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Wed Mar 30 15:09:21 2005
HIV-1 integration in the human genome favors
active genes and local hotspots

SCHRODER ARW, SHINN P, CHEN HM, et al.
CELL 110: 521-529 2002
and the citing papers

Nodes: 158, Authors: 657, Journals: 82, Outer References: 7071, Words: 655
Collection span: 2002 - 2005
View: Overview. Sorted by year, source, volume, issue, page.
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
10541 2002 CELL 110(4):521-529
Schroder ARW; Shinn P; Chen HM; Berry C; Ecker JR; et al.
HIV-1 integration in the human genome favors active genes and local hotspots
157157
2192 2002 GENE THERAPY 9(23):1561-1562
Lemoine NR
Risks and benefits of gene therapy for immunodeficiency: a reality check
06
31183 2002 MOLECULAR THERAPY 6(5):570-571
Bushman F
Targeting retroviral integration?
910
4174 2002 NATURE 420(6912):116-118
Check E
Gene therapy: A tragic setback
1044
54995 2003 ARCHIVES OF MEDICAL RESEARCH 34(6):589-599
Bueren JA; Guenechea G; Casado JA; Lamana ML; Segovia JC
Genetic modification of hematopoietic stem cells: recent advances in the gene therapy of inherited diseases
00
61346 2003 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 23(12):2266-2272
Herder C; Tonn T; Oostendorp R; Becker S; Keller U; et al.
Sustained expansion and transgene expression of coagulation factor VIII-transduced cord blood-derived endothelial progenitor cells
03
71377 2003 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 311(3):641-648
Hejnar J; Elleder D; Hajkova P; Walter J; Blazkova J; et al.
Demethylation of host-cell DNA at the site of avian retrovirus integration
00
831928 2003 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1640(1):1-24
Brenner S; Malech HL
Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy
311
91199 2003 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13(6):1175-1177
Zhao L; O'Reilly MK; Shultz MD; Chmielewski J
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization
16
1021910 2003 BIOTECHNIQUES 35(5):1072-+
Yao AQ; Chiu R; Vora A; Brown DB; Grandgenett D; et al.
Avian retrovirus integrase-enhanced transgene integration into mammalian cell DNA in vivo
01
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
1116411 2003 BIOTECHNOLOGY & GENETIC ENGINEERING REVIEWS, VOL 20 20:77-100
Gentile A; D'Alessandro L; Medico E
Gene trapping: a multi-purpose tool for functional genomics
00
1212912 2003 BLOOD 101(4):1284-1289
Woods NB; Muessig A; Schmidt M; Flygare J; Olsson K; et al.
Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis
1327
13320713 2003 BLOOD 101(6):2099-2114
Baum C; Dullmann J; Li ZX; Fehse B; Meyer J; et al.
Side effects of retroviral gene transfer into hematopoietic stem cells
2171
1415814 2003 BLOOD 101(6):2191-2198
Laufs S; Gentner B; Nagy KZ; Jauch A; Benner A; et al.
Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells
1220
1515715 2003 BLOOD 101(8):2932-2939
Rivella S; May C; Chadburn A; Riviere I; Sadelain M
A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer
616
1626116 2003 BLOOD 101(12):4717-4724
Ramezani A; Hawley TS; Hawley RG
Performance-and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator
719
1736517 2003 BLOOD 102(7):2403-2411
Ehrhardt A; Xu H; Dillow AM; Bellinger DA; Nichols TC; et al.
A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia
06
1871818 2003 CELL 115(2):135-138
Bushman FD
Targeting survival: Integration site selection by retroviruses and LTR-retrotransposons
1220
19115019 2003 CELLULAR FACTORS INVOLVED IN EARLY STEPS OF RETROVIRAL REPLICATON 281:179-208
Dvorin JD; Malim MH
Intracellular trafficking of HIV-1 cores: Journey to the center of the cell
35
20228820 2003 CURRENT HIV RESEARCH 1(3):343-362
Pumfery A; Deng LW; Maddukuri A; de la Fuente C; Li H; et al.
Chromatin remodeling and modification during HIV-1 tat-activated transcription
16
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
21524621 2003 CURRENT HIV RESEARCH 1(4):419-439
Cockrell AS; Kafri T
HIV-1 vectors: Fulfillment of expectations, further advancements, and still a way to go
01
2265222 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(4):376-382
Portlock JL; Calos MP
Site-specific genomic strategies for gene therapy
11
2383723 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):458-462
Baum C; Fehse B
Mutagenesis by retroviral transgene insertion: Risk assessment and potential alternatives
12
2469624 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):508-516
Persons DA
Update on gene therapy for hemoglobin disorders
23
25214425 2003 CURRENT OPINION IN MOLECULAR THERAPEUTICS 5(5):529-540
Poeschla EM
Non-primate lentiviral vectors
14
2613326 2003 EMBO JOURNAL 22(8):1868-1877
Jordan A; Bisgrove D; Verdin E
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
919
2733227 2003 GENE THERAPY 10(24):1999-2004
Gaspar HB; Howe S; Thrasher AJ
Gene therapy progress and prospects: gene therapy for severe combined immunodeficiency
15
2813328 2003 GENOME RESEARCH 13(7):1765-1774
Khambata-Ford S; Liu YY; Gleason C; Dickson M; Altman RB; et al.
Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay
00
2915329 2003 GENOME RESEARCH 13(9):1984-1997
Bowen NJ; Jordan IK; Epstein JA; Wood V; Levin HL
Retrotransposons and their recognition of pol II promoters: A comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe
16
3011530 2003 GENOME RESEARCH 13(9):1998-2004
Versteeg R; van Schaik BDC; van Batenburg MF; Roos M; Monajemi R; et al.
The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
429
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
3113531 2003 HEMATOPOIETIC STEM CELLS 2002: GENETICS AND FUNCTION 996:101-111
Nienhuis AW; Hanawa H; Sawai N; Sorrentino BP; Persons DA
Development of gene therapy for hemoglobin disorders
01
3212032 2003 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 33(3):308-320
Mack KD; Jin X; Yu S; Wei R; Kapp L; et al.
HIV insertions within and proximal to host cell genes are a common finding in tissues containing high levels of HIV DNA and macrophage-associated p24 antigen expression
46
3315633 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(1):372-381
Cherepanov P; Maertens G; Proost P; Devreese B; Van Beeumen J; et al.
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
1430
3436934 2003 JOURNAL OF BIOLOGICAL CHEMISTRY 278(35):33528-33539
Maertens G; Cherepanov P; Pluymers W; Busschots K; De Clercq E; et al.
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
921
3516235 2003 JOURNAL OF VIROLOGY 77(15):8227-8236
Lin X; Irwin D; Kanazawa S; Huang L; Romeo J; et al.
Transcriptional profiles of latent human immunodeficiency virus in infected individuals: Effects of tat on the host and reservoir
29
3638636 2003 JOURNAL OF VIROLOGY 77(23):12507-12522
Violot S; Hong SS; Rakotobe D; Petit C; Gay B; et al.
The human Polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1
56
3726737 2003 JOURNAL OF VIROLOGY 77(24):13084-13092
Mansharamani M; Graham DRM; Monie D; Lee KK; Hildreth JEK; et al.
Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions
36
3817338 2003 MOLECULAR THERAPY 8(2):196-206
Li MJ; Bauer G; Michienzi A; Yee JK; Lee NS; et al.
Inhibition of HIV-1 infection by lentiviral vectors expressing pol III-promoted anti-HIV RNAs
116
3913539 2003 MOLECULAR THERAPY 8(4):674-687
Mitchell R; Chiang CY; Berry C; Bushman F
Global analysis of cellular transcription following infection with an HIV-based vector
15
4022540 2003 MONATSSCHRIFT KINDERHEILKUNDE 151(8):869-874
Urschel S; Schmidt S; Hoffmann F; Chedville G; Fischer A; et al.
Somatic gene therapy for X-chromosomal recessive severe combined immunodeficiency (X-SCID)
00
#LCRNCRNodes / Date / Journal / AuthorsLCSGCS
411341 2003 NATURE 423(6940):573-574
Check E
Harmful potential of viral vectors fuels doubts over gene therapy
04
4212042 2003 NATURE BIOTECHNOLOGY 21(5):569-572
Ikeda Y; Takeuchi Y; Martin F; Cosset FL; Mitrophanous K; et al.
Continuous high-titer HIV-1 vector production
08
4312943 2003 NATURE GENETICS 34(3):297-302
Nakai H; Montini E; Fuess S; Storm TA; Grompe M; et al.
AAV serotype 2 vectors preferentially integrate into active genes in mice
1655
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Stevenson M
HIV-1 pathogenesis
224
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Kohn DB; Sadelain M; Glorioso JC
Occurrence of leukaemia following gene therapy of X-linked SCID
644
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Thomas CE; Ehrhardt A; Kay MA
Progress and problems with the use of viral vectors for gene therapy
981
47113247 2003 NATURE REVIEWS IMMUNOLOGY 3(2):97-107
Peterlin BM; Trono D
Hide, shield and strike back: How HIV-infected cells avoid immune eradication
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Davidson BL; Breakefield XO
Viral vectors for gene delivery to the nervous system
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Rampalli S; Kulkarni A; Kumar P; Mogare D; Galande S; et al.
Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions
26
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Tsai CL; Chatterji M; Schatz DG
DNA mismatches and GC-rich motifs target transposition by the RAG1/RAG2 transposase
06
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Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
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5213752 2003 PLANT CELL 15(8):1771-1780
Miyao A; Tanaka K; Murata K; Sawaki H; Takeda S; et al.
Target site specificity of the Tos17 retrotransposon shows a preference for insertion within genes and against insertion in retrotransposon-rich regions of the genome
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Sandmeyer S
Integration by design
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Zhu YX; Dai JB; Fuerst PG; Voytas DF
Controlling integration specificity of a yeast retrotransposon
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Misplaced
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Trono D
Picking the right spot
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Transcription start regions in the human genome are favored targets for MLV integration
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Genome-wide Insertional mutagenesis of Arabidopsis thaliana
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Williams DA; Baum C
Gene therapy - New challenges ahead
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Hacein-Bey-Abina S; Von Kalle C; Schmidt M; McCcormack MP; Wulffraat N; et al.
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
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Cereseto A; Giacca M
Integration site selection by retroviruses
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Early stages of HIV replication: How to hijack cellular functions for a successful infection
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Genetic control of retrovirus susceptibility in mammalian cells
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Integration of adeno-associated virus (AAV) and recombinant AAV vectors
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Pomerantz RJ
Ludwik Hirszfeld Memorial Lecture: HIV-1 reservoirs: major molecular obstacles to viral eradication
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HIV-1 integration sites are flanked by potential MARs that alone can act as promoters
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HIV-host interactions: vital to the virus and key to its inhibition (vol 7, pg 555, 2004)
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Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites
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