Record 8772   View: Standard Glossary  HistCite Guide
Author(s): Kigoshi H; Hayakawa I
Title: Marine cytotoxic macrolides haterumalides and biselides, and related natural products
Source: CHEMICAL RECORD 7 (4): 254-264
Date: 2007 
Document Type: Journal : Article
DOI:  
Language: English
Comment:  
Address: Univ Tsukuba, Dept Chem, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058571, Japan.
Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058571, Japan.
Reprint: Kigoshi, H, Univ Tsukuba, Dept Chem, Grad Sch Pure & Appl Sci, Tsukuba,
Ibaraki 3058571, Japan.
E-mail: kigoshi@chem.tsukuba.ac.jp
Author Keywords: marine cytotoxic macrolide; haterumalides; biselides; human cancer cell lines
KeyWords Plus: BACTERIUM SERRATIA-PLYMUTHICA; ANTI-HYPERLIPIDEMIC AGENT; ASCIDIAN DIDEMNIDAE-SP; ALLYL HALIDES; METHYL-ESTER; FR177391; NA; IDENTIFICATION; LACTONIZATION; CHLORIDE
Abstract: Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products.(c) 2007 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.
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