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Author(s): Weng GZ; Bhalla US; Iyengar R
Title: Complexity in biological signaling systems
Source: SCIENCE 284 (5411): 92-96
Date: 1999 APR 2
Document Type: Journal : Editorial Material
DOI:
Language: English
Comment:
Address: CUNY Mt Sinai Sch Med, Dept Pharmacol, New York, NY 10029 USA.
Univ Agr Sci Bangalore, Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India. Reprint: Iyengar, R, CUNY Mt Sinai Sch Med, Dept Pharmacol, Box 1215, New York,
NY 10029 USA. E-mail:
Author Keywords:
KeyWords Plus: SIMPLE 2-STATE MODEL; CYCLASE; ULTRASENSITIVITY; TRANSDUCTION;
TRANSIENT; RECEPTOR; PROTEINS; TERMS
Abstract: Biological signaling pathways interact with one another to form complex networks. Complexity arises from the Large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.
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