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Author(s): OHARA PJ; SHEPPARD PO; THOGERSEN H; VENEZIA D; HALDEMAN BA; MCGRANE V; HOUAMED KM; THOMSEN C; GILBERT TL; MULVIHILL ER
Title: THE LIGAND-BINDING DOMAIN IN METABOTROPIC GLUTAMATE RECEPTORS IS RELATED TO BACTERIAL PERIPLASMIC BINDING-PROTEINS
Source: NEURON 11 (1): 41-52
Date: 1993 JUL
Document Type: Journal : Article
DOI:
Language: English
Comment:
Address: NOVO NORDISK,DK-2760 MALOV,DENMARK.
Reprint: OHARA, PJ, ZYMOGENET INC,4225 ROOSEVELT WAY NE,SEATTLE,WA 98105.
E-mail:
Abstract: Receptors for the major excitatory neurotransmitter glutamate include metabotropic (G protein-coupled) and ionotropic (glutamate-gated ion channel) types. These receptors have large, presumably extracellular, amino-terminal domains. Sensitive sequence analysis techniques indicate that the metabotropic receptor extracellular domain is similar to bacterial periplasmic amino acid binding proteins. A structural model built using the observed similarity predicts a ligand-binding site, and mutants with conservative amino acid substitutions at this site are shown to have reduced ligand affinity. The metabotropic receptor extracellular domain is a member of a family of structural domains linked to a variety of receptor types, including ionotropic glutamate receptors.
Cited References: AARONSON SA, 1991, SCIENCE, V254, P1146 ABE T, 1992, J BIOL CHEM, V267, P13361 ADAMS MD, 1989, J BIOL CHEM, V264, P15739 AMES GF, 1990, FEMS MICROBIOL REV, V75, P429 AMES GFL, 1986, ANNU REV BIOCHEM, V55, P397 ANDERSON BF, 1990, NATURE, V344, P784 BAIROCH A, 1992, NUCLEIC ACIDS RES S, V20, P2019 BAKER EN, 1992, J INORG BIOCHEM, V47, P147 BARNES JM, 1992, PROG NEUROBIOL, V39, P113 BERNSTEIN FC, 1977, J MOL BIOL, V112, P535 BERRIDGE MJ, 1982, BIOCHEM J, V206, P587 BETTLER B, 1990, NEURON, V5, P583 BETTLER B, 1992, NEURON, V8, P257 BILOFSKY HS, 1986, NUCLEIC ACIDS RES, V14, P1 BLUNDELL TL, 1987, NATURE, V326, P347 BOWIE JU, 1991, SCIENCE, V253, P164 CONNOLLY ML, 1992, BIOPOLYMERS, V32, P1215 EGEBJERG J, 1991, NATURE, V351, P745 ENGELMAN DM, 1986, ANNU REV BIOPHYS BIO, V15, P321 GASIC GP, 1992, ANNU REV PHYSIOL, V54, P507 GEORGE DG, 1986, NUCLEIC ACIDS RES, V14, P11 GREGOR P, 1989, NATURE, V342, P689 GRIBSKOV M, 1987, P NATL ACAD SCI USA, V84, P4355 HAMM GH, 1986, NUCLEIC ACIDS RES, V14, P5 HENIKOFF S, 1992, P NATL ACAD SCI USA, V89, P10915 HIGGINS CF, 1981, P NATL ACAD SCI-BIOL, V78, P6038 HO SN, 1989, GENE, V77, P51 HOLLMANN M, 1989, NATURE, V342, P643 HOSHINO T, 1989, J BACTERIOL, V171, P6300 HOUAMED KM, 1991, SCIENCE, V252, P1318 JOHANNESSEN M, 1990, THROMB HAEMOSTASIS, V63, P54 JOHNSON JW, 1987, NATURE, V325, P529 JONES TA, 1986, EMBO J, V5, P819 KANG CH, 1991, J BIOL CHEM, V266, P23893 KEINANEN K, 1990, SCIENCE, V249, P556 KLECKNER NW, 1988, SCIENCE, V241, P835 KNIGHTON DR, 1992, SCIENCE, V258, P130 KUMAR KN, 1991, NATURE, V354, P70 KUTSUWADA T, 1992, NATURE, V358, P36 LANDICK R, 1985, J BIOL CHEM, V260, P8257 LEVITT M, 1976, NATURE, V261, P552 LUTHY R, 1992, NATURE, V356, P83 MASU M, 1991, NATURE, V349, P760 MEGURO H, 1992, NATURE, V357, P70 MOLNAR E, 1993, NEUROSCIENCE, V53, P307 MONYER H, 1992, SCIENCE, V256, P1217 MORIYOSHI K, 1991, NATURE, V354, P31 MOWBRAY SL, 1983, J BIOL CHEM, V258, P7991 NAKANISHI N, 1990, NEURON, V5, P569 NAKANISHI S, 1992, SCIENCE, V258, P597 NOHNO T, 1986, MOL GEN GENET, V205, P260 OH BH, 1993, IN PRESS J BIOL CHEM OHNISHI K, 1990, J BIOCHEM-TOKYO, V107, P202 PEARSON WR, 1988, P NATL ACAD SCI USA, V85, P2444 PFLUGRATH JW, 1988, J MOL BIOL, V200, P163 QUIOCHO FA, 1984, NATURE, V310, P381 QUIOCHO FA, 1990, PHILOS T ROY SOC B, V326, P341 RAMACHANDRAN GN, 1968, ADV PROTEIN CHEM, V23, P283 RECASENS M, 1992, MOL NEUROPHARMACOL, V2, P15 SACK JS, 1989, J MOL BIOL, V206, P171 SACK JS, 1989, J MOL BIOL, V206, P193 SAKIMURA K, 1990, FEBS LETT, V272, P73 SAKIMURA K, 1992, NEURON, V8, P267 SANGER F, 1977, P NATL ACAD SCI USA, V74, P5463 SCHOLLE A, 1987, MOL GEN GENET, V208, P247 SCHULZ S, 1991, TRENDS PHARMACOL SCI, V12, P116 SCRIPTURE JB, 1987, J MOL BIOL, V197, P37 SHYJAN AW, 1992, NEURON, V9, P727 SINGH S, 1988, NATURE, V334, P708 SLADECZEK F, 1985, NATURE, V317, P717 SOMMER B, 1990, SCIENCE, V249, P1580 SOMMER B, 1992, TRENDS PHARMACOL SCI, V13, P291 STODDARD BL, 1992, NATURE, V358, P774 SUN W, 1992, P NATL ACAD SCI USA, V89, P1443 TANABE Y, 1992, NEURON, V8, P169 THORPE DS, 1989, J BIOL CHEM, V264, P6545 TOWBIN H, 1979, P NATL ACAD SCI USA, V76, P4350 UCHINO S, 1992, FEBS LETT, V308, P253 UNWIN N, 1993, J MOL BIOL, V229, P1101 VYAS NK, 1987, NATURE, V327, P635 VYAS NK, 1991, J BIOL CHEM, V266, P5226 WADA K, 1989, NATURE, V342, P684 WERNER P, 1991, NATURE, V351, P742 YAMAZAKI M, 1992, BIOCHEM BIOPH RES CO, V183, P886 |