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Wed Mar 30 15:09:21 2005
HIV-1 integration in the human genome favors
active genes and local hotspots

SCHRODER ARW, SHINN P, CHEN HM, et al.
CELL 110: 521-529 2002
and the citing papers

Nodes: 158, Authors: 657, Journals: 82, Outer References: 7071, Words: 655
Collection span: 2002 - 2005
View: Overview. Sorted by first author.
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
1282142 2004 VIROLOGY 325(2):328-339
Albright AV; Vos RM; Gonzalez-Scarano F
Low-level HIV replication in mixed glial cultures is associated with alterations in the processing of p55(Gag)
01
212558 2003 SCIENCE 301(5633):653-657
Alonso JM; Stepanova AN; Leisse TJ; Kim CJ; Chen HM; et al.
Genome-wide Insertional mutagenesis of Arabidopsis thaliana
1201
327589 2004 CURRENT TOPICS IN MEDICINAL CHEMISTRY 4(9):979-990
Anthony NJ
HIV-1 integrase: A target for new AIDS chemotherapeutics
01
4410599 2004 GENETICS 168(3):1159-1176
Aye M; Irwin B; Beliakova-Bethell N; Chen E; Garrus J; et al.
Host factors that affect Ty3 retrotransposition in Saccharomyces cerevisiae
00
5250101 2004 HUMAN GENE THERAPY 15(5):445-456
Bao LL; Jaligam V; Zhang XY; Kutner RH; Kantrow SP; et al.
Stable transgene expression in tumors and metastases after transduction with lentiviral vectors based on human immunodeficiency virus type 1
01
6612692 2004 EXPERT OPINION ON BIOLOGICAL THERAPY 4(9):1423-1434
Barese CN; Goebel WS; Dinauer MC
Gene therapy for chronic granulomatous disease
00
775498 2004 GENE THERAPY 11:S3-S9
Barquinero J; Eixarch H; Perez-Melgosa M
Retroviral vectors: new applications for an old tool
00
8320713 2003 BLOOD 101(6):2099-2114
Baum C; Dullmann J; Li ZX; Fehse B; Meyer J; et al.
Side effects of retroviral gene transfer into hematopoietic stem cells
2171
983723 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):458-462
Baum C; Fehse B
Mutagenesis by retroviral transgene insertion: Risk assessment and potential alternatives
12
10554125 2004 MOLECULAR THERAPY 9(1):5-13
Baum C; von Kalle C; Staal FJT; Li ZX; Fehse B; et al.
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
49
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
112355 2003 QJM-AN INTERNATIONAL JOURNAL OF MEDICINE 96(11):873-874
Berry C
Misplaced
00
1223393 2004 FEBS LETTERS 578(3):291-296
Boese A; Sommer P; Gaussin A; Reimann A; Nehrbass U
Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration
00
1315329 2003 GENOME RESEARCH 13(9):1984-1997
Bowen NJ; Jordan IK; Epstein JA; Wood V; Levin HL
Retrotransposons and their recognition of pol II promoters: A comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe
16
1431928 2003 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1640(1):1-24
Brenner S; Malech HL
Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy
311
1549783 2004 CURRENT GENOMICS 5(1):19-35
Buchschacher GL
Safety considerations associated with development and clinical application of lentiviral vector systems for gene transfer
00
164995 2003 ARCHIVES OF MEDICAL RESEARCH 34(6):589-599
Bueren JA; Guenechea G; Casado JA; Lamana ML; Segovia JC
Genetic modification of hematopoietic stem cells: recent advances in the gene therapy of inherited diseases
00
171183 2002 MOLECULAR THERAPY 6(5):570-571
Bushman F
Targeting retroviral integration?
910
1871818 2003 CELL 115(2):135-138
Bushman FD
Targeting survival: Integration site selection by retroviruses and LTR-retrotransposons
1220
1976461 2004 AIDS REVIEWS 6(1):13-21
Cereseto A; Giacca M
Integration site selection by retroviruses
00
20267144 2004 WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE 16(1):23-33
Chandler LA; Sosnowski BA
Gene therapy for cutaneous wound repair
02
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
21174 2002 NATURE 420(6912):116-118
Check E
Gene therapy: A tragic setback
1044
221341 2003 NATURE 423(6940):573-574
Check E
Harmful potential of viral vectors fuels doubts over gene therapy
04
23343145 2005 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 329(2):646-652
Chen ZYJ; Kren BT; Wong PYP; Low WC; Steer CJ
Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference
00
241059104 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(47):48883-48892
Cherepanov P; Devroe E; Silver PA; Engelman A
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
00
2515633 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(1):372-381
Cherepanov P; Maertens G; Proost P; Devreese B; Van Beeumen J; et al.
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
1430
26685103 2004 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 113(4):595-603
Chinen J; Puck JM
Successes and risks of gene therapy in primary immunodeficiencies
05
27242121 2004 JOURNAL OF VIROLOGY 78(19):10747-10754
Ciuffi A; Bleiber G; Munoz M; Martinez R; Loeuillet C; et al.
Entry and transcription as key determinants of differences in CD4 T-cell permissiveness to human immunodeficiency virus type 1 infection
00
28524621 2003 CURRENT HIV RESEARCH 1(4):419-439
Cockrell AS; Kafri T
HIV-1 vectors: Fulfillment of expectations, further advancements, and still a way to go
01
2933369 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320(3):998-1006
Condiotti R; Curran MA; Nolan GP; Giladi H; Ketzinel-Gilad M; et al.
Prolonged liver-specific transgene expression by a non-primate lentiviral vector
00
30117648 2003 NATURE REVIEWS NEUROSCIENCE 4(5):353-364
Davidson BL; Breakefield XO
Viral vectors for gene delivery to the nervous system
019
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
3116186 2004 CURRENT OPINION IN MICROBIOLOGY 7(4):400-406
Delelis O; Lehmann-Che J; Saib A
Foamy viruses - a world apart
00
32115019 2003 CELLULAR FACTORS INVOLVED IN EARLY STEPS OF RETROVIRAL REPLICATON 281:179-208
Dvorin JD; Malim MH
Intracellular trafficking of HIV-1 cores: Journey to the center of the cell
35
3336517 2003 BLOOD 102(7):2403-2411
Ehrhardt A; Xu H; Dillow AM; Bellinger DA; Nichols TC; et al.
A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia
06
34920156 2005 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(5):1275-1276
Engelman A
The ups and downs of gene expression and retroviral DNA integration
00
35410155 2005 PLOS MEDICINE 2(1):22-24
Fischer A; Cavazzana-Calvo M
Integration of retroviruses: A fine balance between efficiency and danger
00
3619167 2004 BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY 18(6):941-958
Flake AW
In utero stem cell transplantation
00
37211380 2004 CURRENT GENE THERAPY 4(1):65-77
Fuller M; Anson DS
Can the use of HIV-1 derived gene transfer vectors for clinical application be justified?
00
3833227 2003 GENE THERAPY 10(24):1999-2004
Gaspar HB; Howe S; Thrasher AJ
Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency
15
3916411 2003 BIOTECHNOLOGY & GENETIC ENGINEERING REVIEWS, VOL 20 20:77-100
Gentile A; D'Alessandro L; Medico E
Gene trapping: a multi-purpose tool for functional genomics
00
4025475 2004 CELL 118(5):555-566
Gilbert N; Boyle S; Fiegler H; Woodfine K; Carter NP; et al.
Chromatin architecture of the human genome: Gene-rich domains are enriched in open chromatin fibers
17
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
41414163 2004 ANNUAL REVIEW OF GENETICS 38:61-85
Goff SP
Genetic control of retrovirus susceptibility in mammalian cells
01
4223860 2003 SCIENCE 302(5644):415-419
Hacein-Bey-Abina S; Von Kalle C; Schmidt M; McCcormack MP; Wulffraat N; et al.
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
36174
43739115 2004 JOURNAL OF VIROLOGICAL METHODS 121(2):127-136
Hahm SH; Yi YS; Lee DK; Noh MJ; Yun L; et al.
Construction of retroviral vectors with enhanced efficiency of transgene expression
00
44418384 2004 CURRENT HIV RESEARCH 2(2):99-111
Hamer DH
Can HIV be cured? Mechanisms of HIV persistence and strategies to combat it
01
45371118 2004 JOURNAL OF VIROLOGY 78(12):6122-6133
Han YF; Lassen K; Monie D; Sedaghat AR; Shimoji S; et al.
Resting CD4(+) T cells from human immunodeficiency virus type I (HIV-1)-infected individuals carry integrated HIV-1 Genomes within actively transcribed host genes
34
4673873 2004 BLOOD 104(8):2281-2290
Hanawa H; Hargrove PW; Kepes S; Srivastava DK; Nienhuis AW; et al.
Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia
00
4788072 2004 BLOOD 103(11):4062-4069
Hanawa H; Hematti P; Keyvanfar K; Metzger ME; Krouse A; et al.
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system
46
48712881 2004 CURRENT GENE THERAPY 4(3):263-276
Haviernik P; Bunting KD
Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors
00
491377 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 311(3):641-648
Hejnar J; Elleder D; Hajkova P; Walter J; Blazkova J; et al.
Demethylation of host-cell DNA at the site of avian retrovirus integration
00
50753136 2004 PLOS BIOLOGY 2(12):2183-2190
Hematti P; Hong BK; Ferguson C; Adler R; Hanawa H; et al.
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
512172134 2004 NGF AND RELATED MOLECULES IN HEALTH AND DISEASE 146:451-476
Hendriks WTJ; Ruitenberg MJ; Blits B; Boer GJ; Verhaagen J
Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord
05
521346 2003 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 23(12):2266-2272
Herder C; Tonn T; Oostendorp R; Becker S; Keller U; et al.
Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells
03
53487149 2005 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 8(2):199-206
Herzog RW
Recent advances in hepatic gene transfer: More efficacy and less immunogenicity
00
54458124 2004 MOLECULAR CELL 13(3):403-414
Hickman AB; Ronning DR; Perez ZN; Kotin RM; Dyda F
The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces
04
557195129 2004 MOLECULAR THERAPY 10(3):417-431
Horn PA; Morris JC; Neff T; Kiem HP
Stem cell gene transfer-efficacy and safety in large animal studies
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5624594 2004 FOLIA BIOLOGICA 50(3-4):107-119
Hughes SH
The RCAS vector system
00
5712042 2003 NATURE BIOTECHNOLOGY 21(5):569-572
Ikeda Y; Takeuchi Y; Martin F; Cosset FL; Mitrophanous K; et al.
Continuous high-titer HIV-1 vector production
08
58373108 2004 JOURNAL OF CLINICAL INVESTIGATION 114(7):953-962
Imren S; Fabry ME; Westerman KA; Pawliuk R; Tang P; et al.
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells
11
59781126 2004 MOLECULAR THERAPY 9(2):147-156
Izsvak Z; Ivics Z
Sleeping Beauty transposition: Biology and applications for molecular therapy
212
6013326 2003 EMBO JOURNAL 22(8):1868-1877
Jordan A; Bisgrove D; Verdin E
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
919
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
61584137 2004 SCIENCE 303(5664):1626-1632
Kazazian HH
Mobile elements: Drivers of genome evolution
036
6225976 2004 CELLULAR AND MOLECULAR BIOLOGY 50:581-589
Kellebrew DA; Troelstrup D; Shiramizu B
Preferential HIV-1 integration sites in macrophages and HIV-associated malignancies
00
63116571 2004 BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 39:3-16
Kelm JM; Kramer BP; Gonzalez-Nicolini V; Ley B; Fussenegger M
Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine
02
6413328 2003 GENOME RESEARCH 13(7):1765-1774
Khambata-Ford S; Liu YY; Gleason C; Dickson M; Altman RB; et al.
Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay
00
6526385 2004 CURRENT HIV RESEARCH 2(3):215-221
Killebrew D; Shiramizu B
Pathogenesis of HIV-associated non-Hodgkin lymphoma
00
6629845 2003 NATURE REVIEWS CANCER 3(7):477-488
Kohn DB; Sadelain M; Glorioso JC
Occurrence of leukaemia following gene therapy of X-linked SCID
644
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Kremer EJ
Gene transfer to the central nervous system: Current state of the art of the viral vectors
00
6842670 2004 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 322(2):672-677
Kulkarni A; Pavithra L; Rampalli S; Mogare D; Babu K; et al.
HIV-1 integration sites are flanked by potential MARs that alone can act as promoters
11
693180158 2005 SPRINGER SEMINARS IN IMMUNOPATHOLOGY 26(3):309-328
Larsson M
HIV-1 and the hijacking of dendritic cells: a tug of war
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70679141 2004 TRENDS IN MOLECULAR MEDICINE 10(11):525-531
Lassen K; Han YF; Zhou Y; Siliciano J; Siliciano RF
The multifactorial nature of HIV-1 latency
11
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7115814 2003 BLOOD 101(6):2191-2198
Laufs S; Gentner B; Nagy KZ; Jauch A; Benner A; et al.
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
1220
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Laufs S; Nagy KZ; Giordano FA; Hotz-Wagenblatt A; Zeller WJ; et al.
Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns
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731410862 2004 AIDS REVIEWS 6(4):199-207
Lehmann-Che J; Saib A
Early stages of HIV replication: How to hijack cellular functions for a successful infection
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74192 2002 GENE THERAPY 9(23):1561-1562
Lemoine NR
Risks and benefits of gene therapy for immunodeficiency: a reality check
06
75272151 2005 JOURNAL OF VIROLOGY 79(3):1645-1654
Leonard JN; Schaffer DV
Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape
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Inhibition of HIV-1 infection by lentiviral vectors expressing pol III-promoted anti-HIV RNAs
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77124966 2004 BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY 17(3):493-503
Li ZX; Modlich U; Baum C
Safety and efficacy in retrovirally modified haematopoietic cell therapy
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7816235 2003 JOURNAL OF VIROLOGY 77(15):8227-8236
Lin X; Irwin D; Kanazawa S; Huang L; Romeo J; et al.
Transcriptional profiles of latent human immunodeficiency virus in infected individuals: Effects of tat on the host and reservoir
29
79149102 2004 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 36(9):1767-1775
Liou LY; Herrmann CH; Rice AR
HIV-1 infection and regulation of Tat function in macrophages
00
80648105 2004 JOURNAL OF BIOLOGICAL CHEMISTRY 279(53):55570-55577
Llano M; Delgado S; Vanegas M; Poeschla EM
Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase
00
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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
44
82161119 2004 JOURNAL OF VIROLOGY 78(16):8421-8436
Logan AC; Haas DL; Kafri T; Kohn DB
Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration
01
8312032 2003 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 33(3):308-320
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HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression
46
8436934 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33528-33539
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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
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Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions
36
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Nuclear organization and the control of HIV-1 transcription
02
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Relationship between retroviral DNA-integration-site selection and host cell transcription
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McCarty DM; Young SM; Samulski RJ
Integration of adeno-associated virus (AAV) and recombinant AAV vectors
01
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Global analysis of cellular transcription following infection with an HIV-based vector
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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
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AAV serotype 2 vectors preferentially integrate into active genes in mice
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Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver
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Genome-wide analyses of avian sarcoma virus integration sites
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00
9713531 2003 HEMATOPOIETIC STEM CELLS 2002: GENETICS AND FUNCTION 996:101-111
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Development of gene therapy for hemoglobin disorders
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HIV infection of primary human T cells is determined by tunable thresholds of T cell activation
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Toolbox for retrovectorologists
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A stable gene transfer system for hematopoietic progenitor cells from human bone marrow using pseudotyped retroviral vectors
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Update on gene therapy for hemoglobin disorders
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Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
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Lentiviral transgenesis
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Non-primate lentiviral vectors
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Ludwik Hirszfeld Memorial Lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication
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Integrase inhibitors to treat HIV/AIDS
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Site-specific genomic strategies for gene therapy
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Gene therapy of liver diseases
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Chromatin remodeling and modification during HIV-1 tat-activated transcription
16
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Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector
00
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Qasim W; Gaspar HB; Thrasher AJ
T cell suicide gene therapy to aid haematopoietic stem cell transplantation
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Ramezani A; Hawley TS; Hawley RG
Performance-and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator
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Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions
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Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors
00
11715715 2003 BLOOD 101(8):2932-2939
Rivella S; May C; Chadburn A; Riviere I; Sadelain M
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer
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Saenz DT; Poeschla EM
FIV: from lentivirus to lentivector
04
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Thiophilic interaction chromatography for supercoiled plasmid DNA purification
03
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Integration by design
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Schroder ARW; Shinn P; Chen HM; Berry C; Ecker JR; et al.
HIV-1 integration in the human genome favors active genes and local hotspots
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Segura-Totten M; Wilson KL
BAF: roles in chromatin, nuclear structure and retrovirus integration
06
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