Record 5778   View: Standard Glossary  HistCite Guide
Author(s): Lee YJ; Wu TD
Title: Total synthesis of kaempferol and methylated kaempferol derivatives
Source: JOURNAL OF THE CHINESE CHEMICAL SOCIETY 48 (2): 201-206
Date: 2001 APR
Document Type: Journal : Article
DOI:  
Language: English
Comment:  
Address: Natl Changhua Univ Educ, Dept Chem, Changhua, Taiwan.
Reprint: Lee, YJ, Natl Changhua Univ Educ, Dept Chem, Changhua, Taiwan.
E-mail:  
Author Keywords:  
KeyWords Plus:  
Abstract: Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in overall yields of 47% from commercially available 1,3,5-trimethoxybenzene (10). The methylated kaempferols 2-5 were also prepared by use of this concise synthetic methodology. The key transformations in this synthesis involved the It oxidative-promoting-cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.
Cited References:
ADAM W, 1991, J ORG CHEM, V56, P7292
BRINKWORTH RI, 1992, BIOCHEM BIOPH RES CO, V188, P631
CHEN WK, 1999, CHIN PHARM J, V51, P271
CHIKAO N, 1987, AGR BIOL CHEM TOKYO, V51, P139
DIVI RL, 1996, CHEM RES TOXICOL, V9, P16
DONG H, 1999, PHYTOCHEMISTRY, V50, P899
DREYER DL, 1964, TETRAHEDRON, V20, P2977
FERRERES F, 1991, J SCI FOOD AGR, V56, P49
FESEN MR, 1993, P NATL ACAD SCI USA, V90, P2399
GEISSMAN TA, 1946, J AM CHEM SOC, V68, P697
GORMLEY TR, 1973, TETRAHEDRON, V29, P369
HA HR, 1995, EUR J CLIN PHARMACOL, V48, P367
HAVSTEEN B, 1983, BIOCHEM PHARMACOL, V32, P1141
HEMPEL J, 1996, J AGR FOOD CHEM, V44, P2114
HERTOG MGL, 1993, J AGR FOOD CHEM, V41, P1242
HOSHINO Y, 1986, B CHEM SOC JPN, V59, P2351
HUANG YL, 1998, J NAT PROD, V61, P1194
JAIN N, 1990, PHYTOCHEMISTRY, V29, P3988
JOYEUX M, 1995, PLANTA MED, V61, P126
JURENS TM, 1994, J NAT PRODUCTS, V57, P230
KADER F, 1996, FOOD CHEM, V55, P35
KARTNIG T, 1985, PLANTA MED, V51, P288
KIMURA Y, 1967, YAKUGAKU ZASSHI, V87, P1132
KIMURA Y, 1967, YAKUGAKU ZASSHI, V87, P440
KUBO I, 1999, J AGR FOOD CHEM, V47, P4121
KUO YH, 1997, J CHIN CHEM SOC-TAIP, V44, P379
LEE YJ, 2000, CANCER LETT, V153, P51
LIN TC, 1999, PHYTOCHEMISTRY, V51, P793
MACHIDA K, 1989, CHEM PHARM BULL, V37, P1092
MATTHES HWD, 1980, PHYTOCHEMISTRY, V19, P2643
MCGARRY LW, 1990, J ORG CHEM, V55, P4349
MITSCHER LA, 1985, PHYTOCHEMISTRY, V24, P1481
NAKATANI N, 1991, AGR BIOL CHEM TOKYO, V55, P455
NIELSEN JG, 1970, ACTA CHEM SCAND, V24, P724
PARK EJ, 2000, J NAT PROD, V63, P34
PARK YK, 1996, J AGR FOOD CHEM, V44, P34
PRAWAT H, 1995, PHYTOCHEMISTRY, V40, P1167
RAHA P, 1991, PHYTOCHEMISTRY, V30, P3812
RASKU S, 2000, TETRAHEDRON, V56, P913
ROMMEL A, 1993, J AGR FOOD CHEM, V41, P1237
ROSSI MH, 1997, PHYTOCHEMISTRY, V45, P1263
SEKINE T, 1991, PHYTOCHEMISTRY, V30, P991
SHUKLA RVN, 1981, PHYTOCHEMISTRY, V20, P339
WAGNER H, 1977, TETRAHEDRON, V33, P1411
YASUKAWA K, 1990, CHEM PHARM BULL, V38, P774