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Author(s): McAdams HH; Arkin A
Title: It's a noisy business! Genetic regulation at the nanomolar scale
Source: TRENDS IN GENETICS 15 (2): 65-69
Date: 1999 FEB
Document Type: Journal : Review
DOI:
Language: English
Comment:
Address: Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA.
EO Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA. Reprint: McAdams, HH, Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305
USA. E-mail: mcadams@cmgm.stanford.edu
aparkin@lbl.gov Author Keywords:
KeyWords Plus: ESCHERICHIA-COLI; TRANSCRIPTION; EXPRESSION; REDUNDANCY; MODEL; TIME;
CHECKPOINTS; SIMULATION; EVOLUTION; NETWORKS
Abstract: Many molecules that control genetic regulatory circuits act at extremely low intracellular concentrations. Resultant fluctuations (noise) in reaction rates cause large random variation in rates of development, morphology and the instantaneous concentration of each molecular species in each cell. To achieve regulatory reliability in spite of this noise, cells use redundancy in genes as well as redundancy and extensive feedback in regulatory pathways. However, some regulatory mechanisms exploit this noise to randomize outcomes where variability is advantageous.
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