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Tue Aug 31 16:37:45 2004
Dopamine-dependent neurotoxicity of
alpha-synuclein: A mechanism for selective
neurodegeneration in Parkinson disease

Xu J, Kao SY, Lee FJS, Song WH, Jin LW, Yankner BA
NATURE MEDICINE 8 (6): 600-606 JUN 2002
and the citing papers

Nodes: 91
Authors: 315, Journals: 56, Outer References: 3533
Collection span: 2002 - 2004
View: Overview. Sorted by year, source, volume, issue, page.
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
11471 2002 ANNALS OF NEUROLOGY 52(6):722-731
Kawamoto Y; Akiguchi I; Nakamura S; Budka H
Accumulation of 14-3-3 proteins in glial cytoplasmic inclusions in multiple system atrophy
26
2112 2002 CHEMICAL & ENGINEERING NEWS 80(23):34-34
[Anon]
Explanation for Parkinson's degeneration
00
311793 2002 HUMAN MOLECULAR GENETICS 11(20):2395-2407
Lotharius J; Brundin P
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
813
41424 2002 JOURNAL OF BIOLOGICAL CHEMISTRY 277(52):50980-50984
da Costa CA; Paitel E; Vincent B; Checler F
alpha-Synuclein lowers p53-dependent apoptotic response of neuronal cells - Abolishment by 6-hydroxydopamine and implication for Parkinson's disease
511
51415 2002 MOLECULAR BRAIN RESEARCH 108(1-2):33-39
Ubl A; Berg D; Holzmann C; Kruger R; Berger K; Arzberger T; Bornemann A; Riess O
14-3-3 protein is a component of Lewy bodies in Parkinson's disease - Mutation analysis and association studies of 14-3-3 eta
31
61126 2002 NATURE MEDICINE 8(6):564-565
Welch K; Yuan JY
Releasing the nerve cell killers
44
70307 2002 NATURE MEDICINE 8(6):600-606
Xu J; Kao SY; Lee FJS; Song WH; Jin LW; Yankner BA
Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
9090
82358 2002 NATURE NEUROSCIENCE 5:1058-1061
Dawson TM; Dawson VL
Neuroprotective and neurorestorative strategies for Parkinson's disease
114
921379 2002 NATURE REVIEWS NEUROSCIENCE 3(12):932-942
Lotharius J; Brundin P
Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
1340
1012010 2002 NEURON 35(2):219-222
Dawson TM; Mandir AS; Lee MK
Animal models of PD: Pieces of the same puzzle?
921
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
1115311 2002 NEURON 36(6):1007-1019
Petrucelli L; O'Farrell C; Lockhart PJ; Baptista M; Kehoe K; Vink L; Choi P; Wolozin B; Farrer M; Hardy J; Cookson MR
Parkin protects against the toxicity associated with mutant alpha-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
1973
1213812 2002 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(22):13972-13974
Steece-Collier K; Maries E; Kordower JH
Etiology of Parkinson's disease: Genetics and environment revisited
08
1319413 2003 ANNALS OF NEUROLOGY 53:S73-S84
McNaught KS; Olanow CW
Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease
023
142514 2003 ANNALS OF NEUROLOGY 54(1):135-135
Berg D; Riess O; Bornemann A
Specification of 14-3-3 proteins in Lewy bodies
11
15219915 2003 ANNUAL REVIEW OF NEUROSCIENCE 26:267-298
Caughey B; Lansbury PT
Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
231
16113816 2003 ANTIOXIDANTS & REDOX SIGNALING 5(3):337-348
Lee SJ
alpha-synuclein aggregation: A link between mitochondrial defects and Parkinson's disease?
14
1722917 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 309(3):679-684
Oluwatosin-Chigbu Y; Robbins A; Scott CW; Arriza JL; Reid JD; Zysk JR
Parkin suppresses wild-type alpha-synuclein-induced toxicity in SHSY-5Y cells
03
18511818 2003 BIOCHEMISTRY 42(26):7871-7878
Volles MJ; Lansbury PT
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
422
19112019 2003 BRAIN PATHOLOGY 13(4):630-638
Lee HG; Petersen RB; Zhu XW; Honda K; Aliev G; Smith MA; Perry G
Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?
00
2014220 2003 BRAIN RESEARCH 989(2):205-213
Burke WJ; Li SW; Williams EA; Nonneman R; Zahm DS
3,4-dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
21114521 2003 CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES 30:S10-S18
Huang ZA; de la Fuente-Fernandez R; Stoessl AJ
Etiology of Parkinson's disease
02
2223322 2003 CELL 113(4):457-468
Chen HK; Fernandez-Funez P; Acevedo SF; Lam YC; Kaytor MD; Fernandez MH; Aitken A; Skoulakis EMC; Orr HT; Botas J; Zoghbi HY
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
636
2333723 2003 CELL 114(1):1-8
Giasson BI; Lee VMY
Are ubiquitination pathways central to Parkinson's disease?
319
2431724 2003 CURRENT BIOLOGY 12(13):R522-R524
Cookson MR
Neurodegeneration: How does Parkin prevent Parkinson's disease?
00
2523325 2003 DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 16(1):46-51
Tabet N; Walker Z; Mantel D; Costa D; Orrell M
In vivo dopamine pre-synaptic receptors and antioxidant activities in patients with Alzheimer's disease, dementia with Lewy bodies and in controls - A preliminary report
00
2647226 2003 FASEB JOURNAL 17(12)
Wersinger C; Prou D; Vernier P; Sidhu A
Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
00
2734227 2003 HUMAN MOLECULAR GENETICS 12(19):2457-2466
Scherzer CR; Jensen RV; Gullans SR; Feany MB
Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
15
2834028 2003 HUMAN MOLECULAR GENETICS 12(21):2807-2816
Macedo MG; Anar B; Bronner IF; Cannella M; Squitieri F; Bonifati V; Hoogeveen A; Heutink P; Rizzu P
The DJ-1(L166P) mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes
113
29113729 2003 INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 228 228:1-30
Sugaya K
Potential use of stem cells in neuroreplacement therapies for neurodegenerative diseases
00
3044430 2003 IUBMB LIFE 55(6):315-322
Lim KL; Lim TM
Molecular mechanisms of neurodegeneration in Parkinson's disease: Clues from Mendelian syndromes
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
3114531 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(26):24095-24102
Ihara M; Tomimoto H; Kitayama H; Morioka Y; Akiguchi I; Shibasaki H; Noda M; Kinoshita M
Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies
07
3226732 2003 JOURNAL OF CLINICAL INVESTIGATION 111(2):145-151
Dawson TM; Dawson VL
Rare genetic mutations shed light on the pathogenesis of Parkinson disease
634
3317633 2003 JOURNAL OF CLINICAL INVESTIGATION 111(2):163-169
Ischiropoulos H; Beckman JS
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
129
3425834 2003 JOURNAL OF NEUROCHEMISTRY 85(4):957-968
Baptista MJ; O'Farrell C; Daya S; Ahmad R; Miller DW; Hardy J; Farrer MJ; Cookson MR
Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines
35
3515335 2003 JOURNAL OF NEUROCHEMISTRY 85(6):1468-1479
Hashimoto M; Takenouchi T; Rockenstein E; Masliah E
alpha-Synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease
37
3615636 2003 JOURNAL OF NEUROCHEMISTRY 86(1):165-172
Lakso M; Vartiainen S; Moilanen AM; Sirvio J; Thomas JH; Nass R; Blakely RD; Wong G
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein
36
3718337 2003 JOURNAL OF NEUROLOGY 250:2-10
Hattori N; Kobayashi H; Sasaki-Hatano Y; Sato K; Mizuno Y
Familial Parkinson's disease: a hint to elucidate the mechanisms of nigral degeneration
01
3816838 2003 JOURNAL OF NEUROSCIENCE 23(7):2564-2571
Mash DC; Ouyang Q; Pablo J; Basile M; Izenwasser S; Lieberman A; Perrin RJ
Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons
02
3915439 2003 JOURNAL OF NEUROSCIENCE 23(7):2744-2750
Avshalumov MV; Chen BT; Marshall SP; Pena DM; Rice ME
Glutamate-dependent inhibition of dopamine release in striatum is mediated by a new diffusible messenger, H2O2
06
4014340 2003 JOURNAL OF NEUROSCIENCE RESEARCH 74(2):278-285
Yang LC; Sugama S; Chirichigno JW; Gregorio J; Lorenzl S; Shin DH; Browne SE; Shimizu Y; Joh TH; Beal MF; Albers DS
Minocycline enhances MPTP toxicity to dopaminergic neurons
06
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
41310241 2003 LANCET NEUROLOGY 2(4):221-228
Hardy J; Cookson MR; Singleton A
Genes and parkinsonism
216
4221842 2003 M S-MEDECINE SCIENCES 19(5):613-619
Corti O; Brice A
Parkinson's disease: what do the genes involved in familial forms tell us?
00
4311243 2003 MOLECULAR PSYCHIATRY 8(4):369-370
Chesselet MF
Dopamine and Parkinson's disease: is the killer in the house?
11
4428744 2003 MOVEMENT DISORDERS 18(7):729-737
Orth M; Tabrizi SJ
Models of Parkinson's disease
13
4531345 2003 NATURE MEDICINE 9(7):825-826
Paulson H
Polyglutamine neurodegeneration: minding your Ps and Qs
02
4639346 2003 NATURE REVIEWS NEUROSCIENCE 4(9):727-738
Maries E; Dass B; Collier TJ; Kordower JH; Steece-Collier K
The role of alpha-synuclein in Parkinson's disease: Insights from animal models
18
47415747 2003 NATURE REVIEWS NEUROSCIENCE 4(9):752-762
Berg D; Holzmann C; Riess O
14-3-3 proteins in the nervous system
17
48315648 2003 NEUROCHEMICAL RESEARCH 28(11):1743-1756
Hashimoto M; Masliah E
Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies
01
4916349 2003 NEUROCHEMISTRY INTERNATIONAL 43(1):1-7
Shastry BS
Neurodegenerative disorders of protein aggregation
16
5049850 2003 NEUROMOLECULAR MEDICINE 4(1-2):95-108
Moore DJ; Dawson VL; Dawson TM
Role for the ubiquitin-proteasome system in Parkinson's disease and other neurodegenerative brain amyloidoses
01
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
5132651 2003 NEURON 37(1):7-10
Cookson MR
Pathways to parkinsonism
624
5213752 2003 NEURON 37(4):583-595
Sharon R; Bar-Joseph I; Frosch MP; Walsh DM; Hamilton JA; Selkoe DJ
The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease
826
53223553 2003 NEURON 39(6):889-909
Dauer W; Przedborski S
Parkinson's disease: Mechanisms and models
121
54716354 2003 NEURON 40(2):427-446
Ciechanover A; Brundin P
The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
018
5572555 2003 NEURON 40(3):453-456
Eriksen JL; Dawson TM; Dickson DW; Petrucelli L
Caught in the act: alpha-synuclein is the culprit in Parkinson's disease
02
56840256 2003 NEUROPHARMACOLOGY 45(1):14-44
Dev KK; Hofele K; Barbieri S; Buchman VL; van der Putten H
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease
310
5712557 2003 NEUROREPORT 14(4):551-554
Suzuki K; Iseki E; Katsuse O; Yamaguchi A; Katsuyama K; Aoki I; Yamanaka S; Kosaka K
Neuronal accumulation of alpha-and beta-synucleins in the brain of a GM(2) gangliosidosis mouse model
04
5811858 2003 NEUROSCIENCE LETTERS 337(1):5-8
Kelada SN; Stapleton PL; Farin FM; Bammler TK; Eaton DL; Smith-Weller T; Franklin GM; Swanson PD; Longstreth WT; Checkoway H
Glutathione S-transferase M1, T1, and P1 polymorphisms and Parkinson's disease
01
591159 2003 NEUROSCIENTIST 9(3):169-169
[Anon]
Dopamine-dependent alpha-synuclein neurotoxicity
00
6025160 2003 NEUROSIGNALS 12(6):315-324
Kheradpezhouh M; Shavali S; Ebadi M
Salsolinol causing parkinsonism activates endoplasmic reticulum-stress signaling pathways in human dopaminergic SK-N-SH cells
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
61111461 2003 NEUROTOXICITY RESEARCH 5(3):165-176
Asanuma M; Miyazaki I; Ogawa N
Dopamine-or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease
08
6235962 2003 PARKINSON'S DISEASE: THE LIFE CYCLE OF THE DOPAMINE NEURON 991:80-92
Lim KL; Dawson VL; Dawson TM
The cast of molecular characters in Parkinson's disease - Felons, conspirators, and suspects
01
6315363 2003 PARKINSON'S DISEASE: THE LIFE CYCLE OF THE DOPAMINE NEURON 991:93-100
Ischiropoulos H
Oxidative modifications of alpha-synuclein
13
6424064 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(5):2884-2889
Kirik D; Annett LE; Burger C; Muzyczka N; Mandel RJ; Bjorklund A
Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: A new primate model of Parkinson's disease
511
6542465 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(16):9111-9113
Cookson MR
Crystallizing ideas about Parkinson's disease
02
6645666 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(21):12438-12443
Dong ZZ; Ferger B; Paterna JC; Vogel D; Furler S; Osinde M; Feldon J; Bueler H
Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1
04
6716467 2003 TRENDS IN MOLECULAR MEDICINE 9(3):126-132
Barzilai A; Melamed E
Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
03
6812568 2003 TRENDS IN NEUROSCIENCES 26(8):407-410
Forman MS; Lee VMY; Trojanowski JQ
'Unfolding' pathways in neurodegenerative disease
18
6922069 2003 TRENDS IN NEUROSCIENCES 26(10):517-519
Welch K; Yuan JY
alpha-synuclein oligomerization: a role for lipids?
23
7037070 2004 AMERICAN JOURNAL OF PATHOLOGY 165(2):577-592
Satoh J; Yamamura T; Arima K
The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
7136371 2004 BIOCHEMISTRY 43(5):1242-1253
Wersinger C; Vernier P; Sidhu A
Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant
00
7227672 2004 BIOCHEMISTRY 43(18):5539-5550
Moussa CEH; Wersinger C; Tomita Y; Sidhu A
Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine
00
73727873 2004 CELLULAR AND MOLECULAR LIFE SCIENCES 61(14):1729-1750
Bonifati V; Oostra BA; Heutink P
Unraveling the pathogenesis of Parkinson's disease - the contribution of monogenic forms
00
7435474 2004 CURRENT OPINION IN PHARMACOLOGY 4(1):79-84
Le W; Appel SH
Mutant genes responsible for Parkinson's disease
00
75511275 2004 FASEB JOURNAL 18(6):617-626
Recchia A; Debetto P; Negro A; Guidolin D; Skaper SD; Giusti P
alpha-synuclein and Parkinson's Disease
00
76414576 2004 FASEB JOURNAL 18(6):637-647
Sidhu A; Wersinger C; Vernier P
Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?
00
7714877 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(15):15240-15247
Kalivendi SV; Cunningham S; Kotamraju S; Joseph J; Hillard CJ; Kalyanaraman B
alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells - Intermediacy of transferrin receptor iron and hydrogen peroxide
00
7826678 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(18):18614-18622
Palacino JJ; Sagi D; Goldberg MS; Krauss S; Motz C; Wacker M; Klose J; Shen J
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
13
79513779 2004 JOURNAL OF CELL SCIENCE 117(10):1875-1884
Dougherty MK; Morrison DK
Unlocking the code of 14-3-3
00
8024780 2004 JOURNAL OF COMPARATIVE NEUROLOGY 473(1):97-106
Liang CL; Nelson O; Yazdani U; Pasbakhsh P; German DC
Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: Human midbrain dopamine neurons
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
8116681 2004 JOURNAL OF NEURAL TRANSMISSION 111(8):1017-1030
Blandini F; Cosentino M; Mangiagalli A; Marino F; Samuele A; Rasini E; Fancellu R; Tassorelli C; Pacchetti C; Martignoni E; Riboldazzi G; Calandrella D; Lecchini S; Frigo G; Nappi G
Modifications of apoptosis-related protein levels in lymphocytes of patients with Parkinson's disease. The effect of dopaminergic treatment
00
82119182 2004 JOURNAL OF NEUROCHEMISTRY 89(5):1126-1136
Robertson DC; Schmidt O; Ninkina N; Jones PA; Sharkey J; Buchman VL
Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
00
8347983 2004 JOURNAL OF NEUROCHEMISTRY 89(6):1318-1324
Perez RG; Hastings TG
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
00
8412584 2004 NATURE 429(6994):883-891
Lu T; Pan Y; Kao SY; Li C; Kohane I; Chan J; Yankner BA
Gene regulation and DNA damage in the ageing human brain
01
85413785 2004 NATURE REVIEWS DRUG DISCOVERY 3(3):205-214
Barnham KJ; Masters CL; Bush AI
Neurodegenerative diseases and oxidative stress
04
86310586 2004 NATURE REVIEWS GENETICS 5(2):136-U17
Jakel RJ; Schneider BL; Svendsen CN
Using human neural stem cells to model neurological disease
01
8713287 2004 NEUROLOGIA 19(2):53-58
Campos V; Rebollo AC; Jimenez-Hoyuela JM; Gomez-Doblas JJ; Medialdea PO; Vila E; Gutierrez-Hurtado A
Early alterations of adrenergic cardiac function in Parkinson's disease
00
8838088 2004 NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 30(3):215-224
Agorogiannis EI; Agorogiannis GI; Papadimitriou A; Hadjigeorgiou GM
Protein misfolding in neurodegenerative diseases
00
8922789 2004 NEUROSCIENCE LETTERS 357(2):143-146
Hernandez F; Cuadros R; Avila J
Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers
00
9086190 2004 NEUROSCIENTIST 10(1):63-72
Baptista MJ; Cookson MR; Miller DW
Parkin and alpha-synuclein: Opponent actions in the pathogenesis of Parkinson's disease
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
91513991 2004 PROTEIN AND PEPTIDE LETTERS 11(3):213-228
Walsh DM; Selkoe DJ
Oligomers in the brain: The emerging role of soluble protein aggregates in neurodegeneration
00

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