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Author(s): Lee YJ; Wu TD
Title: Total synthesis of kaempferol and methylated kaempferol derivatives
Source: JOURNAL OF THE CHINESE CHEMICAL SOCIETY 48 (2): 201-206
Date: 2001 APR
Document Type: Journal : Article
DOI:
Language: English
Comment:
Address: Natl Changhua Univ Educ, Dept Chem, Changhua, Taiwan.
Reprint: Lee, YJ, Natl Changhua Univ Educ, Dept Chem, Changhua, Taiwan.
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Author Keywords:
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Abstract: Kaempferol (1), a natural product from various plants, was synthesized in which the longest linear sequence is only seven steps in overall yields of 47% from commercially available 1,3,5-trimethoxybenzene (10). The methylated kaempferols 2-5 were also prepared by use of this concise synthetic methodology. The key transformations in this synthesis involved the It oxidative-promoting-cyclization and DDO oxidative hydroxylation. Several strategies to achieve 1 are provided.
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