LCS >= 4
Nodes: 25, Links: 57
LCS >= 4; Min: 4, Max: 157
1. 1 2002 CELL 110(4):521-529
Schroder ARW; Shinn P; Chen HM; Berry C; Ecker JR; et al.
HIV-1 integration in the human genome favors active genes and local hotspots
LCR: 0 NCR: 54 LCS: 157 GCS: 157
2. 3 2002 MOLECULAR THERAPY 6(5):570-571
Bushman F
Targeting retroviral integration?
LCR: 1 NCR: 18 LCS: 9 GCS: 10
3. 4 2002 NATURE 420(6912):116-118
Check E
Gene therapy: A tragic setback
LCR: 1 NCR: 7 LCS: 10 GCS: 44
4. 12 2003 BLOOD 101(4):1284-1289
Woods NB; Muessig A; Schmidt M; Flygare J; Olsson K; et al.
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis
LCR: 1 NCR: 29 LCS: 13 GCS: 27
5. 13 2003 BLOOD 101(6):2099-2114
Baum C; Dullmann J; Li ZX; Fehse B; Meyer J; et al.
Side effects of retroviral gene transfer into hematopoietic stem cells
LCR: 3 NCR: 207 LCS: 21 GCS: 71
6. 14 2003 BLOOD 101(6):2191-2198
Laufs S; Gentner B; Nagy KZ; Jauch A; Benner A; et al.
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
LCR: 1 NCR: 58 LCS: 12 GCS: 20
7. 15 2003 BLOOD 101(8):2932-2939
Rivella S; May C; Chadburn A; Riviere I; Sadelain M
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer
LCR: 1 NCR: 57 LCS: 6 GCS: 16
8. 16 2003 BLOOD 101(12):4717-4724
Ramezani A; Hawley TS; Hawley RG
Performance-and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator
LCR: 2 NCR: 61 LCS: 7 GCS: 19
9. 18 2003 CELL 115(2):135-138
Bushman FD
Targeting survival: Integration site selection by retroviruses and LTR-retrotransposons
LCR: 7 NCR: 18 LCS: 12 GCS: 20
10. 26 2003 EMBO JOURNAL 22(8):1868-1877
Jordan A; Bisgrove D; Verdin E
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
LCR: 1 NCR: 33 LCS: 9 GCS: 19
11. 30 2003 GENOME RESEARCH 13(9):1998-2004
Versteeg R; van Schaik BDC; van Batenburg MF; Roos M; Monajemi R; et al.
The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
LCR: 1 NCR: 15 LCS: 4 GCS: 29
12. 32 2003 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 33(3):308-320
Mack KD; Jin X; Yu S; Wei R; Kapp L; et al.
HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression
LCR: 1 NCR: 20 LCS: 4 GCS: 6
13. 33 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(1):372-381
Cherepanov P; Maertens G; Proost P; Devreese B; Van Beeumen J; et al.
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
LCR: 1 NCR: 56 LCS: 14 GCS: 30
14. 34 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33528-33539
Maertens G; Cherepanov P; Pluymers W; Busschots K; De Clercq E; et al.
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
LCR: 3 NCR: 69 LCS: 9 GCS: 21
15. 36 2003 JOURNAL OF VIROLOGY 77(23):12507-12522
Violot S; Hong SS; Rakotobe D; Petit C; Gay B; et al.
The human Polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1
LCR: 3 NCR: 86 LCS: 5 GCS: 6
16. 43 2003 NATURE GENETICS 34(3):297-302
Nakai H; Montini E; Fuess S; Storm TA; Grompe M; et al.
AAV serotype 2 vectors preferentially integrate into active genes in mice
LCR: 1 NCR: 29 LCS: 16 GCS: 55
17. 45 2003 NATURE REVIEWS CANCER 3(7):477-488
Kohn DB; Sadelain M; Glorioso JC
Occurrence of leukaemia following gene therapy of X-linked SCID
LCR: 2 NCR: 98 LCS: 6 GCS: 44
18. 46 2003 NATURE REVIEWS GENETICS 4(5):346-358
Thomas CE; Ehrhardt A; Kay MA
Progress and problems with the use of viral vectors for gene therapy
LCR: 3 NCR: 120 LCS: 9 GCS: 81
19. 53 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(10):5586-5588
Sandmeyer S
Integration by design
LCR: 3 NCR: 49 LCS: 8 GCS: 13
20. 54 2003 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(10):5891-5895
Zhu YX; Dai JB; Fuerst PG; Voytas DF
Controlling integration specificity of a yeast retrotransposon
LCR: 1 NCR: 36 LCS: 9 GCS: 15
21. 57 2003 SCIENCE 300(5626):1749-1751
Wu XL; Li Y; Crise B; Burgess SM
Transcription start regions in the human genome are favored targets for MLV integration
LCR: 2 NCR: 18 LCS: 66 GCS: 98
22. 60 2003 SCIENCE 302(5644):415-419
Hacein-Bey-Abina S; Von Kalle C; Schmidt M; McCcormack MP; Wulffraat N; et al.
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
LCR: 2 NCR: 38 LCS: 36 GCS: 174
23. 72 2004 BLOOD 103(11):4062-4069
Hanawa H; Hematti P; Keyvanfar K; Metzger ME; Krouse A; et al.
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system
LCR: 8 NCR: 80 LCS: 4 GCS: 6
24. 120 2004 JOURNAL OF VIROLOGY 78(17):9524-9537
Llano M; Vanegas M; Fregoso O; Saenz D; Chung S; et al.
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
LCR: 4 NCR: 79 LCS: 4 GCS: 4
25. 125 2004 MOLECULAR THERAPY 9(1):5-13
Baum C; von Kalle C; Staal FJT; Li ZX; Fehse B; et al.
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
LCR: 5 NCR: 54 LCS: 4 GCS: 9