTS MOL ME, P310 GUTHRIE N, 1999, INFORM S5, V10, PS31 HABTEMARIAN S, 1997, J NAT PROD, V60, P775 HASRAT JA, 1997, J PHARM PHARMACOL, V49, P1150 HIRANO T, 1995, BRIT J CANCER, V72, P1380 HITZENBERGER G, 1997, WIEN MED WOCHENSCHR, V147, P409 HOLLMAN PC, 1998, ARCH TOXICOL S, V20, P237 HOLLMAN PCH, 1996, FREE RADICAL BIO MED, V21, P703 HOLLMAN PCH, 1997, BIOMED PHARMACOTHER, V51, P305 HOPE WC, 1983, BIOCHEM PHARMACOL, V32, P367 HOROWITZ RM, 1960, J ORG CHEM, V25, P2183 HOROWITZ RM, 1961, J ORG CHEM, V26, P2899 HOROWITZ RM, 1977, CITRUS SCI TECHNOLOG, V1, P397 HUANG YT, 1996, EUR J CANCER A, V32, P146 JACOBSON KA, 1998, TRENDS PHARMACOL SCI, V19, P184 JEAN T, 1994, ANGIOLOGY, V45, P554 JINSART W, 1992, BIOL CHEM H-S, V373, P205 KANAZAWA K, 1998, BIOSCI BIOTECH BIOCH, V62, P970 KANDASWAMI C, 1991, CANCER LETT, V56, P147 KAWAGUCHI K, 1999, EUR J PHARMACOL, V368, P245 KAWAII S, 1999, ANTICANCER RES, V19, P1261 KAWAII S, 1999, BIOSCI BIOTECH BIOCH, V63, P896 KAWAII S, 1999, LEUKEMIA RES, V23, P263 KIM DH, 1998, ARCH PHARM RES, V21, P17 KIM HP, 1998, PROSTAG LEUKOTR ESS, V58, P17 KORTHUIS RJ, 1997, INT J MICROCIRC S1, V17, P11 KUMAMOTO H, 1985, AGR BIOL CHEM TOKYO, V49, P2613 KUMAMOTO H, 1986, AGR BIOL CHEM TOKYO, V50, P781 KUO ML, 1995, BIOCHEM BIOPH RES CO, V212, P767 KUPPUSAMY UR, 1994, BIOCHEM PHARMACOL, V47, P521 LABRID C, 1992, PHLEBOLOGY S, V2, P27 LABRID C, 1994, ANGIOLOGY, V45, P524 LAKE BG, 1999, MUTAT RES-GEN TOX EN, V440, P91 LANDOLFI R, 1984, BIOCHEM PHARMACOL, V33, P1525 LASKER JM, 1984, J PHARMACOL EXP THER, V229, P162 LEBRETON, 1828, J PHARM PARIS, V14, P377 LEMANSKE RF, 1988, J CLIN IMMUNOL, V8, P1 LESLIE EM, 1999, AM ASS CANC RES, V40, P663 LI Y, 1994, DRUG METAB DISPOS, V22, P566 LIN JK, 1997, J CELL BIOCHE S28-29, P39 LINDAHL M, 1993, INFLAMMATION, V17, P573 LINDAHL M, 1997, INFLAMMATION, V21, P347 LINDEN J, 1994, TRENDS PHARMACOL SCI, V15, P289 LONCHAMPT M, 1989, ARZNEIMITTEL-FORSCH, V39, P882 MAK NK, 1996, LIFE SCI, V58, P1269 MANACH C, 1995, J NUTR, V125, P1911 MANTHEY JA, 1998, ADV EXP MED BIOL, V439, P85 MANTHEY JA, 1999, J NAT PROD, V62, P441 MARONE G, 1979, J IMMUNOL, V123, P1669 MARONE G, 1980, CLIN IMMUNOL IMMUNOP, V17, P117 MATSUBARA Y, 1985, AGR BIOL CHEM TOKYO, V49, P909 MELIN AM, 1996, BIOCH TOXICOL, V11, P27 MIDDLETON E, 1981, J IMMUNOL, V127, P546 MIDDLETON E, 1982, BIOCHEM PHARMACOL, V31, P1449 MIDDLETON E, 1984, BIOCHEM PHARMACOL, V33, P3333 MIDDLETON E, 1987, BIOCHEM PHARMACOL, V36, P2048 MIDDLETON E, 1988, PLANT FLAVONOIDS BIO, V2, P251 MIDDLETON E, 1993, ADV RES 1986, P619 MIDDLETON E, 1998, ADV EXP MED BIOL, V439, P175 MITCHELL JA, 1998, INFLAMM RES S2, V47, PS88 MIYAKE Y, 1998, LIPIDS, V33, P689 MOOKERJEE BK, 1986, J IMMUNOPHARMACOL, V8, P371 MORAND C, 1998, AM J PHYSIOL-REG I, V275, PR212 MORINO M, 1997, IN VIVO, V11, P265 MORONEY MA, 1988, J PHARM PHARMACOL, V40, P787 NIELSEN SE, 1998, XENOBIOTICA, V28, P389 NIKAIDO T, 1982, PLANTA MED, V46, P162 NIKAIDO T, 1988, CHEM PHARM BULL, V36, P654 NISHIOKA H, 1989, J ANTIBIOT, V42, P823 OBERMEIER MT, 1995, XENOBIOTICA, V25, P575 OBRIEN KD, 1993, J CLIN INVEST, V92, P945 OKURA A, 1988, BIOCHEM BIOPH RES CO, V157, P183 OLAH ME, 1995, ANNU REV PHARMACOL, V35, P581 PANES J, 1996, MICROCIRCULATION, V3, P279 PEREGO R, 1993, XENOBIOTICA, V23, P1345 PETERS SP, 1981, NATURE, V292, P455 PETKOV E, 1981, PLANTA MED, V43, P183 RISCH B, 1987, PHYTOCHEMISTRY, V26, P509 RISCH B, 1988, PHYTOCHEMISTRY, V27, P3327 RISCH B, 1988, Z LEBENSM UNTERS FOR, V187, P530 ROBINSON MJ, 1993, BIOCHEMISTRY-US, V32, P3638 ROGERS EH, 1998, CHEMICOBIOLOGICAL IN, V116, P213 ROSSI F, 1976, AGENTS ACTIONS, V6, P50 SALGADO E, 1956, J APPL PHYSIOL, V8, P647 SALVEMINI D, 1997, CELL MOL LIFE SCI, V53, P576 SATOH Y, 1996, YAKUGAKU ZASSHI, V116, P244 SIESS MH, 1989, XENOBIOTICA, V19, P1379 SIESS MH, 1990, FOOD ADDIT CONTAM, V7, PS178 SIESS MH, 1992, J TOXICOL ENV HEALTH, V35, P141 SIESS MH, 1995, TOXICOL APPL PHARM, V130, P73 SIESS MH, 1996, J TOXICOL ENV HEALTH, V49, P481 SO FV, 1996, NUTR CANCER, V26, P167 SONG LL, 1999, CANCER RES, V59, P578 SPINA D, 1998, ADV PHARMACOL, V44, P33 STANLEY WL, 1971, J AGR FOOD CHEM, V19, P1106 STENSON WF, 1980, BIOCHEM BIOPH RES CO, V96, P1045 STUCKER O, 1989, INT ANGIOL, V8, P39 SUGIYAMA S, 1993, CHEM PHARM BULL, V41, P714 SZENTGYORGY A, 1936, NATURE, V138, P27 TAKAHASHI T, 1998, BIOSCI BIOTECH BIOCH, V62, P2199 TALALAY P, 1988, P NATL ACAD SCI USA, V85, P8261 TANAKA T, 1997, CARCINOGENESIS, V18, P761 TANAKA T, 1997, CARCINOGENESIS, V18, P957 TATUM JH, 1979, PHYTOCHEMISTRY, V18, P500 VANPUIJENBROEK AAFL, 1999, CYTOKINE, V11, P104 VICKERY HB, 1950, SCIENCE, V112, P628 VILLA P, 1992, TOXICOLOGY, V73, P179 WADSWORTH TL, 1999, BIOCHEM PHARMACOL, V57, P941 WATTENBERG LW, 1968, CANCER RES, V28, P934 WATTENBERG LW, 1985, CANCER RES, V45, P1 WATTENBERG LW, 1992, CANCER RES, V52, P2085 WELTON AF, 1986, PLANT FLAVONOIDS BIO, P231 WENZEL SE, 1997, PHARMACOTHERAPY 2, V17, PS3 WHEELER EL, 1986, CARCINOGENESIS, V7, P33 WOLLE J, 1996, ARTERIOSCL THROM VAS, V16, P1501 XIAODUO J, 1996, J MED CHEM, V39, P781 YANG MZ, 1997, INT J CANCER, V73, P719 YANNAI S, 1998, FOOD CHEM TOXICOL, V36, P623 YOSHIMOTO T, 1983, BIOCHEM BIOPH RES CO, V116, P612 ZALLEN G, 1998, ARCH SURG-CHICAGO, V133, P1229 |